[go: up one dir, main page]

MX2020001873A - Agentes de union. - Google Patents

Agentes de union.

Info

Publication number
MX2020001873A
MX2020001873A MX2020001873A MX2020001873A MX2020001873A MX 2020001873 A MX2020001873 A MX 2020001873A MX 2020001873 A MX2020001873 A MX 2020001873A MX 2020001873 A MX2020001873 A MX 2020001873A MX 2020001873 A MX2020001873 A MX 2020001873A
Authority
MX
Mexico
Prior art keywords
antigen
binding portions
antibody molecules
binding
molecules
Prior art date
Application number
MX2020001873A
Other languages
English (en)
Inventor
William James Jonathan Finlay
Original Assignee
Ultrahuman Four Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1713298.6A external-priority patent/GB201713298D0/en
Priority claimed from GBGB1802595.7A external-priority patent/GB201802595D0/en
Priority claimed from GBGB1808570.4A external-priority patent/GB201808570D0/en
Application filed by Ultrahuman Four Ltd filed Critical Ultrahuman Four Ltd
Publication of MX2020001873A publication Critical patent/MX2020001873A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A61K39/001102—Receptors, cell surface antigens or cell surface determinants
    • A61K39/001129—Molecules with a "CD" designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epoxy Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención se refiere a moléculas de anticuerpo y porciones de unión al antígeno de la mismas que se unen específicamente a CD47 (Clúster de Diferenciación 47, también conocido como proteína asociada a integrina [IAP]). En aspectos de la invención, las moléculas de anticuerpo anti-CD47 y las porciones de unión al antígeno de la mismas se unen específicamente a CD47 humana y CD47 de mono cinomolgo. Se describen los usos médicos de las moléculas de anticuerpo anti??CD47 y las porciones de unión al antígeno de la invención. Las moléculas de anticuerpo anti-CD47 y las porciones de unión al antígeno de la invención representan moléculas de unión modificadas y optimizadas en comparación con un anticuerpo anti-CD47 de murino/humanizado VxP037 descrito en W02014/093678A2.
MX2020001873A 2017-08-18 2018-08-17 Agentes de union. MX2020001873A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB1713298.6A GB201713298D0 (en) 2017-08-18 2017-08-18 Binding agents
GBGB1802595.7A GB201802595D0 (en) 2018-02-16 2018-02-16 Binding agents
GBGB1808570.4A GB201808570D0 (en) 2018-05-24 2018-05-24 Binding agents
PCT/GB2018/052347 WO2019034895A1 (en) 2017-08-18 2018-08-17 LIAISON AGENTS

Publications (1)

Publication Number Publication Date
MX2020001873A true MX2020001873A (es) 2020-10-22

Family

ID=63371721

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020001873A MX2020001873A (es) 2017-08-18 2018-08-17 Agentes de union.

Country Status (14)

Country Link
US (4) US10683350B2 (es)
EP (2) EP3668897B1 (es)
JP (3) JP7256580B2 (es)
KR (1) KR102781208B1 (es)
CN (1) CN111212852A (es)
AU (2) AU2018316742B2 (es)
BR (1) BR112020003306A2 (es)
CA (1) CA3072998A1 (es)
ES (1) ES2983651T3 (es)
IL (1) IL272643A (es)
MX (1) MX2020001873A (es)
RU (1) RU2020109544A (es)
SG (1) SG11202001425TA (es)
WO (1) WO2019034895A1 (es)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102781208B1 (ko) 2017-08-18 2025-03-17 센테사 파마슈티칼스 (유케이) 리미티드 결합제
GB201804860D0 (en) 2018-03-27 2018-05-09 Ultrahuman Two Ltd CD47 Binding agents
GB201906685D0 (en) 2019-05-13 2019-06-26 Ultrahuman Six Ltd Activatable protein constructs and uses thereof
PH12021553197A1 (en) 2019-06-19 2022-11-07 Lepu Biopharma Co Ltd Anti-cd47 antibodies and uses thereof
US11795210B2 (en) 2019-07-16 2023-10-24 Gilead Sciences, Inc. HIV vaccines and methods of making and using
EP4034171A1 (en) * 2019-09-23 2022-08-03 Cytomx Therapeutics Inc. Anti-cd47 antibodies, activatable anti-cd47 antibodies, and methods of use thereof
CA3208912A1 (en) 2019-10-18 2021-04-22 Forty Seven, Inc. Combination therapies for treating myelodysplastic syndromes and acute myeloid leukemia
NZ786589A (en) 2019-10-31 2025-03-28 Forty Seven Llc Anti-cd47 and anti-cd20 based treatment of blood cancer
PT4081305T (pt) 2019-12-24 2024-12-04 Gilead Sciences Inc Compostos moduladores da diacilglicerol quinase
WO2021142331A1 (en) * 2020-01-10 2021-07-15 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for modulation of genes associated with cardiac muscle disease
WO2021142269A1 (en) * 2020-01-10 2021-07-15 Dyne Therapeutics, Inc. Muscle targeting complexes and uses thereof for modulation of genes associated with muscle atrophy
CN117964757A (zh) 2020-02-14 2024-05-03 吉利德科学公司 与ccr8结合的抗体和融合蛋白及其用途
WO2021191870A1 (en) 2020-03-27 2021-09-30 Dcprime B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
JP2023531537A (ja) 2020-06-30 2023-07-24 メンドゥス・ベスローテン・フェンノートシャップ 卵巣癌ワクチンでの白血病由来細胞の使用
CN111733162A (zh) * 2020-07-01 2020-10-02 江苏莱森生物科技研究院有限公司 一种经基因修饰的cd47蛋白及其单克隆抗体和应用
WO2022007947A1 (zh) * 2020-07-10 2022-01-13 信达生物制药(苏州)有限公司 抗cd47抗体或其抗原结合片段和dna甲基化转移酶抑制剂的组合及其用途
KR102757518B1 (ko) * 2020-12-07 2025-01-21 (주)이노베이션바이오 Cd47에 특이적인 항체 및 이의 용도
WO2022140659A2 (en) 2020-12-23 2022-06-30 D-10 Therapeutics, Inc. Anti-cd47 antibodies and uses thereof
EP4304633A1 (en) 2021-03-12 2024-01-17 Mendus B.V. Methods of vaccination and use of cd47 blockade
CN112794903B (zh) * 2021-04-14 2021-06-25 广州市雷德生物科技有限公司 一种特异性结合IFN-γ的抗体及其应用
TW202302145A (zh) 2021-04-14 2023-01-16 美商基利科學股份有限公司 ＣＤ４７／ＳＩＲＰα結合及ＮＥＤＤ８活化酶Ｅ１調節次單元之共抑制以用於治療癌症
EP4359413A1 (en) 2021-06-23 2024-05-01 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
CA3222439A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
WO2022271677A1 (en) 2021-06-23 2022-12-29 Gilead Sciences, Inc. Diacylglyercol kinase modulating compounds
KR20240023629A (ko) 2021-06-23 2024-02-22 길리애드 사이언시즈, 인코포레이티드 디아실글리세롤 키나제 조절 화합물
JP2024527335A (ja) * 2021-06-30 2024-07-24 イノベイション バイオ カンパニー リミテッド Ｃｄ４７に特異的なヒト化抗体およびそれを含むｃｄ４７関連疾患の予防または治療用医薬組成物
WO2023070353A1 (en) * 2021-10-27 2023-05-04 Adagene Pte. Ltd. Anti-cd47 antibodies and methods of use thereof
US20230183216A1 (en) 2021-10-28 2023-06-15 Gilead Sciences, Inc. Pyridizin-3(2h)-one derivatives
PE20241186A1 (es) 2021-10-29 2024-06-03 Gilead Sciences Inc Compuestos de cd73
KR20240123836A (ko) 2021-12-22 2024-08-14 길리애드 사이언시즈, 인코포레이티드 이카로스 아연 핑거 패밀리 분해제 및 이의 용도
US12122764B2 (en) 2021-12-22 2024-10-22 Gilead Sciences, Inc. IKAROS zinc finger family degraders and uses thereof
TW202340168A (zh) 2022-01-28 2023-10-16 美商基利科學股份有限公司 Ｐａｒｐ７抑制劑
JP2025504955A (ja) 2022-01-31 2025-02-19 センテッサ ファーマシューティカルズ （ユーケー） リミテッド 活性化可能な二重特異的抗ｃｄ４７および抗ｐｄ－ｌ１タンパク質ならびにその使用
JP2025509610A (ja) 2022-03-17 2025-04-11 ギリアード サイエンシーズ， インコーポレイテッド Ｉｋａｒｏｓジンクフィンガーファミリー分解剤及びその使用
EP4499146A1 (en) 2022-03-24 2025-02-05 Gilead Sciences, Inc. Combination therapy for treating trop-2 expressing cancers
WO2023191117A1 (ko) * 2022-03-28 2023-10-05 (주)이노베이션바이오 친화도가 성숙된 cd47에 특이적인 인간화 항체
TWI876305B (zh) 2022-04-05 2025-03-11 美商基利科學股份有限公司 用於治療結腸直腸癌之組合療法
WO2023205719A1 (en) 2022-04-21 2023-10-26 Gilead Sciences, Inc. Kras g12d modulating compounds
IL317958A (en) 2022-07-01 2025-02-01 Gilead Sciences Inc CD73 compounds
WO2024015741A1 (en) 2022-07-12 2024-01-18 Gilead Sciences, Inc. Hiv immunogenic polypeptides and vaccines and uses thereof
WO2024064668A1 (en) 2022-09-21 2024-03-28 Gilead Sciences, Inc. FOCAL IONIZING RADIATION AND CD47/SIRPα DISRUPTION ANTICANCER COMBINATION THERAPY
US20240254118A1 (en) 2022-12-22 2024-08-01 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2024215754A1 (en) 2023-04-11 2024-10-17 Gilead Sciences, Inc. Kras modulating compounds
WO2024220917A1 (en) 2023-04-21 2024-10-24 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
US20250042922A1 (en) 2023-06-30 2025-02-06 Gilead Sciences, Inc. Kras modulating compounds
WO2025024663A1 (en) 2023-07-26 2025-01-30 Gilead Sciences, Inc. Parp7 inhibitors
US20250100998A1 (en) 2023-07-26 2025-03-27 Gilead Sciences, Inc. Parp7 inhibitors
WO2025054530A1 (en) 2023-09-08 2025-03-13 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
US20250101042A1 (en) 2023-09-08 2025-03-27 Gilead Sciences, Inc. Kras g12d modulating compounds
WO2025096589A1 (en) 2023-11-03 2025-05-08 Gilead Sciences, Inc. Prmt5 inhibitors and uses thereof
WO2025137640A1 (en) 2023-12-22 2025-06-26 Gilead Sciences, Inc. Azaspiro wrn inhibitors

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4637749B2 (ja) * 2003-11-11 2011-02-23 中外製薬株式会社 ヒト化抗ｃｄ４７抗体
DE102007001370A1 (de) * 2007-01-09 2008-07-10 Curevac Gmbh RNA-kodierte Antikörper
CN101231382B (zh) 2008-02-26 2010-09-01 上海激光等离子体研究所 用于啁啾脉冲放大的光谱调制整形装置
DK2569013T3 (da) 2010-05-14 2017-02-13 Univ Leland Stanford Junior Humaniserede og kimære monoklonale antistoffer til cd47
KR102338833B1 (ko) * 2012-02-06 2021-12-13 인히브릭스, 인크. Cd47 항체 및 그 사용 방법
US20140140989A1 (en) 2012-02-06 2014-05-22 Inhibrx Llc Non-Platelet Depleting and Non-Red Blood Cell Depleting CD47 Antibodies and Methods of Use Thereof
EP2931751B1 (en) 2012-12-12 2020-02-05 Arch Oncology, Inc. Therapeutic cd47 antibodies
US9221908B2 (en) * 2012-12-12 2015-12-29 Vasculox, Inc. Therapeutic CD47 antibodies
CA2967379A1 (en) * 2014-11-18 2016-05-26 Janssen Pharmaceutica Nv Cd47 antibodies, methods, and uses
HK1245154A1 (zh) * 2014-12-30 2018-08-24 细胞基因公司 抗cd47抗体及其用途
US10647756B2 (en) * 2015-05-18 2020-05-12 Pfizer Inc. Humanized antibodies
UA126146C2 (uk) * 2015-09-18 2022-08-25 Арч Онколоджі, Інк. Терапевтичне антитіло до cd47
US10927173B2 (en) * 2016-01-11 2021-02-23 Forty Seven, Inc. Humanized, mouse or chimeric anti-CD47 monoclonal antibodies
KR102781208B1 (ko) 2017-08-18 2025-03-17 센테사 파마슈티칼스 (유케이) 리미티드 결합제
GB201804860D0 (en) 2018-03-27 2018-05-09 Ultrahuman Two Ltd CD47 Binding agents

Also Published As

Publication number Publication date
JP2020531048A (ja) 2020-11-05
US10683350B2 (en) 2020-06-16
SG11202001425TA (en) 2020-03-30
US20200277375A1 (en) 2020-09-03
CN111212852A (zh) 2020-05-29
EP3668897A1 (en) 2020-06-24
AU2018316742B2 (en) 2025-04-10
KR102781208B1 (ko) 2025-03-17
BR112020003306A2 (pt) 2020-08-25
ES2983651T3 (es) 2024-10-24
JP7256580B2 (ja) 2023-04-12
EP4435008A2 (en) 2024-09-25
JP2023073339A (ja) 2023-05-25
AU2018316742A1 (en) 2020-03-19
US11370840B2 (en) 2022-06-28
KR20200038533A (ko) 2020-04-13
JP2025000787A (ja) 2025-01-07
US20190375840A1 (en) 2019-12-12
IL272643A (en) 2020-03-31
WO2019034895A1 (en) 2019-02-21
RU2020109544A (ru) 2021-09-20
US20250109202A1 (en) 2025-04-03
US20220332819A1 (en) 2022-10-20
AU2025204808A1 (en) 2025-07-17
CA3072998A1 (en) 2019-02-21
EP3668897B1 (en) 2024-06-05
JP7564274B2 (ja) 2024-10-08

Similar Documents

Publication Publication Date Title
MX2020001873A (es) Agentes de union.
NZ628528A (en) Optimization of antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof
PH12019500545A1 (en) Cd3 binding antibodies
MY190771A (en) Anti-pd-l1 antibodies and uses thereof
SG11201907321TA (en) Anti-gprc5d antibody and molecule comprising the antibody
SA519402358B1 (ar) Ccr7 مترافقات عقار جسم مضاد لـ
PH12019502087A1 (en) Anti-par2 antibodies and uses thereof
EP4374922A3 (en) Anti-c5 antibodies and uses thereof
GB201005064D0 (en) Biological products
NZ630610A (en) Tau peptides, anti-tau antibodies, and methods of use thereof
NZ739028A (en) Humanized or chimeric cd3 antibodies
HK1200468A1 (en) Anti-erbb3 antibodies and uses thereof
WO2008140493A3 (en) Anti-egfr family antibodies, bispecific anti-egfr family antibodies and methods of use thereof
WO2010017103A3 (en) Fully human anti-human nkg2d monoclonal antibodies
NZ595235A (en) Compositions and methods for increasing muscle growth
AU2012307816A8 (en) Anti-alphabeta TCR antibody
MX355268B (es) Anticuerpos de peptido beta amiloide anti-n3pglu y usos de los mismos.
WO2009048537A3 (en) Humanized antibody
WO2018031490A3 (en) Anti-ox40 binding proteins
WO2016130539A3 (en) Multi-specific antibodies with affinity for human a33 antigen and dota metal complex and uses thereof
NZ594682A (en) Fully human antibodies specific to cadm1
SG10201801219VA (en) Anti-HER2 Antibodies
MX381139B (es) Anticuerpo anti-notch4 humano.
MY202157A (en) Anti-pd-l1 antibody and use thereof
WO2018069871A3 (en) Anti-kras binding proteins