ZA976368B - High-affinity interleukin-4 muteins. - Google Patents

High-affinity interleukin-4 muteins.

Info

Publication number: ZA976368B
Authority: ZA; South Africa
Prior art keywords: muteins; affinity interleukin; interleukin; affinity
Prior art date: 1996-07-19

Application number

ZA9706368A

Other languages

English (en)

Inventor

Jeffrey Greve

Armen B Shanafelt

Steven Roczniak

Original Assignee

Bayer Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-19

Filing date

1997-07-18

Publication date

1998-02-19

1997-07-18 Application filed by Bayer Ag filed Critical Bayer Ag

1998-02-19 Publication of ZA976368B publication Critical patent/ZA976368B/xx

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
- G01N33/6869—Interleukin
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5406—IL-4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biomedical Technology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Zoology (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Cell Biology (AREA)
Biotechnology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Microbiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Physics & Mathematics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pathology (AREA)
Wood Science & Technology (AREA)
General Physics & Mathematics (AREA)
Gastroenterology & Hepatology (AREA)
Analytical Chemistry (AREA)
Food Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Plant Pathology (AREA)
Peptides Or Proteins (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

ZA9706368A 1996-07-19 1997-07-18 High-affinity interleukin-4 muteins. ZA976368B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US68780396A	1996-07-19	1996-07-19

Publications (1)

Publication Number	Publication Date
ZA976368B true ZA976368B (en)	1998-02-19

Family

ID=24761912

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA9706368A ZA976368B (en)	1996-07-19	1997-07-18	High-affinity interleukin-4 muteins.

Country Status (23)

Country	Link
EP (1)	EP0939817B1 (fr)
JP (1)	JP2000515016A (fr)
KR (1)	KR100468553B1 (fr)
CN (1)	CN1201006C (fr)
AR (2)	AR007917A1 (fr)
AT (1)	ATE310821T1 (fr)
AU (1)	AU718794B2 (fr)
BR (1)	BR9710733B1 (fr)
CA (1)	CA2259940C (fr)
DE (1)	DE69734723T2 (fr)
DK (1)	DK0939817T3 (fr)
ES (1)	ES2252786T3 (fr)
HU (1)	HU224973B1 (fr)
ID (1)	ID17491A (fr)
IL (2)	IL127934A0 (fr)
MY (1)	MY124565A (fr)
NZ (2)	NZ333748A (fr)
PL (1)	PL188738B1 (fr)
RU (1)	RU2202364C2 (fr)
TR (1)	TR199900100T2 (fr)
TW (1)	TW496871B (fr)
WO (1)	WO1998003654A2 (fr)
ZA (1)	ZA976368B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0911401A1 (fr) *	1997-10-21	1999-04-28	Bayer Ag	Muteines d'interleukine-4 ayant une faible affinité et une interaction de courte durée avec la chaíne gamma commune
EP1022339B1 (fr)	1999-01-20	2006-02-01	Bayer HealthCare AG	Plasmides, leur construction et utilisation pour la préparation d'Interleukine-4 et ses mutéines
EP1022337B1 (fr) *	1999-01-20	2006-07-26	Bayer HealthCare AG	Plasmides,leur construction et leur utilisation pour la préparation d'interleukine-4 et de mutéines d'interleukine-4
CN1306030C (zh) *	2001-09-28	2007-03-21	中山大学	一种人白细胞介素－10基因序列及含该基因序列的大肠杆菌
CA2512709A1 (fr) *	2003-01-17	2004-08-05	Children's Hospital Medical Center	Traitement des allergies a base de tff2 ou d'un agent l'induisant
US7404957B2 (en) *	2003-08-29	2008-07-29	Aerovance, Inc.	Modified IL-4 mutein receptor antagonists
US7785580B2 (en) *	2003-08-29	2010-08-31	Aerovance, Inc.	Modified IL-4 mutein receptor antagonists
RU2389796C2 (ru) *	2003-08-29	2010-05-20	Аэровэнс, Инк.	Модифицированный антагонист рецептора il-4 и предназначенный для его получения очищенный полинуклеотид
ES2357550T3 (es) *	2005-04-18	2011-04-27	Novo Nordisk A/S	Variantes de la il-21.
WO2017001568A1 (fr)	2015-07-01	2017-01-05	Universitat De Lleida	Traitement et prévention de la sclérose latérale amyotrophique
CN113227369B (zh) *	2018-12-19	2025-09-12	生物制药翻译学院德绍研究有限公司	具有改善的酶学特性的胰蛋白酶变体
CN113527485B (zh)	2020-04-17	2024-11-15	湖南麦济生物技术股份有限公司	抗人白细胞介素-4受体α抗体及其制备方法和应用
CN112442504B (zh) *	2020-12-10	2023-01-24	电子科技大学	一种重组草鱼白介素-12活性蛋白的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU620537B2 (en) *	1986-12-19	1992-02-20	Immunex Corporation	Human interleukin-4 muteins
DE4137333A1 (de) *	1991-11-13	1993-05-19	W Prof Dr Sebald	Therapeutische mittel, die antagonisten oder partielle agonisten des humanen interleukin 4 sind oder diese enthalten, hil-4-mutantenproteine sowie vefahren zu deren herstellung
WO1993021308A1 (fr) *	1992-04-17	1993-10-28	The University Hospital	Cytokines mutantes ayant une affinite d'un recepteur amelioree
NZ332790A (en) *	1996-06-14	2000-07-28	Bayer Ag	human interleukin-4 (IL-4) mutein having reduced endothelial cell activating activity for selectively activating T-cells

1997
- 1997-07-04 MY MYPI97003051A patent/MY124565A/en unknown
- 1997-07-09 IL IL12793497A patent/IL127934A0/xx not_active IP Right Cessation
- 1997-07-09 AU AU36545/97A patent/AU718794B2/en not_active Ceased
- 1997-07-09 NZ NZ333748A patent/NZ333748A/xx not_active IP Right Cessation
- 1997-07-09 TR TR1999/00100T patent/TR199900100T2/xx unknown
- 1997-07-09 JP JP10506976A patent/JP2000515016A/ja not_active Ceased
- 1997-07-09 HU HU0000248A patent/HU224973B1/hu not_active IP Right Cessation
- 1997-07-09 ES ES97933333T patent/ES2252786T3/es not_active Expired - Lifetime
- 1997-07-09 CN CNB971979596A patent/CN1201006C/zh not_active Expired - Fee Related
- 1997-07-09 PL PL97331253A patent/PL188738B1/pl not_active IP Right Cessation
- 1997-07-09 NZ NZ505238A patent/NZ505238A/en not_active IP Right Cessation
- 1997-07-09 EP EP97933333A patent/EP0939817B1/fr not_active Expired - Lifetime
- 1997-07-09 KR KR10-1999-7000371A patent/KR100468553B1/ko not_active Expired - Fee Related
- 1997-07-09 DE DE69734723T patent/DE69734723T2/de not_active Expired - Lifetime
- 1997-07-09 DK DK97933333T patent/DK0939817T3/da active
- 1997-07-09 BR BRPI9710733-6A patent/BR9710733B1/pt not_active IP Right Cessation
- 1997-07-09 RU RU99103688/14A patent/RU2202364C2/ru not_active IP Right Cessation
- 1997-07-09 CA CA002259940A patent/CA2259940C/fr not_active Expired - Fee Related
- 1997-07-09 WO PCT/US1997/011909 patent/WO1998003654A2/fr active IP Right Grant
- 1997-07-09 AT AT97933333T patent/ATE310821T1/de active
- 1997-07-15 TW TW086109934A patent/TW496871B/zh not_active IP Right Cessation
- 1997-07-18 AR ARP970103229A patent/AR007917A1/es active IP Right Grant
- 1997-07-18 ZA ZA9706368A patent/ZA976368B/xx unknown
- 1997-07-21 ID IDP972537A patent/ID17491A/id unknown
2007
- 2007-04-12 IL IL182509A patent/IL182509A/en not_active IP Right Cessation
- 2007-04-24 AR ARP070101757A patent/AR060630A2/es active IP Right Grant

Also Published As

Publication number	Publication date
CA2259940A1 (fr)	1998-01-29
JP2000515016A (ja)	2000-11-14
AR060630A2 (es)	2008-07-02
DE69734723D1 (de)	2005-12-29
AU3654597A (en)	1998-02-10
HUP0000248A2 (hu)	2000-06-28
PL331253A1 (en)	1999-07-05
BR9710733B1 (pt)	2012-02-22
IL182509A (en)	2011-03-31
ATE310821T1 (de)	2005-12-15
HU224973B1 (en)	2006-04-28
BR9710733A (pt)	1999-08-17
NZ505238A (en)	2001-06-29
AU718794B2 (en)	2000-04-20
WO1998003654A2 (fr)	1998-01-29
AR007917A1 (es)	1999-11-24
TR199900100T2 (xx)	1999-04-21
DE69734723T2 (de)	2006-06-22
CN1230223A (zh)	1999-09-29
HK1022717A1 (en)	2000-08-18
KR20000067914A (ko)	2000-11-25
WO1998003654A3 (fr)	1998-05-14
CN1201006C (zh)	2005-05-11
ID17491A (id)	1998-01-08
IL182509A0 (en)	2007-09-20
RU2202364C2 (ru)	2003-04-20
PL188738B1 (pl)	2005-04-29
ES2252786T3 (es)	2006-05-16
DK0939817T3 (da)	2006-01-23
HUP0000248A3 (en)	2003-09-29
EP0939817A2 (fr)	1999-09-08
KR100468553B1 (ko)	2005-01-29
EP0939817B1 (fr)	2005-11-23
TW496871B (en)	2002-08-01
CA2259940C (fr)	2008-09-23
MY124565A (en)	2006-06-30
NZ333748A (en)	2000-08-25
IL127934A0 (en)	1999-11-30

Publication	Publication Date	Title
GB2319523B (en)	2000-11-08	Hydroxyphenyltriazines
GB2317174B (en)	2000-05-17	Hydroxyphenyltriazines
ZA972685B (en)	1997-11-20	Medicaments.
GB9611947D0 (en)	1996-08-07	Medicaments
DE69723848D1 (en)	2003-09-04	3-descladinose-2,3-anhydroerythromycin-derivate
ZA976368B (en)	1998-02-19	High-affinity interleukin-4 muteins.
GB9618974D0 (en)	1996-10-23	Medicaments
GB2320563B (en)	2001-01-17	Ventilator
GB9605293D0 (en)	1996-05-15	Medicaments
IL125919A0 (en)	1999-04-11	Cytokine designated lerk-8
GB9611167D0 (en)	1996-07-31	Medicaments
HUP9901287A3 (en)	1999-11-29	Coin-checking arrangement
GB9619677D0 (en)	1996-11-06	Table
GB9613096D0 (en)	1996-08-28	Medicaments
ZA97533B (en)	1997-07-30	Table tennis table.
ZA971302B (en)	1997-09-03	Novel cytokine.
CA79134S (en)	1996-09-27	Table
CA79135S (en)	1996-09-27	Table
GB9611319D0 (en)	1996-08-07	Novel cytokine
AU128694S (en)	1996-11-22	Table
AU136858S (en)	1999-03-26	Table
PL104271U1 (en)	1997-09-01	Small at-the-bed table
GB9605305D0 (en)	1996-05-15	Medicaments
GB9605329D0 (en)	1996-05-15	Medicaments
GB9618975D0 (en)	1996-10-23	Medicaments