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CN103562403A8 - 识别肿瘤起始细胞的抗体和抗原及其应用 - Google Patents

识别肿瘤起始细胞的抗体和抗原及其应用 Download PDF

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CN103562403A8
CN103562403A8 CN201280010033.3A CN201280010033A CN103562403A8 CN 103562403 A8 CN103562403 A8 CN 103562403A8 CN 201280010033 A CN201280010033 A CN 201280010033A CN 103562403 A8 CN103562403 A8 CN 103562403A8
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initiating cells
application
tumor initiating
antigen
antibody
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CN103562403A (zh
CN103562403B (zh
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张志谦
赵威
王力民
韩海勃
刑宝才
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Beijing Cancer Hospital
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Beijing Cancer Hospital
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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Abstract

本发明公开了寻找、鉴别或确认肿瘤起始细胞的标志物CACNA2D1的方法，所述方法包括使用复发性肿瘤来源并富含肿瘤起始细胞的HEP-12细胞来免疫动物的步骤。本发明还公开了特异性识别CACNA2D1的单克隆抗体或其抗原结合片段，以及用于治疗或预防肿瘤或与CACNA2D1相关的疾病或病症的应用。
CN201280010033.3A 2011-02-22 2012-02-22 一个识别肿瘤起始细胞的抗体和抗原及其应用 Active CN103562403B (zh)

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CN2011100421666 2011-02-22
CN2011100421666A CN102251013A (zh) 2011-02-22 2011-02-22 一个识别肿瘤起始细胞的抗体和抗原及其应用
CN201110042166.6 2011-02-22
PCT/CN2012/000227 WO2012113266A1 (zh) 2011-02-22 2012-02-22 识别肿瘤起始细胞的抗体和抗原及其应用
CN201280010033.3A CN103562403B (zh) 2011-02-22 2012-02-22 一个识别肿瘤起始细胞的抗体和抗原及其应用

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CN103562403A8 true CN103562403A8 (zh) 2018-01-26
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US (2) US10174123B2 (zh)
EP (1) EP2682475B1 (zh)
JP (1) JP6084170B2 (zh)
KR (2) KR101797090B1 (zh)
CN (2) CN102251013A (zh)
BR (1) BR112013021350A2 (zh)
WO (1) WO2012113266A1 (zh)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102251013A (zh) * 2011-02-22 2011-11-23 北京市肿瘤防治研究所 一个识别肿瘤起始细胞的抗体和抗原及其应用
CN102653730A (zh) * 2012-04-18 2012-09-05 中国人民解放军第二军医大学 一种肝癌起始细胞及其分离方法与应用
CA2910855C (en) * 2013-04-29 2024-04-02 Ogd2 Pharma Targeting o-acetylated gd2 ganglioside as a new therapeutic and diagnostic strategy for cancer stem cells cancer
CN104634979A (zh) * 2013-11-15 2015-05-20 汕头大学 微生物细胞表面抗原的筛选与鉴定方法
FR3013847A1 (fr) * 2013-11-28 2015-05-29 Univ Lille Sciences Tech Nouveau biomarqueur du cancer de la prostate.
EP3359168A4 (en) 2015-10-06 2019-08-07 Regents of the University of Minnesota THERAPEUTIC COMPOUNDS AND METHOD
CN106432490B (zh) * 2016-09-14 2020-01-07 北京大学 一种abcg2单克隆抗体及其用途
BR112019024944A2 (pt) 2017-05-26 2020-06-23 Novassay Sa Subunidade auxilária de canal de cálcio com porta de tensão alfa 2 delta e suas utilizações
US20210147571A1 (en) * 2017-06-23 2021-05-20 Suzhou Bojuhua Biomedical Technology Co. Ltd Monoclonal antibody targeting human tumor stem cells and use thereof
CN107163146B (zh) * 2017-06-23 2021-04-23 苏州博聚华生物医药科技有限公司 一种靶向人肿瘤干细胞的单克隆抗体及其应用
CN107474139B (zh) * 2017-06-23 2021-04-27 苏州博聚华生物医药科技有限公司 一种靶向人肿瘤干细胞的单克隆抗体及其应用
EP3867278A4 (en) 2018-10-19 2022-11-09 Regents of the University of Minnesota NK CELL RECRUITER MOLECULES AND THEIR METHODS OF USE
CN111304170B (zh) * 2019-12-17 2022-05-13 湖南农业大学 一种稳定共表达cacna2d1、grin1和grin2b的人胚肾细胞株及其构建方法
CN110878330B (zh) * 2019-12-17 2022-06-10 湖南农业大学 一种人胚肾细胞株在药物筛选中的应用
KR102466369B1 (ko) * 2020-08-04 2022-11-14 서울대학교병원 자가면역 뇌염의 진단 방법
JP7440905B2 (ja) * 2020-08-25 2024-02-29 株式会社オンチップ・バイオテクノロジーズ 粒子の純化方法、単一粒子分注方法、及び細胞クラスター解析方法、並びそれに用いる装置
CN114280303B (zh) * 2020-09-28 2024-11-05 天津市肿瘤医院（天津医科大学肿瘤医院） 一种检测肿瘤转移种子细胞的免疫组化染色试剂盒及其应用
CN113203858B (zh) * 2021-05-06 2021-12-07 潍坊三维生物工程集团有限公司 一种肿瘤检测试剂盒
CN114292918A (zh) * 2021-12-31 2022-04-08 刘飞 一种基于LncRNA546标志物的前列腺癌早期诊断方法
KR20240042301A (ko) * 2022-09-23 2024-04-02 동아대학교 산학협력단 방광암의 항암제 내성 진단용 바이오마커 및 이의 용도
CN117065056A (zh) * 2023-08-18 2023-11-17 北京肿瘤医院(北京大学肿瘤医院) 放射性核素标记的1b50-1抗体及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6441156B1 (en) * 1998-12-30 2002-08-27 The United States Of America As Represented By The Department Of Health And Human Services Calcium channel compositions and methods of use thereof
JP2003512602A (ja) 1999-09-16 2003-04-02 ワーナー−ランバート・カンパニー α２δ−１サブユニット結合リガンドのスクリーニング方法
ATE550352T1 (de) * 2001-12-03 2012-04-15 Alexion Pharma Inc Verfahren zur herstellung von hybridantikörper
JP2006524049A (ja) * 2003-04-14 2006-10-26 ワーナー−ランバート カンパニー リミティド ライアビリティー カンパニー 突然変異α２／δ１遺伝子を含有する動物および細胞
EP1639090A4 (en) * 2003-06-09 2008-04-16 Univ Michigan COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
CN1852974A (zh) * 2003-06-09 2006-10-25 密歇根大学董事会 用于治疗和诊断癌症的组合物和方法
WO2006017293A2 (en) 2004-07-13 2006-02-16 Regents Of The University Of California Models and methods for nociception, pain transduction, and screening for analgesic compounds
CN1873410B (zh) * 2005-06-16 2011-11-30 中国医学科学院肿瘤研究所 一种在食管癌病人血清中检测肿瘤相关标志物的方法
EP2236623A1 (en) 2006-06-05 2010-10-06 Cancer Care Ontario Assessment of risk for colorectal cancer
CN102316888A (zh) 2007-08-23 2012-01-11 利兰斯坦福青年大学托管委员会 突触发生的调控
EP2641919A3 (en) * 2007-11-30 2014-05-07 Glaxo Group Limited Antigen-binding constructs
CN102251013A (zh) * 2011-02-22 2011-11-23 北京市肿瘤防治研究所 一个识别肿瘤起始细胞的抗体和抗原及其应用

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KR20170126033A (ko) 2017-11-15
KR101797090B1 (ko) 2017-11-13
EP2682475B1 (en) 2019-11-13
US10174123B2 (en) 2019-01-08
US20200040097A1 (en) 2020-02-06
JP2014507150A (ja) 2014-03-27
JP6084170B2 (ja) 2017-02-22
CN103562403A (zh) 2014-02-05
WO2012113266A1 (zh) 2012-08-30
CN102251013A (zh) 2011-11-23
EP2682475A1 (en) 2014-01-08
KR101885705B1 (ko) 2018-08-06
EP2682475A4 (en) 2015-01-14
BR112013021350A2 (pt) 2016-11-08
US20140044729A1 (en) 2014-02-13
CN103562403B (zh) 2018-11-16
KR20140020922A (ko) 2014-02-19

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