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CR20140215A - Ciclopenta (d) pirimidinas como inhibidores de la proteina cinasa akt - Google Patents

Ciclopenta (d) pirimidinas como inhibidores de la proteina cinasa akt

Info

Publication number
CR20140215A
CR20140215A CR20140215A CR20140215A CR20140215A CR 20140215 A CR20140215 A CR 20140215A CR 20140215 A CR20140215 A CR 20140215A CR 20140215 A CR20140215 A CR 20140215A CR 20140215 A CR20140215 A CR 20140215A
Authority
CR
Costa Rica
Prior art keywords
cinasa
pyrimidins
cyclopenta
akt
inhibitors
Prior art date
Application number
CR20140215A
Other languages
English (en)
Inventor
Ian S Mitchell
James F Blake
Nicholas C Kallan
Rui Xu
Dengming Xiao
Keith Lee Spencer
Josef R Bencsik
Jun Liang
Brian Safina
Eli M Wallace
Anna L Banka
Stephen T Schlachter
Christine Chabot
Jun Li
Original Assignee
Array Biopharma Inc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38686844&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20140215(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Array Biopharma Inc, Genentech Inc filed Critical Array Biopharma Inc
Publication of CR20140215A publication Critical patent/CR20140215A/es

Links

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Dermatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
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  • Urology & Nephrology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
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  • AIDS & HIV (AREA)
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Abstract

La presente invención proporciona compuestos de la Fórmula I, incluyendo tautómeros, enantiómeros reducidos, diastereómeros, solvatos, metaboilitos, sales y profármacos farmacéuticamente aceptables de los mismos. Fórmula (I). También se proporcionan méto
CR20140215A 2006-07-06 2014-05-09 Ciclopenta (d) pirimidinas como inhibidores de la proteina cinasa akt CR20140215A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US81876206P 2006-07-06 2006-07-06

Publications (1)

Publication Number Publication Date
CR20140215A true CR20140215A (es) 2014-07-11

Family

ID=38686844

Family Applications (2)

Application Number Title Priority Date Filing Date
CR10601A CR10601A (es) 2006-07-06 2009-02-05 Ciclopenta (d) pirimidinas como inhibidores de la proteina cinasa akt
CR20140215A CR20140215A (es) 2006-07-06 2014-05-09 Ciclopenta (d) pirimidinas como inhibidores de la proteina cinasa akt

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CR10601A CR10601A (es) 2006-07-06 2009-02-05 Ciclopenta (d) pirimidinas como inhibidores de la proteina cinasa akt

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US (3) US8003651B2 (es)
EP (1) EP2049500B1 (es)
JP (3) JP5268904B2 (es)
KR (2) KR101527232B1 (es)
CN (2) CN103288753A (es)
AR (1) AR061844A1 (es)
AT (1) ATE523499T1 (es)
AU (1) AU2007269052B2 (es)
BR (1) BRPI0713555A2 (es)
CA (1) CA2656618C (es)
CL (1) CL2007001992A1 (es)
CO (1) CO6160229A2 (es)
CR (2) CR10601A (es)
CY (1) CY1112142T1 (es)
DK (1) DK2049500T3 (es)
ES (1) ES2372955T3 (es)
HR (1) HRP20110882T1 (es)
IL (1) IL196051A (es)
MA (1) MA30952B1 (es)
MX (1) MX2008016203A (es)
MY (1) MY147628A (es)
NO (1) NO20090580L (es)
NZ (1) NZ573979A (es)
PL (1) PL2049500T3 (es)
PT (1) PT2049500E (es)
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RU (1) RU2481336C2 (es)
SI (1) SI2049500T1 (es)
TW (1) TWI428335B (es)
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Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE493418T1 (de) * 2006-07-06 2011-01-15 Array Biopharma Inc Dihydrofuropyrimidine als akt- proteinkinaseinhibitoren
US8063050B2 (en) 2006-07-06 2011-11-22 Array Biopharma Inc. Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
AU2014201211B2 (en) * 2006-07-06 2016-04-14 Array Biopharma Inc. Hydroxylated and methoxylated cyclopenta [d] pyrimidines as akt protein kinase inhibitors
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