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BR9807802A - Alquila, arila ou heteroarilamidas n-hidróxi-2-(alquila, arila, ou heteroaril sulfanil, sulfinil ou proteinase de matriz - Google Patents

Alquila, arila ou heteroarilamidas n-hidróxi-2-(alquila, arila, ou heteroaril sulfanil, sulfinil ou proteinase de matriz

Info

Publication number
BR9807802A
BR9807802A BR9807802A BR9807802A BR9807802A BR 9807802 A BR9807802 A BR 9807802A BR 9807802 A BR9807802 A BR 9807802A BR 9807802 A BR9807802 A BR 9807802A BR 9807802 A BR9807802 A BR 9807802A
Authority
BR
Brazil
Prior art keywords
aryl
alkyl
hydroxy
mmps
matrix metalloproteinases
Prior art date
Application number
BR9807802A
Other languages
English (en)
Inventor
Aranapakam Mudumbai Venkatesan
George Theodore Grosu
Jamie Marie Davis
Jannie Lea Baker
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of BR9807802A publication Critical patent/BR9807802A/pt

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
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    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

RILAMIDAS N-HIDRóXI-2-(ALQUILA, ARILA, OU HETEROAR Metaloproteinases de matriz (MMPs) são um grupo de enzimas que têm sido implicadas na destruição patológica do tecido conjuntivo e membranas basais. Estas endopeptidases contendo zinco consistem em várias sub-séries de enzimas inclusive colagenases, estromelisinas e gelatinases. A enzima conversoraia, cataliza a formação de TNF-<244> a partir da proteína precursora de TNF-<244> ligada à membrana.la pequena tenham portanto o potencial para tratarvenção fornece inibidores não-peptídeo de metaloproteinases da matriz (MMPs), de baixo peso molecularatamento de artrite, metástase tumoral, ulceração tecidual, cicatrização anormal, doença periodontal, distúrbio ósseo, diabetes (resistente à insulina) e infecção por HIV tendo a fórmula (I) em que R^ 2^ e R^ 3^ formam um anel heterocíclico e A é S, S(O), ou S(O)~ 2~, e R^ 1^ e R^ 4^ são conforme definido neste relatório.
BR9807802A 1997-02-27 1998-02-17 Alquila, arila ou heteroarilamidas n-hidróxi-2-(alquila, arila, ou heteroaril sulfanil, sulfinil ou proteinase de matriz BR9807802A (pt)

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PCT/US1998/002987 WO1998037877A1 (en) 1997-02-27 1998-02-17 N-hydroxy-2-(alkyl, aryl or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors

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BR9807802A BR9807802A (pt) 1997-02-27 1998-02-17 Alquila, arila ou heteroarilamidas n-hidróxi-2-(alquila, arila, ou heteroaril sulfanil, sulfinil ou proteinase de matriz

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HUP0001463A2 (hu) 2000-08-28
HUP0002092A2 (hu) 2001-04-28
DE69820424T2 (de) 2004-10-14
PT970046E (pt) 2004-04-30
NZ337336A (en) 2001-05-25
NO994125L (no) 1999-10-26
AU748998B2 (en) 2002-06-13
WO1998038163A1 (en) 1998-09-03
EP0970046B1 (en) 2003-12-10
EA199900769A1 (ru) 2000-04-24
SK115899A3 (en) 2000-05-16
KR20000075808A (ko) 2000-12-26
IL131257A0 (en) 2001-01-28
EP0973512A1 (en) 2000-01-26
YU40999A (sh) 2002-06-19
DE69820424D1 (en) 2004-01-22
CN1210263C (zh) 2005-07-13
EA003836B1 (ru) 2003-10-30
ATE256107T1 (de) 2003-12-15
DE69823019D1 (de) 2004-05-13
CA2282656A1 (en) 1998-09-03
HUP0001463A3 (en) 2001-04-28
EA001742B1 (ru) 2001-08-27
EE9900371A (et) 2000-04-17
WO1998037877A1 (en) 1998-09-03
JP2001519777A (ja) 2001-10-23
DE69823019T2 (de) 2005-03-31
AR011451A1 (es) 2000-08-16
NO994124L (no) 1999-10-26
EE04150B1 (et) 2003-10-15
SK115799A3 (en) 2000-09-12
ES2217540T3 (es) 2004-11-01
NZ337298A (en) 2002-11-26
GEP20022626B (en) 2002-02-25
PL335286A1 (en) 2000-04-10
NO314258B1 (no) 2003-02-24
BG103757A (bg) 2000-04-28
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DK0970046T3 (da) 2004-04-13
JP2001513771A (ja) 2001-09-04
YU41099A (sh) 2002-06-19
PL335401A1 (en) 2000-04-25
IL131258A0 (en) 2001-01-28
NO994124D0 (no) 1999-08-26
KR20000075809A (ko) 2000-12-26
DK0973512T3 (da) 2004-07-12
BG103760A (bg) 2000-04-28
AU6436898A (en) 1998-09-18
PT973512E (pt) 2004-07-30
TR199901901T2 (xx) 1999-12-21
EE04295B1 (et) 2004-06-15
GEP20022627B (en) 2002-02-25
ATE263554T1 (de) 2004-04-15
TW568900B (en) 2004-01-01
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EA199900768A1 (ru) 2000-08-28

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