KR970704428A - 활성성분의 선택적 방출을 제공하는 합성물(composition providing selective release of an active ingredient) - Google Patents
활성성분의 선택적 방출을 제공하는 합성물(composition providing selective release of an active ingredient) Download PDFInfo
- Publication number
- KR970704428A KR970704428A KR1019970700903A KR19970700903A KR970704428A KR 970704428 A KR970704428 A KR 970704428A KR 1019970700903 A KR1019970700903 A KR 1019970700903A KR 19970700903 A KR19970700903 A KR 19970700903A KR 970704428 A KR970704428 A KR 970704428A
- Authority
- KR
- South Korea
- Prior art keywords
- layer
- active ingredient
- rti
- water
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000004480 active ingredient Substances 0.000 title claims abstract 6
- 239000000203 mixture Substances 0.000 title claims 8
- 239000000463 material Substances 0.000 claims abstract 9
- 239000003814 drug Substances 0.000 claims abstract 3
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 4
- 239000011248 coating agent Substances 0.000 claims 3
- 238000000576 coating method Methods 0.000 claims 3
- 239000002131 composite material Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000012736 aqueous medium Substances 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 1
- 230000001419 dependent effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 239000002861 polymer material Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 229920003169 water-soluble polymer Polymers 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Furan Compounds (AREA)
Abstract
본 발명은 물에 불을 수 있는 물질인 코어(a)와, 탄력성이며 비수용성이며 투수성인 층(b)와, 하나 이상의 활성성분을 함유하는 층(c)과, 예정된 수성매체에서 투수성인 물질이며 코어의 팽창시에 분열될 수 있는 물질로 이루어진 층(d)과를 차례로 포함하여 구성된 합성물에 관한 것이다. 또한, 상기 합성물을 약품으로써 이용하는 것에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (11)
- 합성물에 있어서, (a) 물에 불을 수 있는 물질로 구성된 코어(1)와, (b)물을 통과시키고 물에 비수용성인 팽창력있는 물질로 이루어진 층(2)과, (c) 적어도 하나의 활성성분으로 구성되는층(3)과, (d)예정된 수성 매체에서 투수성(透水性)인 물질로 이루어지며, 코어(1)의 팽창의 결과로 분열될 수 있는층(4)과, 를 차례로 포함하여 구성된 것을 특징으로 하는 합성물.
- 제1항에 있어서, 상기 코어(1)는 50 내지 700%, 바람직하게는 100 내지500%, 더 바람직하게는 150 내지 300%의 부피팽창을 보여주는 것을 특징으로 하는 합성물.
- 제1또는 제2항에 있어서, 상기 합성물의 전체 무게에 기초하여, 합성물의 다양한 구성요소 (1) 내지 (4)의 무게의 상대적 비율은, (1)의 무게에 있어서는 30 내지 90%, 바람직하게는 50 내지70%, 더 바람직하게는 약 60%이며, (2)의 무게에 있어서는 1 내지 6%, 바람직하게는 2 내지 4%, 더 바람직하게는 약 3%이며,(3)의 무게에 있어서는 1 내지 60%, 바람직하게는 10 내지50%, 더 바람직하게는 약 30%이며, (4)의 무게에 있어서는 3 내지 15%, 바람직하게는 5 내지9%, 더 바람직하게는 약 7%인 것을 특징으로 하는 합성물.
- 제1내지 제3항 중 어느 한 항에 있어서, 예정된 수성매체에서 투수성이 있는 상기 층(4)의 물질은 수용성 중합체 물질이며, 상기 물질의 용해도는 pH에 의존하며, 상기 물질은 pH=6.0과 pH=8.0 사이로 구성된 pH값으로부터 시작하는 용해도를 갖는 것을 특징으로 하는 합성물.
- 제4항에 있어서, 상기 층(4)의 중합체 물질은 6.8의 pH값으로부터 시작하는 용해도를 나타내는 중합체 물질을 포함하여 구성된 것을 특징으로 하는 합성물.
- 제1항 내지 제5항 중 어느 한 항에 있어서, 상기 층 (4)의 물질은 위(胃) 내성 및 장(腸)용성 물질인 것을 특징으로 하는 합성물.
- 제1항 내지 제6항 중 어느 한 항에 있어서, 활성성분은 프레드니솔론 (predn isolon)이거나 약학적으로 수용가능한 그 유도체인 것을 특징으로 하는 합성물.
- 제1항 내지 제6항 중 어느 한 항에 있어서, 상기 층(3)은 1∼500㎎의 활성성분으로 이루어지며, 바람직하게는 5∼100㎎의 활성성분으로 이루어지는 것을 특징으로 하는 합성물.
- 제1항 내지 제8항 중 어느 한 항에 있어서, 약제로써 이용되는 것을 특징으로 하는 합성물.
- 제9항에 있어서, 결장의 병을 치료하기 위한 약제로써 이용되는 것을 특징으로 하는 합성물.
- 제1항 내지 제8항 중 어느 한 항에 따른 합성물을 준비하기 위한 방법에 있어서, (i) 가루형태위 혼합물에서 시작하여 압축된 코어(1)를 제공하는 단계와, (ii) 상기 코어 (1)를 한 층 (2) 코팅하는 단계와, (ⅲ) 상기 층(2)을 적어도 하나의 활성성분으로 구성된 층(3)으로 한 층 코팅하는 단계와, (ⅳ)상기 층(3)위에 한 층(4)을 코팅하는 단와를, 포함하는 것을 특징으로 하는 합성물 준비방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9409963A FR2723536A1 (fr) | 1994-08-11 | 1994-08-11 | Composition permettant une liberation selective d'un principe actif |
| FR9409963 | 1994-08-11 | ||
| PCT/FR1995/001079 WO1996004893A1 (fr) | 1994-08-11 | 1995-08-11 | Composition permettant une liberation selective d'un principe actif |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR970704428A true KR970704428A (ko) | 1997-09-06 |
Family
ID=9466272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019970700903A Withdrawn KR970704428A (ko) | 1994-08-11 | 1995-08-11 | 활성성분의 선택적 방출을 제공하는 합성물(composition providing selective release of an active ingredient) |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US5824341A (ko) |
| EP (1) | EP0774960A1 (ko) |
| JP (1) | JPH10504300A (ko) |
| KR (1) | KR970704428A (ko) |
| AU (1) | AU698240B2 (ko) |
| CA (1) | CA2197234A1 (ko) |
| CZ (1) | CZ41297A3 (ko) |
| FI (1) | FI970530A7 (ko) |
| FR (1) | FR2723536A1 (ko) |
| HU (1) | HUT77387A (ko) |
| NO (1) | NO970610L (ko) |
| NZ (1) | NZ290848A (ko) |
| PL (1) | PL318586A1 (ko) |
| WO (1) | WO1996004893A1 (ko) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
| FR2758459B1 (fr) * | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
| US6511477B2 (en) | 1997-03-13 | 2003-01-28 | Biocardia, Inc. | Method of drug delivery to interstitial regions of the myocardium |
| US6322819B1 (en) * | 1998-10-21 | 2001-11-27 | Shire Laboratories, Inc. | Oral pulsed dose drug delivery system |
| US6555139B2 (en) | 1999-06-28 | 2003-04-29 | Wockhardt Europe Limited | Preparation of micron-size pharmaceutical particles by microfluidization |
| US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
| US20020131908A1 (en) * | 2000-01-13 | 2002-09-19 | George Benda | Selective release apparatus for fluids |
| AR026148A1 (es) * | 2000-01-21 | 2003-01-29 | Osmotica Argentina S A | Dispositivo osmotico con pasaje preformado que aumenta de tamano |
| US20030091634A1 (en) * | 2001-09-14 | 2003-05-15 | Pawan Seth | Delayed release tablet of venlafaxin |
| US20030118647A1 (en) * | 2001-12-04 | 2003-06-26 | Pawan Seth | Extended release tablet of metformin |
| US6913768B2 (en) * | 2002-09-24 | 2005-07-05 | Shire Laboratories, Inc. | Sustained release delivery of amphetamine salts |
| US20040086567A1 (en) * | 2002-10-30 | 2004-05-06 | Pawan Seth | Bioequivalent composition of itraconazole and a hydrophilic polymer |
| US20040162320A1 (en) * | 2003-02-14 | 2004-08-19 | Pawan Seth | Solid composition containing nisoldipine a mixture of polyethylene oxides and an antioxidant |
| US20040249364A1 (en) * | 2003-06-03 | 2004-12-09 | Ilya Kaploun | Device and method for dispensing medication to tissue lining a body cavity |
| US20060024362A1 (en) | 2004-07-29 | 2006-02-02 | Pawan Seth | Composition comprising a benzimidazole and process for its manufacture |
| US8110226B2 (en) * | 2007-07-20 | 2012-02-07 | Mylan Pharmaceuticals Inc. | Drug formulations having inert sealed cores |
| US20090036414A1 (en) * | 2007-08-02 | 2009-02-05 | Mutual Pharmaceutical Company, Inc. | Mesalamine Formulations |
| CA2769760A1 (en) | 2009-07-31 | 2011-02-03 | Ranbaxy Laboratories Limited | Multi-layered, multiple unit pharmaceutical compositions |
| US20140242158A1 (en) * | 2011-09-30 | 2014-08-28 | Astellas Pharma, Inc. | Granular Pharmaceutical Composition |
| KR101384055B1 (ko) * | 2012-02-02 | 2014-04-14 | 한국원자력연구원 | 버스트형 지연 방출 제어 조성물 및 이의 제조방법 |
| WO2017146053A1 (ja) * | 2016-02-23 | 2017-08-31 | ニプロ株式会社 | 医薬組成物粒子とそれを含む口腔内崩壊製剤 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8518301D0 (en) * | 1985-07-19 | 1985-08-29 | Fujisawa Pharmaceutical Co | Hydrodynamically explosive systems |
| DE3629994A1 (de) * | 1986-09-03 | 1988-03-17 | Weissenbacher Ernst Rainer Pro | Vorrichtung zur medikamentenapplikation in koerperhoehlen bzw. auf koerperoberflaechen |
| US4968208A (en) * | 1986-12-09 | 1990-11-06 | Stig Eliasson | Transporting arrangement for transporting motor vehicles |
| IT1230576B (it) * | 1988-10-20 | 1991-10-28 | Angeli Inst Spa | Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon |
| US5178868A (en) * | 1988-10-26 | 1993-01-12 | Kabi Pharmacia Aktiebolaq | Dosage form |
| US5229131A (en) * | 1990-02-05 | 1993-07-20 | University Of Michigan | Pulsatile drug delivery system |
| US5178866A (en) * | 1990-03-23 | 1993-01-12 | Alza Corporation | Dosage form for delivering drug to the intestine |
| IE61651B1 (en) * | 1990-07-04 | 1994-11-16 | Zambon Spa | Programmed release oral solid pharmaceutical dosage form |
| NZ286242A (en) * | 1991-03-26 | 1997-11-24 | Csl Ltd | Use of veterinary implant as a single dose vaccination system: rupturable polymer film coating around core of active agent and water soluble excipient |
| JP2892858B2 (ja) * | 1991-05-15 | 1999-05-17 | 田辺製薬株式会社 | 放出制御製剤およびその製造法 |
| US5656296A (en) * | 1992-04-29 | 1997-08-12 | Warner-Lambert Company | Dual control sustained release drug delivery systems and methods for preparing same |
| US5260069A (en) * | 1992-11-27 | 1993-11-09 | Anda Sr Pharmaceuticals Inc. | Pulsatile particles drug delivery system |
| US5358502A (en) * | 1993-02-25 | 1994-10-25 | Pfizer Inc | PH-triggered osmotic bursting delivery devices |
| DE4406424A1 (de) * | 1994-02-28 | 1995-08-31 | Bayer Ag | Expandierbare Arzneiformen |
| US5536507A (en) * | 1994-06-24 | 1996-07-16 | Bristol-Myers Squibb Company | Colonic drug delivery system |
| US5736159A (en) * | 1995-04-28 | 1998-04-07 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water insoluble drugs in which a passageway is formed in situ |
| US5558879A (en) * | 1995-04-28 | 1996-09-24 | Andrx Pharmaceuticals, Inc. | Controlled release formulation for water soluble drugs in which a passageway is formed in situ |
-
1994
- 1994-08-11 FR FR9409963A patent/FR2723536A1/fr active Pending
-
1995
- 1995-08-11 US US08/776,797 patent/US5824341A/en not_active Expired - Fee Related
- 1995-08-11 KR KR1019970700903A patent/KR970704428A/ko not_active Withdrawn
- 1995-08-11 AU AU31699/95A patent/AU698240B2/en not_active Ceased
- 1995-08-11 HU HU9700399A patent/HUT77387A/hu unknown
- 1995-08-11 NZ NZ290848A patent/NZ290848A/en unknown
- 1995-08-11 EP EP95927782A patent/EP0774960A1/fr not_active Ceased
- 1995-08-11 JP JP8507074A patent/JPH10504300A/ja active Pending
- 1995-08-11 CA CA002197234A patent/CA2197234A1/fr not_active Abandoned
- 1995-08-11 WO PCT/FR1995/001079 patent/WO1996004893A1/fr not_active Application Discontinuation
- 1995-08-11 CZ CZ97412A patent/CZ41297A3/cs unknown
- 1995-08-11 PL PL95318586A patent/PL318586A1/xx unknown
-
1997
- 1997-02-07 FI FI970530A patent/FI970530A7/fi unknown
- 1997-02-10 NO NO970610A patent/NO970610L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| FR2723536A1 (fr) | 1996-02-16 |
| PL318586A1 (en) | 1997-06-23 |
| NZ290848A (en) | 1998-03-25 |
| NO970610L (no) | 1997-03-21 |
| NO970610D0 (no) | 1997-02-10 |
| FI970530A7 (fi) | 1997-04-08 |
| US5824341A (en) | 1998-10-20 |
| JPH10504300A (ja) | 1998-04-28 |
| EP0774960A1 (fr) | 1997-05-28 |
| WO1996004893A1 (fr) | 1996-02-22 |
| CZ41297A3 (cs) | 1998-05-13 |
| AU698240B2 (en) | 1998-10-29 |
| AU3169995A (en) | 1996-03-07 |
| FI970530A0 (fi) | 1997-02-07 |
| HUT77387A (hu) | 1998-04-28 |
| CA2197234A1 (fr) | 1996-02-22 |
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