AR013360A1 - Derivados de 6-azauracilo inhibidores de il-5, procedimiento para su preparacion, composicion que los contiene, procedimiento para preparardicha composicion, uso de dicho compuesto para la manufactura de medicamentos, de composiciones y procedimiento de marcado de un receptor. - Google Patents
Derivados de 6-azauracilo inhibidores de il-5, procedimiento para su preparacion, composicion que los contiene, procedimiento para preparardicha composicion, uso de dicho compuesto para la manufactura de medicamentos, de composiciones y procedimiento de marcado de un receptor.Info
- Publication number
- AR013360A1 AR013360A1 ARP980103336A ARP980103336A AR013360A1 AR 013360 A1 AR013360 A1 AR 013360A1 AR P980103336 A ARP980103336 A AR P980103336A AR P980103336 A ARP980103336 A AR P980103336A AR 013360 A1 AR013360 A1 AR 013360A1
- Authority
- AR
- Argentina
- Prior art keywords
- 4alkyl
- procedure
- mono
- amino
- preparation
- Prior art date
Links
- SSPYSWLZOPCOLO-UHFFFAOYSA-N 6-azauracil Chemical class O=C1C=NNC(=O)N1 SSPYSWLZOPCOLO-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 3
- 239000000203 mixture Substances 0.000 title 3
- 108010002616 Interleukin-5 Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- -1 C1-6 C1-6alkyloxy Chemical group 0.000 abstract 11
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 4
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
- 125000001475 halogen functional group Chemical group 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 abstract 1
- 125000005947 C1-C6 alkylsulfonyloxy group Chemical group 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000004682 aminothiocarbonyl group Chemical group NC(=S)* 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 1
- 125000005110 aryl thio group Chemical group 0.000 abstract 1
- 125000004104 aryloxy group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000006684 polyhaloalkyl group Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Derivados de 6-azauracilo que comprenden la formula (I) al N-oxido, una sal de adicion farmacéuticamente aceptable o una forma estereoquímicamenteisomérica del mismo, donde: p representa un entero que es 0, 1, 2, 3 o 4; q representa un enteroque es 0, 1, 2, 3, 4 o 5; X representa O, S, NR3 o unenlace directo; R1 representa hidrogeno, hidroxi, halo, amino, mono- o di- (alquilo C1-4)amino, C1-6 alquiloxi C1-6, cicloalquilo C3-7, arilalquilo C1-6,amino alquilo C1-4, mono o di (alquiloC1-4)aminoalquilo C1-4 o mono- o di (alquilo C1-4)aminoalquilamino C1-4; R2 representa arilo, Het1, cicloalquiloC3-7, alquilo C1-6 o alquilo C1-6 substituido con uno o dos sustituyentes seleccionados de hidroxi, ciano, amino, mono- o di(alquilo C1-4)amino,alquiloxi C1-6, alquilsulfoniloxi C1-6, alquiloxicarbonilo C1-6, cicloalquilo C3-7, arilo, ariloxi, ariltio, Het1, Het1 oxi y Het1 tio; y si X es O, S oNR3, entonces R2 puede representar también aminocarbonilo, aminotiocarbonilo,alquilcarbonilo C1-4, arilcarbonilo o ariltiocarbonilo; R3 representahidrogeno o alquilo C1-4; cada R4 independientemente representa alquilo C1-6, halo, polihaloalquilo C1-6, hidroxi, mercapto alquiloxi C1-6, alquiltioC1-6, alquilcarboniloxi C1-6, arilo, ciano, nitro, Het3, R6, NR7R8 o alquilo C1-4 substituido con Het3, R6 o NR7R8; cada R5 independientemente representaalquilo C1-6, halo, polihaloalquilo C1-6, hidroxi, mercapto, alquiloxi C1-6, alquiltio C1-6, alquilcarboniloxi C1-6, arilo, ciano, nitro, Het3, R6, NR7R8o alquilo C1-4 substituido con Het3, R6 o NR7R8; cada R6 independientemente representa alquilsulfonilo C1-6, aminosulfonilo, mono- o di-(alquilo C1-4)aminosulfonilo mono- o di(bencilo)aminosulfonilo, polihalo C1-6 alquilsulfonilo , alquilsulfinilo C1-6, fenilo alquilsulfonilo C1-4, piperacinilsulfonilo,
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97202118 | 1997-07-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013360A1 true AR013360A1 (es) | 2000-12-27 |
Family
ID=8228531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980103336A AR013360A1 (es) | 1997-07-10 | 1998-07-08 | Derivados de 6-azauracilo inhibidores de il-5, procedimiento para su preparacion, composicion que los contiene, procedimiento para preparardicha composicion, uso de dicho compuesto para la manufactura de medicamentos, de composiciones y procedimiento de marcado de un receptor. |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1000040B1 (es) |
| JP (1) | JP2002511882A (es) |
| KR (1) | KR20010014049A (es) |
| CN (1) | CN1262679A (es) |
| AR (1) | AR013360A1 (es) |
| AT (1) | ATE364597T1 (es) |
| AU (1) | AU742145B2 (es) |
| BR (1) | BR9811678A (es) |
| CA (1) | CA2294145A1 (es) |
| DE (1) | DE69837922D1 (es) |
| EE (1) | EE200000016A (es) |
| HR (1) | HRP20000003A2 (es) |
| HU (1) | HUP0004687A3 (es) |
| ID (1) | ID24390A (es) |
| IL (1) | IL133916A0 (es) |
| NO (1) | NO20000063L (es) |
| NZ (1) | NZ502180A (es) |
| PL (1) | PL337947A1 (es) |
| SK (1) | SK183999A3 (es) |
| TR (1) | TR200000153T2 (es) |
| TW (1) | TW496865B (es) |
| WO (1) | WO1999002505A1 (es) |
| ZA (1) | ZA986089B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE277609T1 (de) * | 1998-07-30 | 2004-10-15 | Abbott Lab | Glucocorticoid selektive entzündungshemmende mittel |
| EP0987265A1 (en) | 1998-09-18 | 2000-03-22 | Janssen Pharmaceutica N.V. | Interleukin-5 inhibiting 6-azauracil derivatives |
| WO2000037451A1 (en) * | 1998-12-18 | 2000-06-29 | Janssen Pharmaceutica N.V. | Il-5 inhibiting 6-azauracil derivatives |
| HK1048634B (zh) * | 1999-08-06 | 2005-09-30 | 詹森药业有限公司 | 非类固醇类的il-5抑制剂，其制备的方法以及包含该抑制剂的医药组合物 |
| US6743820B2 (en) | 2000-07-07 | 2004-06-01 | University Of Toledo | Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor |
| WO2003072554A1 (en) * | 2002-02-28 | 2003-09-04 | Takeda Chemical Industries, Ltd. | Azole compounds |
| US20040186151A1 (en) * | 2003-02-12 | 2004-09-23 | Mjalli Adnan M.M. | Substituted azole derivatives as therapeutic agents |
| GB0305575D0 (en) | 2003-03-11 | 2003-04-16 | Glaxo Group Ltd | Novel compounds |
| JP2008503447A (ja) * | 2004-05-29 | 2008-02-07 | ７ティーエム ファーマ エイ／エス | Ｃｒｔｈ２リガンドとしての置換チアゾール酢酸 |
| DE102006049618A1 (de) * | 2006-10-20 | 2008-05-08 | Tschesche, Harald, Prof. Dr. | Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren |
| CN101265238B (zh) * | 2007-12-12 | 2010-06-16 | 重庆天极旅业有限公司 | 一种三嗪环衍生物的合成方法 |
| CN101265216B (zh) * | 2007-12-18 | 2012-06-27 | 重庆华邦胜凯制药有限公司 | 4-(取代乙氰基)-苯腙衍生物及其合成方法 |
| WO2012024150A1 (en) * | 2010-08-16 | 2012-02-23 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| CN109963563A (zh) * | 2016-07-13 | 2019-07-02 | 巴黎笛卡尔大学 | 用于预防和/或治疗与痤疮丙酸杆菌诱导的炎症相关的疾病的美克洛嗪衍生物和地克珠利衍生物 |
| JP2022547882A (ja) * | 2019-09-06 | 2022-11-16 | インフレイゾーム リミテッド | Ｎｌｒｐ３阻害剤 |
| CN120346211A (zh) * | 2025-06-20 | 2025-07-22 | 中国科学技术大学 | 二苯乙腈类化合物的用途及蛋白质靶向水解嵌合体类化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2149645A1 (de) * | 1970-10-07 | 1972-09-14 | Pfizer | 2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose |
| US3912723A (en) * | 1971-03-29 | 1975-10-14 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
| US3883528A (en) * | 1974-04-19 | 1975-05-13 | Pfizer | Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats |
| CA1244024A (en) * | 1984-08-01 | 1988-11-01 | Gustaaf M. Boeckx | .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES |
| GB8602342D0 (en) * | 1986-01-30 | 1986-03-05 | Janssen Pharmaceutica Nv | 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones |
| EP0476439A1 (de) * | 1990-09-18 | 1992-03-25 | Bayer Ag | Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung |
| TW403741B (en) * | 1993-10-15 | 2000-09-01 | Takeda Chemical Industries Ltd | Triazine derivative, production and use thereof |
-
1998
- 1998-07-07 AU AU89738/98A patent/AU742145B2/en not_active Ceased
- 1998-07-07 HU HU0004687A patent/HUP0004687A3/hu unknown
- 1998-07-07 CA CA002294145A patent/CA2294145A1/en not_active Abandoned
- 1998-07-07 NZ NZ502180A patent/NZ502180A/xx unknown
- 1998-07-07 TR TR2000/00153T patent/TR200000153T2/xx unknown
- 1998-07-07 PL PL98337947A patent/PL337947A1/xx unknown
- 1998-07-07 CN CN98806978A patent/CN1262679A/zh active Pending
- 1998-07-07 EP EP98941299A patent/EP1000040B1/en not_active Expired - Lifetime
- 1998-07-07 HR HR20000003A patent/HRP20000003A2/xx not_active Application Discontinuation
- 1998-07-07 WO PCT/EP1998/004191 patent/WO1999002505A1/en active IP Right Grant
- 1998-07-07 BR BR9811678-9A patent/BR9811678A/pt not_active IP Right Cessation
- 1998-07-07 IL IL13391698A patent/IL133916A0/xx unknown
- 1998-07-07 JP JP50812699A patent/JP2002511882A/ja not_active Withdrawn
- 1998-07-07 ID IDW20000034A patent/ID24390A/id unknown
- 1998-07-07 EE EEP200000016A patent/EE200000016A/xx unknown
- 1998-07-07 DE DE69837922T patent/DE69837922D1/de not_active Expired - Lifetime
- 1998-07-07 KR KR19997012079A patent/KR20010014049A/ko not_active Withdrawn
- 1998-07-07 SK SK1839-99A patent/SK183999A3/sk unknown
- 1998-07-07 AT AT98941299T patent/ATE364597T1/de not_active IP Right Cessation
- 1998-07-08 AR ARP980103336A patent/AR013360A1/es not_active Application Discontinuation
- 1998-07-08 TW TW087111014A patent/TW496865B/zh active
- 1998-07-09 ZA ZA9806089A patent/ZA986089B/xx unknown
-
2000
- 2000-01-06 NO NO20000063A patent/NO20000063L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20000063D0 (no) | 2000-01-06 |
| AU742145B2 (en) | 2001-12-20 |
| ID24390A (id) | 2000-07-13 |
| HUP0004687A3 (en) | 2002-03-28 |
| AU8973898A (en) | 1999-02-08 |
| ZA986089B (en) | 2000-01-10 |
| IL133916A0 (en) | 2001-04-30 |
| JP2002511882A (ja) | 2002-04-16 |
| HUP0004687A2 (hu) | 2002-02-28 |
| WO1999002505A1 (en) | 1999-01-21 |
| BR9811678A (pt) | 2000-09-19 |
| ATE364597T1 (de) | 2007-07-15 |
| PL337947A1 (en) | 2000-09-11 |
| EP1000040A1 (en) | 2000-05-17 |
| TW496865B (en) | 2002-08-01 |
| CA2294145A1 (en) | 1999-01-21 |
| NZ502180A (en) | 2000-11-24 |
| EE200000016A (et) | 2000-10-16 |
| CN1262679A (zh) | 2000-08-09 |
| DE69837922D1 (de) | 2007-07-26 |
| NO20000063L (no) | 2000-03-10 |
| TR200000153T2 (tr) | 2000-07-21 |
| SK183999A3 (en) | 2000-08-14 |
| EP1000040B1 (en) | 2007-06-13 |
| KR20010014049A (ko) | 2001-02-26 |
| HRP20000003A2 (en) | 2000-12-31 |
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