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DE60141074D1 - Derivate von kettenverzweigten lipophilen molekülen und deren verwendung - Google Patents

Derivate von kettenverzweigten lipophilen molekülen und deren verwendung

Info

Publication number
DE60141074D1
DE60141074D1 DE60141074T DE60141074T DE60141074D1 DE 60141074 D1 DE60141074 D1 DE 60141074D1 DE 60141074 T DE60141074 T DE 60141074T DE 60141074 T DE60141074 T DE 60141074T DE 60141074 D1 DE60141074 D1 DE 60141074D1
Authority
DE
Germany
Prior art keywords
derivatives
chain
lipophiles
molecules
derived
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60141074T
Other languages
English (en)
Inventor
Alexander Kozak
Marina Vinnikova
Michael Polyak
Eliezer Beit-Yannai
Dalia Reznitsky-Cohen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
DPHARM Ltd
D Pharm Ltd
Original Assignee
DPHARM Ltd
D Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DPHARM Ltd, D Pharm Ltd filed Critical DPHARM Ltd
Application granted granted Critical
Publication of DE60141074D1 publication Critical patent/DE60141074D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/11—Esters of phosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Fats And Perfumes (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
DE60141074T 2000-08-03 2001-08-01 Derivate von kettenverzweigten lipophilen molekülen und deren verwendung Expired - Lifetime DE60141074D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13767200A IL137672A0 (en) 2000-08-03 2000-08-03 Derivatives of branched-chain lipophilic molecules and uses thereof
PCT/IL2001/000713 WO2002011666A2 (en) 2000-08-03 2001-08-01 Derivatives of branched-chain lipophilic molecules and uses thereof

Publications (1)

Publication Number Publication Date
DE60141074D1 true DE60141074D1 (de) 2010-03-04

Family

ID=11074480

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60141074T Expired - Lifetime DE60141074D1 (de) 2000-08-03 2001-08-01 Derivate von kettenverzweigten lipophilen molekülen und deren verwendung

Country Status (16)

Country Link
US (2) US7186703B2 (de)
EP (1) EP1305322B1 (de)
JP (1) JP2004505898A (de)
KR (1) KR100801207B1 (de)
CN (1) CN100467476C (de)
AT (1) ATE455120T1 (de)
AU (2) AU2001280043B2 (de)
BR (1) BR0112835A (de)
CA (1) CA2416808C (de)
CZ (1) CZ2003208A3 (de)
DE (1) DE60141074D1 (de)
ES (1) ES2338987T3 (de)
HU (1) HUP0301711A3 (de)
IL (1) IL137672A0 (de)
NZ (1) NZ523664A (de)
WO (1) WO2002011666A2 (de)

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US6518311B2 (en) * 1997-07-09 2003-02-11 D-Pharm Ltd. Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
US7582678B2 (en) 1997-07-09 2009-09-01 D-Pharm Limited Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
US7713949B2 (en) 2000-10-10 2010-05-11 The University Of North Carolina At Chapel Hill Compositions and methods for enhancing paracellular permeability across epithelial and endothelial barriers
AU2003211052A1 (en) 2002-02-11 2003-09-04 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
JP2006500910A (ja) 2002-04-18 2006-01-12 アキュイティ ファーマシューティカルズ、インク． Ｃｎｓと眼の標的遺伝子を特異的に調節するための手段と方法及びその同定法
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
BRPI0416639A (pt) 2003-11-19 2007-01-16 Metabasis Therapeutics Inc tiromiméticos contendo fósforo
AU2006249350B2 (en) 2003-11-19 2012-02-16 Metabasis Therapeutics, Inc. Thyromimetics for the treatment of fatty liver diseases
US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
CN101189248A (zh) * 2005-05-26 2008-05-28 症变治疗公司 新型含磷拟甲状腺素药
US8703179B2 (en) * 2006-05-11 2014-04-22 Kimberly-Clark Worldwide, Inc. Mucosal formulation
CA2705463C (en) * 2007-08-10 2014-10-07 Basil Rigas Anti-inflammatory compounds and uses thereof
AU2009219432A1 (en) * 2008-02-28 2009-09-03 Henry Ford Health System Compositions and methods for using stromal cells to enhance treatment of central nervous system injuries
WO2010107487A2 (en) * 2009-03-18 2010-09-23 Wu Nian Lipid-drug conjugates for drug delivery
JP5853869B2 (ja) * 2012-06-07 2016-02-09 日油株式会社 ホスホリルコリン基含有化合物及びその製造法
US11202789B2 (en) 2016-11-21 2021-12-21 Viking Therapeutics, Inc. Method of treating glycogen storage disease
BR112019025659A2 (pt) 2017-06-05 2020-08-25 Viking Therapeutics, Inc. composições para o tratamento de fibrose
EP3768690B1 (de) 2018-03-22 2025-08-27 Viking Therapeutics, Inc. Kristalline formen und verfahren zur herstellung kristalliner formen einer verbindung
US12102646B2 (en) 2018-12-05 2024-10-01 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation

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US3006946A (en) * 1953-03-04 1961-10-31 Union Carbide Corp Production of heterocyclic phosphoruscontaining compounds and products
US3260688A (en) * 1962-08-10 1966-07-12 Toyo Koatsu Ind Inc Resin compositions for producing cellular masses and process for producing a cellular product
US3260668A (en) * 1964-11-04 1966-07-12 Dow Chemical Co Alkaline scale control in saline water conversion equipment
DE2038829C3 (de) * 1970-08-05 1975-11-13 Chemische Werke Huels Ag, 4370 Marl Zusatzmittel zu Mörtel oder Beton auf Zementbasis
LU65735A1 (de) 1972-07-17 1974-01-28
DE2930756A1 (de) * 1979-07-28 1981-02-26 Cassella Ag Klotzhilfsmittel und verfahren zum faerben von cellulosefasern bzw. gemischen von cellulosefasern zusammen mit synthesefasern mit schwefel-, schwefelkuepen-, kuepen- und reaktivfarbstoffen
JPS6038363B2 (ja) 1979-11-27 1985-08-31 ライオン株式会社 ヘアリンス剤
JPS5716064A (en) * 1980-07-04 1982-01-27 Dai Ichi Kogyo Seiyaku Co Ltd Dye dispersion
JPS57112317A (en) * 1980-12-29 1982-07-13 Lion Corp Hairdressing agent composition
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
JPS6072829A (ja) 1983-09-29 1985-04-24 Kao Corp ベシクル用組成物
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US4670575A (en) * 1984-06-05 1987-06-02 Kao Corporation Process for purification of phosphoric mono esters
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Also Published As

Publication number Publication date
KR20030024823A (ko) 2003-03-26
US20030186897A1 (en) 2003-10-02
AU2001280043B8 (en) 2002-02-18
CA2416808A1 (en) 2002-02-14
CN100467476C (zh) 2009-03-11
CZ2003208A3 (cs) 2003-10-15
WO2002011666A2 (en) 2002-02-14
ATE455120T1 (de) 2010-01-15
EP1305322A2 (de) 2003-05-02
AU2001280043B2 (en) 2007-05-24
NZ523664A (en) 2004-07-30
HUP0301711A3 (en) 2007-05-29
ES2338987T3 (es) 2010-05-14
AU8004301A (en) 2002-02-18
WO2002011666A3 (en) 2002-07-11
EP1305322A4 (de) 2005-04-13
IL137672A0 (en) 2001-10-31
US20070135381A1 (en) 2007-06-14
US7186703B2 (en) 2007-03-06
HUP0301711A2 (hu) 2003-09-29
US7687483B2 (en) 2010-03-30
CA2416808C (en) 2011-11-22
JP2004505898A (ja) 2004-02-26
EP1305322B1 (de) 2010-01-13
BR0112835A (pt) 2003-10-21
KR100801207B1 (ko) 2008-02-05
CN1633440A (zh) 2005-06-29

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