[go: up one dir, main page]

NO20016116L - Substituerte heterocykelfuserte <gamma>-karboliner - Google Patents

Substituerte heterocykelfuserte <gamma>-karboliner

Info

Publication number
NO20016116L
NO20016116L NO20016116A NO20016116A NO20016116L NO 20016116 L NO20016116 L NO 20016116L NO 20016116 A NO20016116 A NO 20016116A NO 20016116 A NO20016116 A NO 20016116A NO 20016116 L NO20016116 L NO 20016116L
Authority
NO
Norway
Prior art keywords
carbolines
gamma
fused
substituted heterocycle
heterocycle
Prior art date
Application number
NO20016116A
Other languages
English (en)
Norwegian (no)
Other versions
NO20016116D0 (no
Inventor
Albert J Robichaud
Taekyu Lee
Wei Deng
Ian S Mitchell
Michael Guang Yang
Simon Haydar
Wenting Chen
Christopher D Mcclung
Emilie J B Calvello
David M Zawrotny
Original Assignee
Bristol Myers Squibb Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Pharma Co filed Critical Bristol Myers Squibb Pharma Co
Publication of NO20016116D0 publication Critical patent/NO20016116D0/no
Publication of NO20016116L publication Critical patent/NO20016116L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/18—Ring systems of four or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/32—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
NO20016116A 1999-06-15 2001-12-14 Substituerte heterocykelfuserte <gamma>-karboliner NO20016116L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13932199P 1999-06-15 1999-06-15
PCT/US2000/016498 WO2000077002A1 (fr) 1999-06-15 2000-06-15 Gamma-carbolines fusionnees a heterocycle substitue

Publications (2)

Publication Number Publication Date
NO20016116D0 NO20016116D0 (no) 2001-12-14
NO20016116L true NO20016116L (no) 2002-02-11

Family

ID=22486095

Family Applications (3)

Application Number Title Priority Date Filing Date
NO20016116A NO20016116L (no) 1999-06-15 2001-12-14 Substituerte heterocykelfuserte <gamma>-karboliner
NO20016115A NO20016115L (no) 1999-06-15 2001-12-14 Substituerte heterosykelkondenserte gamma-karbolin
NO20016128A NO20016128L (no) 1999-06-15 2001-12-14 Substituerte, heterocykliske, fuserte <gamma>-karboliner

Family Applications After (2)

Application Number Title Priority Date Filing Date
NO20016115A NO20016115L (no) 1999-06-15 2001-12-14 Substituerte heterosykelkondenserte gamma-karbolin
NO20016128A NO20016128L (no) 1999-06-15 2001-12-14 Substituerte, heterocykliske, fuserte <gamma>-karboliner

Country Status (19)

Country Link
US (7) US6552017B1 (fr)
EP (3) EP1189904B1 (fr)
JP (3) JP4762465B2 (fr)
CN (3) CN1370169A (fr)
AR (3) AR024379A1 (fr)
AT (3) ATE277928T1 (fr)
AU (3) AU5615900A (fr)
BR (3) BR0012084A (fr)
CA (3) CA2374239A1 (fr)
DE (3) DE60014370T2 (fr)
ES (3) ES2228549T3 (fr)
HK (3) HK1042480A1 (fr)
IL (3) IL147109A0 (fr)
MX (3) MXPA01012914A (fr)
NO (3) NO20016116L (fr)
NZ (1) NZ516031A (fr)
TR (1) TR200103658T2 (fr)
WO (3) WO2000077001A1 (fr)
ZA (1) ZA200109735B (fr)

Families Citing this family (164)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407092B1 (en) 1999-04-23 2002-06-18 Pharmacia & Upjohn Company Tetracyclic azepinoindole compounds
ATE277928T1 (de) * 1999-06-15 2004-10-15 Bristol Myers Squibb Pharma Co Substituierte heterocyclylkondensierte gamma carboline
EP1319004A2 (fr) 2000-09-20 2003-06-18 PHARMACIA &amp; UPJOHN COMPANY Derives d'azepino 4,5b]indol substitues
AR031202A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Ciclopenta(b) (1,4)diazepino(6,7,1-hi) indoles y derivados
AR031200A1 (es) 2000-11-03 2003-09-10 Wyeth Corp Cicloocta [b] [1,4] diazepino [6,7,1-hi] indoles y derivados
US6858604B2 (en) 2000-11-03 2005-02-22 Wyeth Cyclohepta[b][1,4]diazepino[6,7,1-hi]indoles and derivatives
DK1337518T3 (da) 2000-11-20 2009-10-19 Biovitrum Ab Publ Piperazinylpyrazinforbindelser som antagonister for serotonin-5-HT2-receptoren
SE0004245D0 (sv) 2000-11-20 2000-11-20 Pharmacia Ab Novel compounds and their use
US6849619B2 (en) 2000-12-20 2005-02-01 Bristol-Myers Squibb Company Substituted pyridoindoles as serotonin agonists and antagonists
EP1343791A2 (fr) 2000-12-20 2003-09-17 Bristol-Myers Squibb Company Pyridoindoles substitues en tant qu'agonistes et antagonistes de serotonine
EP1392658A4 (fr) * 2001-06-01 2004-10-13 Alcon Inc Indazoles et indoles nouveaux fusionnes et leur utilisation dans le traitement de glaucomes
PL366636A1 (en) * 2001-06-01 2005-02-07 Alcon, Inc. Pyranoindazoles and their use for the treatment of glaucoma
MXPA03010806A (es) * 2001-06-01 2004-11-22 Alcon Inc Nuevos analogos de arilaminopropano y su uso para el tratamiento de glaucoma.
WO2003014125A1 (fr) * 2001-08-06 2003-02-20 Pharmacia & Upjohn Company Ligands tetracycliques a application therapeutique
US20030060462A1 (en) * 2001-08-06 2003-03-27 Hoffman Robert L. Therapeutic compounds
US6887868B2 (en) 2001-09-21 2005-05-03 Pharmacia & Upjohn Company Therapeutic 5-HT ligand compounds
JP2005508969A (ja) 2001-10-18 2005-04-07 ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー ５−ｈｔ活性を有するテトラサイクリックアザインドールおよびインドリン
TW200307682A (en) 2002-04-25 2003-12-16 Wyeth Corp 1,2,3,4,7,8-Hexahydro-6H-[1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
TW200307540A (en) 2002-04-25 2003-12-16 Wyeth Corp [1, 4]Diazocino[7, 8, 1-hi] indole derivatives as antipsychotic and antiobesity agents
TWI312781B (en) 2002-04-25 2009-08-01 [1,4]diazepino[6,7,1-ij]quinoline derivatives as antipsychotic and antiobesity agents
EA008148B1 (ru) 2002-06-19 2007-04-27 Биовитрум Аб Новые соединения, их применение и получение
US6958420B2 (en) * 2002-07-19 2005-10-25 Board Of Trustees Of Michigan State University Synthesis of aminoarylboronic esters and substituted anilines from arenes via catalytic C-H activation/borylation/amination and uses thereof
MXPA05002259A (es) * 2002-08-30 2005-07-05 Alcon Inc Compuestos de 5-croman-5-il-etilamina sustituidos y uso para el tratamiento de glaucoma.
BR0316775A (pt) 2002-12-13 2005-11-01 Alcon Inc Novos análogos de benzopirano e seu uso para o tratamento de glaucoma
AU2003303210A1 (en) 2002-12-19 2004-07-14 Bristol-Myers Squibb Company Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists
CL2004000826A1 (es) 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
US7371759B2 (en) 2003-09-25 2008-05-13 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7728155B2 (en) 2003-10-24 2010-06-01 Wyeth Llc Dihydrobenzofuranyl alkanamines and methods for using same as cns agents
US7435837B2 (en) 2003-10-24 2008-10-14 Wyeth Dihydrobenzofuranyl alkanamine derivatives and methods for using same
US7420059B2 (en) 2003-11-20 2008-09-02 Bristol-Myers Squibb Company HMG-CoA reductase inhibitors and method
US7476687B2 (en) 2003-11-26 2009-01-13 Alcon, Inc. Substituted furo[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
US6989445B2 (en) 2003-12-15 2006-01-24 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
US7767689B2 (en) * 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
MXPA06010543A (es) 2004-03-15 2007-03-26 Ptc Therapeutics Inc Derivados de carbolina utiles en la inhibicion de la angiogenesis.
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
MXPA06014565A (es) 2004-06-18 2007-03-23 Wyeth Corp Procesos para preparar 6-alquil-5-arilsulfonil-dihidrofenantridinas.
EP2248524A3 (fr) 2004-08-25 2011-03-09 Takeda Pharmaceutical Company Limited Agents preventifs/remedes pour l'incontinence de stress et procede de selecetion de ceux-ci
GT200500317A (es) 2004-11-05 2006-10-27 Proceso para preparar compuestos de quinolina y productos obtenidos de los mismos
WO2006062839A1 (fr) 2004-12-08 2006-06-15 Alcon, Inc. Utilisation de dioxindoindazoles et de dioxoloindazoles pour traiter le glaucome
AR054849A1 (es) 2005-07-26 2007-07-18 Wyeth Corp Diazepinoquinolinas, sintesis de las mismas, e intermediarios para obtenerlas
BRPI0707183A2 (pt) * 2006-01-19 2011-04-26 Athersys Inc composto, composição farmacêutica, e, método de tratar uma doença, distúrbio e/ou condição em um paciente
WO2007132841A1 (fr) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited Composé hétérocyclique fusionné et utilisation
EP2061767B1 (fr) 2006-08-08 2014-12-17 Sanofi Imidazolidin-2,4-diones arylaminoaryl-alkyl-substituées, procédé de fabrication, médicaments les contenant et leur utilisation
KR102065319B1 (ko) 2007-03-12 2020-01-10 인트라-셀룰라 써래피스, 인코퍼레이티드. 치환된 헤테로환 융합 감마-카르볼린 합성
JP5546451B2 (ja) 2007-06-04 2014-07-09 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2216023A4 (fr) 2007-11-15 2013-03-13 Takeda Pharmaceutical Dérivé de pyridine condensé et son utilisation
CA2727055C (fr) 2008-01-11 2016-12-20 Albany Molecular Research, Inc. Pyridoindoles (1-azinone)-substitues en tant qu'antagonistes mch
MX2010010024A (es) 2008-03-12 2010-11-09 Intra Cellular Therapies Inc Solido de gamma-carbolinas fusionadas con heterociclos substituidos.
AU2015218433B2 (en) * 2008-05-27 2017-07-27 Intra-Cellular Therapies, Inc. Methods and compositions for sleep disorders and other disorders
CN102105059B (zh) * 2008-05-27 2015-09-30 细胞内治疗公司 用于睡眠障碍和其他疾病的方法和组合物
ES2627848T3 (es) 2008-06-04 2017-07-31 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AR072707A1 (es) 2008-07-09 2010-09-15 Sanofi Aventis Compuestos heterociclicos, procesos para su preparacion, medicamentos que comprenden estos compuestos y el uso de los mismos
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
US9107696B2 (en) * 2008-08-06 2015-08-18 Emory University Method of embryo transfer that eliminates transferred air while hormonally inducing implantation and apparatus
US9625475B2 (en) * 2008-09-29 2017-04-18 Abbvie Inc. Indole and indoline derivatives and methods of use thereof
US9063126B2 (en) * 2008-09-29 2015-06-23 Abbvie Inc. Indole and indoline derivatives and methods of use thereof
WO2010068601A1 (fr) 2008-12-08 2010-06-17 Sanofi-Aventis Hydrate de fluoroglycoside hétéroaromatique cristallin, ses procédés de fabrication, ses procédés d'utilisation et compositions pharmaceutiques le contenant
US9073925B2 (en) * 2009-07-01 2015-07-07 Albany Molecular Research, Inc. Azinone-substituted azabicycloalkane-indole and azabicycloalkane-pyrrolo-pyridine MCH-1 antagonists, methods of making, and use thereof
JP2012532144A (ja) * 2009-07-01 2012-12-13 アルバニー モレキュラー リサーチ， インコーポレイテッド アジノン置換アゼピノ［ｂ］インドールおよびピリド−ピロロ−アゼピンｍｃｈ−１拮抗薬、ならびにその作製方法および使用
WO2011003007A1 (fr) * 2009-07-01 2011-01-06 Albany Molecular Research, Inc. Antagonistes de mch-1 d’azabicycloalcane-indole et d’azabicycloalcane-pyrrolo-pyridine, procédés de préparation, et utilisation de ceux-ci
US8618299B2 (en) * 2009-07-01 2013-12-31 Albany Molecular Research, Inc. Azinone-substituted azapolycycle MCH-1 antagonists, methods of making, and use thereof
CN102510862A (zh) 2009-07-14 2012-06-20 阿尔巴尼分子研究公司 5-ht3受体调节剂、其制备方法和用途
US8785608B2 (en) 2009-08-26 2014-07-22 Sanofi Crystalline heteroaromatic fluoroglycoside hydrates, pharmaceuticals comprising these compounds and their use
WO2011044134A1 (fr) 2009-10-05 2011-04-14 Albany Molecular Research, Inc. Dérivés d'épiminocycloalkyl(b)indole utilisés en tant que modulateurs du récepteur de la sérotonine de sous-type 6 (5-ht6) et leurs utilisations
WO2011071136A1 (fr) 2009-12-11 2011-06-16 アステラス製薬株式会社 Agent thérapeutique pour la fibromyalgie
US9193728B2 (en) * 2010-02-18 2015-11-24 Medivation Technologies, Inc. Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
WO2011103433A1 (fr) 2010-02-18 2011-08-25 Medivation Technologies, Inc. Pyrido[4,3-b]indole et dérivés de pyrido[3,4-b]indole et procédés d'utilisation
WO2011103485A1 (fr) 2010-02-18 2011-08-25 Medivation Technologies, Inc. Dérivés de pyrido[4,3-b]indole et de pyrido[3,4-b]indole tétracycliques condensés et leurs procédés d'utilisation
JP5894574B2 (ja) * 2010-04-22 2016-03-30 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
WO2012030953A1 (fr) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. Agonistes du récepteur 5-ht2c dans traitement de troubles améliorés par réduction du taux de noradrénaline
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US8993765B2 (en) 2010-12-21 2015-03-31 Albany Molecular Research, Inc. Tetrahydro-azacarboline MCH-1 antagonists, methods of making, and uses thereof
WO2012088038A2 (fr) 2010-12-21 2012-06-28 Albany Molecular Research, Inc. Antagonistes de mch-1 consistant en tétrahydro-carbolines substituées par pipérazinone, leurs procédés de fabrication et utilisations
US9067949B2 (en) 2011-01-19 2015-06-30 Albany Molecular Research, Inc. Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
WO2012112961A1 (fr) 2011-02-18 2012-08-23 Medivation Technologies, Inc. Composés et procédés de traitement de l'hypertension
EA201391254A1 (ru) 2011-03-01 2014-02-28 Синерджи Фармасьютикалз Инк. Способ получения агонистов гуанилатциклазы c
EP2683704B1 (fr) 2011-03-08 2014-12-17 Sanofi Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation
US8809324B2 (en) 2011-03-08 2014-08-19 Sanofi Substituted phenyl-oxathiazine derivatives, method for producing them, drugs containing said compounds and the use thereof
EP2683703B1 (fr) 2011-03-08 2015-05-27 Sanofi Nouveaux dérivés phényl-oxathiazine substitués, procédé pour leur préparation, agent pharmaceutique contenant ces composés et leur utilisation
US8710050B2 (en) 2011-03-08 2014-04-29 Sanofi Di and tri- substituted oxathiazine derivatives, method for the production, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120052A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des carbocycles ou des hétérocycles, leur procédé de préparation, médicaments contenant ces composés et leur utilisation
WO2012120056A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine tétra-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
WO2012120051A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés benzyl-oxathiazine substitués avec adamantane ou noradamantane, médicaments contenant ces composés et leur utilisation
WO2012120058A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés d'oxathiazine substitués par des groupes benzyle ou hétérométhylène, leur procédé de production, leur utilisation comme médicament ainsi que produits pharmaceutiques les contenant et leur utilisation
WO2012120054A1 (fr) 2011-03-08 2012-09-13 Sanofi Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation
EP2567959B1 (fr) 2011-09-12 2014-04-16 Sanofi Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase
US11053245B2 (en) * 2012-04-14 2021-07-06 Intra-Cellular Therapies, Inc. Methods
EP2919788A4 (fr) 2012-11-14 2016-05-25 Univ Johns Hopkins Méthodes et compositions pour le traitement de la schizophrénie
US9822117B2 (en) * 2013-03-04 2017-11-21 Daya Drug Discoveries, Inc. Pyridoindolobenz[b,d]azepine derivatives and uses thereof
ES2846823T3 (es) 2013-03-15 2021-07-29 Intra Cellular Therapies Inc Compuestos orgánicos
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
PL3004138T3 (pl) 2013-06-05 2024-07-29 Bausch Health Ireland Limited Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie
WO2015066344A1 (fr) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. Agonistes du récepteur 5-ht2c et compositions et procédés d'utilisation
CA3205777A1 (en) 2013-12-03 2015-06-11 Intra-Cellular Therapies, Inc. Heterocycle fused gamma-carboline compounds for use in treatment of schizophrenia
CN106535898A (zh) 2014-04-04 2017-03-22 细胞内治疗公司 有机化合物
CN106456638A (zh) 2014-04-04 2017-02-22 细胞内治疗公司 有机化合物
US10646648B2 (en) 2015-04-01 2020-05-12 Becton, Dickinson And Company IV flow management systems and methods
EP3286172B1 (fr) 2015-04-23 2019-06-12 Constellation Pharmaceuticals, Inc. Inhibiteurs de lsd1 et leurs utilisations
EP3838274B1 (fr) * 2016-01-26 2023-11-01 Intra-Cellular Therapies, Inc. Dérivé de pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline pour son utilisation dans les traitements de troubles du snc
IL314312A (en) 2016-03-25 2024-09-01 Intra Cellular Therapies Inc A sustained-release or delayed-release pharmaceutical composition comprising a deuterated compound
EP3436083A4 (fr) 2016-03-28 2019-11-27 Intra-Cellular Therapies, Inc. Nouvelles compositions et méthodes
US10654854B2 (en) 2016-03-28 2020-05-19 Intra-Cellular Therapies, Inc. Salts and crystals of ITI-007
EP3436016B1 (fr) * 2016-03-28 2022-04-27 Intra-Cellular Therapies, Inc. Nouveaux co-cristaux
US12343337B2 (en) 2016-09-29 2025-07-01 The Regents Of The University Of California Compounds for increasing neural plasticity
JP7013454B2 (ja) 2016-10-12 2022-02-15 イントラ－セルラー・セラピーズ・インコーポレイテッド アモルファス固体分散体
JP7142633B2 (ja) 2016-10-26 2022-09-27 コンステレーション・ファーマシューティカルズ・インコーポレイテッド Ｌｓｄ１阻害剤およびその医学的使用
WO2018106916A1 (fr) * 2016-12-07 2018-06-14 Concert Pharmaceuticals, Inc. Composés de quinoxaline deutérés
WO2018126140A1 (fr) * 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Composés organiques
WO2018126143A1 (fr) * 2016-12-29 2018-07-05 Intra-Cellular Therapies, Inc. Composés organiques
MX395214B (es) 2017-03-24 2025-03-25 Intra Cellular Therapies Inc Composiciones novedosas y metodos
WO2018189646A1 (fr) 2017-04-10 2018-10-18 Dr. Reddy's Laboratories Limited Forme amorphe et dispersions solides de p-tosylate de lumateperone
BR112020001666A2 (pt) 2017-07-26 2020-07-21 Intra-Cellular Therapies, Inc. compostos orgânicos
AU2018307480B2 (en) 2017-07-26 2023-11-23 Intra-Cellular Therapies, Inc. Organic compounds
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
CN111107847A (zh) 2017-09-26 2020-05-05 细胞内治疗公司 新的盐和晶体
WO2019102240A1 (fr) * 2017-11-27 2019-05-31 Egis Gyógyszergyár Zrt. Procédé pour la fabrication de lumatépérone et de ses sels
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces
EP3765021A4 (fr) 2018-03-16 2022-03-09 Intra-Cellular Therapies, Inc. Nouveaux procédés
MX2020009929A (es) 2018-03-23 2021-01-08 Intra Cellular Therapies Inc Compuestos organicos.
CA3094949A1 (fr) 2018-03-23 2019-09-26 Intra-Cellular Therapies, Inc. Gamma-carbolines fusionnees a heterocycles deuteres
CN112384218B (zh) 2018-06-06 2024-04-26 细胞内治疗公司 盐和晶体
ES3028377T3 (en) 2018-06-08 2025-06-19 Intra Cellular Therapies Inc Fused gamma-carbolines for acute treatment of anxiety or depression
EP3609891A4 (fr) 2018-06-11 2021-04-14 Intra-Cellular Therapies, Inc. Synthèse de gamma-carbolines fusionnées à hétérocycles substitués
US11806311B2 (en) 2018-06-21 2023-11-07 Aquestive Therapeutics, Inc. System and method for making personalized individual unit doses containing pharmaceutical actives
CN109100437A (zh) * 2018-07-22 2018-12-28 邯郸学院 仲胺类抗抑郁药物的质谱检测方法
WO2020023782A1 (fr) 2018-07-27 2020-01-30 Biotheryx, Inc. Composés bifonctionnels agissant par agonisme sur des cdk
EP3843729A4 (fr) 2018-08-29 2022-06-01 Intra-Cellular Therapies, Inc. Nouvelles compositions et méthodes
CN118873536A (zh) 2018-08-31 2024-11-01 细胞内治疗公司 新方法
WO2020047407A1 (fr) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Nouvelles méthodes
CN112955124A (zh) 2018-09-07 2021-06-11 阿奎蒂夫疗法公司 具有精确的活性物溶出谱的口腔膜组合物和剂型
WO2020112941A2 (fr) 2018-11-27 2020-06-04 Teva Czech Industries S.R.O Formes à l'état solide de sels de lumatépérone et procédés de préparation de lumatépérone et de ses sels
EP3898580A4 (fr) 2018-12-17 2022-08-10 Intra-Cellular Therapies, Inc. Synthèse de gamma-carbolines fusionnées à hétérocycles substitués
EP3898581B1 (fr) 2018-12-17 2025-08-27 Intra-Cellular Therapies, Inc. Synthèse de gamma-carbolines fusionnées à hétérocycles substitués
KR20210104785A (ko) * 2018-12-17 2021-08-25 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
US12195463B2 (en) 2018-12-21 2025-01-14 Intra-Cellular Therapies, Inc. Organic compounds
US12331052B2 (en) 2018-12-21 2025-06-17 Intra-Cellular Therapies, Inc. Organic compounds
WO2020154519A2 (fr) * 2019-01-23 2020-07-30 Intra-Cellular Therapies, Inc. Procédés de traitement de la dépendance
CN113784962B (zh) 2019-02-27 2025-04-25 加利福尼亚大学董事会 用于治疗脑部疾病的氮杂环庚三烯并-吲哚类和其他杂环
CN113905737A (zh) * 2019-04-04 2022-01-07 细胞内治疗公司 治疗神经性疼痛的方法
WO2021007245A1 (fr) 2019-07-07 2021-01-14 Intra-Cellular Therapies, Inc. Nouveaux procédés
AU2020373100A1 (en) 2019-11-01 2022-05-19 Aquestive Therapeutics, Inc. Prodrug compositions and methods of treatment
BR112022008784A2 (pt) 2019-11-14 2022-07-26 Aquestive Therapeutics Inc Composições multimodais e métodos de tratamento
JP7261942B2 (ja) * 2019-12-11 2023-04-20 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
US20210186962A1 (en) 2019-12-19 2021-06-24 Intra-Cellular Therapies, Inc. Methods of schizophrenia treatment
WO2021222150A2 (fr) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Polypeptides d'interleukine-2 et protéines de fusion de ceux-ci, ainsi que leurs compositions pharmaceutiques et leurs applications thérapeutiques
MX2023004102A (es) * 2020-10-09 2023-04-27 Shujing Biopharma Co Ltd Derivado de gamma-carbolina fusionado sustituido con heterociclo, metodo de preparacion del mismo, intermediarios del mismo y uso del mismo.
CN112062767B (zh) * 2020-10-20 2022-03-11 杭州科巢生物科技有限公司 一种卢美哌隆的制备方法及其中间体
CA3208345A1 (fr) 2021-01-15 2022-07-21 Aquestive Therapeutics, Inc. Compositions de promedicament et procedes de traitement
EP4304554A1 (fr) 2021-03-09 2024-01-17 Aquestive Therapeutics, Inc. Formes pharmaceutiques ayant des profils biocomparables équivalents
CA3239565A1 (fr) 2021-12-15 2023-06-22 Delix Therapeutics, Inc. Psychoplastogenes substitues par phenoxy et benzyloxy et leurs utilisations
JP2025502334A (ja) * 2022-01-14 2025-01-24 上海科技大学 縮合環式ピペリジン系化合物及びその調製方法と使用
CN114456149A (zh) * 2022-02-24 2022-05-10 中国科学技术大学 一种多巴胺drd2受体拮抗剂及其用途
JP2025509569A (ja) * 2022-03-14 2025-04-11 イントラ－セルラー・セラピーズ・インコーポレイテッド 有機化合物
CN119343348A (zh) * 2022-03-14 2025-01-21 细胞内治疗公司 有机化合物
JP2025521115A (ja) 2022-05-18 2025-07-08 イントラ－セルラー・セラピーズ・インコーポレイテッド 新規方法
US12414948B2 (en) 2022-05-18 2025-09-16 Intra-Cellular Therapies, Inc. Methods
KR20250123225A (ko) 2022-12-30 2025-08-14 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
WO2024173901A1 (fr) 2023-02-17 2024-08-22 Intra-Cellular Therapies, Inc. Lumatépérone et ses dérivés pour moduler le système nerveux
WO2025111568A1 (fr) 2023-11-22 2025-05-30 Intra-Cellular Therapies, Inc. Lumatépérone et analogues, modulateurs du récepteur 5-ht2a ou 5-ht2a/d2, destinés à être utilisés dans le traitement de troubles psychiatriques provoqués par l'encéphalite virale, bactérienne ou auto-immune, et de symptômes psychiatriques de ceux-ci
CN119930620A (zh) * 2024-02-05 2025-05-06 和径医药科技（上海）有限公司 四并环类化合物、其制备方法、药物组合物及应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3299078A (en) * 1962-10-01 1967-01-17 Smith Kline French Lab Pyrido [3', 4': 4, 5] pyrrolo [3, 2, 1-hi] indoles and-[3, 2, 1-ij] quinolines
US3813392A (en) * 1969-06-09 1974-05-28 J Sellstedt Pyrrolo(1,2,3-alpha epsilon)quinoxalin-2(3h)-ones and related compounds
US3892746A (en) * 1969-06-09 1975-07-01 American Home Prod Pyrrolo{8 1,2,3-de{9 quinoxalin-2(3H)-ones and related compounds
US3891643A (en) * 1972-05-15 1975-06-24 American Home Prod Pyrrolo{8 1,2,3-de{9 quinoxalin-2-(3H)-ones and related compounds
US4013652A (en) 1972-06-19 1977-03-22 Endo Laboratories, Inc. Pyridopyrrolobenzoxazine
US4115577A (en) 1972-06-19 1978-09-19 Endo Laboratories, Inc. Pyridopyrrolobenzheterocycles
US3914421A (en) 1972-06-19 1975-10-21 Endo Lab Pyridopyrrolobenzheterocycles for combatting depression
US4238607A (en) 1972-06-19 1980-12-09 Endo Laboratories Inc. Pyridopyrrolo benzheterocycles
US4183936A (en) 1972-06-19 1980-01-15 Endo Laboratories, Inc. Pyridopyrrolobenzheterocycles
JPS4949999A (fr) * 1973-06-19 1974-05-15
FR2213283A1 (en) 1973-11-15 1974-08-02 Inst Im Ordzhonikidze Pyrazino(1,2,3-ab)beta carbolines and homologues - antidepressants not acting by MAO inhibition
JPS569510B2 (fr) * 1973-11-17 1981-03-02
US4088647A (en) 1976-02-04 1978-05-09 Glushkov Robert Georgievich Pyrazino (1,2,3-ab)-β-carboline derivatives and salts thereof and method of preparing same
US4219550A (en) 1978-11-09 1980-08-26 E. I. Du Pont De Nemours And Company Cis- and trans- octahydropyridopyrrolobenzheterocycles
ATE136032T1 (de) 1987-07-20 1996-04-15 Duphar Int Res 8,9-anellierte 1,2,3,4-tetrahydro-beta-carbolin- derivate
US5328905A (en) 1987-07-20 1994-07-12 Duphar International Research B.V. 8,9-anellated-1,2,3,4-tetrahydro-β-carboline derivatives
EP0347980A1 (fr) * 1988-06-20 1989-12-27 Duphar International Research B.V B-carbolines, 8,9-cyclisées et B-carbolines, 3,4-dihydro, 8,9 cyclisées
US4997831A (en) 1988-09-01 1991-03-05 Glaxo Group Limited Lactam derivatives
EP0377238A1 (fr) * 1988-12-22 1990-07-11 Duphar International Research B.V Indolo(3,2-c)-lactames annelés
US5223625A (en) 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
CA2011107A1 (fr) 1990-02-28 1991-08-31 David E. Bays Derives de lactam
US5512575A (en) 1991-08-15 1996-04-30 Zeneca Limited Methanoanthraceneyl methyl piperidinyl compounds
EP0725068A4 (fr) 1993-10-20 1997-01-22 Tokyo Tanabe Co Derive d'indole
US5654139A (en) 1994-09-21 1997-08-05 The United States Of America As Represented By The Department Of Health And Human Services Allelic variation of the serotonin 5HT2c receptor
US5902815A (en) 1996-09-03 1999-05-11 Washington University Use of 5HT-2A serotonin agonists to prevent adverse effects of NMDA receptor hypofunction
US5908830A (en) 1996-10-31 1999-06-01 Merck & Co., Inc. Combination therapy for the treatment of diabetes and obesity
DE1071701T1 (de) 1998-04-14 2001-08-23 Arena Pharmaceuticals, Inc. Non-endogene, konstitutiv aktivierte humane serotonin-rezeptoren und kleine molekülmodulatoren davon
US6140509A (en) 1998-06-26 2000-10-31 Arena Pharmaceuticals, Inc. Non-endogenous, constitutively activated human serotonin receptors and small molecule modulators thereof
AR023574A1 (es) 1999-04-23 2002-09-04 Pharmacia & Upjohn Co Llc Compuestos de azepinindol tetraciclico,composiciones farmaceuticas y el uso de dichos compuestos para preparar un medicamento, e intermediarios
US6407092B1 (en) 1999-04-23 2002-06-18 Pharmacia & Upjohn Company Tetracyclic azepinoindole compounds
ATE277928T1 (de) * 1999-06-15 2004-10-15 Bristol Myers Squibb Pharma Co Substituierte heterocyclylkondensierte gamma carboline

Also Published As

Publication number Publication date
ATE277048T1 (de) 2004-10-15
AR024379A1 (es) 2002-10-02
AU5615900A (en) 2001-01-02
HK1042480A1 (zh) 2002-08-16
CA2381322A1 (fr) 2000-12-21
AR024377A1 (es) 2002-10-02
DE60014370T2 (de) 2006-02-09
TR200103658T2 (tr) 2002-06-21
DE60014083D1 (de) 2004-10-28
EP1192165A2 (fr) 2002-04-03
DE60014079T2 (de) 2006-03-02
US20040209864A1 (en) 2004-10-21
NO20016116D0 (no) 2001-12-14
DE60014079D1 (de) 2004-10-28
JP2003502331A (ja) 2003-01-21
BR0012411A (pt) 2002-04-16
US7238690B2 (en) 2007-07-03
US7081455B2 (en) 2006-07-25
US20060178362A1 (en) 2006-08-10
US6548493B1 (en) 2003-04-15
WO2000077010A3 (fr) 2001-06-28
MXPA01012970A (es) 2003-10-14
IL145998A0 (en) 2002-07-25
JP2003502330A (ja) 2003-01-21
JP2003502336A (ja) 2003-01-21
CN1370169A (zh) 2002-09-18
AR024378A1 (es) 2002-10-02
JP4916633B2 (ja) 2012-04-18
WO2000077001A1 (fr) 2000-12-21
EP1189904A1 (fr) 2002-03-27
CA2374239A1 (fr) 2000-12-21
MXPA01012914A (es) 2004-04-21
CN1371374A (zh) 2002-09-25
EP1192165B1 (fr) 2004-09-22
MXPA01012969A (es) 2003-10-14
AU5737900A (en) 2001-01-02
HK1043112A1 (zh) 2002-09-06
CN1370176A (zh) 2002-09-18
NO20016128L (no) 2002-02-11
ZA200109735B (en) 2004-01-27
BR0012086A (pt) 2002-04-02
BR0012084A (pt) 2002-04-02
NZ516031A (en) 2003-10-31
ATE277055T1 (de) 2004-10-15
DE60014083T2 (de) 2006-03-02
CA2373920A1 (fr) 2000-12-21
US6552017B1 (en) 2003-04-22
HK1042481A1 (zh) 2002-08-16
NO20016128D0 (no) 2001-12-14
WO2000077002A1 (fr) 2000-12-21
WO2000077010A2 (fr) 2000-12-21
US20040127482A1 (en) 2004-07-01
EP1189905A1 (fr) 2002-03-27
NO20016115L (no) 2002-02-12
EP1189905B1 (fr) 2004-09-29
ATE277928T1 (de) 2004-10-15
JP4863591B2 (ja) 2012-01-25
US20040034015A1 (en) 2004-02-19
USRE39680E1 (en) 2007-06-05
ES2228549T3 (es) 2005-04-16
EP1189904B1 (fr) 2004-09-22
DE60014370D1 (de) 2004-11-04
IL147108A0 (en) 2002-08-14
ES2223536T3 (es) 2005-03-01
IL147109A0 (en) 2002-08-14
JP4762465B2 (ja) 2011-08-31
NO20016115D0 (no) 2001-12-14
AU5738000A (en) 2001-01-02
ES2223537T3 (es) 2005-03-01

Similar Documents

Publication Publication Date Title
NO20016116L (no) Substituerte heterocykelfuserte &lt;gamma&gt;-karboliner
PT1224180E (pt) Azois substituidos
NO20025142L (no) PPAR-&lt;gamma&gt;-modulatorer
DE69932650D1 (de) Zementierkopf
NO20016334D0 (no) Boresystem
DE60037697D1 (de) Vermessungssystem
DZ3377A1 (fr) Azaindoles
DE50014679D1 (de) Substituierte indol-mannichbasen
ATE305470T1 (de) Naphthyridinverbindungen
DE60030631D1 (de) Vermessungssystem
DE50013404D1 (de) Substituierte 2-dialkylaminoalkylbiphenyl-derivate
NO20013997L (no) Reseptoranalyse
DE60024400D1 (de) Empfangsgerät
DE50011953D1 (de) Bohrwerkzeug
DE50004713D1 (de) Bohrgerät
DE50011611D1 (de) Bohrwerkzeug
DE60017700D1 (de) Bildgebungsverfahren
NO20022927L (no) Substituerte pyrrazoler
DE50011494D1 (de) Bohrwerkzeug
NO20021295L (no) Nikotinsyreacetylcholin-reseptor
DE50011100D1 (de) Bohrwerkzeug
DE19945322B8 (de) Spannfutter
ATE251154T1 (de) Substituierte phenyluracile
ID30507A (id) Diarilamina tersubstitusi 1-heterosiklus
UA3532S (uk) Лещата

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application