ATE407127T1 - Verfahren zur herstellung von beraprost und dessen salzen - Google Patents

Verfahren zur herstellung von beraprost und dessen salzen

Info

Publication number: ATE407127T1
Authority: AT; Austria
Prior art keywords: salts; beraprost; producing; producing beraprost; new
Prior art date: 2001-07-30

Application number

AT02755382T

Other languages

English (en)

Inventor

Tibor Szabo

Jozsef Bodi

Gyula Dalmadi

Kardos Zsuzsanna Baloghne

Zoltan Szeverenyi

Original Assignee

Chinoin Gyogyszer Es Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-30

Filing date

2002-07-25

Publication date

2008-09-15

2002-07-25 Application filed by Chinoin Gyogyszer Es Vegyeszet filed Critical Chinoin Gyogyszer Es Vegyeszet

2008-09-15 Application granted granted Critical

2008-09-15 Publication of ATE407127T1 publication Critical patent/ATE407127T1/de

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Steroid Compounds (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Furan Compounds (AREA)
Error Detection And Correction (AREA)

AT02755382T 2001-07-30 2002-07-25 Verfahren zur herstellung von beraprost und dessen salzen ATE407127T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU0103089A HU227157B1 (en)	2001-07-30	2001-07-30	Production of beraprost ester by selective oxidation

Publications (1)

Publication Number	Publication Date
ATE407127T1 true ATE407127T1 (de)	2008-09-15

Family

ID=90001541

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT02755382T ATE407127T1 (de)	2001-07-30	2002-07-25	Verfahren zur herstellung von beraprost und dessen salzen

Country Status (25)

Country	Link
US (1)	US7005527B2 (de)
EP (1)	EP1412342B1 (de)
JP (1)	JP4440506B2 (de)
KR (1)	KR100604699B1 (de)
CN (2)	CN100347165C (de)
AT (1)	ATE407127T1 (de)
AU (1)	AU2002321670B8 (de)
BR (1)	BR0211514A (de)
CA (1)	CA2453649C (de)
CU (1)	CU23324B7 (de)
DE (1)	DE60228724D1 (de)
ES (1)	ES2314083T3 (de)
HR (1)	HRP20040198B1 (de)
HU (1)	HU227157B1 (de)
IL (2)	IL159814A0 (de)
ME (2)	ME00089B (de)
MX (1)	MXPA04000847A (de)
NO (1)	NO328695B1 (de)
NZ (1)	NZ531264A (de)
PL (1)	PL216072B1 (de)
RS (1)	RS51314B (de)
RU (1)	RU2272033C2 (de)
UA (1)	UA75692C2 (de)
WO (1)	WO2003011849A1 (de)
ZA (1)	ZA200400748B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0215757D0 (en) *	2002-07-08	2002-08-14	Cascade Biochem Ltd	Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
WO2012174407A1 (en) *	2011-06-16	2012-12-20	Lung LLC	Method of producing beraprost
CN102952107B (zh) *	2011-08-29	2015-10-07	上海天伟生物制药有限公司	一种高纯度的贝前列素钠及其制备方法和用途
US9388154B2 (en)	2011-09-12	2016-07-12	Lund Biotechnology PBC	Process for preparing synthetic prostacyclins
CN103509044A (zh) *	2012-06-21	2014-01-15	上海天伟生物制药有限公司	贝前列素钠中间体及其制备方法
KR20150132440A (ko) *	2013-03-15	2015-11-25	젬머스 파마 인코포레이티드	바이러스 감염의 치료제로서의 베라프로스트 이성질체
CN103242274B (zh) *	2013-05-22	2014-11-05	孙威	一种贝前列素钠化合物及其制备方法
CN106573904B (zh)	2014-05-20	2019-11-08	朗格生物技术公共公益股份有限公司	用于产生贝前列素及其衍生物的方法
WO2017027706A1 (en) *	2015-08-12	2017-02-16	United Therapeutics Corporation	Process for making beraprost
HU231080B1 (hu) *	2016-04-05	2020-07-28	CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt.	Eljárás optikailag aktív Beraprost előállítására
HU231212B1 (hu) *	2018-04-16	2021-11-29	CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt.	Eljárás iloprost előállítására
US10577340B1 (en) *	2018-11-26	2020-03-03	Chirogate International Inc.	Beraprost-314d crystals and methods for preparation thereof
EP4103192A4 (de)	2020-02-12	2024-02-21	Cytoagents, Inc.	Zusammensetzungen und verfahren zur behandlung von coronavirusinfektionen
WO2023276983A1 (ja) *	2021-06-28	2023-01-05	大内新興化学工業株式会社	ベラプロストまたは光学活性体の合成中間体およびその製造方法
CN115611838A (zh) *	2021-07-15	2023-01-17	四川国为制药有限公司	一种前列环素衍生物的晶型

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5931510B2 (ja) *	1979-09-03	1984-08-02	東レ株式会社	５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS58124778A (ja) *	1982-01-20	1983-07-25	Toray Ind Inc	５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS59134787A (ja) *	1983-01-19	1984-08-02	Toray Ind Inc	５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体の製造法
HU197733B (en) *	1985-05-29	1989-05-29	Chinoin Gyogyszer Es Vegyeszet	Process for producing ephedrin-salts of 7-oxo-prosta-cyclin derivatives
CA1284642C (en) *	1986-03-31	1991-06-04	Hikozo Iwakura	Prostacyclin (pgi ) analogues
JP2594118B2 (ja) *	1987-07-01	1997-03-26	塩野義製薬株式会社	ベンゾジオキサンプロスタサイクリン類縁体
JP2542429B2 (ja) *	1987-10-27	1996-10-09	三共株式会社	オクタヒドロナフタリン置換オキシム誘導体
GB8929059D0 (en) *	1989-12-22	1990-02-28	Leo Pharm Prod Ltd	Chemical compounds
JP3025056B2 (ja) *	1991-03-12	2000-03-27	財団法人微生物化学研究会	２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノース誘導体の製造法
JP3024298B2 (ja) *	1991-09-13	2000-03-21	住友化学工業株式会社	シクロペンテンエステル類及びその利用
DE4226615C1 (de) *	1992-08-07	1994-05-19	Schering Ag	Verwendung von Prostan-Derivaten zur Behandlung von chronischer Polyarthritis
DE19530884C2 (de) *	1995-08-11	1997-07-31	Schering Ag	Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis
JPH09132589A (ja) *	1995-09-08	1997-05-20	Microbial Chem Res Found	糖部分の水酸基をモノ−または−ジ−ｏ−アミノアルカノイル化された含フッ素アンスラサイクリン誘導体

2001
- 2001-07-30 HU HU0103089A patent/HU227157B1/hu unknown
- 2001-12-28 JP JP2001398828A patent/JP4440506B2/ja not_active Expired - Lifetime
2002
- 2002-07-25 EP EP02755382A patent/EP1412342B1/de not_active Expired - Lifetime
- 2002-07-25 CN CNB2005100702984A patent/CN100347165C/zh not_active Expired - Lifetime
- 2002-07-25 IL IL15981402A patent/IL159814A0/xx active IP Right Grant
- 2002-07-25 PL PL367298A patent/PL216072B1/pl unknown
- 2002-07-25 DE DE60228724T patent/DE60228724D1/de not_active Expired - Lifetime
- 2002-07-25 ME MEP-2008-187A patent/ME00089B/me unknown
- 2002-07-25 RS YUP-86/04A patent/RS51314B/sr unknown
- 2002-07-25 WO PCT/HU2002/000074 patent/WO2003011849A1/en active IP Right Grant
- 2002-07-25 KR KR1020047001320A patent/KR100604699B1/ko not_active Expired - Lifetime
- 2002-07-25 AU AU2002321670A patent/AU2002321670B8/en not_active Ceased
- 2002-07-25 NZ NZ531264A patent/NZ531264A/en not_active IP Right Cessation
- 2002-07-25 BR BR0211514-0A patent/BR0211514A/pt active Search and Examination
- 2002-07-25 HR HR20040198A patent/HRP20040198B1/xx not_active IP Right Cessation
- 2002-07-25 US US10/484,209 patent/US7005527B2/en not_active Expired - Lifetime
- 2002-07-25 ES ES02755382T patent/ES2314083T3/es not_active Expired - Lifetime
- 2002-07-25 ME MEP-187/08A patent/MEP18708A/xx unknown
- 2002-07-25 AT AT02755382T patent/ATE407127T1/de not_active IP Right Cessation
- 2002-07-25 MX MXPA04000847A patent/MXPA04000847A/es active IP Right Grant
- 2002-07-25 CA CA002453649A patent/CA2453649C/en not_active Expired - Lifetime
- 2002-07-25 UA UA2004021460A patent/UA75692C2/uk unknown
- 2002-07-25 CN CNB02815021XA patent/CN1235896C/zh not_active Expired - Lifetime
- 2002-07-25 RU RU2004105959/04A patent/RU2272033C2/ru active
2004
- 2004-01-11 IL IL159814A patent/IL159814A/en unknown
- 2004-01-26 CU CU20040014A patent/CU23324B7/es unknown
- 2004-01-29 ZA ZA2004/00748A patent/ZA200400748B/en unknown
- 2004-01-29 NO NO20040388A patent/NO328695B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO2003011849A1 (en)	2003-02-13
RU2272033C2 (ru)	2006-03-20
HK1068877A1 (en)	2005-05-06
MXPA04000847A (es)	2004-03-26
CA2453649C (en)	2009-12-22
UA75692C2 (uk)	2006-05-15
US20040209945A1 (en)	2004-10-21
CN1680351A (zh)	2005-10-12
AU2002321670B2 (en)	2008-08-14
CU23324B7 (es)	2008-11-27
WO2003011849A8 (en)	2004-03-11
MEP18708A (en)	2010-06-10
NO20040388L (no)	2004-01-29
KR100604699B1 (ko)	2006-07-31
KR20040043169A (ko)	2004-05-22
HUP0103089D0 (en)	2001-10-28
RS8604A (en)	2007-02-05
US7005527B2 (en)	2006-02-28
PL216072B1 (pl)	2014-02-28
PL367298A1 (en)	2005-02-21
RU2004105959A (ru)	2005-03-27
ZA200400748B (en)	2005-01-26
AU2002321670B8 (en)	2008-09-11
CN100347165C (zh)	2007-11-07
BR0211514A (pt)	2004-09-14
NO328695B1 (no)	2010-04-26
JP4440506B2 (ja)	2010-03-24
JP2003055368A (ja)	2003-02-26
EP1412342B1 (de)	2008-09-03
HUP0103089A2 (hu)	2003-07-28
NZ531264A (en)	2005-09-30
DE60228724D1 (de)	2008-10-16
RS51314B (sr)	2010-12-31
CN1235896C (zh)	2006-01-11
HRP20040198B1 (hr)	2012-02-29
EP1412342A1 (de)	2004-04-28
ES2314083T3 (es)	2009-03-16
IL159814A (en)	2008-08-07
IL159814A0 (en)	2004-06-20
ME00089B (me)	2010-10-10
CA2453649A1 (en)	2003-02-13
CN1537107A (zh)	2004-10-13
HRP20040198A2 (en)	2005-04-30
HK1078857A1 (zh)	2006-03-24
HU227157B1 (en)	2010-09-28
HUP0103089A3 (en)	2005-01-28

Publication	Publication Date	Title
ATE407127T1 (de)	2008-09-15	Verfahren zur herstellung von beraprost und dessen salzen
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Legal Events

Date	Code	Title	Description
2009-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties