CN118831230A - Inhalable dry powder formulation atomizing device - Google Patents

Abstract

The invention discloses inhalable dry powder preparation atomizing equipment, and belongs to the technical field of medical equipment. This kind of inhalable dry powder preparation atomizing equipment includes the atomizing equipment frame, the placing bin has been seted up to atomizing equipment frame one side, be equipped with medicine feeding mechanism and separating mechanism in the placing bin, separating mechanism includes the separator box, still including medicine feeding mechanism, medicine feeding mechanism includes, medicine cabin is placed in placing bin, a plurality of hemisphere medicine grooves have been seted up on the medicine cabin, medicine outlet hole has been seted up to the separator box bottom, medicine cabin bottom is equipped with the rack, the meshing of rack bottom has first gear, medicine cabin bottom is equipped with the spill frame, the spill frame downside is equipped with driving motor, the rack both sides are equipped with the slider, the slider passes through crank rocker subassembly with the swivelling lever end and is connected, the slider top is connected with the ejector pin, first gear has been adopted, second gear and rack, crank slider, multiple mechanical mechanism organically combines, can realize the orderly, accurate supply to the dry powder preparation of multiple doses.

Description

Inhalable dry powder atomization equipment

Technical Field

The present invention relates to the technical field of medical equipment, and in particular to an atomization device for an inhalable dry powder preparation.

Background Art

In the treatment of respiratory diseases such as chronic obstructive pulmonary disease, asthma and local lung infections, dry powder inhalers (DPI) have the advantages of high drug dosage carrying capacity, high drug stability, and low biological contamination compared to liquid-based nebulizers and metered dose inhalers. Therefore, they are highly competitive in the market.

The drug particles (1-5 microns, also known as Active Pharmaceutical Ingredient, API particles) used in dry powder inhalers are usually attached to the surface of larger carrier particles (40-500 microns, mostly made of lactose) to form a particle aggregate. By modifying the surface of the carrier particles, the adhesion between the drug particles and the carrier particles can be effectively reduced. Its working principle is to use the design of the internal flow area of the inhaler to make the particle aggregates separate from the surface of the carrier particles in the inhaler under the combined effect of fluid stress and wall collision, and then enter the human respiratory tract to achieve a therapeutic effect.

In the prior art, CN113750331A discloses a dry powder inhaler, which is designed with a particle rotation collision chamber structure with different inclined walls, which greatly increases the number of collisions between carrier particles and the wall, thereby effectively improving the separation efficiency of drug particles from carrier particles; in addition, a blister-type drug is used to avoid the need to put in a capsule, puncture the capsule, remove the capsule after inhalation, and other actions like a traditional dry powder inhaler, which can effectively improve the user's experience, but before use, the patient usually has to fill all the medicine chambers at one time. If a single-dose medicine chamber is used, the patient's experience will be greatly reduced. In this case, it is necessary to accurately control the supply time interval of each dose of dry powder preparation. In addition, there is a gap between the blister structure and the particle rotation collision chamber. When an external power drive device is used to inject airflow into the dry powder inhaler, the gap will be further expanded, which will greatly reduce the sealing performance of the device.

Summary of the invention

The purpose of the present invention is to overcome the problems in the prior art. The first gear, the second gear and the rack, the crank slider and various mechanical mechanisms are organically combined to achieve orderly and accurate supply of multiple doses of dry powder preparations, and provide an inhalable dry powder preparation atomization device.

The present invention provides an inhalable dry powder preparation atomization device, comprising a separation box and a drug supply mechanism, wherein the drug supply mechanism is placed below the separation box, the drug supply mechanism comprises a medicine cabin, the medicine cabin is placed in the placement bin, a plurality of hemispherical medicine grooves are provided on the medicine cabin, and the plurality of hemispherical medicine grooves are arranged in a single row along the length direction of the medicine cabin, a medicine outlet hole is provided at the bottom of the separation box, the medicine outlet hole has the same radius as the hemispherical medicine groove, a gap exists between the top of the medicine cabin and the bottom of the separation box, a horizontal moving part is provided at the lower side of the medicine cabin, the horizontal moving part comprises a rack fixedly connected to the bottom of the medicine cabin, and the rack has the same direction as the hemispherical medicine groove array; first The gear is meshed with the bottom of the rack and is arranged at the bottom of the medicine cabin with a concave frame. The first gear is rotatably installed on the concave frame through a rotating rod. Both ends of the rotating rod pass through the concave frame. The first gear is provided with a driving member. A vertical jacking part is provided on the lower side of the medicine cabin. The vertical jacking part includes a slider. A sliding groove is provided in the slider. The slider is arranged on both sides of the rack. The slider is connected to the axial end of the rotating rod through a crank rocker assembly. A mounting frame is fixedly connected to the bottom of the concave frame, and the slider is slidably embedded in the mounting frame. A push rod is slidably provided in the sliding groove, and the top of the push rod abuts against the bottom of the medicine cabin at the farthest stroke.

The present invention adopts a gear rack structure to realize the orderly and accurate supply of dry powder preparations in a multi-dose medicine cabin. The upper part of the medicine cabin is a hemispherical medicine groove arranged at equal intervals, and the lower part is a rack structure; and to ensure the normal operation of the second gear rack structure, there is a gap between the top of the medicine cabin and the bottom of the rotating chamber (as shown in Figure 2). During the execution of the dry powder preparation supply action, the top action of the medicine cabin is completed by a mechanical mechanism, which can effectively realize the sealing of the medicine supply structure and ensure that a large amount of dry powder preparations can enter the separation mechanism to complete depolymerization. Based on this demand, the present invention introduces a crank slider mechanism and a push rod mechanism. During the first half of the rotation of the drive shaft, since the crank is coaxial with the first gear, the connecting rod will push the slider to move during the meshing of the gear rack; and since the push rod can only move up and down and is located in the groove of the slider, when the supply action is completed, the push rod will make the top of the medicine cabin fit tightly with the bottom of the rotating chamber (at this time, the gear rack is no longer meshed). During the second half of the rotation of the drive shaft, the push rod will gradually move down, and the medicine cabin will continue to descend under the action of gravity until the rack at its bottom re-engages with the gear. In short, the two actions of medicine supply and lifting (ensuring sealing) can be achieved simultaneously through a single rotation of the drive shaft.

Preferably, the crank rocker assembly comprises a crank and a connecting rod, one end of the connecting rod is fixedly sleeved on the rotating rod, the crank is hinged to the connecting rod, and the connecting rod is hinged to the slider.

Preferably, the slide groove consists of a first groove and a second groove which are horizontally arranged, the first groove and the second groove are opened along the length direction of the rack, there is a height difference between the first groove and the second groove in the vertical direction, the vertical height of the slide groove depends on the gap between the top of the medicine cabin and the separation box, and the first groove and the second groove are connected by a third groove which is inclined.

Preferably, the separation mechanism also includes a rotating chamber, a first airflow pipe, a grid and a diversion chamber. The rotating chamber is placed in the separation box. The rotating chamber is arranged at the top of the medicine outlet hole. The rotating chamber and the diversion chamber are connected through the first airflow pipe. A conveying pipe is connected to the top of the rotating chamber, and a grid is provided at the connecting position between the conveying pipe and the rotating chamber.

Preferably, the separation mechanism further comprises a second airflow tube, a buffer chamber and a third airflow tube, one side of the buffer chamber is connected to a pair of the diversion chambers through the second airflow tube, and the other side of the buffer chamber is connected to the third airflow tube.

The high-pressure airflow enters from the third airflow pipe, passes through the buffer chamber, the diversion chamber, and the first airflow pipe in sequence, and then enters the rotating chamber, blowing up the dry powder preparation in the medicine cabin directly below the rotating chamber. The dry powder preparation rises to the rotating chamber under the action of the airflow and continuously collides with its wall. The drug particles will be separated from the surface of the carrier particles due to inertia. The separated drug particles pass through the grid under the action of the flow field and finally enter the human airway through the delivery pipe.

Preferably, the diversion chamber is arranged as a pair, and the pair of diversion chambers are respectively placed on both sides of the rotating chamber, the inlet cross-section of the first airflow pipe is a parallelogram shape, and the first airflow pipe used for communication is respectively connected to the farthest two sides of the rotating chamber and is tangent to the rotating chamber.

Since the rotating chamber has an inclined wall and the airflow inlet of the rotating chamber needs to be tangent to it, the cross-section of the airflow inlet of the rotating chamber is a quadrilateral with a corresponding inclination angle. During the operation of the device, the flow rates of the two rotating chamber airflow inlets must be similar to ensure a symmetrical and stable flow field in the rotating chamber, thereby improving the separation of drug particles. Therefore, two symmetrically arranged diversion chambers are introduced. Considering that the power source is usually a single-outlet structure, a buffer chamber is added with both ends connected to the diversion chamber through a circular tube.

Preferably, the rotating chamber and the separation box are spliced with a plug-in structure, the grid is detachably plugged into the medicine outlet hole of the rotating chamber, and the conveying pipe is detachably plugged into the medicine outlet hole of the rotating chamber.

Preferably, the driving member comprises a driving motor, the driving motor is mounted on a frame of the atomizing device, an output end of the driving motor is fixedly connected to a second gear, and the second gear is meshed with a bottom of the first gear.

Compared with the prior art, the present invention has the following beneficial effects:

1. The drug supply mechanism of the present invention adopts a combination of various mechanical mechanisms such as gear racks, crank sliders, and push rods, which can realize the orderly and accurate supply of multi-dose dry powder preparations. In addition, during the atomization process, the sealing between the upper end of the drug cabin and the bottom end of the separation mechanism can be fully guaranteed, so that a large amount of dry powder preparations can enter the separation mechanism to complete deagglomeration;

2. The internal flow structure of the separation mechanism of the present invention introduces a flow distribution chamber and a buffer chamber. For a single outlet power source, the flow rates of the air flow inlets of the two rotating chambers can be similar, thereby ensuring a symmetrical and stable flow field in the rotating chamber, which is beneficial to improving the separation of drug particles;

3. The airflow delivery mechanism of the present invention can provide a continuous airflow with a large enough flow rate to fully separate the drug particles, and ensure that the gas inhaled by the patient is clean and sterile through a bacterial filter, so it is suitable for critically ill patients.

BRIEF DESCRIPTION OF THE DRAWINGS

Fig. 1 is a schematic diagram of the overall structure of the present invention;

FIG2 is a schematic diagram of the structure of the medicine supply mechanism of the present invention;

FIG3 is a schematic structural diagram of a slider according to the present invention;

FIG4 is a schematic diagram of the layout of the slider push rod of the present invention;

FIG. 5 is a schematic diagram of the internal flow structure of the separation mechanism of the present invention.

FIG6 is a pneumatic circuit diagram of the air flow conveying mechanism of the present invention;

Description of the accompanying drawings: 1. Atomizer rack; 2. Placement bin; 3. Medicine supply mechanism; 31. Medicine chamber; 32. Hemispherical medicine slot; 33. Medicine outlet; 34. Rack; 35. Concave frame; 36. Rotating rod; 37. Driving motor; 38. First gear; 39. Second gear; 310. Sliding block; 311. Push rod; 4. Crank rocker assembly; 41. Crank; 42. Connecting rod; 5. Sliding groove; 51. First groove; 52. Second groove; 53. Third groove connection; 6. Separation mechanism; 61. Separation box; 62. Rotation chamber; 63. First airflow pipe; 64. Grid; 65. Diversion chamber; 66. Delivery pipe; 67. Second airflow pipe; 68. Buffer chamber; 69. Third airflow pipe; 7. Mounting frame; 8. Airflow delivery mechanism; 81. Bacteria filter; 82. Turbofan; 83. Pressure reducing valve; 84. One-way valve; 85. Pressure sensor; 86. Flow sensor; 87. Safety valve; 88. Gas electromagnetic reversing valve; 89. Respirator.

DETAILED DESCRIPTION

In order to make the purpose, technical solution and advantages of the embodiment of the present invention clearer, the technical solution of the embodiment of the present invention will be clearly and completely described in conjunction with the accompanying drawings of the embodiment of the present invention. Obviously, the described embodiment is a part of the embodiment of the present invention, not all of the embodiments. Based on the described embodiment of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention. Unless otherwise defined, the technical terms or scientific terms used herein should be the common meanings understood by people with general skills in the field to which the present invention belongs.

The words "first", "second" and similar words used in the patent application specification and claims of the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. Words such as "include" or "comprise" and similar words mean that the elements or objects appearing before the word include the elements or objects listed after the word and their equivalents, but do not exclude other elements or objects. "Inside", "outside", "upper", "lower", "far", "near", "front", "back" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly. The drawings in this disclosure are not drawn strictly according to the actual scale. The specific size and quantity of each structure can be determined according to actual needs. The drawings described in this disclosure are only schematic diagrams of the structure.

The present invention provides an inhalable dry powder preparation atomization device, as shown in Figures 1-4, including a separation box 61, and also including a drug supply mechanism 3, the drug supply mechanism 3 is placed below the separation box, the drug supply mechanism 3 includes a medicine cabin 31, the medicine cabin 31 is placed in the placement bin 2, a plurality of hemispherical medicine grooves 32 are opened on the medicine cabin 31, and the plurality of hemispherical medicine grooves 32 are arranged in a single row along the length direction of the medicine cabin 31, a medicine outlet hole 33 is opened at the bottom of the separation box 61, and the radius of the medicine outlet hole 33 and the hemispherical medicine groove 32 are the same, and the top of the medicine cabin 31 is connected to the separation box There is a gap at the bottom of the medicine cabin 31, and a horizontal moving part is provided at the lower side of the medicine cabin 31. The horizontal moving part includes a rack 34, which is fixedly connected to the bottom of the medicine cabin 31. The rack 34 has the same array direction as the hemispherical medicine groove 32; a first gear 38 is meshed with the bottom of the rack 34, and a concave frame is provided at the bottom of the medicine cabin 31. The first gear 38 is rotatably installed on the concave frame 35 through a rotating rod 36. Both ends of the rotating rod 36 pass through the concave frame 35. The first gear 38 is provided with a driving member. A vertical jacking part is provided at the lower side of the medicine cabin 31. The vertical jacking part The slide 310 includes a slide 5, the slide 310 is provided with a slide groove 5, the slide 310 is arranged on both sides of the rack 34, the slide 310 is connected to the shaft end of the rotating rod 36 through the crank rocker assembly 4, the bottom of the concave frame 35 is fixedly connected with the mounting frame 7, the slide 310 is slidably embedded in the mounting frame 7, a push rod 311 is slidably arranged in the slide groove 5, and the top of the push rod 311 abuts against the bottom of the medicine cabin 31 at the farthest stroke, and the slide groove 5 is composed of a first groove 51 and a second groove 52 arranged horizontally, and the first groove 51 and the second groove 52 are connected to each other. 52 is opened along the length direction of the rack 34, there is a height difference between the first groove 51 and the second groove 52 in the vertical direction, the vertical height of the slide 5 depends on the gap between the top of the medicine cabin 31 and the rotating chamber 62, the first groove 51 and the second groove 52 are connected by an inclined third groove 53, the driving part includes a driving motor 37, the driving motor 37 is installed on the atomization equipment frame 1, the output end of the driving motor 37 is fixedly connected to the second gear 39, and the second gear 39 is meshed with the bottom of the first gear 38.

The drug supply mechanism 3 of the present invention adopts a combination of various mechanical mechanisms such as gear racks, crank sliders, cam push rods, etc., which can realize the orderly and accurate supply of multi-dose dry powder preparations, and in the atomization process, can fully ensure the sealing between the upper end of the drug cabin and the bottom end of the separation mechanism 6, so that a large amount of dry powder preparations can enter the separation mechanism 6 to complete deagglomeration;

In order to realize the orderly and accurate supply of dry powder preparations in multi-dose medicine cabins, a gear rack structure is adopted. The upper part of the medicine cabin is a hemispherical medicine groove 32 arranged at equal distances, and the lower part is a rack structure; and to ensure the normal operation of the gear rack structure, there is a gap between the top of the medicine cabin and the bottom of the rotating chamber 62. During the execution of the dry powder preparation supply action, the top action of the medicine cabin is completed by a mechanical mechanism, which can effectively realize the sealing of the medicine supply structure and ensure that a large amount of dry powder preparations can enter the separation mechanism 6 to complete the depolymerization. Based on this demand, the present invention introduces a crank slider mechanism and a push rod mechanism. During the first half of the rotation of the drive shaft, since the crank 41 is coaxial with the first gear 38, the connecting rod 42 will push the slider 310 to move during the meshing process of the rack 34 of the first gear 38; and since the push rod 311 can only move up and down and is located in the groove of the slider 310, when the supply action is completed, the push rod 311 will make the top of the medicine cabin 31 fit tightly with the bottom of the rotating chamber 62 (at this time, the gear rack is no longer meshed). During the second half of the rotation of the drive shaft, the push rod 311 will gradually move downward and continue to fall under the action of gravity until the rack 34 at its bottom re-engages with the first gear 38. In short, only a single rotation of the drive shaft is required to simultaneously achieve the two actions of drug supply and push-up (ensuring sealing).

Preferably, as shown in Figures 5-6, the separation mechanism 6 also includes a rotating chamber 62, a first airflow pipe 63, a grid 64 and a diversion chamber 65. The rotating chamber 62 is placed in the separation box 61, and the rotating chamber 62 is buckled on the top of the medicine outlet hole 33. The rotating chamber 62 and the diversion chamber 65 are connected through the first airflow pipe 63. The top of the rotating chamber 62 is connected to a conveying pipe 66, and a grid 64 is provided at the position where the conveying pipe 66 communicates with the rotating chamber 62. The diversion chamber 65 is set as a pair, and the pair of diversion chambers 65 are respectively placed on both sides of the rotating chamber 62. The separation mechanism 6 also includes a second airflow pipe 6 7. Buffer chamber 68 and third air flow pipe 69. One side of the buffer chamber 68 is connected to a pair of diverter chambers 65 through a second air flow pipe 67. The inlet cross-section of the first air flow pipe 63 is a parallelogram shape, and the first air flow pipe 63 used for communication is respectively connected to the farthest two sides of the rotating chamber 62, and the other side of the buffer chamber 68 tangent to the rotating chamber 62 is connected to the third air flow pipe 69. The rotating chamber 62 and the separation box 61 are spliced with a plug-in structure. The grid 64 can be detachably plugged into the medicine outlet hole of the rotating chamber 62, and the conveying pipe 66 can be detachably plugged into the medicine outlet hole of the rotating chamber 62.

Since the rotating chamber 62 has an inclined cross-section, and the airflow inlet of the rotating chamber 62 needs to be tangent to it, the cross-section of the airflow inlet of the rotating chamber 62 is a quadrilateral with a corresponding inclination angle. During the operation of the device, the flow rates of the airflow inlets of the two rotating chambers 62 must be similar to ensure that a symmetrical and stable flow field is generated in the rotating chamber 62, thereby improving the separation of drug particles, so two symmetrically arranged diverter chambers 65 are introduced. Considering that the power source is usually a single-outlet structure, a buffer chamber 68 is added with two ends connected to the diverter chamber 65 by a circular tube. The internal flow structure of the separation mechanism 6 of the present invention introduces the diverter chamber 65 and the buffer chamber 68. For a single-outlet power source, the flow rates of the airflow inlets of the two rotating chambers 62 can be similar, thereby ensuring that a symmetrical and stable flow field is generated in the rotating chamber 62, which is beneficial to improving the separation of drug particles.

Preferably, as shown in Figures 5-6, the airflow conveying mechanism 8 includes a turbofan 82, a one-way valve 84, a pressure sensor 85, a flow sensor 86, a safety valve 87, a gas electromagnetic reversing valve 88 and a circuit control element to achieve continuous airflow delivery with different durations of 0.5s to 60s and different flow ranges of 5L/min to 400L/min, and an additional bacterial filter 81 is provided.

The flow conveying mechanism provides a high-pressure airflow for the separation mechanism 6. The high-pressure airflow enters from the third airflow pipe 69, passes through the buffer chamber 68, the diversion chamber 65, and the first airflow pipe 63 in sequence, and then enters the rotating chamber 62, blowing up the dry powder preparation in the medicine cabin directly below the rotating chamber 62. The dry powder preparation rises to the rotating chamber 62 under the action of the airflow and continuously collides with its wall. The drug particles will be separated from the surface of the carrier particles due to inertia. The separated drug particles pass through the grid 64 under the action of the flow field, and finally enter the human airway through the outlet.

The method of using the inhalable dry powder preparation atomization device of the present invention is as follows:

The driving motor 37 drives the second gear 39 to rotate, thereby making the first gear 38 mesh with the rack 34 at the bottom of the medicine chamber 31, and finally achieving the precise matching of the hemispherical medicine groove 32 and the medicine chamber medicine outlet 33 of the separation mechanism 6. Since one end of the crank 41 is connected to the rotating rod 36, the crank 41 in circular motion will drive the connecting rod 42 to move in the process of the rack 34 driving the medicine chamber 31, and finally the connecting rod 42 will push the slider 310 to make horizontal linear motion; when the slider 310 reaches the shortest stroke, the push rod 311 in its groove moves upward, completing the push action and thus ensuring the sealing of the device, and during the return stroke of the slider 310, the push rod 311 will gradually move downward, and the medicine chamber 31 will continue to descend under the action of gravity until the rack 34 at its bottom re-engages with the first gear 38.

First, switch the gas electromagnetic reversing valve 88 to the left position, turn on the turbofan 82, and let the air enter the turbofan 82 directly after being processed by the bacterial filter 81. Adjust the safety valve 87 and observe the indications of the pressure sensor 85 and the flow sensor 86. When the flow sensor 86 reaches the predetermined working flow and the pressure is stable, switch the gas electromagnetic reversing valve 88 to the right position. Finally, the pressurized airflow is directly injected into the third airflow pipe 69 of the separation mechanism 6 at a certain flow rate. In view of the fact that the output airflow duration and flow rate of the airflow conveying mechanism 8 will also directly affect the atomization effect of the dry powder preparation in the separation mechanism 6, it is necessary to realize continuous airflow delivery with different durations of 0.5.s to 60s and different flow ranges of 5L/min to 400L/min. In addition, the power source can also be replaced by compressed oxygen, and the pressure reducing valve 83 can be directly connected to the pneumatic circuit.

The high-pressure airflow injected into the third airflow pipe 69 of the separation mechanism 6 enters the rotating chamber 62 after passing through the buffer chamber 68, the diversion chamber 65, and the first airflow pipe 63 in sequence, blowing up the dry powder preparation in the medicine cabin directly below the rotating chamber 62. The dry powder preparation rises to the rotating chamber 62 under the action of the airflow and continuously collides with its wall surface. The drug particles will be separated from the surface of the carrier particles due to inertia. The separated drug particles pass through the grid 64 under the action of the flow field and finally enter the aerosol chamber through the delivery pipe 66. For critically ill patients, it is difficult to actively inhale the atomized drug particles in the aerosol chamber into the respiratory tract, so a ventilator 89 is required for auxiliary inhalation treatment.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims (8)

1. An inhalable dry powder formulation nebulization device comprising a separation tank (61), characterized in that it further comprises a dosing mechanism (3), the dosing mechanism (3) being arranged below the separation tank (61), the dosing mechanism (3) comprising:

The medicine cabin (31) is placed in the placement cabin (2), a plurality of hemispherical medicine grooves (32) are formed in the medicine cabin (31), the hemispherical medicine grooves (32) are arranged in a single row along the length direction of the medicine cabin (31), medicine outlet holes (33) are formed in the bottom of the separation box (61), the radius of the medicine outlet holes (33) is the same as that of the hemispherical medicine grooves (32), and gaps exist between the top of the medicine cabin (31) and the bottom of the separation box (61);

The horizontal moving part is arranged at the lower side of the medicine cabin (31), and comprises a rack (34) fixedly connected to the bottom of the medicine cabin (31), and the direction of the rack (34) is the same as that of the hemispherical medicine groove (32); a first gear (38) engaged to the bottom of the rack (34); the concave frame (35) is arranged at the bottom of the medicine cabin (31), the first gear (38) is rotatably arranged on the concave frame (35) through a rotating rod (36), two ends of the rotating rod (36) penetrate through the concave frame (35), and a driving piece is arranged on the first gear (38);

The vertical jacking part is arranged at the lower side of the medicine cabin (31) and comprises a sliding block (310), a sliding groove (5) is formed in the sliding block (310), the sliding block (310) is arranged at two sides of the rack (34), the sliding block (310) is connected with the shaft end of the rotating rod (36) through a crank rocker assembly (4), the installation frame (7) is fixedly connected to the bottom of the concave frame (35), and the sliding block (310) is slidably embedded on the installation frame (7); the ejector rod (311) is arranged in the chute (5), and the top of the ejector rod (311) is abutted with the bottom of the medicine cabin (31) in the farthest stroke.

2. An inhalable dry powder formulation nebulizing device according to claim 1, characterized in that the crank and rocker assembly (4) comprises a crank (41) and a connecting rod (42), wherein one end of the connecting rod (42) is fixedly sleeved on the rotating rod (36), the crank (41) is hinged to the connecting rod (42), and the connecting rod (42) is hinged to the slider (310).

3. An inhalable dry powder formulation nebulizing device according to claim 1, characterized in that the chute (5) consists of a first channel (51) and a second channel (52) arranged horizontally, the first channel (51) and the second channel (52) being open in the longitudinal direction of the rack (34), the first channel (51) and the second channel (52) being vertically level-different, the vertical height of the chute (5) being dependent on the gap between the top of the capsule (31) and the separating tank (61), the first channel (51) and the second channel (52) being connected by a third channel (53) arranged obliquely.

4. An inhalable dry powder formulation nebulization device according to claim 1, characterized in that the separation mechanism (6) further comprises a rotation chamber (62), a first air flow tube (63), a grid (64) and a diversion chamber (65), the rotation chamber (62) is arranged in the separation box (61), the rotation chamber (62) is buckled at the top of the drug outlet hole (33), the rotation chamber (62) is communicated with the diversion chamber (65) through the first air flow tube (63), the top of the rotation chamber (62) is connected with a conveying pipe (66), and the grid (64) is arranged at the position where the conveying pipe (66) is communicated with the rotation chamber (62).

5. An inhalable dry powder formulation nebulization device according to claim 1, characterized in that the separating means (6) further comprises a second gas flow tube (67), a buffer chamber (68) and a third gas flow tube (69), one side of the buffer chamber (68) being in communication with a pair of the shunting chambers (65) via the second gas flow tube (67), the other side of the buffer chamber (68) being connected to the third gas flow tube (69).

6. An inhalable dry powder formulation nebulization device according to claim 4, characterized in that the said diverting chambers (65) are provided in a pair, one pair of said diverting chambers (65) being placed on each side of the said rotating chamber (62), the inlet section of the said first air flow tube (63) being parallelogram-shaped, and the said first air flow tube (63) for communication being connected to the furthest side of the said rotating chamber (62) and being tangential to the rotating chamber (62), respectively.

7. An inhalable dry powder formulation nebulizing apparatus according to claim 4, characterized in that the rotating chamber (62) is spliced with the separating box (61) by a plug-in structure, the grid (64) is detachably plugged into the drug outlet of the rotating chamber (62), and the delivery tube (66) is detachably plugged into the drug outlet of the rotating chamber (62).

8. An inhalable dry powder formulation nebulizing device according to claim 1, the driving member comprising a driving motor (37), the driving motor (37) being mounted on the nebulizing device housing (1), the output end of the driving motor (37) being connected with a second gear (39), the second gear (39) being engaged with the bottom of the first gear (38).