HUP0004687A3 - Il-5 inhibiting 6-azauracil derivatives, process for producing them and their use - Google Patents
Il-5 inhibiting 6-azauracil derivatives, process for producing them and their useInfo
- Publication number
- HUP0004687A3 HUP0004687A3 HU0004687A HUP0004687A HUP0004687A3 HU P0004687 A3 HUP0004687 A3 HU P0004687A3 HU 0004687 A HU0004687 A HU 0004687A HU P0004687 A HUP0004687 A HU P0004687A HU P0004687 A3 HUP0004687 A3 HU P0004687A3
- Authority
- HU
- Hungary
- Prior art keywords
- inhibiting
- producing
- azauracil derivatives
- azauracil
- derivatives
- Prior art date
Links
- SSPYSWLZOPCOLO-UHFFFAOYSA-N 6-azauracil Chemical class O=C1C=NNC(=O)N1 SSPYSWLZOPCOLO-UHFFFAOYSA-N 0.000 title 1
- 101150015560 IL5 gene Proteins 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97202118 | 1997-07-10 | ||
| PCT/EP1998/004191 WO1999002505A1 (en) | 1997-07-10 | 1998-07-07 | Il-5 inhibiting 6-azauracil derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0004687A2 HUP0004687A2 (hu) | 2002-02-28 |
| HUP0004687A3 true HUP0004687A3 (en) | 2002-03-28 |
Family
ID=8228531
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0004687A HUP0004687A3 (en) | 1997-07-10 | 1998-07-07 | Il-5 inhibiting 6-azauracil derivatives, process for producing them and their use |
Country Status (23)
| Country | Link |
|---|---|
| EP (1) | EP1000040B1 (hu) |
| JP (1) | JP2002511882A (hu) |
| KR (1) | KR20010014049A (hu) |
| CN (1) | CN1262679A (hu) |
| AR (1) | AR013360A1 (hu) |
| AT (1) | ATE364597T1 (hu) |
| AU (1) | AU742145B2 (hu) |
| BR (1) | BR9811678A (hu) |
| CA (1) | CA2294145A1 (hu) |
| DE (1) | DE69837922D1 (hu) |
| EE (1) | EE200000016A (hu) |
| HR (1) | HRP20000003A2 (hu) |
| HU (1) | HUP0004687A3 (hu) |
| ID (1) | ID24390A (hu) |
| IL (1) | IL133916A0 (hu) |
| NO (1) | NO20000063L (hu) |
| NZ (1) | NZ502180A (hu) |
| PL (1) | PL337947A1 (hu) |
| SK (1) | SK183999A3 (hu) |
| TR (1) | TR200000153T2 (hu) |
| TW (1) | TW496865B (hu) |
| WO (1) | WO1999002505A1 (hu) |
| ZA (1) | ZA986089B (hu) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE277609T1 (de) * | 1998-07-30 | 2004-10-15 | Abbott Lab | Glucocorticoid selektive entzündungshemmende mittel |
| EP0987265A1 (en) | 1998-09-18 | 2000-03-22 | Janssen Pharmaceutica N.V. | Interleukin-5 inhibiting 6-azauracil derivatives |
| WO2000037451A1 (en) * | 1998-12-18 | 2000-06-29 | Janssen Pharmaceutica N.V. | Il-5 inhibiting 6-azauracil derivatives |
| HK1048634B (zh) * | 1999-08-06 | 2005-09-30 | 詹森药业有限公司 | 非类固醇类的il-5抑制剂,其制备的方法以及包含该抑制剂的医药组合物 |
| US6743820B2 (en) | 2000-07-07 | 2004-06-01 | University Of Toledo | Methods for protection of stratified squamous epithelium against injury by noxious substances and novel agents for use therefor |
| WO2003072554A1 (en) * | 2002-02-28 | 2003-09-04 | Takeda Chemical Industries, Ltd. | Azole compounds |
| US20040186151A1 (en) * | 2003-02-12 | 2004-09-23 | Mjalli Adnan M.M. | Substituted azole derivatives as therapeutic agents |
| GB0305575D0 (en) | 2003-03-11 | 2003-04-16 | Glaxo Group Ltd | Novel compounds |
| JP2008503447A (ja) * | 2004-05-29 | 2008-02-07 | 7ティーエム ファーマ エイ/エス | Crth2リガンドとしての置換チアゾール酢酸 |
| DE102006049618A1 (de) * | 2006-10-20 | 2008-05-08 | Tschesche, Harald, Prof. Dr. | Triazine und Ihre Verwendung als Metalloproteinase-Inhibitoren |
| CN101265238B (zh) * | 2007-12-12 | 2010-06-16 | 重庆天极旅业有限公司 | 一种三嗪环衍生物的合成方法 |
| CN101265216B (zh) * | 2007-12-18 | 2012-06-27 | 重庆华邦胜凯制药有限公司 | 4-(取代乙氰基)-苯腙衍生物及其合成方法 |
| WO2012024150A1 (en) * | 2010-08-16 | 2012-02-23 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
| CN109963563A (zh) * | 2016-07-13 | 2019-07-02 | 巴黎笛卡尔大学 | 用于预防和/或治疗与痤疮丙酸杆菌诱导的炎症相关的疾病的美克洛嗪衍生物和地克珠利衍生物 |
| JP2022547882A (ja) * | 2019-09-06 | 2022-11-16 | インフレイゾーム リミテッド | Nlrp3阻害剤 |
| CN120346211A (zh) * | 2025-06-20 | 2025-07-22 | 中国科学技术大学 | 二苯乙腈类化合物的用途及蛋白质靶向水解嵌合体类化合物 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2149645A1 (de) * | 1970-10-07 | 1972-09-14 | Pfizer | 2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose |
| US3912723A (en) * | 1971-03-29 | 1975-10-14 | Pfizer | 2-Phenyl-as-triazine-3,5(2H,4H)diones |
| US3883528A (en) * | 1974-04-19 | 1975-05-13 | Pfizer | Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats |
| CA1244024A (en) * | 1984-08-01 | 1988-11-01 | Gustaaf M. Boeckx | .alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES |
| GB8602342D0 (en) * | 1986-01-30 | 1986-03-05 | Janssen Pharmaceutica Nv | 5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones |
| EP0476439A1 (de) * | 1990-09-18 | 1992-03-25 | Bayer Ag | Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung |
| TW403741B (en) * | 1993-10-15 | 2000-09-01 | Takeda Chemical Industries Ltd | Triazine derivative, production and use thereof |
-
1998
- 1998-07-07 AU AU89738/98A patent/AU742145B2/en not_active Ceased
- 1998-07-07 HU HU0004687A patent/HUP0004687A3/hu unknown
- 1998-07-07 CA CA002294145A patent/CA2294145A1/en not_active Abandoned
- 1998-07-07 NZ NZ502180A patent/NZ502180A/xx unknown
- 1998-07-07 TR TR2000/00153T patent/TR200000153T2/xx unknown
- 1998-07-07 PL PL98337947A patent/PL337947A1/xx unknown
- 1998-07-07 CN CN98806978A patent/CN1262679A/zh active Pending
- 1998-07-07 EP EP98941299A patent/EP1000040B1/en not_active Expired - Lifetime
- 1998-07-07 HR HR20000003A patent/HRP20000003A2/xx not_active Application Discontinuation
- 1998-07-07 WO PCT/EP1998/004191 patent/WO1999002505A1/en active IP Right Grant
- 1998-07-07 BR BR9811678-9A patent/BR9811678A/pt not_active IP Right Cessation
- 1998-07-07 IL IL13391698A patent/IL133916A0/xx unknown
- 1998-07-07 JP JP50812699A patent/JP2002511882A/ja not_active Withdrawn
- 1998-07-07 ID IDW20000034A patent/ID24390A/id unknown
- 1998-07-07 EE EEP200000016A patent/EE200000016A/xx unknown
- 1998-07-07 DE DE69837922T patent/DE69837922D1/de not_active Expired - Lifetime
- 1998-07-07 KR KR19997012079A patent/KR20010014049A/ko not_active Withdrawn
- 1998-07-07 SK SK1839-99A patent/SK183999A3/sk unknown
- 1998-07-07 AT AT98941299T patent/ATE364597T1/de not_active IP Right Cessation
- 1998-07-08 AR ARP980103336A patent/AR013360A1/es not_active Application Discontinuation
- 1998-07-08 TW TW087111014A patent/TW496865B/zh active
- 1998-07-09 ZA ZA9806089A patent/ZA986089B/xx unknown
-
2000
- 2000-01-06 NO NO20000063A patent/NO20000063L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20000063D0 (no) | 2000-01-06 |
| AU742145B2 (en) | 2001-12-20 |
| ID24390A (id) | 2000-07-13 |
| AU8973898A (en) | 1999-02-08 |
| ZA986089B (en) | 2000-01-10 |
| IL133916A0 (en) | 2001-04-30 |
| JP2002511882A (ja) | 2002-04-16 |
| HUP0004687A2 (hu) | 2002-02-28 |
| WO1999002505A1 (en) | 1999-01-21 |
| BR9811678A (pt) | 2000-09-19 |
| AR013360A1 (es) | 2000-12-27 |
| ATE364597T1 (de) | 2007-07-15 |
| PL337947A1 (en) | 2000-09-11 |
| EP1000040A1 (en) | 2000-05-17 |
| TW496865B (en) | 2002-08-01 |
| CA2294145A1 (en) | 1999-01-21 |
| NZ502180A (en) | 2000-11-24 |
| EE200000016A (et) | 2000-10-16 |
| CN1262679A (zh) | 2000-08-09 |
| DE69837922D1 (de) | 2007-07-26 |
| NO20000063L (no) | 2000-03-10 |
| TR200000153T2 (tr) | 2000-07-21 |
| SK183999A3 (en) | 2000-08-14 |
| EP1000040B1 (en) | 2007-06-13 |
| KR20010014049A (ko) | 2001-02-26 |
| HRP20000003A2 (en) | 2000-12-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HU9802224D0 (en) | Pyrazol derivatives, process for producing them and their use as medicament | |
| HUP9802653A3 (en) | Substituted imidazolidine derivatives, process for producing them, and pharmaceutical compositions containing them | |
| HU9702507D0 (en) | Substituted purine derivatives, process for producing them and compositions containing them | |
| HUP9800555A3 (en) | 3,3-diphenylallylamine derivatives and process for their preparation | |
| HUP0004687A3 (en) | Il-5 inhibiting 6-azauracil derivatives, process for producing them and their use | |
| HUP0001522A3 (en) | Benzoimidazole derivatives, process for producing them and pharmaceutical compositions containing them | |
| HU9700595D0 (en) | Fluoro-alkyl- and fluoro-alkoxy-substituted heterocyclic bradiquinine-antagonists, process for producing them and their use | |
| HUP0003148A3 (en) | Cyanoguanidine derivatives, process for producing them and pharmaceutical compositions containing them | |
| HU9700566D0 (en) | Amino-alkyl- and acyl-amino-alkyl-ethers, process for producing them and their use as bradiquinine-receptor-antagonists | |
| HUP0003150A3 (en) | Cyanoguanidine derivatives, process for producing them and pharmaceutical compositions containing them | |
| HUP0104819A3 (en) | Chroman derivatives, their use intermediate and process for their preparation | |
| HUP0003997A3 (en) | 3-benzylpiperidine derivatives, pharmaceutical compositions containing them and process for producing them | |
| HUP0003766A2 (en) | Isoguinolin derivatives, process for producing them and pharmaceutical compositions containing them | |
| HUP0003829A3 (en) | Cyanoguanidine derivatives, process for producing them and pharmaceutical compositions containing them | |
| HUP0101235A3 (en) | Hyperhydrated citicoline, process for preparing it and use | |
| GR3035834T3 (en) | Benzoxazindione derivatives, process for their preparation and their use | |
| ZA986095B (en) | 6-azauracil derivatives as IL-5 inhibitors. | |
| EP1081159A4 (en) | PURIFIED HUMAN ACTIVIN AND PROCESS FOR PRODUCING THE SAME | |
| HUP9802105A3 (en) | Process for producing 2,3,4,5-tetrafluorbenzene derivatives | |
| HUP0104641A3 (en) | Il-5 inhibiting 6-azauracil derivatives process for their preparation and medicaments containing them | |
| HU9602080D0 (en) | 12,13-epoxi-tylosin derivatives and process for producing them | |
| HUP9700502A2 (en) | Orto-substituted benzoyl-guanidine derivatives, process for producing them and use of them | |
| HUP9700542A3 (en) | Orto-substituted benzoyl-guanidine derivatives, process for producing them and use of them | |
| HUP9702472A3 (en) | Process for producing allyl-amine derivative and salts thereof | |
| HUP9700543A2 (en) | Orto-substituted benzoyl-guanidine derivatives, process for producing them and use of them |