CY2446B1 - Phthalazinones. - Google Patents

Phthalazinones.

Info

Publication number: CY2446B1
Authority: CY; Cyprus
Prior art keywords: pct; date jul; sec; pub; phthalazinones
Prior art date: 1997-01-15

Application number

CY0400064A

Other languages

English (en)

Inventor

Van Der Margaretha Mey

Van Der Ivonne Johanna Laan

Hendrik Timmerman

Armin Hatzelmann

Hildegard Boss

Dietrich Haefner

Rolf Beume

Hans-Peter Kley

Geert Jan Sterk

Original Assignee

Byk Gulden Lomberg Chem Fab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-15

Filing date

2004-08-11

Publication date

2004-11-12

2004-08-11 Application filed by Byk Gulden Lomberg Chem Fab filed Critical Byk Gulden Lomberg Chem Fab

2004-11-12 Publication of CY2446B1 publication Critical patent/CY2446B1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Dermatology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Plural Heterocyclic Compounds (AREA)
Compositions Of Macromolecular Compounds (AREA)
Lubricants (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

CY0400064A 1997-01-15 2004-08-11 Phthalazinones. CY2446B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97100488		1997-01-15

Publications (1)

Publication Number	Publication Date
CY2446B1 true CY2446B1 (en)	2004-11-12

Family

ID=8226366

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CY0400064A CY2446B1 (en)	1997-01-15	2004-08-11	Phthalazinones.

Country Status (26)

Country	Link
US (1)	US6103718A (xx)
EP (1)	EP0971901B1 (xx)
JP (1)	JP2001508078A (xx)
KR (1)	KR20000070150A (xx)
CN (1)	CN1127487C (xx)
AT (1)	ATE233247T1 (xx)
AU (1)	AU735934B2 (xx)
BR (1)	BR9806752A (xx)
CA (1)	CA2276455C (xx)
CY (1)	CY2446B1 (xx)
CZ (1)	CZ293815B6 (xx)
DE (1)	DE69811645T2 (xx)
DK (1)	DK0971901T3 (xx)
EA (1)	EA002764B1 (xx)
EE (1)	EE03968B1 (xx)
ES (1)	ES2193508T3 (xx)
HU (1)	HUP0001541A3 (xx)
IL (1)	IL130659A (xx)
NO (1)	NO313137B1 (xx)
NZ (1)	NZ336573A (xx)
PL (1)	PL189418B1 (xx)
PT (1)	PT971901E (xx)
SI (1)	SI0971901T1 (xx)
SK (1)	SK283270B6 (xx)
TR (1)	TR199901653T2 (xx)
WO (1)	WO1998031674A1 (xx)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SI1070056T1 (en) *	1998-03-14	2004-12-31	Altana Pharma Ag	Phthalazinone pde iii/iv inhibitors
TR200909479T2 (tr)	1999-08-21	2012-02-21	Nycomed Gmbh	Sinerjistik kombinasyon.
AU7654200A (en) *	1999-09-14	2001-04-17	Byk Gulden Lomberg Chemische Fabrik Gmbh	Phthalazinone derivatives as pd3/4 inhibitors
EA005856B1 (ru) *	1999-10-25	2005-06-30	Алтана Фарма Аг	Тетрагидротиопиранфталазиноновые производные в качестве ингибиторов pde4
EP1228046B1 (en) *	1999-10-25	2007-09-26	Nycomed GmbH	Phthalazinone derivatives as pde 4 inhibitors
CZ20023997A3 (cs) *	2000-06-05	2003-05-14	Altana Pharma Ag	Pyridazinonové deriváty
US7868015B2 (en) *	2000-08-10	2011-01-11	Cold Spring Harbor Laboratory	Phosphodiesesterase 4 inhibitors for the treatment of a cognitive deficit
US20040224316A1 (en) *	2000-08-10	2004-11-11	Tully Timothy P.	Augmented cognitive training
CA2438520C (en) *	2001-02-15	2011-10-04	Altana Pharma Ag	Phthalazinone-piperidino-derivatives as pde4 inhibitors
AU2002317733B2 (en) *	2001-04-25	2007-12-13	Altana Pharma Ag	Phthalazinones derivatives useful as PDE4/7 inhibitors
JP4021329B2 (ja) *	2001-04-25	2007-12-12	ニコメッドゲゼルシャフトミットベシュレンクテルハフツング	ピペラジノ誘導体およびｐｄｅ４阻害剤としてのその使用
EP1477175B1 (en)	2002-02-19	2011-04-27	Ono Pharmaceutical Co., Ltd.	Fused pyridazine derivative compounds and drugs containing the compounds as the active ingredient
AU2003255376A1 (en) *	2002-08-10	2004-03-11	Altana Pharma Ag	Piperidine-derivatives as pde4 inhibitors
HRP20050197A2 (en) *	2002-08-10	2006-06-30	Altana Pharma Ag	Piperidine-n-oxide-derivatives
WO2004018451A1 (en) *	2002-08-10	2004-03-04	Altana Pharma Ag	Pyridazinone-derivatives as pde4 inhibitors
CA2494634A1 (en) *	2002-08-10	2004-03-04	Altana Pharma Ag	Piperidine-pyridazones and phthalazones as pde4 inhibitors
CA2517487A1 (en)	2003-04-01	2004-10-14	Applied Research Systems Ars Holding N.V.	Inhibitors of phosphodiesterases in infertility
WO2004098633A1 (en) *	2003-05-12	2004-11-18	Altana Pharma Ag	Composition comprising a pde-4 inhibitor and a tnf alpha antagonist
JP4591349B2 (ja) *	2003-07-14	2010-12-01	宇部興産株式会社	４−アミノテトラヒドロピラン化合物及びその酸塩の製法、その合成中間体およびその製法
WO2005075456A1 (en) *	2004-02-04	2005-08-18	Altana Pharma Ag	2-(piperidin-4-yl) -4, 5-dihydro-2h-pyridazin-3-one derivatives as pde4 inhibitors
US20080227790A1 (en) *	2004-02-04	2008-09-18	Altana Pharma Ag	Pyridazinone Derivatives and their Use as Pde4 Inhibitors
AU2006240730A1 (en) *	2005-04-21	2006-11-02	Nippon Shinyaku Co., Ltd.	Phthalazinone derivative and pharmaceutical comprising the same
EP2258358A3 (en)	2005-08-26	2011-09-07	Braincells, Inc.	Neurogenesis with acetylcholinesterase inhibitor
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
EP2377530A3 (en)	2005-10-21	2012-06-20	Braincells, Inc.	Modulation of neurogenesis by PDE inhibition
US20070112017A1 (en)	2005-10-31	2007-05-17	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
JP2009536669A (ja)	2006-05-09	2009-10-15	ブレインセルス，インコーポレイティド	アンジオテンシン調節による神経新生
AU2007249435A1 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 HT receptor mediated neurogenesis
AU2007292848A1 (en)	2006-09-08	2008-03-13	Braincells, Inc.	Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
ES2427442T3 (es)	2007-05-16	2013-10-30	Takeda Gmbh	Derivados de pirazolona como inhibidores de PDE4
AR074318A1 (es)	2008-11-14	2011-01-05	Nycomed Gmbh	Derivados heterociclicos de pirazolona, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento de enfermedades de las vias respiratorias.
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
PE20140648A1 (es) *	2011-06-17	2014-05-30	Takeda Gmbh	Novedosos derivados de ftalazinona-pirrolopirimidinacarboxamida
US20150119399A1 (en)	2012-01-10	2015-04-30	President And Fellows Of Harvard College	Beta-cell replication promoting compounds and methods of their use
EP2968323A4 (en)	2013-03-13	2016-12-14	Flatley Discovery Lab	PYRIDAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS
US20150050626A1 (en) *	2013-03-15	2015-02-19	Dart Neuroscience, Llc	Systems, Methods, and Software for Improving Cognitive and Motor Abilities

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2845456A1 (de) *	1978-10-19	1980-08-14	Merck Patent Gmbh	6-arylpyridazin-3-one und verfahren zu ihrer herstellung
CZ141795A3 (en) *	1992-12-02	1995-11-15	Pfizer	4-substituted catechol diethers as such and for treating diseases and pharmaceutical preparations based thereon
EP0634404A1 (en) *	1993-07-13	1995-01-18	Rhone Poulenc Agriculture Ltd.	Phtalazin derivatives and their use as pesticides
EP0722936B1 (en) *	1994-08-09	2004-05-19	Eisai Co., Ltd.	Fused pyridazine compound

1998
- 1998-01-12 EA EA199900620A patent/EA002764B1/ru not_active IP Right Cessation
- 1998-01-12 SI SI9830396T patent/SI0971901T1/xx unknown
- 1998-01-12 PT PT98901959T patent/PT971901E/pt unknown
- 1998-01-12 EP EP98901959A patent/EP0971901B1/en not_active Expired - Lifetime
- 1998-01-12 DE DE69811645T patent/DE69811645T2/de not_active Expired - Fee Related
- 1998-01-12 WO PCT/EP1998/000124 patent/WO1998031674A1/en not_active Application Discontinuation
- 1998-01-12 BR BR9806752-4A patent/BR9806752A/pt active Search and Examination
- 1998-01-12 EE EEP199900274A patent/EE03968B1/xx not_active IP Right Cessation
- 1998-01-12 AT AT98901959T patent/ATE233247T1/de not_active IP Right Cessation
- 1998-01-12 TR TR1999/01653T patent/TR199901653T2/xx unknown
- 1998-01-12 AU AU58629/98A patent/AU735934B2/en not_active Ceased
- 1998-01-12 DK DK98901959T patent/DK0971901T3/da active
- 1998-01-12 CZ CZ19992533A patent/CZ293815B6/cs not_active IP Right Cessation
- 1998-01-12 NZ NZ336573A patent/NZ336573A/xx unknown
- 1998-01-12 CA CA002276455A patent/CA2276455C/en not_active Expired - Fee Related
- 1998-01-12 CN CN98803169A patent/CN1127487C/zh not_active Expired - Fee Related
- 1998-01-12 PL PL98334561A patent/PL189418B1/pl not_active IP Right Cessation
- 1998-01-12 HU HU0001541A patent/HUP0001541A3/hu unknown
- 1998-01-12 IL IL13065998A patent/IL130659A/en not_active IP Right Cessation
- 1998-01-12 ES ES98901959T patent/ES2193508T3/es not_active Expired - Lifetime
- 1998-01-12 US US09/341,135 patent/US6103718A/en not_active Expired - Fee Related
- 1998-01-12 KR KR1019997006376A patent/KR20000070150A/ko not_active Ceased
- 1998-01-12 SK SK951-99A patent/SK283270B6/sk unknown
- 1998-01-12 JP JP53363598A patent/JP2001508078A/ja not_active Ceased
1999
- 1999-07-02 NO NO19993301A patent/NO313137B1/no unknown
2004
- 2004-08-11 CY CY0400064A patent/CY2446B1/xx unknown

Also Published As

Publication number	Publication date
NO993301L (no)	1999-09-10
EA002764B1 (ru)	2002-08-29
JP2001508078A (ja)	2001-06-19
EP0971901B1 (en)	2003-02-26
KR20000070150A (ko)	2000-11-25
ES2193508T3 (es)	2003-11-01
AU735934B2 (en)	2001-07-19
SI0971901T1 (en)	2003-10-31
EA199900620A1 (ru)	2000-04-24
IL130659A (en)	2002-07-25
IL130659A0 (en)	2000-06-01
CA2276455C (en)	2006-10-31
CN1249749A (zh)	2000-04-05
AU5862998A (en)	1998-08-07
BR9806752A (pt)	2000-03-14
TR199901653T2 (xx)	1999-10-21
SK95199A3 (en)	1999-12-10
EE9900274A (et)	2000-02-15
CA2276455A1 (en)	1998-07-23
NO313137B1 (no)	2002-08-19
NO993301D0 (no)	1999-07-02
CZ293815B6 (cs)	2004-08-18
US6103718A (en)	2000-08-15
CZ253399A3 (cs)	2000-05-17
NZ336573A (en)	2000-10-27
DE69811645D1 (de)	2003-04-03
HUP0001541A2 (hu)	2001-05-28
ATE233247T1 (de)	2003-03-15
PL189418B1 (pl)	2005-08-31
DE69811645T2 (de)	2003-12-04
WO1998031674A1 (en)	1998-07-23
CN1127487C (zh)	2003-11-12
PL334561A1 (en)	2000-03-13
EE03968B1 (et)	2003-02-17
SK283270B6 (sk)	2003-04-01
HK1024692A1 (en)	2000-10-20
EP0971901A1 (en)	2000-01-19
DK0971901T3 (da)	2003-06-10
PT971901E (pt)	2003-07-31
HUP0001541A3 (en)	2001-11-28

Publication	Publication Date	Title
CY2446B1 (en)	2004-11-12	Phthalazinones.
SI1070056T1 (en)	2004-12-31	Phthalazinone pde iii/iv inhibitors
DE69809754D1 (en)	2003-01-09	Substituierte 6-phenylphenanthridine
SI1075477T1 (en)	2003-08-31	Novel Benzonaphthyridine-N-oxides
IL129054A0 (en)	2000-02-17	Benzonaphthyridines as bronchial therapeutics
BG105561A (en)	2001-12-29	Phenylphenanthridines with pde-iv inhibiting activity
BR9811956A (pt)	2000-08-15	Naftiridinonas para a inibição de proteìna tirosina cinase e de proliferação celular mediada por cinase de ciclo de célula
SI0998460T1 (en)	2004-08-31	Novel tetrazole derivatives
MY135909A (en)	2008-07-31	Treatment of pulmonary hypertension
PT920426E (pt)	2004-02-27	Novos derivados de tiazole com efeito inibidor de fosfodiesterase
PT941221E (pt)	2003-07-31	Dihidrobenzofuranos substituidos como inibidores de fosfodiesterase (pde)
PT1147103E (pt)	2005-08-31	Fenantridina-n-oxidos com actividade inibitoria de pde-iv
MXPA02012470A (es)	2004-01-26	Inhibidores de fosfodiesterasa especificos para gmp ciclico.
SI1377574T1 (xx)	2005-08-31