EE9900348A - Asendatud (1,3-bis (tsükloheksüülmetüül)-1,2,3,6-tetrahüdro- 2,6-diokso-9H-puriin-8-üül)fenüülderivaadid, nende valmistamine ja kasutamine põletikuliste seisundite ja immuunhaiguste raviks - Google Patents
Asendatud (1,3-bis (tsükloheksüülmetüül)-1,2,3,6-tetrahüdro- 2,6-diokso-9H-puriin-8-üül)fenüülderivaadid, nende valmistamine ja kasutamine põletikuliste seisundite ja immuunhaiguste raviksInfo
- Publication number
- EE9900348A EE9900348A EEP199900348A EEP9900348A EE9900348A EE 9900348 A EE9900348 A EE 9900348A EE P199900348 A EEP199900348 A EE P199900348A EE P9900348 A EEP9900348 A EE P9900348A EE 9900348 A EE9900348 A EE 9900348A
- Authority
- EE
- Estonia
- Prior art keywords
- purin
- cyclohexylmethyl
- dioxo
- tetrahydro
- bis
- Prior art date
Links
- -1 (1,3-bis (cyclohexylmethyl) -1,2,3,6-tetrahydro-2,6-dioxo-9H-purin-8-yl) phenyl Chemical class 0.000 title 1
- 208000026278 immune system disease Diseases 0.000 title 1
- 230000004968 inflammatory condition Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9703044.9A GB9703044D0 (en) | 1997-02-14 | 1997-02-14 | Phenyl xanthine esters and amides |
| PCT/EP1998/000784 WO1998035966A1 (en) | 1997-02-14 | 1998-02-12 | Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9h-purin-8-yl)phenyl derivatives, their preparation and their use in the treatment of inflammatory conditions and immune disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE9900348A true EE9900348A (et) | 2000-02-15 |
Family
ID=10807635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP199900348A EE9900348A (et) | 1997-02-14 | 1998-02-12 | Asendatud (1,3-bis (tsükloheksüülmetüül)-1,2,3,6-tetrahüdro- 2,6-diokso-9H-puriin-8-üül)fenüülderivaadid, nende valmistamine ja kasutamine põletikuliste seisundite ja immuunhaiguste raviks |
Country Status (37)
| Country | Link |
|---|---|
| US (3) | US6355646B1 (xx) |
| EP (1) | EP0970081B1 (xx) |
| JP (1) | JP2001511792A (xx) |
| KR (1) | KR100522639B1 (xx) |
| CN (1) | CN1140527C (xx) |
| AP (1) | AP1000A (xx) |
| AR (1) | AR011441A1 (xx) |
| AT (1) | ATE304542T1 (xx) |
| AU (1) | AU754456B2 (xx) |
| BG (1) | BG103722A (xx) |
| BR (1) | BR9807682B1 (xx) |
| CA (1) | CA2280730C (xx) |
| CO (1) | CO4940444A1 (xx) |
| CZ (1) | CZ298764B6 (xx) |
| DE (1) | DE69831559T2 (xx) |
| DK (1) | DK0970081T3 (xx) |
| EA (1) | EA199900648A1 (xx) |
| EE (1) | EE9900348A (xx) |
| ES (1) | ES2249822T3 (xx) |
| GB (1) | GB9703044D0 (xx) |
| HR (1) | HRP980077A2 (xx) |
| HU (1) | HU225962B1 (xx) |
| ID (1) | ID22770A (xx) |
| IL (1) | IL131179A (xx) |
| IS (1) | IS5144A (xx) |
| MY (1) | MY118545A (xx) |
| NO (1) | NO325685B1 (xx) |
| NZ (1) | NZ336923A (xx) |
| PE (1) | PE58899A1 (xx) |
| PL (1) | PL188018B1 (xx) |
| SK (1) | SK110399A3 (xx) |
| TR (1) | TR199901942T2 (xx) |
| TW (1) | TW520371B (xx) |
| UA (1) | UA57767C2 (xx) |
| WO (1) | WO1998035966A1 (xx) |
| YU (1) | YU38399A (xx) |
| ZA (1) | ZA981175B (xx) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9703044D0 (en) * | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
| GB9817623D0 (en) | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| US6545002B1 (en) * | 1999-06-01 | 2003-04-08 | University Of Virginia Patent Foundation | Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors |
| FR2804958B1 (fr) * | 2000-02-15 | 2005-07-08 | Hoechst Marion Roussel Inc | Derives de xanthine, leur procede de preparation et les intermediaires de ce procede, leur application comme medicament et les compositions pharmaceutiques les renfermant |
| AU2002252134A1 (en) * | 2001-02-28 | 2002-09-12 | Smithkline Beecham Corporation | Methods of treating irritable bowel syndrome and functional dyspepsia |
| US20080318983A1 (en) * | 2001-11-09 | 2008-12-25 | Rao Kalla | A2b adenosine receptor antagonists |
| US7125993B2 (en) * | 2001-11-09 | 2006-10-24 | Cv Therapeutics, Inc. | A2B adenosine receptor antagonists |
| US20040072848A1 (en) * | 2002-02-26 | 2004-04-15 | Huber Brian E | Methods of treating irritable bowel syndrome and functional dyspepsia |
| EA018427B1 (ru) * | 2003-12-16 | 2013-07-30 | Нектар Терапьютикс | Химически модифицированный налоксон |
| AU2012227249B2 (en) * | 2003-12-16 | 2014-10-02 | Nektar Therapeutics | Chemically modified small molecules |
| US20060182692A1 (en) | 2003-12-16 | 2006-08-17 | Fishburn C S | Chemically modified small molecules |
| WO2005102976A1 (en) * | 2004-04-21 | 2005-11-03 | Smithkline Beecham Corporation | Process for preparing nonaethylene glycol monomethyl ether |
| CN101043889B (zh) * | 2004-09-01 | 2010-11-03 | 吉利德帕洛阿尔托股份有限公司 | A2b腺苷受体拮抗剂在制备促使伤口愈合的药物中的应用 |
| US20070059740A1 (en) * | 2005-08-26 | 2007-03-15 | Linden Joel M | Method of targeting a2b adenosine receptor antagonist therapy |
| US8193200B2 (en) * | 2007-01-04 | 2012-06-05 | University Of Virginia Patent Foundation | Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8510758D0 (en) | 1985-04-27 | 1985-06-05 | Wellcome Found | Compounds |
| US4968672A (en) | 1987-01-02 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Adenosine receptor prodrugs |
| US5015647A (en) | 1987-04-24 | 1991-05-14 | Burroughs Wellcome Co. | Method for treating viral infections |
| GB8826595D0 (en) | 1988-11-14 | 1988-12-21 | Beecham Wuelfing Gmbh & Co Kg | Active compounds |
| GB8906792D0 (en) | 1989-03-23 | 1989-05-10 | Beecham Wuelfing Gmbh & Co Kg | Treatment and compounds |
| NZ240644A (en) | 1990-11-21 | 1994-08-26 | Smithkline Beecham Corp | Use of xanthine derivatives to inhibit the production of tumour necrosis factor (tnf) |
| GB9210839D0 (en) * | 1992-05-21 | 1992-07-08 | Smithkline Beecham Plc | Novel compounds |
| TW252044B (xx) | 1992-08-10 | 1995-07-21 | Boehringer Ingelheim Kg | |
| JP2613355B2 (ja) | 1992-09-28 | 1997-05-28 | 協和醗酵工業株式会社 | パーキンソン氏病治療剤 |
| GB9415529D0 (en) | 1994-08-01 | 1994-09-21 | Wellcome Found | Phenyl xanthine derivatives |
| DE19535504A1 (de) | 1995-09-25 | 1997-03-27 | Bayer Ag | Substituierte Xanthine |
| DK0812844T3 (da) | 1996-06-07 | 2003-02-17 | Hoechst Ag | Anvendelse af theophyllinderivater til behandling og profylakse af choktilstande, nye xanthinforbindelser og fremgangsmåder til deres fremstilling |
| GB9703044D0 (en) * | 1997-02-14 | 1997-04-02 | Glaxo Group Ltd | Phenyl xanthine esters and amides |
| US6117878A (en) | 1998-02-24 | 2000-09-12 | University Of Virginia | 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors |
| WO1999043673A1 (fr) | 1998-02-26 | 1999-09-02 | Zenyaku Kogyo Kabushiki Kaisha | Derives de 1-aza-indolizine |
| GB9817623D0 (en) * | 1998-08-13 | 1998-10-07 | Glaxo Group Ltd | Pharmaceutical compounds |
| IL150368A0 (en) | 1999-12-23 | 2002-12-01 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use |
| US6751206B1 (en) * | 2000-06-29 | 2004-06-15 | Qualcomm Incorporated | Method and apparatus for beam switching in a wireless communication system |
-
1997
- 1997-02-14 GB GBGB9703044.9A patent/GB9703044D0/en active Pending
-
1998
- 1998-02-11 PE PE1998000099A patent/PE58899A1/es not_active Application Discontinuation
- 1998-02-11 CO CO98007044A patent/CO4940444A1/es unknown
- 1998-02-11 MY MYPI98000546A patent/MY118545A/en unknown
- 1998-02-12 JP JP53534098A patent/JP2001511792A/ja not_active Ceased
- 1998-02-12 ID IDW990879A patent/ID22770A/id unknown
- 1998-02-12 ES ES98908090T patent/ES2249822T3/es not_active Expired - Lifetime
- 1998-02-12 BR BRPI9807682-5A patent/BR9807682B1/pt not_active IP Right Cessation
- 1998-02-12 EE EEP199900348A patent/EE9900348A/xx unknown
- 1998-02-12 KR KR10-1999-7007276A patent/KR100522639B1/ko not_active Expired - Fee Related
- 1998-02-12 AU AU66221/98A patent/AU754456B2/en not_active Ceased
- 1998-02-12 DK DK98908090T patent/DK0970081T3/da active
- 1998-02-12 PL PL98335135A patent/PL188018B1/pl unknown
- 1998-02-12 AT AT98908090T patent/ATE304542T1/de active
- 1998-02-12 EP EP98908090A patent/EP0970081B1/en not_active Expired - Lifetime
- 1998-02-12 AP APAP/P/1999/001622A patent/AP1000A/en active
- 1998-02-12 IL IL13117998A patent/IL131179A/en not_active IP Right Cessation
- 1998-02-12 US US09/367,313 patent/US6355646B1/en not_active Expired - Lifetime
- 1998-02-12 CN CNB988039419A patent/CN1140527C/zh not_active Expired - Fee Related
- 1998-02-12 CA CA002280730A patent/CA2280730C/en not_active Expired - Fee Related
- 1998-02-12 HU HU0000894A patent/HU225962B1/hu not_active IP Right Cessation
- 1998-02-12 CZ CZ0288799A patent/CZ298764B6/cs not_active IP Right Cessation
- 1998-02-12 NZ NZ336923A patent/NZ336923A/en unknown
- 1998-02-12 YU YU38399A patent/YU38399A/sh unknown
- 1998-02-12 ZA ZA9801175A patent/ZA981175B/xx unknown
- 1998-02-12 TR TR1999/01942T patent/TR199901942T2/xx unknown
- 1998-02-12 EA EA199900648A patent/EA199900648A1/ru unknown
- 1998-02-12 DE DE69831559T patent/DE69831559T2/de not_active Expired - Lifetime
- 1998-02-12 SK SK1103-99A patent/SK110399A3/sk unknown
- 1998-02-12 WO PCT/EP1998/000784 patent/WO1998035966A1/en active IP Right Grant
- 1998-02-13 AR ARP980100664A patent/AR011441A1/es active IP Right Grant
- 1998-02-13 HR HR9703044.9A patent/HRP980077A2/hr not_active Application Discontinuation
- 1998-02-24 TW TW087102632A patent/TW520371B/zh not_active IP Right Cessation
- 1998-12-02 UA UA99084601A patent/UA57767C2/uk unknown
-
1999
- 1999-07-30 IS IS5144A patent/IS5144A/is unknown
- 1999-08-13 NO NO19993915A patent/NO325685B1/no not_active IP Right Cessation
- 1999-09-09 BG BG103722A patent/BG103722A/xx unknown
-
2001
- 2001-06-01 US US09/872,546 patent/US6437124B1/en not_active Expired - Fee Related
-
2002
- 2002-06-17 US US10/174,414 patent/US7002012B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EE9900348A (et) | Asendatud (1,3-bis (tsükloheksüülmetüül)-1,2,3,6-tetrahüdro- 2,6-diokso-9H-puriin-8-üül)fenüülderivaadid, nende valmistamine ja kasutamine põletikuliste seisundite ja immuunhaiguste raviks | |
| FI944549A7 (fi) | Allergisten ja tulehdussairauksien hoidossa käyttökelpoiset yhdisteet | |
| BR9106864A (pt) | Composicoes de liberacao prolongada para o tratamento de doencas periodontais | |
| KR100344712B1 (ko) | 알러지성및염증성질환의치료에유용한화합물 | |
| FI930747A7 (fi) | Heterosyklisiä yhdisteitä ja niiden valmistus ja käyttö | |
| FI963630A7 (fi) | IFN-beta:n uusia muteiineja | |
| DE69130089D1 (de) | Hemmung der menschlichen Serumalbuminfärbung | |
| FI935887A7 (fi) | Tiatzolidiinidionijohdannaiset, niiden valmistus ja käyttö | |
| DE69027170D1 (de) | Uracilderivate, ihre Herstellung und ihre Verwendung | |
| FI924118A7 (fi) | Kinoksaliiniyhdisteet ja niiden valmistus ja käyttö | |
| FI913067A7 (fi) | Bisfosfonihappojohdannaiset, niiden valmistus ja käyttö | |
| IT1297205B1 (it) | Composizioni farmaceutiche di somatostatina con assorbimento migliorato, loro preparazione e loro impiego | |
| IT1234230B (it) | Solfonammidi di benzilidene canfora derivanti da amminoacidi e loro impiego in cosmesi particolarmente come filtri solari | |
| FI925544A7 (fi) | Bentsoehappojohdannaisia leukotrieeniin liittyvien sairauksien hoitami seen | |
| FI925850A7 (fi) | Pyridyylitiatsolidinikarboksyylihapon amidijohdannaiset, niiden valmistus ja niiden terapeuttiset käytöt | |
| FI945438A7 (fi) | N-/N'-(5-amino-4-hydroksiasyloyyli)-alfa aminoasyloyyli/substituoidut heterosyklit ja niiden käyttö antiviraalisina aineina | |
| ITMI912290A0 (it) | Miscele di n-alchilftalimmidi, loro preparazione e loro impiego | |
| FI925546A7 (fi) | Amidiliittyneitä pyridyylihappojohdannaisia leukotrieeniin liittyvien sairauksien hoitamiseksi | |
| SI0970081T1 (sl) | Substituirani (1,3-bis(cikloheksilmetil)-1,2,3,6-tetrahidro-2,6-diokso-9h-purin-8-il) fenilni derivati, njihova priprava in njihova uporaba pri zdravljenju vnetnih stanj in imunskih motenj | |
| EE03796B1 (et) | 3,5-difluoropüridiinid, nende valmistamismeetod, herbitsiidne kompositsioon, nende kasutamine ja vaheühend | |
| FI911084A7 (fi) | 5-fenyyli-1H-pyrazoli-4-propionihappojohdannaisia, niiden valmistus jakäyttö | |
| IT8822858A0 (it) | Composizioni per la riduzione di flebectasie e procedimento per la loro preparazione | |
| FI935915L (fi) | 2-tienyyli-imidatso(2,1-b)bentsotiatsol-3-etikkahappojohdannaiset, niiden valmistus ja terapeuttinen käyttö | |
| IT9036120V0 (it) | Struttura di pantaloni perfezionata | |
| IT9040160A1 (it) | Tecnica di applicazione di smalti ceramici spatolati manualmente in bassorilievo |