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YU41099A - N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-substituisani alkil, aril ili heteroaril- amidi, kao inhibitori za metaloproteinaze - Google Patents

N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-substituisani alkil, aril ili heteroaril- amidi, kao inhibitori za metaloproteinaze

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Publication number
YU41099A
YU41099A YU41099A YU41099A YU41099A YU 41099 A YU41099 A YU 41099A YU 41099 A YU41099 A YU 41099A YU 41099 A YU41099 A YU 41099A YU 41099 A YU41099 A YU 41099A
Authority
YU
Yugoslavia
Prior art keywords
alpha
tnf
aryl
tace
mmps
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Application number
YU41099A
Other languages
English (en)
Inventor
Aranapakam Mudumbai Venkatesan
George Theodore Grosu
Jamie Marie Davis
Jannie Lea Baker
Original Assignee
American Cyanamid Company
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Filing date
Publication date
Application filed by American Cyanamid Company filed Critical American Cyanamid Company
Publication of YU41099A publication Critical patent/YU41099A/sh

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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
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    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

Maticne metaloproteinaze (MMP) su grupa enzima koja ucestvuje u pataloskoj razgradnji vezivnog tkiva i osnovnih membrana. Ove endopeptidaze, koje sadrze cink, sastoje se od nekoliko podvrsta enzima, u koje dolaze kolagenaze, stromelizini i zelatinaze. Enzimi za konverziju TNF-α (TACE), proinflamatorni citokin, katalizuju stvaranje TNF-α- vezanog u membrani. Ocekuje sa da ce mali molekukli, kao inhibitori MMP i TACE, posedovati potencijal za lecenje niza bolesnih stanja. Sadasnji pronalazak daje ne-peptidne inhibitore matricnih metaloproteinaza (MMP) i enzima za konverziju TNF-α (TACE), niske molarne mase, za lecenje artritisa, metastaza tumora, ulceracije tkiva, abnomarlnog zarastanja rana, periodontalnih oboljenja, oboljenja kostiju, dijabetesa (rezistentnost prema insulinu) i HIV infekcije. Jedinjenja ovog pronalaska predstavlja formula (I) gde su R1, R2, R3 i R4 opisani u tekstu.
YU41099A 1997-02-27 1998-02-17 N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-substituisani alkil, aril ili heteroaril- amidi, kao inhibitori za metaloproteinaze YU41099A (sh)

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YU40999A YU40999A (sh) 1997-02-27 1998-02-17 N-hidroksi-2-(alkil,aril ili heteroaril sulfanil,sulfinil ili sulfonil)-3-supstituisani alkil,aril ili heteroarilamidi, kao inhibitori za matrične metaloproteinaze

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HUP0001463A2 (hu) 2000-08-28
HUP0002092A2 (hu) 2001-04-28
DE69820424T2 (de) 2004-10-14
PT970046E (pt) 2004-04-30
NZ337336A (en) 2001-05-25
NO994125L (no) 1999-10-26
AU748998B2 (en) 2002-06-13
WO1998038163A1 (en) 1998-09-03
EP0970046B1 (en) 2003-12-10
EA199900769A1 (ru) 2000-04-24
SK115899A3 (en) 2000-05-16
KR20000075808A (ko) 2000-12-26
IL131257A0 (en) 2001-01-28
EP0973512A1 (en) 2000-01-26
YU40999A (sh) 2002-06-19
DE69820424D1 (en) 2004-01-22
CN1210263C (zh) 2005-07-13
EA003836B1 (ru) 2003-10-30
ATE256107T1 (de) 2003-12-15
DE69823019D1 (de) 2004-05-13
CA2282656A1 (en) 1998-09-03
HUP0001463A3 (en) 2001-04-28
EA001742B1 (ru) 2001-08-27
EE9900371A (et) 2000-04-17
WO1998037877A1 (en) 1998-09-03
JP2001519777A (ja) 2001-10-23
DE69823019T2 (de) 2005-03-31
AR011451A1 (es) 2000-08-16
NO994124L (no) 1999-10-26
EE04150B1 (et) 2003-10-15
SK115799A3 (en) 2000-09-12
ES2217540T3 (es) 2004-11-01
NZ337298A (en) 2002-11-26
GEP20022626B (en) 2002-02-25
PL335286A1 (en) 2000-04-10
NO314258B1 (no) 2003-02-24
BG103757A (bg) 2000-04-28
EP0973512B1 (en) 2004-04-07
DK0970046T3 (da) 2004-04-13
JP2001513771A (ja) 2001-09-04
PL335401A1 (en) 2000-04-25
IL131258A0 (en) 2001-01-28
NO994124D0 (no) 1999-08-26
KR20000075809A (ko) 2000-12-26
DK0973512T3 (da) 2004-07-12
BG103760A (bg) 2000-04-28
AU6436898A (en) 1998-09-18
PT973512E (pt) 2004-07-30
TR199901901T2 (xx) 1999-12-21
EE04295B1 (et) 2004-06-15
GEP20022627B (en) 2002-02-25
ATE263554T1 (de) 2004-04-15
TW568900B (en) 2004-01-01
NO314302B1 (no) 2003-03-03
ZA981628B (en) 2000-02-28
EA199900768A1 (ru) 2000-08-28

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