[go: up one dir, main page]

HRP20050417B1 - Antiviralni derivati nukleozida - Google Patents

Antiviralni derivati nukleozida

Info

Publication number
HRP20050417B1
HRP20050417B1 HRP20050417AA HRP20050417A HRP20050417B1 HR P20050417 B1 HRP20050417 B1 HR P20050417B1 HR P20050417A A HRP20050417A A HR P20050417AA HR P20050417 A HRP20050417 A HR P20050417A HR P20050417 B1 HRP20050417 B1 HR P20050417B1
Authority
HR
Croatia
Prior art keywords
nucleoside derivatives
compounds
hepatitis
antiviral nucleoside
nucleosides
Prior art date
Application number
HRP20050417AA
Other languages
English (en)
Inventor
Joseph Armstrong Martin
Keshab Sarma
David Bernard Smith
Mark Smith
Original Assignee
F. Hoffmann - La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32329161&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20050417(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by F. Hoffmann - La Roche Ag filed Critical F. Hoffmann - La Roche Ag
Publication of HRP20050417A2 publication Critical patent/HRP20050417A2/hr
Publication of HRP20050417B1 publication Critical patent/HRP20050417B1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Ovaj izum odnosi se na derivate nukleozida za liječenje infekcija virusom Hepatitisa C uključujući spojeve formule 1(1), na farmaceutske pripravke koji sadrže te spojeve i na postupke za liječenje ili profilaksu bolesti posredovanih virusom Hepatitisa C primjenom spomenutih spojeva u monoterapiji ili kombinacijskoj terapiji. Izum nadalje donosi proces za pripravljanje 1',3',4'-triacil pirimidin nukleozida iz N,1',3',4'-tetraacilpirimidin nukleozida.
HRP20050417AA 2002-11-19 2003-11-14 Antiviralni derivati nukleozida HRP20050417B1 (hr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42744702P 2002-11-19 2002-11-19
US48397003P 2003-07-01 2003-07-01
PCT/EP2003/012733 WO2004046159A1 (en) 2002-11-19 2003-11-14 Antiviral nucleoside derivatives

Publications (2)

Publication Number Publication Date
HRP20050417A2 HRP20050417A2 (en) 2006-06-30
HRP20050417B1 true HRP20050417B1 (hr) 2013-11-08

Family

ID=32329161

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20050417AA HRP20050417B1 (hr) 2002-11-19 2003-11-14 Antiviralni derivati nukleozida

Country Status (29)

Country Link
US (1) US6846810B2 (hr)
EP (1) EP1565481B1 (hr)
JP (1) JP4362450B2 (hr)
KR (1) KR100676662B1 (hr)
AR (1) AR042192A1 (hr)
AT (1) ATE335755T1 (hr)
AU (1) AU2003288064B2 (hr)
BR (1) BR0316407A (hr)
CA (1) CA2504846C (hr)
CO (1) CO5550501A2 (hr)
CY (1) CY1106207T1 (hr)
DE (1) DE60307503T2 (hr)
DK (1) DK1565481T3 (hr)
ES (1) ES2270136T3 (hr)
HR (1) HRP20050417B1 (hr)
IL (1) IL168266A (hr)
JO (1) JO2403B1 (hr)
MX (1) MXPA05005282A (hr)
MY (1) MY136229A (hr)
NO (1) NO330424B1 (hr)
NZ (1) NZ539644A (hr)
PA (1) PA8588501A1 (hr)
PE (1) PE20040836A1 (hr)
PL (1) PL210967B1 (hr)
PT (1) PT1565481E (hr)
RU (1) RU2327701C2 (hr)
TW (1) TWI332507B (hr)
UY (1) UY28084A1 (hr)
WO (1) WO2004046159A1 (hr)

Families Citing this family (120)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CA2410579C (en) 2000-05-26 2010-04-20 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses
AU2002330154A1 (en) * 2001-09-28 2003-04-07 Centre National De La Recherche Scientifique Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
FR2830447B1 (fr) * 2001-10-09 2004-04-16 Flamel Tech Sa Forme galenique orale microparticulaire pour la liberation retardee et controlee de principes actifs pharmaceutiques
US8101209B2 (en) * 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
IL164221A0 (en) * 2002-04-09 2005-12-18 Flamel Tech Sa Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillim
US7906145B2 (en) 2002-04-09 2011-03-15 Flamel Technologies Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s)
CN101172993A (zh) 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
US7662798B2 (en) 2002-06-28 2010-02-16 Idenix Pharmaceuticals, Inc. 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
BR0316363A (pt) 2002-11-15 2005-10-04 Idenix Cayman Ltd Nucleosìdeos 2'-ramificado e mutação de flaviviridae
RU2005121904A (ru) 2002-12-12 2006-01-20 Айденикс (Кайман) Лимитед (Ky) Способ получения 2`-разветвленных нуклеозидов
KR20050110611A (ko) * 2002-12-23 2005-11-23 이데닉스 (케이만) 리미티드 3'-뉴클레오사이드 프로드럭의 생산 방법
WO2005000864A1 (en) * 2003-06-19 2005-01-06 F. Hoffmann-La Roche Ag Processes for preparing 4’azido nucleoside derivatives
CA2571675A1 (en) * 2004-06-23 2006-01-05 Idenix (Cayman) Limited 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
WO2006021341A1 (en) * 2004-08-23 2006-03-02 F. Hoffmann-La Roche Ag Antiviral 4’-azido-nucleosides
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
US20070166378A1 (en) * 2005-06-09 2007-07-19 Flamel Technologies, Inc. Oral ribavirin pharmaceutical compositions
JP2009504704A (ja) * 2005-08-15 2009-02-05 エフ．ホフマン−ラ ロシュ アーゲー 抗ウイルス４′−置換プロヌクレオチドホスホルアミダート
AU2006298891A1 (en) * 2005-09-22 2007-04-12 F. Hoffmann-La Roche Ag Selective O-acylation of nucleosides
WO2007065829A1 (en) * 2005-12-09 2007-06-14 F. Hoffmann-La Roche Ag Antiviral nucleosides
BRPI0619890A2 (pt) * 2005-12-14 2011-10-25 Hoffmann La Roche composição farmacêutica e processo para preparação de uma suspensão sólida
CN101330906B (zh) * 2005-12-14 2010-12-29 弗·哈夫曼-拉罗切有限公司 Hcv前药制剂
EP1976382B1 (en) * 2005-12-23 2013-04-24 IDENIX Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
JP2009532411A (ja) * 2006-04-04 2009-09-10 エフ．ホフマン−ラ ロシュ アーゲー Ｈｃｖ治療のための３’，５’−ジ−ｏ−アシル化ヌクレオシド
JP5252459B2 (ja) * 2006-10-10 2013-07-31 ギリアド ファーマセット エルエルシー リボフラノシルピリミジンヌクレオシドの調製
CA2665049C (en) 2006-10-10 2012-12-04 Medivir Ab Hcv nucleoside inhibitor
CN101528717B (zh) 2006-11-09 2013-04-24 弗·哈夫曼-拉罗切有限公司 噻唑和*唑-取代的芳基酰胺类化合物
US8501933B2 (en) 2006-11-09 2013-08-06 Roche Palo Alto Llc Thiazole and oxazole-substituted arylamides as P2X3 and P2X2/3 antagonists
ES2348687T3 (es) * 2006-12-11 2010-12-10 F. Hoffmann-La Roche Ag Procedimiento para la preparaciã“n de derivados de 4'-azidocitidina.
US20080261913A1 (en) 2006-12-28 2008-10-23 Idenix Pharmaceuticals, Inc. Compounds and pharmaceutical compositions for the treatment of liver disorders
WO2008106167A1 (en) * 2007-02-28 2008-09-04 Conatus Pharmaceuticals, Inc. Combination therapy comprising matrix metalloproteinase inhibitors and caspase inhibitors for the treatment of liver diseases
ATE525068T1 (de) 2007-02-28 2011-10-15 Conatus Pharmaceuticals Inc Verfahren zur behandlung von chronischer viraler hepatitis c mithilfe von ro 113-0830
CA2682638C (en) * 2007-03-29 2012-07-17 F. Hoffmann-La Roche Ag Pharmaceutical composition comprising (2r, 3s, 4r, 5r)-5-(4-amino-2-oxo-2h-pyrimidin-1-yl)-2-azido-3,4-bis-iso-butyryloxy-tetrahydro-furan-2-ylmethyl isobutyrate
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
AR069740A1 (es) * 2007-11-29 2010-02-17 Metabasis Therapeutics Inc Compuestos nucleosidos antivirales
CN101903362B (zh) * 2007-12-17 2013-07-17 霍夫曼-拉罗奇有限公司 四唑取代的芳基酰胺衍生物和它们作为p2x3和/或p2x2/3嘌呤能受体拮抗物的用途
PL2234976T3 (pl) * 2007-12-17 2013-09-30 Hoffmann La Roche Nowe aryloamidy podstawione pirazolem
ES2570628T3 (es) 2007-12-17 2016-05-19 Hoffmann La Roche Nuevas arilamidas con sustitución imidazol
KR101284510B1 (ko) * 2007-12-17 2013-07-23 에프. 호프만-라 로슈 아게 트리아졸 치환된 아릴아미드 유도체 및 ｐ２ｘ３ 및/또는 ｐ２ｘ２／３ 퓨린성 수용체 길항제로서의 용도
US8173621B2 (en) * 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
ES2458358T3 (es) * 2008-07-02 2014-05-05 Idenix Pharmaceuticals, Inc. Compuestos y composiciones farmacéuticas para el tratamiento de infecciones víricas
CN102164999B (zh) * 2008-07-31 2014-05-14 3M创新有限公司 叠氮化物组合物及其制备和使用方法
EP2379745A1 (en) * 2008-12-18 2011-10-26 F. Hoffmann-La Roche AG Biomarkers for hcv treatment response
EP2376515A1 (en) 2008-12-23 2011-10-19 Pharmasset, Inc. Synthesis of purine nucleosides
NZ593795A (en) * 2009-01-21 2013-02-22 Hoffmann La Roche Pharmaceutical compositions comprising a hcv polymerase inhibitor prodrug
JP5690286B2 (ja) 2009-03-04 2015-03-25 イデニク プハルマセウティカルス，インコーポレイテッド ホスホチオフェン及びホスホチアゾールｈｃｖポリメラーゼ阻害剤
WO2010100178A1 (en) 2009-03-06 2010-09-10 F. Hoffmann-La Roche Ag Heterocyclic antiviral compounds
TWI576352B (zh) 2009-05-20 2017-04-01 基利法瑪席特有限責任公司 核苷磷醯胺
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
CA2754654A1 (en) * 2009-06-22 2010-12-29 F. Hoffmann-La Roche Ag Novel oxazolone and pyrrolidinone-substituted arylamides
SG177301A1 (en) * 2009-06-22 2012-02-28 Hoffmann La Roche Novel indole, indazole and benzimidazole arylamides as p2x3 and/or p2x2/3 antagonists
CA2764956A1 (en) * 2009-06-22 2010-12-29 F. Hoffmann-La Roche Ag Novel biphenyl and phenyl-pyridine amides
EP2445875A2 (en) 2009-06-24 2012-05-02 F. Hoffmann-La Roche AG Heterocyclic antiviral compound
WO2011017389A1 (en) 2009-08-05 2011-02-10 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors useful against viral infections, particularly hcv
CN102498100A (zh) 2009-09-21 2012-06-13 弗·哈夫曼-拉罗切有限公司 抗病毒杂环化合物
US20110117055A1 (en) 2009-11-19 2011-05-19 Macdonald James E Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds
EP2501679A1 (en) 2009-11-21 2012-09-26 F. Hoffmann-La Roche AG Heterocyclic antiviral compounds
RU2554087C2 (ru) 2009-12-18 2015-06-27 Айденикс Фармасьютикалз, Инк. 5,5-конденсированные ариленовые или гетероариленовые ингибиторы вируса гепатита с
MX337050B (es) * 2010-01-28 2016-02-10 Riboscience Llc Compuestos 4'-azido-nucleósidos como anti-vhc.
US8563530B2 (en) 2010-03-31 2013-10-22 Gilead Pharmassel LLC Purine nucleoside phosphoramidate
AP2012006535A0 (en) 2010-03-31 2012-10-31 Gilead Pharmasset Llc Stereoselective synthesis of phosphorous containing actives
BR112012024661A2 (pt) 2010-04-01 2015-09-15 Centre Nat Rech Scient composto, composição farmacêutica e método de tratamento de um hospedeiro infectado com vírus de hepatite c
WO2012040124A1 (en) 2010-09-22 2012-03-29 Alios Biopharma, Inc. Azido nucleosides and nucleotide analogs
PT3042910T (pt) 2010-11-30 2019-04-16 Gilead Pharmasset Llc 2'-espiro-nucleósidos para utilização na terapia da hepatite c
WO2012080050A1 (en) 2010-12-14 2012-06-21 F. Hoffmann-La Roche Ag Solid forms of a phenoxybenzenesulfonyl compound
WO2012109398A1 (en) 2011-02-10 2012-08-16 Idenix Pharmaceuticals, Inc. Macrocyclic serine protease inhibitors, pharmaceutical compositions thereof, and their use for treating hcv infections
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US20120252721A1 (en) 2011-03-31 2012-10-04 Idenix Pharmaceuticals, Inc. Methods for treating drug-resistant hepatitis c virus infection with a 5,5-fused arylene or heteroarylene hepatitis c virus inhibitor
US9403863B2 (en) 2011-09-12 2016-08-02 Idenix Pharmaceuticals Llc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
CN103906759A (zh) 2011-09-12 2014-07-02 埃迪尼克斯医药公司 用于治疗病毒感染的化合物和药物组合物
CA2840242C (en) 2011-09-16 2019-03-26 Gilead Sciences, Inc. Methods for treating hcv
EP2768838A1 (en) 2011-10-14 2014-08-27 IDENIX Pharmaceuticals, Inc. Substituted 3',5'-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
WO2013082476A1 (en) 2011-11-30 2013-06-06 Emory University Antiviral jak inhibitors useful in treating or preventing retroviral and other viral infections
US20130217644A1 (en) 2012-02-13 2013-08-22 Idenix Pharmaceuticals, Inc. Pharmaceutical Compositions of 2'-C-Methyl-Guanosine, 5'-[2[(3-Hydroxy-2,2-Dimethyl-1-Oxopropyl)Thio]Ethyl N-(Phenylmethyl)Phosphoramidate]
EP2852605B1 (en) 2012-05-22 2018-01-31 Idenix Pharmaceuticals LLC 3',5'-cyclic phosphate prodrugs for hcv infection
EA031301B1 (ru) 2012-05-22 2018-12-28 Иденикс Фармасьютикалз Ллс D-аминокислотные химические соединения для лечения заболеваний печени
US9109001B2 (en) 2012-05-22 2015-08-18 Idenix Pharmaceuticals, Inc. 3′,5′-cyclic phosphoramidate prodrugs for HCV infection
KR20150014457A (ko) 2012-05-25 2015-02-06 얀센 알 앤드 디 아일랜드 우라실 스피로옥세탄 뉴클레오시드
US9192621B2 (en) 2012-09-27 2015-11-24 Idenix Pharmaceuticals Llc Esters and malonates of SATE prodrugs
WO2014058801A1 (en) 2012-10-08 2014-04-17 Idenix Pharmaceuticals, Inc. 2'-chloro nucleoside analogs for hcv infection
EP2909223B1 (en) 2012-10-19 2017-03-22 Idenix Pharmaceuticals LLC Dinucleotide compounds for hcv infection
US10723754B2 (en) 2012-10-22 2020-07-28 Idenix Pharmaceuticals Llc 2′,4′-bridged nucleosides for HCV infection
US20140140952A1 (en) 2012-11-14 2014-05-22 Idenix Pharmaceuticals, Inc. D-Alanine Ester of Sp-Nucleoside Analog
WO2014078427A1 (en) 2012-11-14 2014-05-22 Idenix Pharmaceuticals, Inc. D-alanine ester of rp-nucleoside analog
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
EP2950786B1 (en) 2013-01-31 2019-11-27 Gilead Pharmasset LLC Combination formulation of two antiviral compounds
WO2014137930A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Thiophosphate nucleosides for the treatment of hcv
WO2014137926A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. 3'-deoxy nucleosides for the treatment of hcv
US20140271547A1 (en) 2013-03-13 2014-09-18 Idenix Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
EP2981542B1 (en) 2013-04-01 2021-09-15 Idenix Pharmaceuticals LLC 2',4'-fluoro nucleosides for the treatment of hcv
US10005779B2 (en) 2013-06-05 2018-06-26 Idenix Pharmaceuticals Llc 1′,4′-thio nucleosides for the treatment of HCV
CA2913206C (en) 2013-06-26 2022-08-02 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
US20150037282A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
CN105517540B (zh) 2013-08-27 2019-08-23 吉利德制药有限责任公司 两种抗病毒化合物的复方制剂
EP3046924A1 (en) 2013-09-20 2016-07-27 IDENIX Pharmaceuticals, Inc. Hepatitis c virus inhibitors
WO2015061683A1 (en) 2013-10-25 2015-04-30 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate and d-alanine thiophosphoramidate pronucleotides of nucleoside compounds useful for the treatment of hcv
WO2015066370A1 (en) 2013-11-01 2015-05-07 Idenix Pharmaceuticals, Inc. D-alanine phosphoramidate pronucleotides of 2'-methyl 2'-fluoro guanosine nucleoside compounds for the treatment of hcv
US20170198005A1 (en) 2013-11-27 2017-07-13 Idenix Pharmaceuticals Llc 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection
EP3083654A1 (en) 2013-12-18 2016-10-26 Idenix Pharmaceuticals LLC 4'-or nucleosides for the treatment of hcv
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
EP3114122A1 (en) 2014-03-05 2017-01-11 Idenix Pharmaceuticals LLC Solid forms of a flaviviridae virus inhibitor compound and salts thereof
WO2015134561A1 (en) 2014-03-05 2015-09-11 Idenix Pharmaceuticals, Inc. Pharmaceutical compositions comprising a 5,5-fused heteroarylene flaviviridae inhibitor and their use for treating or preventing flaviviridae infection
US10202411B2 (en) 2014-04-16 2019-02-12 Idenix Pharmaceuticals Llc 3′-substituted methyl or alkynyl nucleosides nucleotides for the treatment of HCV
EP3164136A4 (en) 2014-07-02 2018-04-04 Ligand Pharmaceuticals, Inc. Prodrug compounds and uses therof
KR102573609B1 (ko) * 2014-09-26 2023-08-31 리보사이언스 엘엘씨 호흡기 세포융합 바이러스 rna 복제 억제제로서의 4'-비닐 치환된 뉴클레오시드 유도체
SMT202100592T1 (it) 2014-12-26 2021-11-12 Univ Emory Derivati antivirali della n4-idrossicitidina
EP3651734B1 (en) 2017-07-11 2024-11-13 Gilead Sciences, Inc. Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections
DK3706762T3 (da) * 2017-12-07 2024-12-16 Univ Emory N4-hydroxycytidin og derivater og antivirale anvendelser relateret dertil
EP3737676B1 (en) 2018-01-09 2024-03-06 Ligand Pharmaceuticals, Inc. Acetal compounds and therapeutic uses thereof
US11660307B2 (en) 2020-01-27 2023-05-30 Gilead Sciences, Inc. Methods for treating SARS CoV-2 infections
WO2021207049A1 (en) 2020-04-06 2021-10-14 Gilead Sciences, Inc. Inhalation formulations of 1'-cyano substituted carbanucleoside analogs
TW202203941A (zh) 2020-05-29 2022-02-01 美商基利科學股份有限公司 瑞德西韋之治療方法
WO2021262826A2 (en) 2020-06-24 2021-12-30 Gilead Sciences, Inc. 1'-cyano nucleoside analogs and uses thereof
WO2022008025A1 (en) * 2020-07-05 2022-01-13 Since & Technology Development Fund Authority 2-hydroxyiminopyrimidine nucleosides and derivitives and antiviral uses thereto
CA3190702A1 (en) 2020-08-27 2022-03-03 Elaine Bunyan Compounds and methods for treatment of viral infections
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
IL315102A (en) 2022-03-02 2024-10-01 Gilead Sciences Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS
US12357577B1 (en) 2024-02-02 2025-07-15 Gilead Sciences, Inc. Pharmaceutical formulations and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017651A2 (de) * 1992-03-04 1993-09-16 Max-Delbrück-Centrum für Molekulare Medizin Antivirale nucleosidanaloge, ihre herstellung und ihre verwendung
WO2002018404A2 (en) * 2000-08-30 2002-03-07 F. Hoffmann-La Roche Ag Nucleoside derivatives for the treatment of hepatitis c
WO2002100415A2 (en) * 2001-06-12 2002-12-19 F. Hoffmann-La Roche Ag 4'-substituted nucleosides for the treatment of diseases mediated by the hepatitis c virus

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3998807A (en) 1972-03-03 1976-12-21 Syntex (U.S.A.) Inc. Arabinofuranosyl cytosines and methods of making
GB8719367D0 (en) 1987-08-15 1987-09-23 Wellcome Found Therapeutic compounds
SE8801729D0 (sv) 1988-05-06 1988-05-06 Astra Ab Purine derivatives for use in therapy
US5449664A (en) * 1988-11-21 1995-09-12 Syntex (U.S.A.) Inc. Antiviral agents
DE68922903T2 (de) 1988-12-19 1995-11-23 Wellcome Found Antivirale Pyrimidin- und Purinverbindungen, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Präparate.
US5216142A (en) 1989-04-17 1993-06-01 Efamol Holdings Plc Anti-virals
GB2260319B (en) * 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
GB9307043D0 (en) * 1993-04-05 1993-05-26 Norsk Hydro As Chemical compounds
DE4311801A1 (de) 1993-04-09 1994-10-13 Hoechst Ag Neue Carbonsäureester von 2-Amino-7-(1,3-dihydroxy-2-propoxymethyl)purin, deren Herstellung sowie deren Verwendung
US6184376B1 (en) 1997-02-10 2001-02-06 Mediver Ab Synthesis of acyclic nucleoside derivatives
CZ20011130A3 (cs) 1998-10-16 2001-08-15 Schering Corporation Sloučenina, farmaceutický prostředek a jejich použití pro ribavirin-interferon alfa kombinovanou terapii
MXPA02006251A (es) 1999-12-23 2003-01-28 Ribapharm Inc Composiciones y metodos para l-nucleosidos, l-nucleotidos y sus analogos.
US6495677B1 (en) 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
WO2002057425A2 (en) * 2001-01-22 2002-07-25 Merck & Co., Inc. Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993017651A2 (de) * 1992-03-04 1993-09-16 Max-Delbrück-Centrum für Molekulare Medizin Antivirale nucleosidanaloge, ihre herstellung und ihre verwendung
WO2002018404A2 (en) * 2000-08-30 2002-03-07 F. Hoffmann-La Roche Ag Nucleoside derivatives for the treatment of hepatitis c
WO2002100415A2 (en) * 2001-06-12 2002-12-19 F. Hoffmann-La Roche Ag 4'-substituted nucleosides for the treatment of diseases mediated by the hepatitis c virus

Also Published As

Publication number Publication date
PE20040836A1 (es) 2004-11-25
JP2006519169A (ja) 2006-08-24
HRP20050417A2 (en) 2006-06-30
CY1106207T1 (el) 2011-06-08
KR20050083909A (ko) 2005-08-26
TW200426154A (en) 2004-12-01
ES2270136T3 (es) 2007-04-01
JO2403B1 (en) 2007-06-17
ATE335755T1 (de) 2006-09-15
TWI332507B (en) 2010-11-01
WO2004046159A8 (en) 2005-06-30
NO330424B1 (no) 2011-04-11
PA8588501A1 (es) 2004-05-26
NO20052304L (no) 2005-06-23
JP4362450B2 (ja) 2009-11-11
AU2003288064A1 (en) 2004-06-15
DK1565481T3 (da) 2006-12-18
PL377632A1 (pl) 2006-02-06
CO5550501A2 (es) 2005-08-31
IL168266A (en) 2010-11-30
CA2504846C (en) 2012-01-03
KR100676662B1 (ko) 2007-02-01
AU2003288064B2 (en) 2008-10-09
RU2005119633A (ru) 2006-01-27
PT1565481E (pt) 2006-12-29
EP1565481A1 (en) 2005-08-24
US20040121980A1 (en) 2004-06-24
RU2327701C2 (ru) 2008-06-27
NZ539644A (en) 2007-01-26
US6846810B2 (en) 2005-01-25
MY136229A (en) 2008-08-29
AR042192A1 (es) 2005-06-15
UY28084A1 (es) 2004-05-31
WO2004046159A1 (en) 2004-06-03
DE60307503D1 (de) 2006-09-21
MXPA05005282A (es) 2005-07-25
PL210967B1 (pl) 2012-03-30
CA2504846A1 (en) 2004-06-03
DE60307503T2 (de) 2007-08-16
EP1565481B1 (en) 2006-08-09
BR0316407A (pt) 2005-10-11

Similar Documents

Publication Publication Date Title
HRP20050417B1 (hr) Antiviralni derivati nukleozida
PL366726A1 (en) 4'-substituted nucleosides for the treatment of diseases mediated by the hepatitis c virus
MY128463A (en) 4' substituted nucleosides for the treatment of diseases mediated by the hepatitis c virus
ATE512973T1 (de) Nukleosid-arylphosphoramidate und ihre verwendung als antivirale mittel zur behandlung von hepatitis-c-virus
PH12022553530A1 (en) 1'-cyano nucleoside analogs and uses thereof
CA2445744A1 (en) Antiviral nucleoside derivatives
EA200600582A1 (ru) Способы и композиции для лечения вирусного гепатита с
EA200400735A1 (ru) 3-β-D-РИБОФУРАНОЗИЛТИАЗОЛО[4,5-d]ПИРИМИДИННУКЛЕОЗИДЫ И ИХ ПРИМЕНЕНИЯ
EA200300819A1 (ru) Производные нуклеозидов в качестве ингибиторов рнк-зависимой рнк вирусной полимеразы
ATE505474T1 (de) Inhibitoren von nukleosidphosphorylasen und nukleosidasen
NZ600371A (en) Uracil or thymine derivative for treating hepatitis c
MXPA04005156A (es) Antagonistas del receptor de adenosina a2a.
BR9909474A (pt) Formas ii, cristalina e v de 5,6-dicloro-2-(isopropilamino)-1-beta-l-ribofuranosil -1h-benzimidazol, solvato de etanol de 5,6-dicloro-2-(isopropilamino)-1-beta-l-ribofuranosil -1h-benzimidazol, composição, composto, uso de 5,6-dicloro-2-(isopropilamino)-1-beta-l-ribofuranosil -1h-benzimidazol, e, processos para o tratamento de uma infecção viral em um humano e para a produção de 5,6-dicloro-2-(isopropilamino)-1-beta-l-ribofuranosil -1h-benzimidazol
EA200702637A1 (ru) Производные пурина
WO2004052905A3 (en) Antiviral nucleoside derivatives
WO2005084315A3 (en) Pyranoindole derivatives and the use thereof for the treatment of hepatitis c virus infection or disease
ATE480238T1 (de) Analoge des 5(e)bromovinyluracils und verwandte pyrimidinnucleoside als antivirale mittel und verwendungsmethoden
UY28110A1 (es) Derivados de nucleosido antivirales
DE602005006397D1 (de) Nukleosidanaloga mit antiviraler wirkung

Legal Events

Date Code Title Description
A1OB Publication of a patent application
ARAI Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application
B1PR Patent granted
PPPP Transfer of rights

Owner name: RIBOSCIENCE LLC, US

ODRP Renewal fee for the maintenance of a patent

Payment date: 20171027

Year of fee payment: 15

PBON Lapse due to non-payment of renewal fee

Effective date: 20181114