CN105815314B - A kind of bactericidal composition containing metrafenone and methoxy acrylic - Google Patents
A kind of bactericidal composition containing metrafenone and methoxy acrylic Download PDFInfo
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- CN105815314B CN105815314B CN201610221177.3A CN201610221177A CN105815314B CN 105815314 B CN105815314 B CN 105815314B CN 201610221177 A CN201610221177 A CN 201610221177A CN 105815314 B CN105815314 B CN 105815314B
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- Prior art keywords
- metrafenone
- active
- active constituent
- bactericidal composition
- disease
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- 239000005810 Metrafenone Substances 0.000 title claims abstract description 84
- AMSPWOYQQAWRRM-UHFFFAOYSA-N metrafenone Chemical compound COC1=CC=C(Br)C(C)=C1C(=O)C1=C(C)C=C(OC)C(OC)=C1OC AMSPWOYQQAWRRM-UHFFFAOYSA-N 0.000 title claims abstract description 84
- 239000000203 mixture Substances 0.000 title claims abstract description 42
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 18
- 239000000470 constituent Substances 0.000 claims abstract description 59
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 44
- 201000010099 disease Diseases 0.000 claims abstract description 42
- 239000005762 Dimoxystrobin Substances 0.000 claims abstract description 19
- WXUZAHCNPWONDH-DYTRJAOYSA-N dimoxystrobin Chemical compound CNC(=O)C(=N\OC)\C1=CC=CC=C1COC1=CC(C)=CC=C1C WXUZAHCNPWONDH-DYTRJAOYSA-N 0.000 claims abstract description 19
- 241000221785 Erysiphales Species 0.000 claims description 19
- 239000000375 suspending agent Substances 0.000 claims description 18
- 239000003094 microcapsule Substances 0.000 claims description 14
- 239000000839 emulsion Substances 0.000 claims description 13
- 235000007164 Oryza sativa Nutrition 0.000 claims description 12
- 235000009566 rice Nutrition 0.000 claims description 12
- 239000003795 chemical substances by application Substances 0.000 claims description 11
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 9
- 241000233679 Peronosporaceae Species 0.000 claims description 9
- 239000004563 wettable powder Substances 0.000 claims description 9
- 206010039509 Scab Diseases 0.000 claims description 8
- 239000000725 suspension Substances 0.000 claims description 8
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 6
- 239000004530 micro-emulsion Substances 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 5
- 239000004615 ingredient Substances 0.000 claims description 5
- 241001530056 Athelia rolfsii Species 0.000 claims description 4
- 241000582441 Peronospora tabacina Species 0.000 claims description 4
- 230000035613 defoliation Effects 0.000 claims description 4
- 150000002576 ketones Chemical class 0.000 claims description 3
- 240000007594 Oryza sativa Species 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract description 19
- 239000005800 Kresoxim-methyl Substances 0.000 abstract description 18
- ZOTBXTZVPHCKPN-HTXNQAPBSA-N kresoxim-methyl Chemical compound CO\N=C(\C(=O)OC)C1=CC=CC=C1COC1=CC=CC=C1C ZOTBXTZVPHCKPN-HTXNQAPBSA-N 0.000 abstract description 18
- 239000005784 Fluoxastrobin Substances 0.000 abstract description 17
- UFEODZBUAFNAEU-NLRVBDNBSA-N fluoxastrobin Chemical compound C=1C=CC=C(OC=2C(=C(OC=3C(=CC=CC=3)Cl)N=CN=2)F)C=1C(=N/OC)\C1=NOCCO1 UFEODZBUAFNAEU-NLRVBDNBSA-N 0.000 abstract description 17
- JHIPUJPTQJYEQK-ZLHHXESBSA-N orysastrobin Chemical compound CNC(=O)C(=N\OC)\C1=CC=CC=C1CO\N=C(/C)\C(=N\OC)\C(\C)=N\OC JHIPUJPTQJYEQK-ZLHHXESBSA-N 0.000 abstract description 17
- 239000000575 pesticide Substances 0.000 abstract description 17
- 150000001875 compounds Chemical class 0.000 abstract description 9
- 206010059866 Drug resistance Diseases 0.000 abstract description 2
- 238000012271 agricultural production Methods 0.000 abstract description 2
- 230000007613 environmental effect Effects 0.000 abstract description 2
- 238000003912 environmental pollution Methods 0.000 abstract description 2
- 244000144972 livestock Species 0.000 abstract description 2
- 238000012360 testing method Methods 0.000 description 34
- 238000013329 compounding Methods 0.000 description 32
- 239000003814 drug Substances 0.000 description 24
- 230000003449 preventive effect Effects 0.000 description 21
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 239000012071 phase Substances 0.000 description 19
- 230000000694 effects Effects 0.000 description 14
- 230000002265 prevention Effects 0.000 description 14
- 239000008367 deionised water Substances 0.000 description 13
- 229910021641 deionized water Inorganic materials 0.000 description 13
- 239000002270 dispersing agent Substances 0.000 description 13
- 239000002518 antifoaming agent Substances 0.000 description 12
- 241000209094 Oryza Species 0.000 description 11
- 239000003995 emulsifying agent Substances 0.000 description 9
- 238000002474 experimental method Methods 0.000 description 9
- 240000008067 Cucumis sativus Species 0.000 description 8
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 8
- 241000209140 Triticum Species 0.000 description 8
- 235000021307 Triticum Nutrition 0.000 description 8
- 230000002528 anti-freeze Effects 0.000 description 8
- 239000002904 solvent Substances 0.000 description 8
- 239000002562 thickening agent Substances 0.000 description 8
- 239000000080 wetting agent Substances 0.000 description 8
- 206010067482 No adverse event Diseases 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 241000227653 Lycopersicon Species 0.000 description 5
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 5
- 240000001987 Pyrus communis Species 0.000 description 5
- 235000014443 Pyrus communis Nutrition 0.000 description 5
- 231100000820 toxicity test Toxicity 0.000 description 5
- 206010011732 Cyst Diseases 0.000 description 4
- 241000510928 Erysiphe necator Species 0.000 description 4
- 238000004458 analytical method Methods 0.000 description 4
- 235000013339 cereals Nutrition 0.000 description 4
- 208000031513 cyst Diseases 0.000 description 4
- 235000013399 edible fruits Nutrition 0.000 description 4
- 238000013401 experimental design Methods 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 229920002521 macromolecule Polymers 0.000 description 4
- 239000003002 pH adjusting agent Substances 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 235000010149 Brassica rapa subsp chinensis Nutrition 0.000 description 3
- 235000000536 Brassica rapa subsp pekinensis Nutrition 0.000 description 3
- 241000499436 Brassica rapa subsp. pekinensis Species 0.000 description 3
- 239000011149 active material Substances 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
- 230000010165 autogamy Effects 0.000 description 3
- 238000000498 ball milling Methods 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000007884 disintegrant Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 230000001629 suppression Effects 0.000 description 3
- 230000001018 virulence Effects 0.000 description 3
- 241000219112 Cucumis Species 0.000 description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 2
- 150000001412 amines Chemical class 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 239000012752 auxiliary agent Substances 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000009036 growth inhibition Effects 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 235000021374 legumes Nutrition 0.000 description 2
- 239000010871 livestock manure Substances 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000010008 shearing Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 239000005730 Azoxystrobin Substances 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 208000031968 Cadaver Diseases 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 208000020282 anthrax disease Diseases 0.000 description 1
- -1 azoxystrobin compound Chemical class 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 239000010242 baoji Substances 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002068 microbial inoculum Substances 0.000 description 1
- SQDFHQJTAWCFIB-UHFFFAOYSA-N n-methylidenehydroxylamine Chemical compound ON=C SQDFHQJTAWCFIB-UHFFFAOYSA-N 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
- A01N37/50—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids the nitrogen atom being doubly bound to the carbon skeleton
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/04—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aldehyde or keto groups, or thio analogues thereof, directly attached to an aromatic ring system, e.g. acetophenone; Derivatives thereof, e.g. acetals
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pest Control & Pesticides (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses a kind of bactericidal composition containing metrafenone and methoxy acrylic, the bactericidal composition containing active components A and active constituent B, wherein active components A are selected from metrafenone, and active constituent B is selected from any one following compound：Fluoxastrobin, kresoxim-methyl, dimoxystrobin, orysastrobin, and active components A and the weight ratio of active constituent B are 1 ︰, 80~80 ︰ 1.The present composition has synergistic effect to the multiple diseases for endangering agricultural production, reduces pesticide usage amount, reduces residual quantity of the pesticide on crop, alleviate environmental pollution, to safety of human and livestock, Environmental compatibility is good, and disease is not likely to produce drug resistance.
Description
The application is divisional application, and original application is that the patent application of Shaanxi Meibang Pesticide Co., Ltd. is " a kind of to contain metrafenone
With the bactericidal composition of methoxy acrylic ", the application Wei ︰ 201210535240.2 of original application, original application day is
2012.12.12。
Technical field
The invention belongs to technical field of pesticide, are related to a kind of bactericidal composition containing metrafenone and methoxy acrylic
Application on corps diseases.
Background technology
Metrafenone (metrafenone), molecular formula：C19H21BrO5, it is that the Benzophenones of BASF Aktiengesellschaft's exploitation kill
Microbial inoculum is mainly used for preventing powdery mildew.
Fluoxastrobin, kresoxim-methyl, dimoxystrobin, orysastrobin belong to methoxy acrylic bactericide, are widely used in
In the disease of crops.
However, in the real process of agricultural production, the problem of controlling disease most easily produces is the production of disease drug resistance
It is raw.Different cultivars ingredient is compounded, and is to prevent the very common method of resistance disease.Heterogeneity is compounded, according to reality
Application effect, to judge that certain compounding is synergy, adduction or antagonism.In most cases, the compounding effect of sterilization
All it is additive effect, really has the compounding of synergistic effect seldom, especially synergistic effect is clearly, synergy ratio is very high answers
With just less.It studies, is found energy after metrafenone and Fluoxastrobin, kresoxim-methyl, dimoxystrobin, orysastrobin compounding by inventor
Good synergistic effect is generated, and about metrafenone and Fluoxastrobin, the related report of kresoxim-methyl, dimoxystrobin, orysastrobin compounding
Road not yet discloses.
Invention content
The purpose of the present invention is to propose to it is a kind of with synergistic function, use cost is low, preventive effect is good containing metrafenone with
The bactericidal composition of methoxy acrylic.
Bactericidal composition proposed by the present invention containing metrafenone and methoxy acrylic contains active components A and activity
Ingredient B, active components A and active constituent B weight ratios are 1 ︰, 80~80 ︰ 1, and the active components A is selected from metrafenone, activity at
B is divided to be selected from one of Fluoxastrobin, kresoxim-methyl, dimoxystrobin, orysastrobin kind, active components A and the preferred weight ratios of active constituent B
For 1 ︰, 50~50 ︰ 1；More preferably the weight ratio of metrafenone and Fluoxastrobin is 1 ︰, 30~10 ︰ 1, metrafenone and kresoxim-methyl or ether bacterium
The weight ratio of amine or orysastrobin is 1 ︰, 20~10 ︰ 1；Most preferably the weight ratio of metrafenone and Fluoxastrobin is 1 ︰, 15~5 ︰ 1, benzene
Bacterium ketone is 1 ︰, 8~4 ︰ 1 with kresoxim-methyl or the weight ratio of dimoxystrobin or orysastrobin.
Bactericidal composition proposed by the present invention containing metrafenone and methoxy acrylic is sick on crops for preventing
Harmful purposes, the crops include cereal crops, legume crop, fibre crops, sugar crop, melon crop, fruits
Crop, dry fruit crop, hobby crop, root crop, oil crops, flower crop, medicinal crop, crop, green manure
Pasture crop；The disease includes downy mildew, powdery mildew, epidemic disease, leaf mold, shot hole, scab, peronospora tabacina, anthrax
Disease, spot defoliation, rust, rice blast, banded sclerotial blight, brown spot.
Active components A, the weight ratio of active constituent B are 1 ︰, 80~80 ︰ 1.The weight hundred of active component in usual composition
Divide content for the 0.5%~90% of total weight, preferably 5%~80%.According to different preparation types, active component content
Range is different.In general, liquid preparation contains by weight 1%~70% active material, preferably 5%~50%；
Solid pharmaceutical preparation contains by weight 5%~80% active material, preferably 10%~80%.
The present invention bactericidal composition at least contain a kind of surfactant, in favor of application when active component in water
Dispersion.Surface-active contents are the 5%~30% of total formulation weight, and surplus is solid or liquid diluent.
The bactericidal composition of the present invention can used before through dilution or directly by user.Its preparation can be by usual
Processing method known in those skilled in the art prepare, i.e., after active material being mixed with liquid flux or solid carrier,
Add one kind in surfactant such as dispersant, stabilizer, wetting agent, binder, antifoaming agent, disintegrant, antifreeze
Or it is several.
The bactericidal composition of the present invention, can be processed into acceptable dosage form in any sterilization, wherein more preferably on demand
Dosage form be that wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspending agent, micro-capsule are outstanding
Floating-suspending agent.
Composition includes following constituent content when wettable powder is made：Active components A 1%~80%, active constituent
B1%~80%, dispersant 2%~10%, wetting agent 2%~10%, filler surplus.
Composition includes following constituent content when water dispersible granules are made：Active components A 1%~80%, active constituent
B1%~80%, dispersant 3%~12%, wetting agent 1%~8%, disintegrant 1%~10%, binder 0~8%, more than filler
Amount.
Composition includes following constituent content when suspending agent is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, dispersant 2%~10%, wetting agent 2%~10%, antifoaming agent 0.01%~2%, thickener 0~2%,
Antifreeze 0~8%, deionized water add to 100%.
Composition includes following constituent content when suspension emulsion is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, dispersant 2%~10%, antifoaming agent 0.01%~2%, solvent 1%~15%, thickener 0~2%, breast
Agent 2%~12%, antifreeze 0~8%, deionized water add to 100%.
Composition includes following constituent content when aqueous emulsion is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, solvent 1%~30%, emulsifier 1%~15%, antifreeze 0~8%, thickener 0~2%, antifoaming agent
0.01%~2%, deionized water supplies surplus.
Composition includes following constituent content when microemulsion is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, emulsifier 3%~25%, antifreeze 0~8%, antifoaming agent 0.01%~2%, is gone solvent 1%~30%
Ionized water supplies surplus.
Composition includes following constituent content when microcapsule suspending agent is made：Active components A 0.5%~50%, active constituent
B0.5%~50%, macromolecule cyst material 2%~10%, dispersant 1%~10%, organic solvent 1%~10%, emulsifier
1%~7%, antifoaming agent 0.01%~2%, pH adjusting agent 0.01%~5%, deionized water add to 100%.
Composition includes following constituent content when microcapsule suspension-suspendinagent agent is made：Active components A 0.5%~50%, activity
It is ingredient B0.5%~50%, macromolecule cyst material 2%~10%, dispersant 1%~12%, wetting agent 1%~8%, organic
Solvent 1%~15%, emulsifier 1%~6%, antifoaming agent 0.01%~2%, thickener 0~2%, pH adjusting agent 0.01%~
5%, deionized water adds to 100%；
The wettable powder the key technical indexes of the present invention：
The water dispersible granules the key technical indexes of the present invention：
The suspending agent the key technical indexes of the present invention：
The suspension emulsion the key technical indexes of the present invention：
The aqueous emulsion the key technical indexes of the present invention：
The microemulsion the key technical indexes of the present invention：
The microcapsule suspending agent the key technical indexes of the present invention：
The microcapsule suspension-suspendinagent agent the key technical indexes of the present invention：
The advantage of the invention is that：
(1) metrafenone with after Fluoxastrobin, kresoxim-methyl, dimoxystrobin, orysastrobin compounding there is apparent synergy and holding effect to make
With；(2) to cereal crops, legume crop, fibre crops, sugar crop, melon crop, fruits crop, dry fruit crop, thermophilic
Good crop, root crop, oil crops, flower crop, medicinal crop, crop, the disease on green manure pasture crop are equal
There is greater activity；(3) reduce pesticide usage amount, reduce residual quantity of the pesticide on crop, alleviate environmental pollution；(4)
To safety of human and livestock, Environmental compatibility is good；And preparation adhesion strength enhances, resistance of rainwater washing against.
Specific implementation mode
With reference to embodiment to further instruction of the present invention, the percentage in embodiment is weight percentage, but
The present invention is not limited thereto.
Application Example one
1~12 wettable powder of embodiment
Metrafenone, active constituent B, dispersant, wetting agent, filler are uniformly mixed in mixed cylinder, through airslide disintegrating mill
It is remixed after crushing uniformly, you can wettable powder product of the present invention is made, is specifically shown in Table 1.
1 embodiment of table, 1~12 each component and parts by weight
13~24 water dispersible granules of embodiment
Metrafenone, active constituent B, dispersant, wetting agent, disintegrant, filler etc. are needed through air-flow crushing together
Grain size, add other auxiliary agents such as binder (can add can be not added with), obtain granulation materials.Item is quantified into the fluid bed system of feeding
In grain drying machine after granulation and drying, you can water dispersible granules product of the present invention is made, is specifically shown in Table 2.
2 embodiment of table, 13~24 each component and parts by weight
25~36 suspending agent of embodiment
By dispersant, wetting agent, antifoaming agent, thickener (can add can be not added with), antifreeze (can add can be not added with), by high speed
Shear-mixed is uniform, metrafenone, active constituent B is added, ball milling 2~3 hours, make diameter of particle all at 5 μm in the ball mill
Hereinafter, surplus is supplied with deionized water, you can suspending agent product of the present invention is made, is specifically shown in Table 3.
3 embodiment of table, 25~36 each component and parts by weight
37~40 suspension emulsion of embodiment
Dispersant, antifoaming agent, thickener (can add can be not added with), antifreeze (can add can be not added with) are mixed by high speed shear
Uniformly, metrafenone is added, in the ball mill ball milling 2~3 hours, makes diameter of particle all at 5 μm and suspends hereinafter, metrafenone is made
Then agent directly emulsifies active constituent B, solvent, emulsifier and various auxiliary agents in suspending agent with high speed agitator, surplus is used
Deionized water is supplied, and suspension emulsion product of the present invention is made, is specifically shown in Table 4.
4 embodiment of table, 37~40 each component and parts by weight
41~48 aqueous emulsion of embodiment
Metrafenone, active constituent B, solvent, emulsifier are added together, make to be dissolved into homogeneous oil phase；By deionized water, resist
Jelly agent (can add can be not added with), thickener (can add can be not added with), antifoaming agent mix, at uniform water phase.Under high velocity agitation,
Oil phase is added in water phase, surplus is supplied with deionized water；Aqueous emulsion product of the present invention is can be prepared by, is specifically shown in Table 5.
5 embodiment of table, 47~48 each component and parts by weight
Fluoxastrobin, kresoxim-methyl, dimoxystrobin, orysastrobin in table 1~5 are exchanged, novel formulation can be made.
49~51 microemulsion of embodiment
Metrafenone, active constituent B, solvent, emulsifier, antifreeze (can add can be not added with), antifoaming agent are sufficiently mixed into equal
Even transparent oil phase is slowly added into deionized water under stiring, forms WO emulsion, then agitated heating, is allowed to fast
Fast phase inversion is cooled to room temperature and makes up to balance at oil-in-water type, and through filtering, surplus is supplied with deionized water；It can be prepared by this hair
The bright microemulsion product, is specifically shown in Table 6.
6 embodiment of table, 67~69 each component and parts by weight
Embodiment 52,53 microcapsule suspending agents
Metrafenone, active constituent B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, in shearing bar
Under part, by oil phase be added to containing emulsifier, pH adjusting agent, dispersant aqueous phase solution in, surplus is supplied with deionized water, two
Kind material reacts in oil-water interfaces, forms high score ascus wall, the well dispersed microcapsule suspending agent of the present composition is made
Product.Specifically it is shown in Table 7.
7 embodiment 52 of table, 53 each components and parts by weight
Embodiment 54,55 microcapsule suspension-suspendinagent agents
Active constituent B, macromolecule cyst material, solvent are mixed, make to be dissolved into homogeneous oil phase, by oil phase in shearing condition
Under be added to containing emulsifier, pH adjusting agent aqueous phase solution in, well dispersed microcapsule suspending agent is made.By dispersant, wet
Profit agent, antifoaming agent, thickener (can add can be not added with) are uniformly mixed by high speed shear, metrafenone are added, in the ball mill ball milling 2
~3 hours, makes diameter of particle all at 5 μm hereinafter, suspending agent is made, then suspending agent is added to the water of micro-capsule suspension
In phase solution, deionized water supplies surplus, the well dispersed microcapsule suspension-suspendinagent agent product of the present composition is made, specifically
It is shown in Table 8.
8 embodiment 54 of table, 55 each components and parts by weight
The embodiment of the present invention is the method being combined using Toxicity Determination and field trial.First pass through indoor virulence survey
It is fixed, the synergy ratio (SR) after two kinds of medicaments compound by a certain percentage is defined, SR ＜ 0.5 are antagonism, 0.5≤SR≤1.5
For summation action, SR ＞ 1.5 are synergistic effect, on this basis, then carry out field trial.
Test method：After prerun determines the effective inhibition concentration range of each medicament, medicament sets 5 respectively by active constituent content
A dosage processing, if clear water compares.Reference《Farm-chemical indoor determination test rule fungicide》It carries out, speed is grown using mycelia
Rate method measures virulence of the medicament to crop germ.Colony diameter is measured with crossing method after 72h, calculates the net growth of each processing
Amount, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter -5
Mycelial growth inhibition rate is converted into probit value (y), liquor strength (μ g/mL) is converted into logarithm (x), with minimum
Square law acquires virulence regression equation (y=a+bx), and thus calculates the EC of each medicament50Value.Simultaneously according to Wadley methods
Two medicament different ratio synergy ratios (SR) are calculated, SR ＜ 0.5 are antagonism, and 0.5≤SR≤1.5 are summation action,
SR ＞ 1.5 are synergistic effect.Calculation formula is as follows：
Wherein：A, b is respectively active components A and active constituent B ratio shared in combination；
A is metrafenone；
B is selected from one of Fluoxastrobin, kresoxim-methyl, dimoxystrobin, orysastrobin kind.
Application Example two：
For trying disease：Powdery mildew of cucumber
Test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..
Experimental design：Effective suppression of metrafenone and Fluoxastrobin active compound and the two different ratio mixture is determined by pilot study
Concentration range processed.
Toxicity test result
9 metrafenone of table is with azoxystrobin compound to the toxicity test analysis of results table of powdery mildew of cucumber
As shown in Table 9, metrafenone matches equal to the synergy ratio SR of powdery mildew of cucumber in 1 80~80 ︰ 1 of ︰ with Fluoxastrobin
More than 1.5, illustrate that the two mixture in 1 ︰, 80~80 ︰, 1 ranges shows synergistic effect, when the proportioning of metrafenone and Fluoxastrobin
In 1 30~10 ︰ 1 of ︰, synergistic effect is more prominent, and synergy ratio is 2.25 or more.Through applicant test find metrafenone with
The optimum ratio of Fluoxastrobin is 10：1、6:1、5：1、4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：10、1：13、
1：15、1：20、1：25、1：30, especially when metrafenone and Fluoxastrobin weight ratio are 1：Synergy ratio is maximum when 3, synergistic effect
It is the most apparent.
Application Example three
For trying disease：Wheat powdery mildew
Test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..
Experimental design：Effective suppression of metrafenone and kresoxim-methyl active compound and the two different ratio mixture is determined by pilot study
Concentration range processed.
10 metrafenone of table compounds the toxicity test analysis of results table to wheat powdery mildew with kresoxim-methyl
As shown in Table 10, metrafenone matches equal to the synergy ratio SR of wheat powdery mildew in 1 80~80 ︰ 1 of ︰ with kresoxim-methyl
More than 1.5, illustrate that the two mixture in 1 ︰, 80~80 ︰, 1 ranges shows synergistic effect, when the proportioning of metrafenone and kresoxim-methyl
In 1 20~10 ︰ 1 of ︰, synergistic effect is more prominent, and synergy ratio is 2.30 or more.Through applicant test find metrafenone with
The optimum ratio of kresoxim-methyl is 10：1、8：1、7：1、6：1、5：1、4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：
8、1：10、1：12、1：15、1：20, especially when metrafenone and kresoxim-methyl weight ratio are 1：Synergy ratio is maximum when 2, and synergy is made
With the most obviously.
Application Example four
For trying disease：Chinese cabbage downy mildew
Test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..
Experimental design：Effective suppression of metrafenone and dimoxystrobin active compound and the two different ratio mixture is determined by pilot study
Concentration range processed.
11 metrafenone of table compounds the toxicity test analysis of results table to Chinese cabbage downy mildew with dimoxystrobin
As shown in Table 11, metrafenone matches equal to the synergy ratio SR of Chinese cabbage downy mildew in 1 80~80 ︰ 1 of ︰ with dimoxystrobin
More than 1.5, illustrate that the two mixture in 1 ︰, 80~80 ︰, 1 ranges shows synergistic effect, when the proportioning of metrafenone and dimoxystrobin
In 1 20~10 ︰ 1 of ︰, synergistic effect is more prominent, and synergy ratio is 2.25 or more.Through applicant test find metrafenone with
The optimum ratio of dimoxystrobin is 10：1、8：1、7：1、6：1、5：1、4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、1：6、1：
8、1：10、1：12、1：15、1：20, especially when metrafenone and dimoxystrobin weight ratio are 1：Synergy ratio is maximum when 2, and synergy is made
With the most obviously.
Application Example five
For trying disease：Rice sheath blight disease
Test medicine is provided by Shanxi Thompson Biological Technology Co., Ltd..
Experimental design：The effective of metrafenone and orysastrobin active compound and the two different ratio mixture is determined by pilot study
Inhibition concentration range.
12 metrafenone of table compounds the toxicity test analysis of results table to rice sheath blight disease with orysastrobin
As shown in Table 12, metrafenone is matched in 1 80~80 ︰ 1 of ︰ with orysastrobin to the synergy ratio SR of rice sheath blight disease
1.5 are all higher than, both illustrates that mixture shows synergistic effect in 1 ︰, 80~80 ︰, 1 ranges, when metrafenone and orysastrobin
For proportioning in 1 20~10 ︰ 1 of ︰, synergistic effect is more prominent, and synergy ratio is 2.25 or more.It is tested through applicant and finds benzene bacterium
The optimum ratio of ketone and orysastrobin is 10：1、8：1、7：1、6：1、5：1、4：1、3：1、2：1、1：1、1：2、1：3、1：4、1：5、
1：6、1：8、1：10、1：12、1：15、1：20, especially when metrafenone and orysastrobin weight ratio are 1：Synergy ratio is most when 2
Greatly, synergistic effect is the most apparent.
It is found through experiment that：To the downy mildew in various crop, powdery mildew, epidemic disease, leaf after metrafenone and active constituent B compoundings
The prevention of mildew, shot hole, scab, peronospora tabacina, anthracnose, spot defoliation, rust, rice blast, banded sclerotial blight, brown spot
There are apparent synergistic effect, synergy ratio SR to be all higher than 1.5.
Effect experiment part：Test medicine is researched and developed by Shanxi Thompson Biological Technology Co., Ltd., is provided, comparison medicament
20% metrafenone suspending agent (autogamy), 250 grams per liter Fluoxastrobin suspending agents (purchased in market), 30% kresoxim-methyl wettable powder (purchased in market),
20% dimoxystrobin wettable powder (autogamy), 20% orysastrobin wettable powder (autogamy).
Six metrafenone of Application Example and active constituent B and its compounding prevention powdery mildew of cucumber test of pesticide effectiveness
This test arrangement investigates powdery mildew of cucumber disease index before Xian District, Shanxi Province suburban area, medicine, occurs just in disease
Phase dispenser 5 days after dispenser, investigates disease indexes and calculates preventive effect for 15 days, 30 days.Test result is as follows：
13 metrafenone of table and active constituent B and its compounding prevention powdery mildew of cucumber test of pesticide effectiveness
As can be seen from Table 13, powdery mildew of cucumber can be effectively prevented after metrafenone and active constituent B compoundings, is tried through applicant
Cucumber downy mildew, epidemic disease can also be effectively prevented after issuing after examination and approval existing metrafenone and active constituent B compoundings, control effect is above
96%, it is better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
Seven metrafenone of Application Example and active constituent B and its compounding prevention tomato blight test of pesticide effectiveness
This test arrangement investigates tomato blight disease index before Xian District, Shanxi Province suburban area, medicine, in the early stages of disease
Dispenser 3 days after dispenser, investigates disease indexes and calculates preventive effect for 10 days, 20 days.Test result is as follows：
14 metrafenone of table and active constituent B and its compounding prevention tomato blight test of pesticide effectiveness
As can be seen from Table 14, tomato blight can be effectively prevented after metrafenone and active constituent B compoundings, is tested through applicant
It was found that can also effectively prevent leaf muld of tomato after metrafenone and active constituent B compoundings, control effect is above 96%, better than single
The preventive effect of agent, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
Eight metrafenone of Application Example and active constituent B and its compounding prevention rice blast test of pesticide effectiveness
This test arrangement investigates rice blast disease index before Shaanxi Province Hanzhong suburban area, medicine, occurs just in disease
Phase dispenser 5 days after dispenser, investigates disease indexes and calculates preventive effect for 15 days, 30 days.Test result is as follows：
15 metrafenone of table and active constituent B and its compounding prevention rice blast test of pesticide effectiveness
As can be seen from Table 15, metrafenone and active constituent B and its compounding prevention rice blast, test through applicant and send out
Rice sheath blight disease can also be effectively prevented after existing metrafenone and active constituent B compoundings, control effect is above 95%, is better than single dose
Preventive effect, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
Nine metrafenone of Application Example and active constituent B and its compounding prevention pear scab test of pesticide effectiveness
This test arrangement investigates pear scab disease index before Shaanxi Province Weinan City Pucheng County, medicine, occurs in disease
Initial stage dispenser 3 days after dispenser, investigates disease indexes and calculates preventive effect for 10 days, 20 days.Test result is as follows：
16 metrafenone of table and active constituent B and its compounding prevention pear scab test of pesticide effectiveness
As can be seen from Table 16, pear scab can be effectively prevented after metrafenone and active constituent B compoundings, is tried through applicant
Pear tree rust, brown spot can also be effectively prevented after issuing after examination and approval existing metrafenone and active constituent B compoundings, control effect is above
95%, it is better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
Ten metrafenone of Application Example and active constituent B and its compounding prevention wheat powdery mildew test of pesticide effectiveness
This test arrangement investigates wheat powdery mildew disease index before Baoji, Shaanxi province city Chencang District, medicine, occurs in disease
Initial stage dispenser 10 days after dispenser, investigates disease indexes and calculates preventive effect for 20 days, 30 days.Test result is as follows：
17 metrafenone of table and active constituent B and its compounding prevention wheat powdery mildew test of pesticide effectiveness
As can be seen from Table 17, wheat powdery mildew can be effectively prevented after metrafenone and active constituent B compoundings, is tried through applicant
Wheat sharp eyespot, rust can also be effectively prevented after issuing after examination and approval existing metrafenone and active constituent B compoundings, control effect is above
95%, it is better than the preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
11 metrafenone of Application Example and active constituent B and its compounding prevention uncinula necator test of pesticide effectiveness
This test arrangement investigates uncinula necator disease index before Shaanxi Province Weinan City Dali County, medicine, occurs in disease
Initial stage dispenser 7 days after dispenser, investigates disease indexes and calculates preventive effect for 14 days, 25 days.Test result is as follows：
18 metrafenone of table and active constituent B and its compounding prevention uncinula necator test of pesticide effectiveness
As can be seen from Table 18, uncinula necator can be effectively prevented after metrafenone and active constituent B compoundings, is tried through applicant
Downy mildew of garpe can also be effectively prevented after issuing after examination and approval existing metrafenone and active constituent B compoundings, control effect is above 96%, is better than
The preventive effect of single dose, and preventive effect phase is long.It has no adverse effects to target crop in experiment scope of medication.
The experiment by different places throughout the country obtains afterwards, metrafenone and Fluoxastrobin, kresoxim-methyl, dimoxystrobin, oxime ether
To downy mildew, powdery mildew, epidemic disease, leaf mold, shot hole, scab, peronospora tabacina, the anthrax in various crop after bacterium amine compounding
The preventive effect of the Common Diseases such as disease, spot defoliation, rust, rice blast, banded sclerotial blight, brown spot 95% or more, is better than single dose
Preventive effect, synergistic effect are apparent.
Claims (6)
1. a kind of bactericidal composition containing metrafenone and methoxy acrylic, effective active composition is active components A and work
Property ingredient B, it is characterised in that：Active components A is 1 ︰, 80~60 ︰ 1 with active constituent B weight ratios, and the active components A is selected from
Metrafenone, active constituent B are dimoxystrobin.
2. the bactericidal composition according to claim 1 containing metrafenone and methoxy acrylic, it is characterised in that：It is living
Property ingredient A and active constituent B weight ratio be 1 ︰, 60~40 ︰ 1.
3. the bactericidal composition according to claim 2 containing metrafenone and methoxy acrylic, it is characterised in that：Benzene
The weight ratio of bacterium ketone and dimoxystrobin is 1 ︰, 20~10 ︰ 1.
4. the bactericidal composition according to any one of claim 1 to 3 containing metrafenone and methoxy acrylic,
It is characterized in that：Wettable powder, water dispersible granules, suspending agent, suspension emulsion, aqueous emulsion, microemulsion, microcapsule suspension is made in composition
Agent or microcapsule suspension-suspendinagent agent.
5. the bactericidal composition according to claim 4 containing metrafenone and methoxy acrylic is for preventing crops
The purposes of upper disease.
6. purposes according to claim 5, which is characterized in that the disease includes：Powdery mildew, downy mildew, epidemic disease, leaf
Mildew, shot hole, scab, peronospora tabacina, anthracnose, spot defoliation, rust, rice blast, banded sclerotial blight or brown spot.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1023834A1 (en) * | 1999-01-29 | 2000-08-02 | American Cyanamid Company | Fungicidal mixtures |
| WO2001080643A1 (en) * | 2000-04-26 | 2001-11-01 | Syngenta Participations Ag | Fungicidal compositions |
| WO2002067679A1 (en) * | 2001-02-19 | 2002-09-06 | Basf Aktiengesellschaft | Fungicidal mixtures |
| CN1874680A (en) * | 2003-10-31 | 2006-12-06 | 石原产业株式会社 | Fungicide composition and method for preventing and controlling plant diseases |
| CN101080170A (en) * | 2004-12-20 | 2007-11-28 | 巴斯福股份公司 | Methods of controlling fungal diseases in leguminous plants |
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2012
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1023834A1 (en) * | 1999-01-29 | 2000-08-02 | American Cyanamid Company | Fungicidal mixtures |
| WO2001080643A1 (en) * | 2000-04-26 | 2001-11-01 | Syngenta Participations Ag | Fungicidal compositions |
| WO2002067679A1 (en) * | 2001-02-19 | 2002-09-06 | Basf Aktiengesellschaft | Fungicidal mixtures |
| CN1874680A (en) * | 2003-10-31 | 2006-12-06 | 石原产业株式会社 | Fungicide composition and method for preventing and controlling plant diseases |
| CN101080170A (en) * | 2004-12-20 | 2007-11-28 | 巴斯福股份公司 | Methods of controlling fungal diseases in leguminous plants |
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