ATE261452T1 - Neue kristallformen einer antiviralen benzimidazolverbindung - Google Patents

Neue kristallformen einer antiviralen benzimidazolverbindung

Info

Publication number: ATE261452T1
Authority: AT; Austria
Prior art keywords: crystal forms; new crystal; benzimidazole compound; antiviral; antiviral benzimidazole
Prior art date: 1998-04-07

Application number

AT99917935T

Other languages

English (en)

Inventor

Barry Carter

Bobby Neal Glover

Lian Huang

Robert William Lancaster

Stacey Todd Long

Michele Catherine Rizzolio

Eric Allen Schmitt

Barry Sickles

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-07

Filing date

1999-04-01

Publication date

2004-03-15

1999-04-01 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

2004-03-15 Application granted granted Critical

2004-03-15 Publication of ATE261452T1 publication Critical patent/ATE261452T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Virology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

AT99917935T 1998-04-07 1999-04-01 Neue kristallformen einer antiviralen benzimidazolverbindung ATE261452T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9807354.7A GB9807354D0 (en)	1998-04-07	1998-04-07	Antiviral compound
PCT/EP1999/002214 WO1999051618A1 (en)	1998-04-07	1999-04-01	Novel crystalline forms of an antiviral benzimidazole compound

Publications (1)

Publication Number	Publication Date
ATE261452T1 true ATE261452T1 (de)	2004-03-15

Family

ID=10829932

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99917935T ATE261452T1 (de)	1998-04-07	1999-04-01	Neue kristallformen einer antiviralen benzimidazolverbindung

Country Status (28)

Country	Link
US (9)	US6469160B1 (de)
EP (1)	EP1071693B1 (de)
JP (1)	JP2002510703A (de)
KR (1)	KR20010074472A (de)
CN (1)	CN1303390A (de)
AP (1)	AP2000001947A0 (de)
AT (1)	ATE261452T1 (de)
AU (1)	AU752877B2 (de)
BR (1)	BR9909474A (de)
CA (1)	CA2327494C (de)
DE (1)	DE69915461T2 (de)
EA (1)	EA002970B1 (de)
EE (1)	EE04120B1 (de)
ES (1)	ES2216503T3 (de)
GB (1)	GB9807354D0 (de)
HR (1)	HRP20000669A2 (de)
HU (1)	HUP0101669A3 (de)
ID (1)	ID27109A (de)
IL (1)	IL138697A0 (de)
IS (1)	IS5640A (de)
NO (1)	NO20005005L (de)
NZ (1)	NZ507173A (de)
PL (1)	PL343397A1 (de)
SK (1)	SK14832000A3 (de)
TR (1)	TR200002860T2 (de)
WO (1)	WO1999051618A1 (de)
YU (1)	YU60900A (de)
ZA (1)	ZA200005153B (de)

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GB9807354D0 (en) *	1998-04-07	1998-06-03	Glaxo Group Ltd	Antiviral compound
GB9807355D0 (en)	1998-04-07	1998-06-03	Glaxo Group Ltd	Antiviral compound
GB0008939D0 (en)	2000-04-11	2000-05-31	Glaxo Group Ltd	Process for preparing substituted benzimidazole compounds
EP2767539B1 (de)	2002-05-16	2017-07-12	Janssen Sciences Ireland UC	Pseudopolymorphe Formen eines HIV-Proteaseinhibitors
ES2370829T3 (es) *	2004-06-02	2011-12-23	Sandoz Ag	Producto intermedio de meropenem en forma cristalina.
EP1910393A2 (de) *	2005-07-05	2008-04-16	Hetero Drugs Limited	Neues verfahren zur herstellung von didanosin unter verwendung neuer zwischenprodukte
US9198862B2 (en) *	2005-07-22	2015-12-01	Rubicon Research Private Limited	Dispersible tablet composition
JP5305909B2 (ja) *	2005-09-21	2013-10-02	フォーエスシーアクチエンゲゼルシャフト	ヒストンデアセチラーゼインヒビターとしてのスルホニルピロール塩酸塩
CN101389617A (zh) *	2005-10-31	2009-03-18	詹森药业有限公司	制备哌嗪基和二氮杂环庚烷基苯甲酰胺衍生物的新方法
PL2044020T3 (pl) *	2006-06-16	2011-09-30	H Lundbeck As	Krystaliczne postaci 4-[2-(4-metylofenylosulfanylo)-fenylo]piperydyny z równoczesnym hamowaniem wychwytu zwrotnego serotoniny i norepinefryny do leczenia bólu neuropatycznego
US7919598B2 (en) *	2006-06-28	2011-04-05	Bristol-Myers Squibb Company	Crystal structures of SGLT2 inhibitors and processes for preparing same
ES2567051T3 (es) *	2006-10-27	2016-04-19	Signal Pharmaceuticals, Llc	Formas sólidas que comprenden 4-[9-(3S)-(tetrahidro-furan-3-il)-8-(2,4,6-trifluoro-fenilamino)-9H-purin-2-ilamino]-trans-ciclohexan-1-ol, sus composiciones y sus usos
EP2085397A1 (de) *	2008-01-21	2009-08-05	Esteve Quimica, S.A.	Kristalline Form von Abacavir
US7935817B2 (en) *	2008-03-31	2011-05-03	Apotex Pharmachem Inc.	Salt form and cocrystals of adefovir dipivoxil and processes for preparation thereof
AR071318A1 (es) *	2008-04-15	2010-06-09	Basilea Pharmaceutica Ag	Benzhidril ester del acido (6r,7r)-7-{2-(5-amino-[1,2,4]tiadiazol-3-il)-2-[(z)-tritiloxiimino]-acetilamino}-3-[(r)-1'-terc-butoxicarbonil-2-oxo-[1,3']bipirrolidinil-(3e)-ilidenometil]-8-oxo-5-tia-1-aza-biciclo[4.2.0]oct-2-eno-2-carboxilico cristalino; su elaboracion y uso
US8097719B2 (en) *	2008-07-15	2012-01-17	Genesen Labs	Meropenem intermediate in novel crystalline form and a method of manufacture of meropenem
KR101043794B1 (ko) *	2009-04-13	2011-06-27	청우산업 주식회사	황토판재로 제공되는 기능성 황토방
KR101713453B1 (ko)	2010-03-12	2017-03-07	오메로스 코포레이션	Pde10 억제제 및 관련 조성물 및 방법
EP2611433A2 (de) *	2010-09-01	2013-07-10	Arena Pharmaceuticals, Inc.	Nicht-hygroskopische salze aus 5-ht2c-agonisten
US8940707B2 (en)	2010-10-28	2015-01-27	Viropharma Incorporated	Maribavir isomers, compositions, methods of making and methods of using
US8546344B2 (en)	2010-10-28	2013-10-01	Viropharma Incorporated	Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
US8541391B2 (en)	2010-10-28	2013-09-24	Viropharma Incorporated	Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl-1H-benzimidazole
WO2013044816A1 (en) *	2011-09-30	2013-04-04	Sunshine Lake Pharma Co., Ltd.	Crystalline forms of azilsartan and preparation and uses thereof
NZ716462A (en) *	2014-04-28	2017-11-24	Omeros Corp	Optically active pde10 inhibitor
NZ716494A (en)	2014-04-28	2017-07-28	Omeros Corp	Processes and intermediates for the preparation of a pde10 inhibitor
CN107530313A (zh)	2015-04-24	2018-01-02	奥默罗斯公司	Pde10抑制剂以及相关组合物和方法
JP2018535969A (ja)	2015-11-04	2018-12-06	オメロスコーポレーション	Ｐｄｅ１０阻害剤の固体状態形態
WO2020087031A1 (en)	2018-10-26	2020-04-30	The Research Foundation For The State University Of New York	Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia
CN111303230B (zh) *	2020-03-09	2021-07-13	中国食品药品检定研究院	一种黄体酮共晶物及其制备方法和用途
US20240277748A1 (en)	2022-10-12	2024-08-22	Takeda Pharmaceutical Company Limited	Viral inhibitors, the synthesis thereof, and intermediates thereto

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US3399987A (en) *	1965-08-02	1968-09-03	United States Borax Chem	2-alkylaminobenzimidazoles as herbicides
CH443777A (de) *	1965-08-06	1968-02-15	Agripat Sa	Verfahren zum Schützen textiler Keratinfasern vor Insektenfrass und Mittel zur Durchführung dieses Verfahrens
US3655901A (en) *	1970-07-30	1972-04-11	Merck & Co Inc	Method of inhibiting the formation of phenylethanalamine-n-methyl transferase with 2-aminobenzimidazoles
SE9003151D0 (sv) *	1990-10-02	1990-10-02	Medivir Ab	Nucleoside derivatives
US5248672A (en) *	1990-11-01	1993-09-28	The Regents Of The University Of Michigan	Polysubstituted benzimidazole nucleosides as antiviral agents
AU5447094A (en) *	1992-10-21	1994-05-09	Regents Of The University Of Michigan, The	Polysubstituted benzimidazoles as antiviral agents
GB9413724D0 (en) *	1994-07-07	1994-08-24	Wellcome Found	Therapeutic nucleosides
GB9600143D0 (en)	1996-01-05	1996-03-06	Wellcome Found	Therapeutic compounds
GB9807354D0 (en) *	1998-04-07	1998-06-03	Glaxo Group Ltd	Antiviral compound
GB9807355D0 (en)	1998-04-07	1998-06-03	Glaxo Group Ltd	Antiviral compound

1998
- 1998-04-07 GB GBGB9807354.7A patent/GB9807354D0/en not_active Ceased
1999
- 1999-04-01 DE DE69915461T patent/DE69915461T2/de not_active Expired - Lifetime
- 1999-04-01 AT AT99917935T patent/ATE261452T1/de not_active IP Right Cessation
- 1999-04-01 BR BR9909474-6A patent/BR9909474A/pt not_active IP Right Cessation
- 1999-04-01 YU YU60900A patent/YU60900A/sh unknown
- 1999-04-01 TR TR2000/02860T patent/TR200002860T2/xx unknown
- 1999-04-01 US US09/647,962 patent/US6469160B1/en not_active Expired - Lifetime
- 1999-04-01 CN CN99806894A patent/CN1303390A/zh active Pending
- 1999-04-01 JP JP2000542339A patent/JP2002510703A/ja active Pending
- 1999-04-01 WO PCT/EP1999/002214 patent/WO1999051618A1/en not_active Application Discontinuation
- 1999-04-01 HR HR20000669A patent/HRP20000669A2/hr not_active Application Discontinuation
- 1999-04-01 EE EEP200000584A patent/EE04120B1/xx not_active IP Right Cessation
- 1999-04-01 NZ NZ507173A patent/NZ507173A/en unknown
- 1999-04-01 HU HU0101669A patent/HUP0101669A3/hu unknown
- 1999-04-01 SK SK1483-2000A patent/SK14832000A3/sk unknown
- 1999-04-01 AU AU36034/99A patent/AU752877B2/en not_active Ceased
- 1999-04-01 PL PL99343397A patent/PL343397A1/xx unknown
- 1999-04-01 ES ES99917935T patent/ES2216503T3/es not_active Expired - Lifetime
- 1999-04-01 IL IL13869799A patent/IL138697A0/xx unknown
- 1999-04-01 AP APAP/P/2000/001947A patent/AP2000001947A0/en unknown
- 1999-04-01 EA EA200000911A patent/EA002970B1/ru not_active IP Right Cessation
- 1999-04-01 EP EP99917935A patent/EP1071693B1/de not_active Expired - Lifetime
- 1999-04-01 KR KR1020007011089A patent/KR20010074472A/ko not_active Withdrawn
- 1999-04-01 CA CA2327494A patent/CA2327494C/en not_active Expired - Lifetime
- 1999-04-01 ID IDW20002036A patent/ID27109A/id unknown
2000
- 2000-09-26 ZA ZA200005153A patent/ZA200005153B/en unknown
- 2000-09-26 IS IS5640A patent/IS5640A/is unknown
- 2000-10-04 NO NO20005005A patent/NO20005005L/no not_active Application Discontinuation
2001
- 2001-10-29 US US10/007,272 patent/US7297683B2/en not_active Expired - Fee Related
2007
- 2007-10-25 US US11/924,204 patent/US7714123B2/en not_active Expired - Fee Related
2010
- 2010-03-26 US US12/732,302 patent/US20100179101A1/en not_active Abandoned
2011
- 2011-01-25 US US13/012,924 patent/US9163052B2/en not_active Expired - Fee Related
2013
- 2013-02-01 US US13/756,612 patent/US20130261294A1/en not_active Abandoned
2015
- 2015-10-12 US US14/880,600 patent/US20160030460A1/en not_active Abandoned
2016
- 2016-09-19 US US15/268,949 patent/US20170002035A1/en not_active Abandoned
2017
- 2017-10-05 US US15/725,785 patent/US20180044366A1/en not_active Abandoned

Also Published As

Publication number	Publication date
KR20010074472A (ko)	2001-08-04
HUP0101669A2 (hu)	2001-10-28
US20130261294A1 (en)	2013-10-03
ID27109A (id)	2001-03-01
PL343397A1 (en)	2001-08-13
US20020177703A1 (en)	2002-11-28
US20080103186A1 (en)	2008-05-01
US20110118203A1 (en)	2011-05-19
AP2000001947A0 (en)	2000-12-31
NO20005005D0 (no)	2000-10-04
IL138697A0 (en)	2001-10-31
AU3603499A (en)	1999-10-25
EA200000911A1 (ru)	2001-04-23
NO20005005L (no)	2000-12-06
US7297683B2 (en)	2007-11-20
WO1999051618A1 (en)	1999-10-14
US20100179101A1 (en)	2010-07-15
HUP0101669A3 (en)	2003-07-28
CA2327494C (en)	2010-10-26
EP1071693B1 (de)	2004-03-10
DE69915461D1 (de)	2004-04-15
NZ507173A (en)	2003-07-25
YU60900A (sh)	2003-07-07
US9163052B2 (en)	2015-10-20
BR9909474A (pt)	2000-12-19
ZA200005153B (en)	2001-09-26
EP1071693A1 (de)	2001-01-31
JP2002510703A (ja)	2002-04-09
US20180044366A1 (en)	2018-02-15
CN1303390A (zh)	2001-07-11
EE200000584A (et)	2002-04-15
IS5640A (is)	2000-09-26
DE69915461T2 (de)	2005-03-03
CA2327494A1 (en)	1999-10-14
US7714123B2 (en)	2010-05-11
TR200002860T2 (tr)	2000-12-21
AU752877B2 (en)	2002-10-03
EA002970B1 (ru)	2002-12-26
ES2216503T3 (es)	2004-10-16
US20160030460A1 (en)	2016-02-04
HRP20000669A2 (en)	2001-08-31
US6469160B1 (en)	2002-10-22
GB9807354D0 (en)	1998-06-03
SK14832000A3 (sk)	2001-07-10
US20170002035A1 (en)	2017-01-05
EE04120B1 (et)	2003-08-15

Publication	Publication Date	Title
ATE261452T1 (de)	2004-03-15	Neue kristallformen einer antiviralen benzimidazolverbindung
DE69818266D1 (de)	2003-10-23	Neue substituierte imidazolverbindungen
ATE246674T1 (de)	2003-08-15	Neue 3-aryl-2-hydroxypropionsäure-derivate
ID24638A (id)	2000-07-27	Senyawa-senyawa anti aritmia bispidina
ATE261429T1 (de)	2004-03-15	Neue 3-aryl-2-hydroxypropionsäure-derivate iii
NO20010899L (no)	2001-04-24	Forbedring av ugunstige apomorfin-effekter
DK1107980T3 (da)	2003-04-22	Krystallinske former af EtO2C-CH2-(R)Cgl-Aze-Pab-OH
DE69925229D1 (de)	2005-06-16	Beschichtungsstruktur
NO20005795D0 (no)	2000-11-16	Antivirale forbindelser
DE59812234D1 (de)	2004-12-16	Verbundwasserzähler
DE50209255D1 (de)	2007-02-22	Befestigung einer wischeranlage
ATE337307T1 (de)	2006-09-15	Neue dihydroxyhexansäurederivate
FI981191A7 (fi)	1999-11-29	Siltanosturi
ID30516A (id)	2001-12-13	Senyawa-senyawa (aminoiminometil atau aminometil) benzoheteroaril tersubstitusi
DE69920215D1 (de)	2004-10-21	Struktur einer tintenstrahlpatrone
ID28032A (id)	2001-05-03	TRISIKLIK PIPERIDIN-Δ3-SEBAGAI ANTAGONIS-α2
ID27298A (id)	2001-03-22	Peningkatan hidrolik komponen-komponen
DK1102747T3 (da)	2003-09-29	Krystalformer af osenetant
EE200100017A (et)	2002-06-17	N-tert-butüülhüdroksüülamiini uued soolad
DE59503689D1 (de)	1998-10-29	Keramische Überzugsmasse
PT1175417E (pt)	2004-04-30	Compostos substituidos de benzolactamas
DE69833783D1 (de)	2006-05-04	Komponente einer platine
ID23099A (id)	2000-02-10	Alat penahan posisi badan ritsleting
DE59910977D1 (de)	2004-12-09	Motorradverkleidung
NO994838D0 (no)	1999-10-04	<pi>-kompleks-forbindelser

Legal Events

Date	Code	Title	Description
2004-09-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties