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MX341687B - "anticuerpos cd20 y su utilización". - Google Patents

"anticuerpos cd20 y su utilización".

Info

Publication number
MX341687B
MX341687B MX2012009352A MX2012009352A MX341687B MX 341687 B MX341687 B MX 341687B MX 2012009352 A MX2012009352 A MX 2012009352A MX 2012009352 A MX2012009352 A MX 2012009352A MX 341687 B MX341687 B MX 341687B
Authority
MX
Mexico
Prior art keywords
cells
cell
antibodies
found
lymphoid tissues
Prior art date
Application number
MX2012009352A
Other languages
English (en)
Other versions
MX2012009352A (es
Inventor
Deckert Jutta
Rui Lingyun
U Park Peter
Original Assignee
Immunogen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Immunogen Inc filed Critical Immunogen Inc
Publication of MX2012009352A publication Critical patent/MX2012009352A/es
Publication of MX341687B publication Critical patent/MX341687B/es

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    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/68Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407Specifically defined cancers
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Abstract

La presente invención se refiere a un anticuerpo o un fragmento que se une a un antígeno del mismo que se une de manera específica a un CD20, que se caracteriza porque dicho anticuerpo o fragmento, comprende una región variable de cadena liviana y una región variable de cadena pesada, en donde el CDR-L1, CDR-L2 y CDR-L3 de la región variable de cadena liviana comprende las secuencias de aminoácidos con Nos. de ID de SEQ: 17-19, respectivamente, y en donde el CDR-H1, CDR-H2 y CDR-H3 de la región variable de cadena pesada comprende las secuencias de aminoácidos con Nos. de ID de SEQ: 20-22, respectivamente.
MX2012009352A 2010-02-10 2011-02-10 "anticuerpos cd20 y su utilización". MX341687B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30324910P 2010-02-10 2010-02-10
US40646410P 2010-10-25 2010-10-25
PCT/US2011/024312 WO2011100403A1 (en) 2010-02-10 2011-02-10 Cd20 antibodies and uses thereof

Publications (2)

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MX2012009352A MX2012009352A (es) 2012-10-01
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