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KR890000465A - 환상 아민 화합물 - Google Patents

환상 아민 화합물 Download PDF

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KR890000465A
KR890000465A KR1019880007562A KR880007562A KR890000465A KR 890000465 A KR890000465 A KR 890000465A KR 1019880007562 A KR1019880007562 A KR 1019880007562A KR 880007562 A KR880007562 A KR 880007562A KR 890000465 A KR890000465 A KR 890000465A
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South Korea
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chr
pharmacologically acceptable
cyclic amine
indanon
benzyl
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KR910003618B1 (ko
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하찌로오 스끼모노
유다까 쓰찌야
구니조오 히구라시
노리오 가리베
요오이찌 이이무라
준 사사끼
요시하루 야마니시
히로오 오구라
신 아라끼
다까시 고자사
아쓰히고 구보따
미찌꼬오 고자사
기요미 야마쓰
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나이또오 유우지
에자이 가부시끼가이샤
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Abstract

내용 없음

Description

환상 아민 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (15)

  1. 다음식(XXV)을 갖는 환상아민화합물 및 약리학적으로 허용되는 그의 염.
    상기식에서 J는 : (a) (1) 페닐, (2) 피리딜, (3) 피라질, (4) 퀴놀릴, (5) 시클로헥실, (6) 퀴녹살릴 및 (7) 푸릴로 구성되는 군으로부터 선택된 치환 또는 비치환된 기; (b) (1) 인다닐, (2) 인다노닐, (3) 인데닐, (4) 인데노닐, (5) 인단디오닐, (6) 테트라로닐, (7) 벤조수베로닐, (8) 인다놀일 및 (9) C6H5-CO-CH(CH3)-로 구성되는 군으로부터 선택된 여기서 페닐은 치환기를 가질수도 있는 1가 또는 2가지; (c) 환상아미드 화합물로부터 유도된 1가지; (b) 저급알킬 또는 (e) R21은 수소 또는 저급 알콕시카르보닐인 R21-CH=CH-기이며; B는 -(CHR22)r-CO-(CH22)r-, -NR4-(CH22)r-, R4는 수소, 저급알킬, 아실, 저급알킬 술포닐, 페닐, 치환된 페닐, 벤질 또는 치환된 벤질이며, -CO-NR5-(CHR22)r-, R5는 수소, 저급알킬 또는 페닐이며, -CH=CH-(CHR22)r-, -OCOO-(CHR22)r-, -OOC -NH-(CHR22)r-, -NH-CO-(CHR22)r-, -CH2-CO-NH-(CHR2)r, (-CH2-)CO-NH-(CHR22)r-(CH2)2-CO-NH-(CHR22)r-, CH(OH)-(CHR22)r-, r은 제로
    또는 1내지 10의 정수이며, R22는 알킬렌기가 메틸 분기를 갖지않거나 또는 1또는 그 이상의 메틸분기를 갖도록 수소 또는 메틸이며, =(CH-CH=CH)b-, b는 1내지 3의 정수이며, =CH-(CH2)c-, C는 제로 또는 1내지 9의 정수이며, =(CH-CH)d=, d는 제로 또는 1내지 9의 정수이며, -CO-CH=CH-CH2-, -CO-CH2-CH(OH)-CH2-, -CH-(CH3)-CO-NH-CH2-, -CH=CH-CO-NH-(CH2)2-, NH-, -O-, -S-, 디알킬아미노 알킬카르보닐 또는 저급 알콕시 카르보닐이며; T는 질소 또는 탄소이고; Q는 질소, 탄소 또는이며; q는 1내지 3의 정수이고; K는 수소, 페닐, 치환된 페닐, 페닐이 치환기를 가질 수도 있는 아릴알킬, 신나밀, 저급알킬, 피리딜메틸, 시클로알킬알킬, 아다만탄메틸, 푸릴메틸, 시클ㄹ알킬, 저급알콕시 카르보닐 또는 아실이며;는 단일결합 또는 이중 결합을 나타낸다.
  2. 제1항에 있어서, J는 (a) 인 것을 특징으로 하는 환상아민 화합물 및 약리학적으로 허용되는 그의 염.
  3. 제1항에 있어서, J는 (b)인 것을 특징으로 하는 환상이만 화합물 및 약리학적으로 허용되는 그의 염.
  4. 제1항에 있어서, J는 (2), (3) 및 (5)의 1가지와 (2)의 2가지로 구성되는 군으로부터 선택되는 (b)인 것을 특징으로 하는 환상아민 화합물 및 약리학적으로 허용되는 그의 염.
  5. 제1항에 있어서, J는 (b)이고 B는 (CHR22)r-, =(CH-CH=CH) b-, =CH-(CH2)c- 또는 =(CH-CH)d=인 것을 특징으로 하는 환상아민 화합물 및 약리학적으로 허용되는 그의염.
  6. 제1항에 있어서, J는 (b)의 (2)이고 B는 (CHR22)r-, =(CH-CH=CH)b-, =CH-(CH2)c-또는 =(CH-CH)d=인 것을 특징으로 하는 환상아민 화합물 및 약리학적으로 허용되는 그의염.
  7. 제5항에 있어서, Q는 질소이고, T는 탄소 또는 질소이며 n은 2이고; Q는 탄소, T는 질소이고 n은 2이고; Q는 탄소, T는 질소이고 n은 2인 것을 특징으로 하는 환상아민 화합물 및 약리학적으로 허용되는 그의염.
  8. 제1항에 있어서, Q는 질소이고, T는 탄소이며 n은 2인 것을 특징으로 하는 환상아민 화합물 및 약리학적으로 허용되는 그의염.
  9. 제7항에 있어서, K는 페닐알킬 또는 페닐상에 치환기를 갖는 페닐알킬인 것을 특징으로 하는 환상아민 화합물 및 약리학적으로 허용되는 그의 염.
  10. 제1항에 있어서, 1-벤질-4-((5,6-디메톡시-1-인다논)-2-일)메틸피페리딘인 것 특징으로 하는 환상아민 화합물 및 약리학적으로 허용되는 그의 염.
  11. 1-벤질-4-((5,6-디메톡시-1-인다논)-2-일리데닐)메틸피페리딘, 1-벤질-4-((5-메톡시-1-인다논)-2-일)메틸피페리딘, 1-벤질-4-((5,6-디메톡시-1-인다논)-2-일)메틸피페리딘-1-벤질-4-((5-메틸렌디옥시-1-인다논)-2-일)메틸피페리딘, 1-(m-니트로벤질)-4-((5,6-디메톡시-1-인다논)-2-일)메틸피페리딘, 1-시클로헥실메틸-4-((5,6-디메톡시-1-인다논)-2-일)메틸피페리딘, 1-(m-플로로벤질)-4-((5,6-디메톡시-1-인다논)-2-일)메틸피페리딘, 1-벤질-4-((5,6-디메톡시-1-인다논)-2-일)프로필피페리딘, 1-벤질-4-((5-이소프로폭시-6-메톡시-1-인다논)-2-일)메틸피페리딘 및 1-벤질-4-(5,6-디메톡시-1-옥소인다논)-2-일)프로페닐피페리딘을 구성되는 군으로부터 선택되는 것을 특징으로 하는 환상아민 화합물 및 약리학적으로 허용되는 그의 염.
  12. 약리학적 유료량의 제1항에 정의된 환상 아민 화합물 또는 약리학적으로 허용되는 그의 염과 약리학적으로 허용되는 담체로 이루어진 것을 특징으로 하는 치료 조성물.
  13. 제1항에 정의된 한상 아민 화합물 또는 약리학적으로 허용되는 그의염을 사람 환자에게 투여함으로써 에스테라제 활성으로 인한 질병을 예방 및 치료하는 방법.
  14. 제13항에 있어서, 질병은 노년성 치매인 것을 특징으로 하는 방법.
  15. 제13항에 있어서, 질병은 알쯔하이머형의 노년상 치매인 것을 특징으로 하는 방법.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880007562A 1987-06-22 1988-06-22 환상 아민 화합물 Expired KR910003618B1 (ko)

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