DK0619806T3 - Fremstilling af substituerede piperidiner - Google Patents
Fremstilling af substituerede piperidinerInfo
- Publication number
- DK0619806T3 DK0619806T3 DK92925298.9T DK92925298T DK0619806T3 DK 0619806 T3 DK0619806 T3 DK 0619806T3 DK 92925298 T DK92925298 T DK 92925298T DK 0619806 T3 DK0619806 T3 DK 0619806T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- substituted piperidines
- processes
- novel
- piperidines
- Prior art date
Links
- 150000003053 piperidines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/800,667 US5364943A (en) | 1991-11-27 | 1991-11-27 | Preparation of substituted piperidines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0619806T3 true DK0619806T3 (da) | 1996-02-05 |
Family
ID=25179032
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK92925298.9T DK0619806T3 (da) | 1991-11-27 | 1992-11-24 | Fremstilling af substituerede piperidiner |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US5364943A (da) |
| EP (1) | EP0619806B1 (da) |
| JP (1) | JP2587903B2 (da) |
| KR (1) | KR0150254B1 (da) |
| AT (1) | ATE132487T1 (da) |
| AU (1) | AU670765B2 (da) |
| BR (1) | BR9206823A (da) |
| CA (1) | CA2124083C (da) |
| CZ (1) | CZ292947B6 (da) |
| DE (1) | DE69207429T2 (da) |
| DK (1) | DK0619806T3 (da) |
| ES (1) | ES2081636T3 (da) |
| FI (1) | FI107049B (da) |
| GR (1) | GR3018679T3 (da) |
| HU (1) | HUT70514A (da) |
| NO (1) | NO300970B1 (da) |
| PL (1) | PL173659B1 (da) |
| RU (1) | RU2081112C1 (da) |
| WO (1) | WO1993011110A1 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0654029A1 (en) * | 1992-08-04 | 1995-05-24 | Pfizer Inc. | 3-benzylamino-2-phenyl-piperidine derivatives as substance p receptor antagonists |
| ES2105664T3 (es) * | 1993-05-28 | 1997-10-16 | Pfizer | Procedimiento para la preparacion y resolucion de 2-fenil-3-aminopiperidina. |
| GB9317987D0 (en) * | 1993-08-26 | 1993-10-13 | Glaxo Group Ltd | Chemical compounds |
| TW340842B (en) * | 1995-08-24 | 1998-09-21 | Pfizer | Substituted benzylaminopiperidine compounds |
| ATE223896T1 (de) | 1995-12-21 | 2002-09-15 | Pfizer | 3-((5-substituierte benzyl)amino)-2- phenylpiperidine als substance-p-antagonisten |
| US5922898A (en) * | 1997-04-08 | 1999-07-13 | Catalytica Pharmaceuticals, Inc. | Process for preparing biaryl compounds |
| US6194599B1 (en) | 1997-04-08 | 2001-02-27 | Catalytica, Inc. | Process for preparing biaryl compounds |
| NZ329807A (en) * | 1997-04-23 | 2000-07-28 | Pfizer | NK-1 receptor antagonists and P receptor antagonists 2-Diarylmethyl-3-amino-1-azabicyclo[2.2.2]octane derivatives and amino substituted N-containing rings as agents for treating irritable bowel syndrome |
| WO1999000368A1 (en) * | 1997-06-27 | 1999-01-07 | Merck Sharp & Dohme Limited | Substituted 3-(benzylamino)piperidine derivatives and their use as therapeutic agents |
| DE19824470A1 (de) * | 1998-05-30 | 1999-12-02 | Boehringer Ingelheim Pharma | Neue Neurokininantagonisten, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen |
| EP1394150B1 (en) | 1999-02-24 | 2011-01-19 | F. Hoffmann-La Roche AG | 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists |
| RS49964B (sr) * | 1999-05-17 | 2008-09-29 | Pfizer Products Inc., | Postupak za dobijanje 2-fenil-3-aminopiridina,njegovih supstituisanih fenil derivata, i njegovih soli |
| US6962999B2 (en) * | 2001-07-25 | 2005-11-08 | Pharmacore, Inc. | Process for preparing unsymmetrical biaryls and alkylated aromatic compounds from arylnitriles |
| US6911544B2 (en) * | 2002-10-23 | 2005-06-28 | Pfizer Inc. | Process for the preparation of (S,S)-cis-2-phenyl-3-aminopiperidine |
| US7105467B2 (en) * | 2003-07-08 | 2006-09-12 | Pharmacore, Inc. | Nickel catalyzed cross-coupling reactions between organomagnesium compounds and anisole derivatives |
| US7288658B2 (en) | 2003-07-15 | 2007-10-30 | Hoffmann-La Roche Inc. | Process for preparation of pyridine derivatives |
| US7105707B2 (en) * | 2003-12-17 | 2006-09-12 | Pharmacore, Inc. | Process for preparing alkynyl-substituted aromatic and heterocyclic compounds |
| MY143784A (en) | 2005-09-23 | 2011-07-15 | Hoffmann La Roche | Novel dosage formulation |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3560510A (en) * | 1969-03-05 | 1971-02-02 | Aldrich Chem Co Inc | 2-benzhydrylquinuclidines |
| CA1160229A (en) * | 1979-03-13 | 1984-01-10 | Pieter T. Haken | Pyridyliminomethylbenzene derivatives |
| CA1231710A (en) * | 1979-07-19 | 1988-01-19 | Haken Pieter Ten | Heterocyclic compounds having fungicidal, herbicidal and plant-growth regulating properties |
| GB2056974B (en) * | 1979-07-19 | 1984-02-29 | Shell Int Research | Heterocyclic acylamino compounds having fungicidal herbicidal and plant-growth regulating properties |
| GB2067187B (en) * | 1979-12-07 | 1983-11-30 | Cosmos Enterprise | Process for the preparation of 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)-1-propanol and acid addition salts thereof |
| EP0100158A3 (en) * | 1982-07-28 | 1985-03-27 | The Upjohn Company | (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters |
| US4552960A (en) * | 1983-06-20 | 1985-11-12 | Eli Lilly And Company | Fungicidal amines |
| US4680283A (en) * | 1984-09-26 | 1987-07-14 | Merck & Co., Inc. | Analogs of substance P and eledoisin |
| MX18467A (es) * | 1988-11-23 | 1993-07-01 | Pfizer | Agentes terapeuticos de quinuclidinas |
| UA41251C2 (uk) * | 1990-01-04 | 2001-09-17 | Пфайзер, Інк. | Гідровані азотвмісні гетероциклічні сполуки, похідні піперидину, фармацевтична композиція та спосіб пригнічення активності речовини р в організмі |
| AU648558B2 (en) * | 1990-05-31 | 1994-04-28 | Pfizer Inc. | Preparation of substituted piperidines |
| US5138060A (en) * | 1991-01-03 | 1992-08-11 | Pfizer Inc. | Process and intermediates for preparing azabicyclo(2.2.2)octan-3-imines |
| EP0566589A1 (en) * | 1991-01-10 | 1993-10-27 | Pfizer Inc. | N-alkyl quinuclidinium salts as substance p antagonists |
| JPH0794440B2 (ja) * | 1991-03-26 | 1995-10-11 | フアイザー・インコーポレイテツド | 置換ピペリジンの立体選択的製造 |
| HU221634B1 (hu) * | 1991-06-20 | 2002-12-28 | Pfizer Inc. | Nitrogéntartalmú heterociklusos vegyületek fluor-alkoxi-benzilamino-származékai, eljárás előállításukra és az ezeket tartalmazó gyógyszerkészítmények |
| TW202432B (da) * | 1991-06-21 | 1993-03-21 | Pfizer |
-
1991
- 1991-11-27 US US07/800,667 patent/US5364943A/en not_active Expired - Lifetime
-
1992
- 1992-11-24 JP JP5510148A patent/JP2587903B2/ja not_active Expired - Fee Related
- 1992-11-24 KR KR1019940701782A patent/KR0150254B1/ko not_active Expired - Fee Related
- 1992-11-24 DK DK92925298.9T patent/DK0619806T3/da active
- 1992-11-24 HU HU9401584A patent/HUT70514A/hu unknown
- 1992-11-24 AT AT92925298T patent/ATE132487T1/de not_active IP Right Cessation
- 1992-11-24 WO PCT/US1992/009929 patent/WO1993011110A1/en not_active Application Discontinuation
- 1992-11-24 AU AU31408/93A patent/AU670765B2/en not_active Ceased
- 1992-11-24 RU RU9294027570A patent/RU2081112C1/ru not_active IP Right Cessation
- 1992-11-24 DE DE69207429T patent/DE69207429T2/de not_active Expired - Fee Related
- 1992-11-24 CZ CZ19941300A patent/CZ292947B6/cs not_active IP Right Cessation
- 1992-11-24 ES ES92925298T patent/ES2081636T3/es not_active Expired - Lifetime
- 1992-11-24 PL PL92303982A patent/PL173659B1/pl not_active IP Right Cessation
- 1992-11-24 CA CA002124083A patent/CA2124083C/en not_active Expired - Fee Related
- 1992-11-24 EP EP92925298A patent/EP0619806B1/en not_active Expired - Lifetime
- 1992-11-24 BR BR9206823A patent/BR9206823A/pt not_active Application Discontinuation
-
1994
- 1994-05-26 FI FI942457A patent/FI107049B/fi not_active IP Right Cessation
- 1994-05-26 NO NO941958A patent/NO300970B1/no unknown
- 1994-07-12 US US08/273,662 patent/US5663349A/en not_active Expired - Fee Related
-
1996
- 1996-01-17 GR GR960400080T patent/GR3018679T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2081112C1 (ru) | 1997-06-10 |
| US5663349A (en) | 1997-09-02 |
| ES2081636T3 (es) | 1996-03-16 |
| NO300970B1 (no) | 1997-08-25 |
| BR9206823A (pt) | 1995-04-25 |
| CA2124083A1 (en) | 1993-06-10 |
| EP0619806B1 (en) | 1996-01-03 |
| FI942457A0 (fi) | 1994-05-26 |
| US5364943A (en) | 1994-11-15 |
| AU3140893A (en) | 1993-06-28 |
| EP0619806A1 (en) | 1994-10-19 |
| FI942457L (fi) | 1994-05-26 |
| PL173659B1 (pl) | 1998-04-30 |
| AU670765B2 (en) | 1996-08-01 |
| JP2587903B2 (ja) | 1997-03-05 |
| ATE132487T1 (de) | 1996-01-15 |
| CZ292947B6 (cs) | 2004-01-14 |
| DE69207429D1 (de) | 1996-02-15 |
| GR3018679T3 (en) | 1996-04-30 |
| DE69207429T2 (de) | 1996-05-15 |
| KR0150254B1 (ko) | 1998-10-15 |
| HU9401584D0 (en) | 1994-08-29 |
| FI107049B (fi) | 2001-05-31 |
| HUT70514A (en) | 1995-10-30 |
| WO1993011110A1 (en) | 1993-06-10 |
| NO941958D0 (no) | 1994-05-26 |
| CZ130094A3 (en) | 1995-11-15 |
| CA2124083C (en) | 2001-08-14 |
| NO941958L (no) | 1994-05-26 |
| JPH06510795A (ja) | 1994-12-01 |
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