CN102641517B - Amorphous hydrocolloid dressing - Google Patents
Amorphous hydrocolloid dressing Download PDFInfo
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- CN102641517B CN102641517B CN 201110344631 CN201110344631A CN102641517B CN 102641517 B CN102641517 B CN 102641517B CN 201110344631 CN201110344631 CN 201110344631 CN 201110344631 A CN201110344631 A CN 201110344631A CN 102641517 B CN102641517 B CN 102641517B
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- Prior art keywords
- hydrocolloid dressing
- amorphous
- grams
- irradiation
- dressing
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- 239000000416 hydrocolloid Substances 0.000 title claims abstract description 22
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920001661 Chitosan Polymers 0.000 claims abstract description 9
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 claims abstract description 8
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000001768 carboxy methyl cellulose Substances 0.000 claims abstract description 7
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims abstract description 7
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 7
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 4
- 229910021607 Silver chloride Inorganic materials 0.000 claims abstract description 4
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 4
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims abstract description 4
- 229910001961 silver nitrate Inorganic materials 0.000 claims abstract description 4
- 229910017052 cobalt Inorganic materials 0.000 claims description 5
- 239000010941 cobalt Substances 0.000 claims description 5
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims description 5
- 229920003023 plastic Polymers 0.000 claims description 5
- 239000004033 plastic Substances 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 238000000034 method Methods 0.000 claims 2
- 206010052428 Wound Diseases 0.000 abstract description 22
- 208000027418 Wounds and injury Diseases 0.000 abstract description 22
- 230000001154 acute effect Effects 0.000 abstract description 4
- 230000001684 chronic effect Effects 0.000 abstract description 4
- 230000029663 wound healing Effects 0.000 abstract description 3
- 208000009043 Chemical Burns Diseases 0.000 abstract description 2
- 230000035876 healing Effects 0.000 abstract description 2
- 208000015181 infectious disease Diseases 0.000 abstract description 2
- 230000014759 maintenance of location Effects 0.000 abstract description 2
- 208000002847 Surgical Wound Diseases 0.000 abstract 2
- 238000004132 cross linking Methods 0.000 abstract 2
- 230000001954 sterilising effect Effects 0.000 abstract 2
- 238000004659 sterilization and disinfection Methods 0.000 abstract 2
- 230000007547 defect Effects 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 239000004745 nonwoven fabric Substances 0.000 description 3
- 239000002131 composite material Substances 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- -1 polyethylene Polymers 0.000 description 2
- 208000018380 Chemical injury Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 210000000589 cicatrix Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
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- Materials For Medical Uses (AREA)
Abstract
The invention discloses amorphous hydrocolloid dressing formed by high-energy ray irradiation proper crosslinking. The amorphous hydrocolloid dressing disclosed by the invention has good deformability, film forming property, moisture retention, biocompatibility and wound healing facilitation, and can protect various surgical incisions, cover various acute and chronic wounds and wound surfaces, prevent infection, accelerate healing and relive cicatrization. The amorphous hydrocolloid dressing is suitable for the filling covering protection on various wounds with tissue defects and for the protection and treatment of the surgical incisions and burns and scales including the wound surfaces formed by chemical burns as well as various acute and chronic wounds and wound surfaces. Moreover, through radiation sterilization, the amorphous hydrocolloid dressing can be stored for a long time. The formula of the amorphous hydrocolloid dressing disclosed by the invention comprises the following components in percentage by weight: 2-8% of sodium carboxymethylcellulose, 1-6% of chitosan and the balance of water. The amorphous hydrocolloid dressing also can comprise 0.1-0.3% of silver nitrate or silver chloride, 3-8% of polyvinyl alcohol, 15-25% of propylene glycol and the like all by weight. The amorphous hydrocolloid dressing is subjected to high-energy ray irradiation proper crosslinking and sterilization, thus the irradiation dose is 5-15KGy.
Description
Technical field
The present invention relates to a kind ofly be applicable to that the damaged wound of various accompanied by tissue is filled covering protection and operative incision, burn and scald comprises wound surface, various acute and chronic wounds, the protection of wound surface and the filling dressing for the treatment of that chemical burn forms, and specifically is a kind of amorphous bearing hydrocolloid dressing.
Background technology
Being used for the protection of various operative incisions, wound and wound surface and the composite medical dressing for the treatment of at present mainly contains following several:
(1) applies medical pressure-sensitive adhesive at back lining materials such as polrvinyl chloride, polyethylene, polypropylene, non-woven fabrics polyurethane, the film that makes is directly sticked on the wound surface as medical dressing.
(2) three layers of compound medical dressing use ventilative continuous film as the protection backing layer usually; Non-woven fabrics, foamed materials or fabric etc. are as the occlusion backing layer; With the adhesion layer of skin adhesion totally three layers be composited.
(3) glue build based composite dressing for medical use.This class dressing is composited by several parts such as continuous ventilated membrane, non-woven fabrics or fabric skeleton, lamellar hydrocolloid, adhesive usually.
Though existing these wound dressings have solved problems such as absorption transudate, breathability, obstruct antibacterial, waterproof, wound comfort level, but all has fixed shape, wound surface for all kinds of traumatic wounds is difficult to cover and operation comprehensively, can't fill covering for damaged wound especially.Therefore amorphous dressing had vast demand.
Summary of the invention
The object of the present invention is to provide a kind of have good deformation behavior, film property, moisture retention, biocompatibility and wound healing facilitation; can protect all kinds of operative incisions; cover various acute, chronic wounds, wound surface, prevention infection, healing acceleration also alleviate synulotic amorphous bearing hydrocolloid dressing.
Amorphous bearing hydrocolloid dressing of the present invention forms through high-energy ray irradiation is appropriately crosslinked, and the irradiation dose scope is 5KGy-15KGy.
Amorphous bearing hydrocolloid dressing of the present invention is to comprise sodium carboxymethyl cellulose 2%-8wt%, chitosan 1%-6wt% by weight percentage, and surplus is water.
Chitosan of the present invention is for water-soluble through processing.
Amorphous bearing hydrocolloid dressing of the present invention can also contain 0.1%-0.3wt% silver nitrate or silver chloride by weight percentage.
Amorphous bearing hydrocolloid dressing of the present invention can also contain by weight percentage the 3%-8% polyvinyl alcohol to improve film property.
Amorphous bearing hydrocolloid dressing of the present invention can also contain 15%-25wt% propylene glycol by weight percentage.
Amorphous bearing hydrocolloid dressing of the present invention has good deformation nature and filming performance, can fill all kinds of otch, wound and wound surface quickly and easily to cover.The effect that institute's chitosan-containing component also has hemostasis, promotes wound healing and alleviate cicatrix.
The specific embodiment
Embodiment 1:
Take by weighing sodium carboxymethyl cellulose 200 gram, chitosan 150 grams, add 4650 gram water, quietly after the abundant stirring and dissolving of constant temperature blender cause 30 minutes, solution is taken out in the adding filling machine, be respectively charged in 100 milliliters of plastic tubes and seal, put into the irradiation 10KGy of irradiation chamber of cobalt source, after the taking-up namely.
Embodiment 2:
Take by weighing sodium carboxymethyl cellulose 150 grams, chitosan 200 grams, silver nitrate or silver chloride 0.5 gram, add 4649.5 gram water, quietly after the abundant stirring and dissolving of constant temperature blender cause 30 minutes, solution is taken out in the adding filling machine, be respectively charged in 100 milliliters of plastic tubes and seal, put into the irradiation 6KGy of irradiation chamber of cobalt source, after the taking-up namely.
Embodiment 3:
Take by weighing sodium carboxymethyl cellulose 125 grams, chitosan 175 grams, polyvinyl alcohol 150 grams, propylene glycol 1000 grams, add 3550 gram water, quietly after the abundant stirring and dissolving of constant temperature blender cause 45 minutes, solution is taken out in the adding filling machine, be respectively charged in 100 milliliters of plastic tubes and seal, put into the irradiation 15KGy of irradiation chamber of cobalt source, after the taking-up namely.
Claims (2)
1. one kind through the appropriately crosslinked amorphous bearing hydrocolloid dressing that forms of high-energy ray irradiation, it is characterized in that, described amorphous bearing hydrocolloid dressing is prepared by following method: take by weighing sodium carboxymethyl cellulose 150 grams, chitosan 200 grams, silver nitrate or silver chloride 0.5 gram, add 4649.5 gram water, after the abundant stirring and dissolving of constant temperature blender, left standstill 30 minutes, solution take out is added in the filling machine, be respectively charged in 100 milliliters of plastic tubes and seal, put into the irradiation 6KGy of irradiation chamber of cobalt source, after the taking-up namely.
2. one kind through the appropriately crosslinked amorphous bearing hydrocolloid dressing that forms of high-energy ray irradiation, it is characterized in that, described amorphous bearing hydrocolloid dressing is prepared by following method: take by weighing sodium carboxymethyl cellulose 125 grams, chitosan 175 grams, polyvinyl alcohol 150 grams, propylene glycol 1000 grams, add 3550 gram water, after the abundant stirring and dissolving of constant temperature blender, left standstill 45 minutes, solution is taken out in the adding filling machine, be respectively charged in 100 milliliters of plastic tubes and seal, put into the irradiation 15KGy of irradiation chamber of cobalt source, after the taking-up namely.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110344631 CN102641517B (en) | 2011-11-04 | 2011-11-04 | Amorphous hydrocolloid dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110344631 CN102641517B (en) | 2011-11-04 | 2011-11-04 | Amorphous hydrocolloid dressing |
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| Publication Number | Publication Date |
|---|---|
| CN102641517A CN102641517A (en) | 2012-08-22 |
| CN102641517B true CN102641517B (en) | 2013-08-28 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201110344631 Active CN102641517B (en) | 2011-11-04 | 2011-11-04 | Amorphous hydrocolloid dressing |
Country Status (1)
| Country | Link |
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| CN (1) | CN102641517B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103127544A (en) * | 2013-03-13 | 2013-06-05 | 潘华倩 | Silver-containing chitosan dressing as well as preparation method and application thereof |
| CN103191461B (en) * | 2013-04-26 | 2015-09-16 | 华熙福瑞达生物医药有限公司 | A kind of containing hyaluronic wound care dressing |
| CN104382915B (en) * | 2014-10-28 | 2017-06-16 | 天津嘉氏堂科技有限公司 | A kind of wound repair hydrocolloid |
| CN106474526B (en) * | 2015-08-28 | 2019-08-06 | 贵州扬生医用器材有限公司 | A kind of amorphous bearing hydrocolloid dressing and preparation method thereof containing liposome |
| CN105311684A (en) * | 2015-11-13 | 2016-02-10 | 邢月军 | Surgical film for stopping bleeding and relieving pain |
| CN105363065A (en) * | 2015-11-13 | 2016-03-02 | 邢月军 | Antibacterial and anti-inflammatory membrane |
| CN105288697A (en) * | 2015-11-13 | 2016-02-03 | 邢月军 | Medical film for surgery |
| CN105327384A (en) * | 2015-11-19 | 2016-02-17 | 耿文真 | Absorbable medical biological membrane dressing and preparation method thereof |
| CN105396171A (en) * | 2015-11-19 | 2016-03-16 | 耿文真 | Medical film with antisepsis and anti-inflammation effects and preparation process thereof |
| CN105381499A (en) * | 2015-11-19 | 2016-03-09 | 耿文真 | Medical membrane with effect of promoting wound healing and preparation process thereof |
| CN105797202B (en) * | 2016-03-23 | 2020-04-24 | 广州瑞辉生物科技股份有限公司 | Liquid band-aid and preparation method thereof |
| CN110881974B (en) * | 2019-11-15 | 2025-06-24 | 青岛光电医疗科技有限公司 | An eccentric electrocardiogram electrode |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1721004A (en) * | 2004-07-15 | 2006-01-18 | 深圳市清华源兴生物医药科技有限公司 | Biological active antibiotic dressing |
| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
| CN101569758A (en) * | 2008-12-31 | 2009-11-04 | 褚加冕 | Preparation method for medical use hydrocolloid dressing |
| US20100295219A1 (en) * | 2007-12-12 | 2010-11-25 | Ylitalo Caroline M | Methods of making shaped polymeric materials |
| CN102206355A (en) * | 2011-03-28 | 2011-10-05 | 东华大学 | Silver nanoparticle-containing bacterial cellulose membrane and preparation method thereof |
-
2011
- 2011-11-04 CN CN 201110344631 patent/CN102641517B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1721004A (en) * | 2004-07-15 | 2006-01-18 | 深圳市清华源兴生物医药科技有限公司 | Biological active antibiotic dressing |
| CN1944495A (en) * | 2006-09-29 | 2007-04-11 | 北京大学 | Water gel containing natural high molecule and its radiation preparing method |
| US20100295219A1 (en) * | 2007-12-12 | 2010-11-25 | Ylitalo Caroline M | Methods of making shaped polymeric materials |
| CN101569758A (en) * | 2008-12-31 | 2009-11-04 | 褚加冕 | Preparation method for medical use hydrocolloid dressing |
| CN102206355A (en) * | 2011-03-28 | 2011-10-05 | 东华大学 | Silver nanoparticle-containing bacterial cellulose membrane and preparation method thereof |
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| Publication number | Publication date |
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| CN102641517A (en) | 2012-08-22 |
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Application publication date: 20120822 Assignee: Beijing utrust Haibo technology development Limited by Share Ltd Assignor: Zhou Yeping Contract record no.: 2015990000408 Denomination of invention: Amorphous hydrocolloid dressing Granted publication date: 20130828 License type: Exclusive License Record date: 20150602 |
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| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model |