[go: up one dir, main page]

DE69207429D1 - Verfahren zur herstellung von substituierten piperidinen - Google Patents

Verfahren zur herstellung von substituierten piperidinen

Info

Publication number
DE69207429D1
DE69207429D1 DE69207429T DE69207429T DE69207429D1 DE 69207429 D1 DE69207429 D1 DE 69207429D1 DE 69207429 T DE69207429 T DE 69207429T DE 69207429 T DE69207429 T DE 69207429T DE 69207429 D1 DE69207429 D1 DE 69207429D1
Authority
DE
Germany
Prior art keywords
substituted piperidines
producing substituted
processes
novel
piperidines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69207429T
Other languages
English (en)
Other versions
DE69207429T2 (de
Inventor
Dennis Godek
Sally RUGGERI
Terry Rosen
Lewin Wint
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Inc
Original Assignee
Pfizer Corp Belgium
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Inc filed Critical Pfizer Corp Belgium
Publication of DE69207429D1 publication Critical patent/DE69207429D1/de
Application granted granted Critical
Publication of DE69207429T2 publication Critical patent/DE69207429T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/73—Unsubstituted amino or imino radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
DE69207429T 1991-11-27 1992-11-24 Verfahren zur herstellung von substituierten piperidinen Expired - Fee Related DE69207429T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/800,667 US5364943A (en) 1991-11-27 1991-11-27 Preparation of substituted piperidines
PCT/US1992/009929 WO1993011110A1 (en) 1991-11-27 1992-11-24 Preparation of substituted piperidines

Publications (2)

Publication Number Publication Date
DE69207429D1 true DE69207429D1 (de) 1996-02-15
DE69207429T2 DE69207429T2 (de) 1996-05-15

Family

ID=25179032

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69207429T Expired - Fee Related DE69207429T2 (de) 1991-11-27 1992-11-24 Verfahren zur herstellung von substituierten piperidinen

Country Status (19)

Country Link
US (2) US5364943A (de)
EP (1) EP0619806B1 (de)
JP (1) JP2587903B2 (de)
KR (1) KR0150254B1 (de)
AT (1) ATE132487T1 (de)
AU (1) AU670765B2 (de)
BR (1) BR9206823A (de)
CA (1) CA2124083C (de)
CZ (1) CZ292947B6 (de)
DE (1) DE69207429T2 (de)
DK (1) DK0619806T3 (de)
ES (1) ES2081636T3 (de)
FI (1) FI107049B (de)
GR (1) GR3018679T3 (de)
HU (1) HUT70514A (de)
NO (1) NO300970B1 (de)
PL (1) PL173659B1 (de)
RU (1) RU2081112C1 (de)
WO (1) WO1993011110A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0654029A1 (de) * 1992-08-04 1995-05-24 Pfizer Inc. 3-benzylamino-2-phenyl-piperidin-derivate als substanz p rezeptor antagonisten
ES2105664T3 (es) * 1993-05-28 1997-10-16 Pfizer Procedimiento para la preparacion y resolucion de 2-fenil-3-aminopiperidina.
GB9317987D0 (en) * 1993-08-26 1993-10-13 Glaxo Group Ltd Chemical compounds
TW340842B (en) * 1995-08-24 1998-09-21 Pfizer Substituted benzylaminopiperidine compounds
ATE223896T1 (de) 1995-12-21 2002-09-15 Pfizer 3-((5-substituierte benzyl)amino)-2- phenylpiperidine als substance-p-antagonisten
US5922898A (en) * 1997-04-08 1999-07-13 Catalytica Pharmaceuticals, Inc. Process for preparing biaryl compounds
US6194599B1 (en) 1997-04-08 2001-02-27 Catalytica, Inc. Process for preparing biaryl compounds
NZ329807A (en) * 1997-04-23 2000-07-28 Pfizer NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome
WO1999000368A1 (en) * 1997-06-27 1999-01-07 Merck Sharp & Dohme Limited Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents
DE19824470A1 (de) * 1998-05-30 1999-12-02 Boehringer Ingelheim Pharma Neue Neurokininantagonisten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
EP1394150B1 (de) 1999-02-24 2011-01-19 F. Hoffmann-La Roche AG 4-Phenylpyridinderivate und deren Verwendung als NK-1 Rezeptorantagonisten
RS49964B (sr) * 1999-05-17 2008-09-29 Pfizer Products Inc., Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli
US6962999B2 (en) * 2001-07-25 2005-11-08 Pharmacore, Inc. Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles
US6911544B2 (en) * 2002-10-23 2005-06-28 Pfizer Inc. Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine
US7105467B2 (en) * 2003-07-08 2006-09-12 Pharmacore, Inc. Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives
US7288658B2 (en) 2003-07-15 2007-10-30 Hoffmann-La Roche Inc. Process for preparation of pyridine derivatives
US7105707B2 (en) * 2003-12-17 2006-09-12 Pharmacore, Inc. Process for preparing alkynyl-substituted aromatic and heterocyclic compounds
MY143784A (en) 2005-09-23 2011-07-15 Hoffmann La Roche Novel dosage formulation

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3560510A (en) * 1969-03-05 1971-02-02 Aldrich Chem Co Inc 2-benzhydrylquinuclidines
CA1160229A (en) * 1979-03-13 1984-01-10 Pieter T. Haken Pyridyliminomethylbenzene derivatives
CA1231710A (en) * 1979-07-19 1988-01-19 Haken Pieter Ten Heterocyclic compounds having fungicidal, herbicidal and plant-growth regulating properties
GB2056974B (en) * 1979-07-19 1984-02-29 Shell Int Research Heterocyclic acylamino compounds having fungicidal herbicidal and plant-growth regulating properties
GB2067187B (en) * 1979-12-07 1983-11-30 Cosmos Enterprise Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof
EP0100158A3 (de) * 1982-07-28 1985-03-27 The Upjohn Company (3-Pyridinyl)-heteroalkarylalkanole, ihre Alkansäuren und ihre Ester
US4552960A (en) * 1983-06-20 1985-11-12 Eli Lilly And Company Fungicidal amines
US4680283A (en) * 1984-09-26 1987-07-14 Merck & Co., Inc. Analogs of substance P and eledoisin
MX18467A (es) * 1988-11-23 1993-07-01 Pfizer Agentes terapeuticos de quinuclidinas
UA41251C2 (uk) * 1990-01-04 2001-09-17 Пфайзер, Інк. Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі
AU648558B2 (en) * 1990-05-31 1994-04-28 Pfizer Inc. Preparation of substituted piperidines
US5138060A (en) * 1991-01-03 1992-08-11 Pfizer Inc. Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines
EP0566589A1 (de) * 1991-01-10 1993-10-27 Pfizer Inc. N-alkyl chinuclidiniumsalze als substanz-p-antagoniste
JPH0794440B2 (ja) * 1991-03-26 1995-10-11 フアイザー・インコーポレイテツド 置換ピペリジンの立体選択的製造
HU221634B1 (hu) * 1991-06-20 2002-12-28 Pfizer Inc. Nitrogéntartalmú heterociklusos vegyületek fluor-alkoxi-benzilamino-származékai, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények
TW202432B (de) * 1991-06-21 1993-03-21 Pfizer

Also Published As

Publication number Publication date
RU2081112C1 (ru) 1997-06-10
US5663349A (en) 1997-09-02
ES2081636T3 (es) 1996-03-16
NO300970B1 (no) 1997-08-25
BR9206823A (pt) 1995-04-25
CA2124083A1 (en) 1993-06-10
EP0619806B1 (de) 1996-01-03
FI942457A0 (fi) 1994-05-26
US5364943A (en) 1994-11-15
DK0619806T3 (da) 1996-02-05
AU3140893A (en) 1993-06-28
EP0619806A1 (de) 1994-10-19
FI942457L (fi) 1994-05-26
PL173659B1 (pl) 1998-04-30
AU670765B2 (en) 1996-08-01
JP2587903B2 (ja) 1997-03-05
ATE132487T1 (de) 1996-01-15
CZ292947B6 (cs) 2004-01-14
GR3018679T3 (en) 1996-04-30
DE69207429T2 (de) 1996-05-15
KR0150254B1 (ko) 1998-10-15
HU9401584D0 (en) 1994-08-29
FI107049B (fi) 2001-05-31
HUT70514A (en) 1995-10-30
WO1993011110A1 (en) 1993-06-10
NO941958D0 (no) 1994-05-26
CZ130094A3 (en) 1995-11-15
CA2124083C (en) 2001-08-14
NO941958L (no) 1994-05-26
JPH06510795A (ja) 1994-12-01

Similar Documents

Publication Publication Date Title
DE59108707D1 (de) Verfahren zur Herstellung von Oxetanonen
DE69207429D1 (de) Verfahren zur herstellung von substituierten piperidinen
DE59209643D1 (de) Verfahren zur trennung von 5-methyl-tetrahydrofolsäure
ATE181074T1 (de) Vinylen-azaindolderivate und verfahren zu ihrer herstellung
DE69122866D1 (de) Herstellung von substituierten piperidinen
DE69027221D1 (de) Substituierte 4-phenyl-4-piperidincarboxamide mit sowohl lokalanästhetischer als auch schmerzlindernder wirkung sowie verfahren zur herstellung
ATE86978T1 (de) Verfahren zur herstellung von 3,5-dimethyl-4methoxypyridinderivaten sowie neues zwischenprodukt hierfuer.
DE3576952D1 (de) Verfahren zur herstellung von 4-phenyl-pyrrol-derivaten.
DE3668621D1 (de) Verfahren zur herstellung von pteridinderivaten.
ATE130845T1 (de) Verfahren zur herstellung von 3-amino-2- (het)aroyl-acrylsäurederivaten.
ATE176463T1 (de) Verfahren zur herstellung von 2-substituierten 4,6-dialkoxypyrimidinen
DE59309077D1 (de) Verfahren zur Herstellung von 2-Halogen-4,6-dialkoxypyrimidinen
ATE152729T1 (de) Verfahren zur herstellung von 3beta- aminocholansäurederivaten
ATE173259T1 (de) Verfahren zur herstellung von indolizinderivaten
ATE111093T1 (de) Verfahren zur herstellung von enantiomeren von 3- aminchromanderivaten.
DE69405507D1 (de) Zwischenprodukte zur Herstellung von Vitamin A und von Carotenoiden und Verfahren zu deren Herstellung
ATE33837T1 (de) Azolylmethylcycloacetale, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE122656T1 (de) Verfahren zur herstellung substituierter indole.
ATE208388T1 (de) Eintopfverfahren zur herstellung von 2- oxazolidinonderivate
ATE145642T1 (de) Verfahren zur herstellung von 1,3-dialkyl-5- hydroxyoxindolen und deren etherderivaten

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee