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HUP0004687A3 - Il-5 inhibiting 6-azauracil derivatives, process for producing them and their use - Google Patents

Il-5 inhibiting 6-azauracil derivatives, process for producing them and their use

Info

Publication number
HUP0004687A3
HUP0004687A3 HU0004687A HUP0004687A HUP0004687A3 HU P0004687 A3 HUP0004687 A3 HU P0004687A3 HU 0004687 A HU0004687 A HU 0004687A HU P0004687 A HUP0004687 A HU P0004687A HU P0004687 A3 HUP0004687 A3 HU P0004687A3
Authority
HU
Hungary
Prior art keywords
inhibiting
producing
azauracil derivatives
azauracil
derivatives
Prior art date
Application number
HU0004687A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HUP0004687A2 publication Critical patent/HUP0004687A2/hu
Publication of HUP0004687A3 publication Critical patent/HUP0004687A3/hu

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D253/00Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
    • C07D253/02Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/061,2,4-Triazines
    • C07D253/0651,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/071,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075Two hetero atoms, in positions 3 and 5
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HU0004687A 1997-07-10 1998-07-07 Il-5 inhibiting 6-azauracil derivatives, process for producing them and their use HUP0004687A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP97202118 1997-07-10
PCT/EP1998/004191 WO1999002505A1 (en) 1997-07-10 1998-07-07 Il-5 inhibiting 6-azauracil derivatives

Publications (2)

Publication Number Publication Date
HUP0004687A2 HUP0004687A2 (hu) 2002-02-28
HUP0004687A3 true HUP0004687A3 (en) 2002-03-28

Family

ID=8228531

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0004687A HUP0004687A3 (en) 1997-07-10 1998-07-07 Il-5 inhibiting 6-azauracil derivatives, process for producing them and their use

Country Status (23)

Country Link
EP (1) EP1000040B1 (hu)
JP (1) JP2002511882A (hu)
KR (1) KR20010014049A (hu)
CN (1) CN1262679A (hu)
AR (1) AR013360A1 (hu)
AT (1) ATE364597T1 (hu)
AU (1) AU742145B2 (hu)
BR (1) BR9811678A (hu)
CA (1) CA2294145A1 (hu)
DE (1) DE69837922D1 (hu)
EE (1) EE200000016A (hu)
HR (1) HRP20000003A2 (hu)
HU (1) HUP0004687A3 (hu)
ID (1) ID24390A (hu)
IL (1) IL133916A0 (hu)
NO (1) NO20000063L (hu)
NZ (1) NZ502180A (hu)
PL (1) PL337947A1 (hu)
SK (1) SK183999A3 (hu)
TR (1) TR200000153T2 (hu)
TW (1) TW496865B (hu)
WO (1) WO1999002505A1 (hu)
ZA (1) ZA986089B (hu)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE277609T1 (de) * 1998-07-30 2004-10-15 Abbott Lab Glucocorticoid selektive entzündungshemmende mittel
EP0987265A1 (en) 1998-09-18 2000-03-22 Janssen Pharmaceutica N.V. Interleukin-5 inhibiting 6-azauracil derivatives
WO2000037451A1 (en) * 1998-12-18 2000-06-29 Janssen Pharmaceutica N.V. Il-5 inhibiting 6-azauracil derivatives
HK1048634B (zh) * 1999-08-06 2005-09-30 詹森药业有限公司 非类固醇类的il-5抑制剂,其制备的方法以及包含该抑制剂的医药组合物
US6743820B2 (en) 2000-07-07 2004-06-01 University Of Toledo Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor
WO2003072554A1 (en) * 2002-02-28 2003-09-04 Takeda Chemical Industries, Ltd. Azole compounds
US20040186151A1 (en) * 2003-02-12 2004-09-23 Mjalli Adnan M.M. Substituted azole derivatives as therapeutic agents
GB0305575D0 (en) 2003-03-11 2003-04-16 Glaxo Group Ltd Novel compounds
JP2008503447A (ja) * 2004-05-29 2008-02-07 7ティーエム ファーマ エイ/エス Crth2リガンドとしての置換チアゾール酢酸
DE102006049618A1 (de) * 2006-10-20 2008-05-08 Tschesche, Harald, Prof. Dr. Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren
CN101265238B (zh) * 2007-12-12 2010-06-16 重庆天极旅业有限公司 一种三嗪环衍生物的合成方法
CN101265216B (zh) * 2007-12-18 2012-06-27 重庆华邦胜凯制药有限公司 4-(取代乙氰基)-苯腙衍生物及其合成方法
WO2012024150A1 (en) * 2010-08-16 2012-02-23 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
CN109963563A (zh) * 2016-07-13 2019-07-02 巴黎笛卡尔大学 用于预防和/或治疗与痤疮丙酸杆菌诱导的炎症相关的疾病的美克洛嗪衍生物和地克珠利衍生物
JP2022547882A (ja) * 2019-09-06 2022-11-16 インフレイゾーム リミテッド Nlrp3阻害剤
CN120346211A (zh) * 2025-06-20 2025-07-22 中国科学技术大学 二苯乙腈类化合物的用途及蛋白质靶向水解嵌合体类化合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2149645A1 (de) * 1970-10-07 1972-09-14 Pfizer 2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose
US3912723A (en) * 1971-03-29 1975-10-14 Pfizer 2-Phenyl-as-triazine-3,5(2H,4H)diones
US3883528A (en) * 1974-04-19 1975-05-13 Pfizer Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats
CA1244024A (en) * 1984-08-01 1988-11-01 Gustaaf M. Boeckx .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
GB8602342D0 (en) * 1986-01-30 1986-03-05 Janssen Pharmaceutica Nv 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
EP0476439A1 (de) * 1990-09-18 1992-03-25 Bayer Ag Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
TW403741B (en) * 1993-10-15 2000-09-01 Takeda Chemical Industries Ltd Triazine derivative, production and use thereof

Also Published As

Publication number Publication date
NO20000063D0 (no) 2000-01-06
AU742145B2 (en) 2001-12-20
ID24390A (id) 2000-07-13
AU8973898A (en) 1999-02-08
ZA986089B (en) 2000-01-10
IL133916A0 (en) 2001-04-30
JP2002511882A (ja) 2002-04-16
HUP0004687A2 (hu) 2002-02-28
WO1999002505A1 (en) 1999-01-21
BR9811678A (pt) 2000-09-19
AR013360A1 (es) 2000-12-27
ATE364597T1 (de) 2007-07-15
PL337947A1 (en) 2000-09-11
EP1000040A1 (en) 2000-05-17
TW496865B (en) 2002-08-01
CA2294145A1 (en) 1999-01-21
NZ502180A (en) 2000-11-24
EE200000016A (et) 2000-10-16
CN1262679A (zh) 2000-08-09
DE69837922D1 (de) 2007-07-26
NO20000063L (no) 2000-03-10
TR200000153T2 (tr) 2000-07-21
SK183999A3 (en) 2000-08-14
EP1000040B1 (en) 2007-06-13
KR20010014049A (ko) 2001-02-26
HRP20000003A2 (en) 2000-12-31

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