DE102017002810A1 - Sialinsäurederivate mit C-C Dreifachbindung und deren Herstellung - Google Patents

Sialinsäurederivate mit C-C Dreifachbindung und deren Herstellung Download PDF

Info

Publication number: DE102017002810A1
Authority: DE; Germany
Prior art keywords: diyl; oder; sialic acid; group; formula
Prior art date: 2017-03-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Ceased

Application number

DE102017002810.9A

Other languages

German (de)

English (en)

Inventor

Horst Prescher

Reinhard Brossmer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Individual

Original Assignee

Individual

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-03-22

Filing date

2017-03-22

Publication date

2018-09-27

2017-03-22 Application filed by Individual filed Critical Individual

2017-03-22 Priority to DE102017002810.9A priority Critical patent/DE102017002810A1/de

2018-03-13 Priority to PCT/EP2018/056147 priority patent/WO2018172129A1/fr

2018-09-27 Publication of DE102017002810A1 publication Critical patent/DE102017002810A1/de

Status Ceased legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/18—Acyclic radicals, substituted by carbocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Hematology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE102017002810.9A 2017-03-22 2017-03-22 Sialinsäurederivate mit C-C Dreifachbindung und deren Herstellung Ceased DE102017002810A1 (de)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
DE102017002810.9A DE102017002810A1 (de)	2017-03-22	2017-03-22	Sialinsäurederivate mit C-C Dreifachbindung und deren Herstellung
PCT/EP2018/056147 WO2018172129A1 (fr)	2017-03-22	2018-03-13	Dérivés d'acide sialique à liaison triple c-c et leur production

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE102017002810.9A DE102017002810A1 (de)	2017-03-22	2017-03-22	Sialinsäurederivate mit C-C Dreifachbindung und deren Herstellung

Publications (1)

Publication Number	Publication Date
DE102017002810A1 true DE102017002810A1 (de)	2018-09-27

Family

ID=61655770

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE102017002810.9A Ceased DE102017002810A1 (de)	2017-03-22	2017-03-22	Sialinsäurederivate mit C-C Dreifachbindung und deren Herstellung

Country Status (2)

Country	Link
DE (1)	DE102017002810A1 (fr)
WO (1)	WO2018172129A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20250064941A1 (en) *	2023-06-14	2025-02-27	Osprey Biopharmaceuticals, Inc.	Siglec ligands, conjugates, and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998003573A1 (fr)	1996-07-17	1998-01-29	Biomolecular Research Institute Ltd.	Composes inhibiteurs angiogeniques
WO2015128344A1 (fr)	2014-02-25	2015-09-03	Reinhard Brossmer	Dérivés d'acide sialique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9539336B2 (en) *	2012-06-21	2017-01-10	Reinhard Brossmer	Sialic acid derivatives

2017
- 2017-03-22 DE DE102017002810.9A patent/DE102017002810A1/de not_active Ceased
2018
- 2018-03-13 WO PCT/EP2018/056147 patent/WO2018172129A1/fr not_active Ceased

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1998003573A1 (fr)	1996-07-17	1998-01-29	Biomolecular Research Institute Ltd.	Composes inhibiteurs angiogeniques
WO2015128344A1 (fr)	2014-02-25	2015-09-03	Reinhard Brossmer	Dérivés d'acide sialique

Non-Patent Citations (26)

* Cited by examiner, † Cited by third party
Title
„Carbohydrates: Best synthetic methods" H.M.I. Osborn, Academic Press 2003
„Current Medicinal Chemistry 2011, 18, 3537-3550"
„Glycochemical Synthesis: Strategies" and Applications Editor: Shang-Cheng Hung and Medel Manuel L. Zulueta (Editor) ISBN: 978-1-118-29984-5
„Pharmacological Sciences 2009, 30 (5), 240-248"
„Protecting Groups" Philip J. Kocienski, 3rd Edition, Thieme 2005
„Protecting Groups" Philip J. Kocienski, 3rd Edition, Thieme 2005, Chem. Rev. 2009, 109, 2455-2504
„Protecting Groups", Philip J. Kocienski, 3rd Edition, Thieme 2005, Chem. Rev. 2009, 109, 2455-2504 und „Protective Groups in Organic Chemistry" Peter G. M. Wuts, Wiley, 2014
„Protective Groups in Organic Chemistry" Peter G. M. Wuts, Wiley, 2014
Bioorg. Med. Chem. Lett. 1994, 4, 2457-2460
chauer (2004) Zoology, 107, 49-64
Chen et al. 2010 Blood 115(23):4778-86
Collins et al (2006) Journal of Immunology 177, 2994-3003
Courtney et al (2009) PNAS 106, 8, 2500-505
Glycoconjugate J. 2006, vol. 23, issue 1-2, alle Artikel
KELM, S.; MADGE, P.; ISLAM, T.; BENNETT, R.; KOLIWER-BRANDL, H.; WAESPY, M.; von ITZSTEIM, M.; HASELHORST, T: C-4 Modified Sialosides Enhance Binding to Siglec-2 (CD 22): Towards Potent Siglec Inhibitors for Immunoglycotherapy. In: Angew. Chem. Int. Ed., 2013, 52, S. 3616-3620. *
Lehmann et al (2006) Cell- Mol. Life Sci. 63, 1331-1354
Macauley et al 2013 J Clin Invest. 123(7):3074-83
Macauley et al. 2016 J Allergy Clin Immunol. pii: S0091-6749(16)30799-0
Madge et al. 2016 Scientific Reports 6, Article number: 36012
Madge et al., 2016, Scientific Reports 6, Article number: 36012) aus Methyl 5-acetamido-7,8,9-tri-O-acetyl-2,6-anhydro-4-azido-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonate (Carbohydr. Res. 1993, 244, 181-185)
Prescher et al. 2014 ACS Chem Biol.9(7):1444-50
Schweizer et al. Eur J Immunol. 2012 42(10):2792-802
Tetrahedron 2005, 61, 10827-10852, Chem. Eur. J. 2009, 15, 9040-9416
Tetrahedron 2005, 61, 10827-10852, Chem. Eur. J. 2009, 15, 9040-9416 Mini-Reviews in Organic Chemistry, 2013, 10 (2), 160-170, Journal of Molecular Catalysis A: Chemical 271 (2007) 89-92, Volume 42, Issue 31, 30 July 2001, Pages 5227-5229, Reinhard Brückner: Reaktionsmechanismen 3. Auflage, Springer Spektrum, Berlin und Heidelberg 2004 und Synthesis, 2007, 3497-3506, Org. Lett., 2012, 14, 2814-2817
Tetrahedron 57, 2001, 7785-7811, Tetrahedron 2005, 61, 10827-10852, Chem. Eur. J. 2009, 15, 9040-9416 Mini-Reviews in Organic Chemistry, 2013, 10 (2), 160-170, Journal of Molecular Catalysis A: Chemical 271 (2007) 89-92, Volume 42, Issue 31, 30 July 2001, Pages 5227-5229, Reinhard Brückner: Reaktionsmechanismen 3. Auflage, Springer Spektrum, Berlin und Heidelberg 2004 und Synthesis, 2007, 3497-3506, Org. Lett., 2012, 14, 2814-2817
Varki (2008) Trends in Mol. Med., 14, 8, 351- 360

Also Published As

Publication number	Publication date
WO2018172129A1 (fr)	2018-09-27

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EP2797946B1 (fr)	2016-05-04	Dimères d'acide sialique
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WO1996039411A1 (fr)	1996-12-12	Liposaccharides substitues utiles dans le traitement et la prevention de l'endotoxemie
WO2015128344A1 (fr)	2015-09-03	Dérivés d'acide sialique
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EP2863925B1 (fr)	2016-09-14	Dérivé d'acide sialique
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JPH10101692A (ja)	1998-04-21	１−（５’−Ｏ−アシル−β−Ｄ−アラビノフラノシル）−２−チオシトシンおよび該化合物を活性成分として含有する抗癌剤

Legal Events

Date	Code	Title
2017-03-22	R012	Request for examination validly filed
2020-07-17	R002	Refusal decision in examination/registration proceedings
2020-08-25	R003	Refusal decision now final