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HUP0103089A2 - Beraproszt észter előállítása szelektív oxidációval - Google Patents

Beraproszt észter előállítása szelektív oxidációval

Info

Publication number
HUP0103089A2
HUP0103089A2 HU0103089A HUP0103089A HUP0103089A2 HU P0103089 A2 HUP0103089 A2 HU P0103089A2 HU 0103089 A HU0103089 A HU 0103089A HU P0103089 A HUP0103089 A HU P0103089A HU P0103089 A2 HUP0103089 A2 HU P0103089A2
Authority
HU
Hungary
Prior art keywords
selective oxidation
production
beraprost ester
beraprost
ester
Prior art date
Application number
HU0103089A
Other languages
English (en)
Inventor
dr. Kardos Zsuzsanna Baloghné
Zoltán Szeverényi
Gyula Dalmadi
Tibor Szabó
József Bódi
Original Assignee
Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. filed Critical Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt.
Priority to HU0103089A priority Critical patent/HU227157B1/hu
Publication of HUP0103089D0 publication Critical patent/HUP0103089D0/hu
Priority to JP2001398828A priority patent/JP4440506B2/ja
Priority to UA2004021460A priority patent/UA75692C2/uk
Priority to PCT/HU2002/000074 priority patent/WO2003011849A1/en
Priority to DE60228724T priority patent/DE60228724D1/de
Priority to MEP-187/08A priority patent/MEP18708A/xx
Priority to MXPA04000847A priority patent/MXPA04000847A/es
Priority to IL15981402A priority patent/IL159814A0/xx
Priority to YUP-86/04A priority patent/RS51314B/sr
Priority to BR0211514-0A priority patent/BR0211514A/pt
Priority to US10/484,209 priority patent/US7005527B2/en
Priority to AU2002321670A priority patent/AU2002321670B8/en
Priority to RU2004105959/04A priority patent/RU2272033C2/ru
Priority to CA002453649A priority patent/CA2453649C/en
Priority to ES02755382T priority patent/ES2314083T3/es
Priority to NZ531264A priority patent/NZ531264A/en
Priority to CNB02815021XA priority patent/CN1235896C/zh
Priority to MEP-2008-187A priority patent/ME00089B/me
Priority to HR20040198A priority patent/HRP20040198B1/xx
Priority to EP02755382A priority patent/EP1412342B1/en
Priority to CNB2005100702984A priority patent/CN100347165C/zh
Priority to HK05101229.6A priority patent/HK1068877B/xx
Priority to PL367298A priority patent/PL216072B1/pl
Priority to KR1020047001320A priority patent/KR100604699B1/ko
Priority to AT02755382T priority patent/ATE407127T1/de
Publication of HUP0103089A2 publication Critical patent/HUP0103089A2/hu
Priority to IL159814A priority patent/IL159814A/en
Priority to CU20040014A priority patent/CU23324B7/es
Priority to NO20040388A priority patent/NO328695B1/no
Priority to ZA2004/00748A priority patent/ZA200400748B/en
Publication of HUP0103089A3 publication Critical patent/HUP0103089A3/hu
Priority to HK05110705.0A priority patent/HK1078857B/xx
Publication of HU227157B1 publication Critical patent/HU227157B1/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Furan Compounds (AREA)
  • Error Detection And Correction (AREA)

Abstract

A jelen találmány az (I) képletű beraprost és sói előállításáravonatkozik, mely során új intermediereket és szelektív oxidációtalkalmaznak. Ó
HU0103089A 2001-07-30 2001-07-30 Production of beraprost ester by selective oxidation HU227157B1 (en)

Priority Applications (30)

Application Number Priority Date Filing Date Title
HU0103089A HU227157B1 (en) 2001-07-30 2001-07-30 Production of beraprost ester by selective oxidation
JP2001398828A JP4440506B2 (ja) 2001-07-30 2001-12-28 ケミカルプロセス
AT02755382T ATE407127T1 (de) 2001-07-30 2002-07-25 Verfahren zur herstellung von beraprost und dessen salzen
ES02755382T ES2314083T3 (es) 2001-07-30 2002-07-25 Procedimiento para la produccion de beraprost y sus sales.
MEP-2008-187A ME00089B (me) 2001-07-30 2002-07-25 Postupak za produkciju beraprosta i njegovih soli
DE60228724T DE60228724D1 (de) 2001-07-30 2002-07-25 Verfahren zur herstellung von beraprost und dessen salzen
MEP-187/08A MEP18708A (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts
MXPA04000847A MXPA04000847A (es) 2001-07-30 2002-07-25 Procedimiento para la obtencion de beraprost y sus sales.
IL15981402A IL159814A0 (en) 2001-07-30 2002-07-25 Process for the production of beraprost an its salts
YUP-86/04A RS51314B (sr) 2001-07-30 2002-07-25 Postupak za produkciju beraprosta i njegovih soli
BR0211514-0A BR0211514A (pt) 2001-07-30 2002-07-25 Processo para produção de beraprost e seus sais
US10/484,209 US7005527B2 (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts
AU2002321670A AU2002321670B8 (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts
RU2004105959/04A RU2272033C2 (ru) 2001-07-30 2002-07-25 Способ получения берапроста и его солей
CA002453649A CA2453649C (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts
UA2004021460A UA75692C2 (uk) 2001-07-30 2002-07-25 Спосіб одержання берапросту і його солей
NZ531264A NZ531264A (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts
CNB02815021XA CN1235896C (zh) 2001-07-30 2002-07-25 制备贝前列素及其盐的方法
PCT/HU2002/000074 WO2003011849A1 (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts
HR20040198A HRP20040198B1 (hr) 2001-07-30 2002-07-25 POSTUPAK PROIZVODNJE BERAPROST-a I NJEGOVIH SOLI
EP02755382A EP1412342B1 (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts
CNB2005100702984A CN100347165C (zh) 2001-07-30 2002-07-25 制备贝前列素及其盐的中间体
HK05101229.6A HK1068877B (en) 2001-07-30 2002-07-25 Process for the production of beraprost and its salts
PL367298A PL216072B1 (pl) 2001-07-30 2002-07-25 Sposób wytwarzania beraprostu i jego soli oraz nowe zwiazki
KR1020047001320A KR100604699B1 (ko) 2001-07-30 2002-07-25 베라프로스트와 이의 염을 제조하는 방법
IL159814A IL159814A (en) 2001-07-30 2004-01-11 Process for the production of Brafrost and its salts
CU20040014A CU23324B7 (es) 2001-07-30 2004-01-26 Proceso para la producción de berapost y sus sales
NO20040388A NO328695B1 (no) 2001-07-30 2004-01-29 Fremgangsmate for fremstilling av beraprost og salter derav, samt forbindelser som er mellomprodukter i fremgangsmaten
ZA2004/00748A ZA200400748B (en) 2001-07-30 2004-01-29 Process for the production of beraprost and its salts
HK05110705.0A HK1078857B (en) 2001-07-30 2005-11-25 Intermediates for the production of beraprost and its salts

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0103089A HU227157B1 (en) 2001-07-30 2001-07-30 Production of beraprost ester by selective oxidation

Publications (4)

Publication Number Publication Date
HUP0103089D0 HUP0103089D0 (en) 2001-10-28
HUP0103089A2 true HUP0103089A2 (hu) 2003-07-28
HUP0103089A3 HUP0103089A3 (en) 2005-01-28
HU227157B1 HU227157B1 (en) 2010-09-28

Family

ID=90001541

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0103089A HU227157B1 (en) 2001-07-30 2001-07-30 Production of beraprost ester by selective oxidation

Country Status (25)

Country Link
US (1) US7005527B2 (hu)
EP (1) EP1412342B1 (hu)
JP (1) JP4440506B2 (hu)
KR (1) KR100604699B1 (hu)
CN (2) CN100347165C (hu)
AT (1) ATE407127T1 (hu)
AU (1) AU2002321670B8 (hu)
BR (1) BR0211514A (hu)
CA (1) CA2453649C (hu)
CU (1) CU23324B7 (hu)
DE (1) DE60228724D1 (hu)
ES (1) ES2314083T3 (hu)
HR (1) HRP20040198B1 (hu)
HU (1) HU227157B1 (hu)
IL (2) IL159814A0 (hu)
ME (2) ME00089B (hu)
MX (1) MXPA04000847A (hu)
NO (1) NO328695B1 (hu)
NZ (1) NZ531264A (hu)
PL (1) PL216072B1 (hu)
RS (1) RS51314B (hu)
RU (1) RU2272033C2 (hu)
UA (1) UA75692C2 (hu)
WO (1) WO2003011849A1 (hu)
ZA (1) ZA200400748B (hu)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0215757D0 (en) * 2002-07-08 2002-08-14 Cascade Biochem Ltd Benzoprostacyclin intermediates methods for their preparation and products derived therefrom
WO2012174407A1 (en) * 2011-06-16 2012-12-20 Lung LLC Method of producing beraprost
CN102952107B (zh) * 2011-08-29 2015-10-07 上海天伟生物制药有限公司 一种高纯度的贝前列素钠及其制备方法和用途
US9388154B2 (en) 2011-09-12 2016-07-12 Lund Biotechnology PBC Process for preparing synthetic prostacyclins
CN103509044A (zh) * 2012-06-21 2014-01-15 上海天伟生物制药有限公司 贝前列素钠中间体及其制备方法
KR20150132440A (ko) * 2013-03-15 2015-11-25 젬머스 파마 인코포레이티드 바이러스 감염의 치료제로서의 베라프로스트 이성질체
CN103242274B (zh) * 2013-05-22 2014-11-05 孙威 一种贝前列素钠化合物及其制备方法
CN106573904B (zh) 2014-05-20 2019-11-08 朗格生物技术公共公益股份有限公司 用于产生贝前列素及其衍生物的方法
WO2017027706A1 (en) * 2015-08-12 2017-02-16 United Therapeutics Corporation Process for making beraprost
HU231080B1 (hu) * 2016-04-05 2020-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás optikailag aktív Beraprost előállítására
HU231212B1 (hu) * 2018-04-16 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás iloprost előállítására
US10577340B1 (en) * 2018-11-26 2020-03-03 Chirogate International Inc. Beraprost-314d crystals and methods for preparation thereof
EP4103192A4 (en) 2020-02-12 2024-02-21 Cytoagents, Inc. COMPOSITIONS AND METHODS FOR TREATING CORONAVIRUS INFECTIONS
WO2023276983A1 (ja) * 2021-06-28 2023-01-05 大内新興化学工業株式会社 ベラプロストまたは光学活性体の合成中間体およびその製造方法
CN115611838A (zh) * 2021-07-15 2023-01-17 四川国为制药有限公司 一种前列环素衍生物的晶型

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JPS5931510B2 (ja) * 1979-09-03 1984-08-02 東レ株式会社 ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS58124778A (ja) * 1982-01-20 1983-07-25 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体
JPS59134787A (ja) * 1983-01-19 1984-08-02 Toray Ind Inc ５，６，７−トリノル−４，８−インタ−ｍ−フエニレンＰＧＩ↓２誘導体の製造法
HU197733B (en) * 1985-05-29 1989-05-29 Chinoin Gyogyszer Es Vegyeszet Process for producing ephedrin-salts of 7-oxo-prosta-cyclin derivatives
CA1284642C (en) * 1986-03-31 1991-06-04 Hikozo Iwakura Prostacyclin (pgi ) analogues
JP2594118B2 (ja) * 1987-07-01 1997-03-26 塩野義製薬株式会社 ベンゾジオキサンプロスタサイクリン類縁体
JP2542429B2 (ja) * 1987-10-27 1996-10-09 三共株式会社 オクタヒドロナフタリン置換オキシム誘導体
GB8929059D0 (en) * 1989-12-22 1990-02-28 Leo Pharm Prod Ltd Chemical compounds
JP3025056B2 (ja) * 1991-03-12 2000-03-27 財団法人微生物化学研究会 ２，６−ジデオキシ−２−フルオロ−ｌ−タロピラノース誘導体の製造法
JP3024298B2 (ja) * 1991-09-13 2000-03-21 住友化学工業株式会社 シクロペンテンエステル類及びその利用
DE4226615C1 (de) * 1992-08-07 1994-05-19 Schering Ag Verwendung von Prostan-Derivaten zur Behandlung von chronischer Polyarthritis
DE19530884C2 (de) * 1995-08-11 1997-07-31 Schering Ag Verwendung von Prostan-Derivaten sowie deren Kombination mit Antibiotika zur Behandlung von bakteriellen Meningitis
JPH09132589A (ja) * 1995-09-08 1997-05-20 Microbial Chem Res Found 糖部分の水酸基をモノ−または−ジ−ｏ−アミノアルカノイル化された含フッ素アンスラサイクリン誘導体

Also Published As

Publication number Publication date
WO2003011849A1 (en) 2003-02-13
RU2272033C2 (ru) 2006-03-20
HK1068877A1 (en) 2005-05-06
MXPA04000847A (es) 2004-03-26
CA2453649C (en) 2009-12-22
UA75692C2 (uk) 2006-05-15
US20040209945A1 (en) 2004-10-21
CN1680351A (zh) 2005-10-12
AU2002321670B2 (en) 2008-08-14
CU23324B7 (es) 2008-11-27
WO2003011849A8 (en) 2004-03-11
MEP18708A (en) 2010-06-10
NO20040388L (no) 2004-01-29
KR100604699B1 (ko) 2006-07-31
KR20040043169A (ko) 2004-05-22
HUP0103089D0 (en) 2001-10-28
RS8604A (en) 2007-02-05
US7005527B2 (en) 2006-02-28
PL216072B1 (pl) 2014-02-28
PL367298A1 (en) 2005-02-21
RU2004105959A (ru) 2005-03-27
ZA200400748B (en) 2005-01-26
AU2002321670B8 (en) 2008-09-11
CN100347165C (zh) 2007-11-07
BR0211514A (pt) 2004-09-14
NO328695B1 (no) 2010-04-26
JP4440506B2 (ja) 2010-03-24
JP2003055368A (ja) 2003-02-26
EP1412342B1 (en) 2008-09-03
NZ531264A (en) 2005-09-30
DE60228724D1 (de) 2008-10-16
ATE407127T1 (de) 2008-09-15
RS51314B (sr) 2010-12-31
CN1235896C (zh) 2006-01-11
HRP20040198B1 (hr) 2012-02-29
EP1412342A1 (en) 2004-04-28
ES2314083T3 (es) 2009-03-16
IL159814A (en) 2008-08-07
IL159814A0 (en) 2004-06-20
ME00089B (me) 2010-10-10
CA2453649A1 (en) 2003-02-13
CN1537107A (zh) 2004-10-13
HRP20040198A2 (en) 2005-04-30
HK1078857A1 (zh) 2006-03-24
HU227157B1 (en) 2010-09-28
HUP0103089A3 (en) 2005-01-28

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Legal Events

Date Code Title Description
HC9A Change of name, address

Owner name: CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA, HU

Free format text: FORMER OWNER(S): CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT., HU