PT99901A - Processo para preparacao de novos derivados da 3,4-dihidro-isoquinolina e de composicoes farmaceuticas que os contem - Google Patents

Processo para preparacao de novos derivados da 3,4-dihidro-isoquinolina e de composicoes farmaceuticas que os contem

Info

Publication number: PT99901A
Authority: PT; Portugal
Prior art keywords: opt; substd; alkyl; dihydro; new
Prior art date: 1990-12-22

Application number

PT99901A

Other languages

English (en)

Other versions

PT99901B (pt

Inventor

Franz Josef Kuhn

Walter Losel

Otto Roos

Dietrich Arndts

Ilse Streller

Original Assignee

Boehringer Ingelheim Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-12-22

Filing date

1991-12-20

Publication date

1992-12-31

1991-12-20 Application filed by Boehringer Ingelheim Kg filed Critical Boehringer Ingelheim Kg

1992-12-31 Publication of PT99901A publication Critical patent/PT99901A/pt

1999-06-30 Publication of PT99901B publication Critical patent/PT99901B/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pretreatment Of Seeds And Plants (AREA)

PT99901A 1990-12-22 1991-12-20 Processo para preparacao de novos derivados da 3,4-dihidro-isoquinolina e de composicoes farmaceuticas que os contem PT99901B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4041482A DE4041482A1 (de)	1990-12-22	1990-12-22	Neue pharmazeutische verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine

Publications (2)

Publication Number	Publication Date
PT99901A true PT99901A (pt)	1992-12-31
PT99901B PT99901B (pt)	1999-06-30

Family

ID=6421218

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT99901A PT99901B (pt)	1990-12-22	1991-12-20	Processo para preparacao de novos derivados da 3,4-dihidro-isoquinolina e de composicoes farmaceuticas que os contem

Country Status (32)

Country	Link
US (3)	US6034094A (pt)
EP (2)	EP0563128B1 (pt)
JP (1)	JP3283877B2 (pt)
KR (1)	KR100227953B1 (pt)
AT (1)	ATE177948T1 (pt)
AU (1)	AU666107B2 (pt)
BR (1)	BR1100520A (pt)
CA (1)	CA2098917A1 (pt)
CZ (3)	CZ289533B6 (pt)
DE (3)	DE9017900U1 (pt)
DK (1)	DK0563128T3 (pt)
ES (1)	ES2129040T3 (pt)
FI (1)	FI105026B (pt)
GR (1)	GR3030341T3 (pt)
HR (1)	HRP940721B1 (pt)
HU (1)	HU217819B (pt)
ID (1)	ID16001A (pt)
IE (3)	IE990430A1 (pt)
IL (1)	IL100450A (pt)
MX (1)	MX9102765A (pt)
NO (1)	NO179515C (pt)
NZ (1)	NZ241140A (pt)
PL (1)	PL172262B1 (pt)
PT (1)	PT99901B (pt)
RU (2)	RU2149000C1 (pt)
SG (1)	SG43064A1 (pt)
SI (1)	SI9111975B (pt)
SK (1)	SK281017B6 (pt)
TW (1)	TW283145B (pt)
WO (1)	WO1992011010A1 (pt)
YU (1)	YU48063B (pt)
ZA (1)	ZA9110116B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0957092A1 (de) *	1992-06-22	1999-11-17	Boehringer Ingelheim Pharma KG	Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
DE4343683A1 (de) *	1993-12-21	1995-06-22	Boehringer Ingelheim Kg	Anellierte Dihydropyridine und deren Verwendung für die Herstellung von pharmazeutischen Zubereitungen
EP0736012B1 (de) *	1993-12-21	2000-11-22	Boehringer Ingelheim Pharma KG	Anellierte dihydropyridine und deren verwendung für die herstellung von pharmazeutischen zubereitungen
GB2341318A (en) *	1998-09-14	2000-03-15	Boehringer Ingelheim Pharma	A Dihydroisoquinoline (LOE 908) and Traumatic Brain Injury.
IT1318650B1 (it) *	2000-07-28	2003-08-27	Dompe Spa	1,3-diossolani ad attivita' antitosse.
ATE524146T1 (de) *	2002-02-11	2011-09-15	Gold T Tech Inc	Implantierbares gerät zur prävention von thrombusbildung
BRPI0408681A (pt) *	2003-03-26	2006-03-28	Actelion Pharmaceuticals Ltd	compostos, composições farmacêuticas, uso de um derivado da 1,2,3,4-tetraidroisoquinolina, método para tratar ou prevenir doenças, processo para a manufatura de composições farmacêuticas, e, uso de um ou mais compostos
RU2355686C2 (ru) *	2003-10-16	2009-05-20	Ф.Хоффманн-Ля Рош Аг	Ингибиторы глутаминфруктозо-6-фосфатамидотрансферазы
DE102004055633A1 (de) *	2004-11-12	2006-05-18	Schering Ag	5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
AU2008225922B2 (en) *	2007-03-15	2012-04-26	F. Hoffmann-La Roche Ag	Malonamides as orexin antagonists
CZ302637B6 (cs) *	2010-01-05	2011-08-10	Zentiva, K. S	Zpusob prípravy 6,7-dimethoxy-1-[2-(4-trifluormethylfenyl)ethyl]-3,4-dihydroisochinolinu
EP2420237A1 (en)	2010-08-11	2012-02-22	Ville Takio	Fluorinated derivatives of endogenous isoquinolines for use in the treatment of diseases mediated through endogenous isoquinoline pathways
KR101645930B1 (ko)	2014-12-16	2016-08-05	(주) 우수	타월 거치대

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3013906A1 (de) *	1980-04-11	1981-10-15	C.H. Boehringer Sohn, 6507 Ingelheim	Substituierte (alpha) -aminocarbonyl-l-benzyl-3,4-dihydro-isochinoline, verfahren zu deren herstellung und deren verwendung
DE3621413A1 (de) *	1986-06-26	1988-01-07	Boehringer Ingelheim Kg	Verwendung carbocyclisch und heterocyclisch annelierter dihydropyridine als cardioprotektive mittel sowie neue heterocyclisch und carbocyclisch anellierte dihydropyridine, verfahren zu deren herstellung und zwischenstufen fuer deren herstellung
IL86131A0 (en) *	1987-04-24	1988-11-15	Boehringer Ingelheim Kg	Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
DE3827727A1 (de) *	1988-08-16	1990-02-22	Boehringer Ingelheim Kg	Anellierte tetrahydropyridinessigsaeurederivate, verfahren zu deren herstellung und verwendung solcher verbindungen zur kardioprotektion

1990
- 1990-12-22 DE DE9017900U patent/DE9017900U1/de not_active Expired - Lifetime
- 1990-12-22 DE DE4041482A patent/DE4041482A1/de not_active Ceased
1991
- 1991-12-20 IE IE19990430A patent/IE990430A1/en unknown
- 1991-12-20 ES ES92901178T patent/ES2129040T3/es not_active Expired - Lifetime
- 1991-12-20 AT AT92901178T patent/ATE177948T1/de not_active IP Right Cessation
- 1991-12-20 DE DE59109115T patent/DE59109115D1/de not_active Expired - Fee Related
- 1991-12-20 DK DK92901178T patent/DK0563128T3/da active
- 1991-12-20 IE IE448691A patent/IE914486A1/en not_active Application Discontinuation
- 1991-12-20 SG SG1996003170A patent/SG43064A1/en unknown
- 1991-12-20 WO PCT/EP1991/002470 patent/WO1992011010A1/de active IP Right Grant
- 1991-12-20 IL IL10045091A patent/IL100450A/xx not_active IP Right Cessation
- 1991-12-20 EP EP92901178A patent/EP0563128B1/de not_active Expired - Lifetime
- 1991-12-20 RU RU94046320/14A patent/RU2149000C1/ru not_active IP Right Cessation
- 1991-12-20 EP EP96119881A patent/EP0781556A1/de not_active Withdrawn
- 1991-12-20 IE IE20001043A patent/IE20001043A1/en unknown
- 1991-12-20 PT PT99901A patent/PT99901B/pt not_active IP Right Cessation
- 1991-12-20 KR KR1019930701908A patent/KR100227953B1/ko not_active Expired - Fee Related
- 1991-12-20 JP JP50207392A patent/JP3283877B2/ja not_active Expired - Fee Related
- 1991-12-20 SK SK617-93A patent/SK281017B6/sk unknown
- 1991-12-20 HU HU9301820A patent/HU217819B/hu not_active IP Right Cessation
- 1991-12-20 CA CA002098917A patent/CA2098917A1/en not_active Abandoned
- 1991-12-20 RU RU93046319A patent/RU2115647C1/ru not_active IP Right Cessation
- 1991-12-20 PL PL91299674A patent/PL172262B1/pl unknown
- 1991-12-20 CZ CZ19931213A patent/CZ289533B6/cs not_active IP Right Cessation
- 1991-12-20 CZ CZ952846A patent/CZ284695A3/cs not_active IP Right Cessation
- 1991-12-20 AU AU90802/91A patent/AU666107B2/en not_active Ceased
- 1991-12-23 SI SI9111975A patent/SI9111975B/sl unknown
- 1991-12-23 TW TW080110028A patent/TW283145B/zh active
- 1991-12-23 YU YU197591A patent/YU48063B/sh unknown
- 1991-12-23 MX MX9102765A patent/MX9102765A/es not_active IP Right Cessation
- 1991-12-23 ZA ZA9110116A patent/ZA9110116B/xx unknown
- 1991-12-23 NZ NZ241140A patent/NZ241140A/en unknown
1993
- 1993-06-14 FI FI932709A patent/FI105026B/fi active
- 1993-06-21 NO NO932279A patent/NO179515C/no unknown
1994
- 1994-10-21 HR HRP-1975/91A patent/HRP940721B1/xx not_active IP Right Cessation
1995
- 1995-06-01 US US08/458,069 patent/US6034094A/en not_active Expired - Fee Related
- 1995-06-01 US US08/456,357 patent/US5665729A/en not_active Expired - Fee Related
- 1995-06-01 US US08/456,889 patent/US5686462A/en not_active Expired - Fee Related
1996
- 1996-05-27 CZ CZ19961523A patent/CZ289685B6/cs not_active IP Right Cessation
1997
- 1997-05-13 BR BR1100520-3A patent/BR1100520A/pt active IP Right Grant
- 1997-06-13 ID IDP972024A patent/ID16001A/id unknown
1999
- 1999-05-27 GR GR990401430T patent/GR3030341T3/el unknown

Also Published As

Publication number	Publication date
GR3030341T3 (en)	1999-09-30
CA2098917A1 (en)	1992-06-23
AU9080291A (en)	1992-07-22
ZA9110116B (en)	1992-08-26
FI932709A7 (fi)	1993-06-14
SI9111975A (en)	1997-06-30
CZ289685B6 (cs)	2002-03-13
NO179515B (no)	1996-07-15
ATE177948T1 (de)	1999-04-15
YU197591A (sh)	1994-06-24
RU2149000C1 (ru)	2000-05-20
KR930702973A (ko)	1993-11-29
JP3283877B2 (ja)	2002-05-20
NO932279L (no)	1993-06-21
SI9111975B (en)	2001-06-30
NO179515C (no)	1996-10-23
NO932279D0 (no)	1993-06-21
BR1100520A (pt)	2000-06-06
IE914486A1 (en)	1992-07-01
PL172262B1 (pl)	1997-08-29
IL100450A0 (en)	1992-09-06
WO1992011010A1 (de)	1992-07-09
EP0781556A1 (de)	1997-07-02
DE59109115D1 (de)	1999-04-29
DE9017900U1 (de)	1993-01-28
MX9102765A (es)	1994-03-31
US5686462A (en)	1997-11-11
HK1010683A1 (en)	1999-06-25
SG43064A1 (en)	1997-10-17
NZ241140A (en)	1997-06-24
PT99901B (pt)	1999-06-30
EP0563128B1 (de)	1999-03-24
ID16001A (id)	1997-08-21
JPH06504277A (ja)	1994-05-19
HRP940721A2 (en)	1996-12-31
KR100227953B1 (ko)	1999-11-01
AU666107B2 (en)	1996-02-01
CZ282454B6 (cs)	1997-07-16
FI105026B (fi)	2000-05-31
US5665729A (en)	1997-09-09
SK61793A3 (en)	1994-01-12
HU217819B (hu)	2000-04-28
ES2129040T3 (es)	1999-06-01
DE4041482A1 (de)	1992-06-25
HU9301820D0 (en)	1993-09-28
TW283145B (pt)	1996-08-11
CZ289533B6 (cs)	2002-02-13
IL100450A (en)	1997-01-10
CZ284695A3 (en)	1997-07-16
IE20001043A1 (en)	2001-05-30
EP0563128A1 (de)	1993-10-06
HRP940721B1 (en)	2000-02-29
SK281017B6 (sk)	2000-10-09
FI932709A0 (fi)	1993-06-14
US6034094A (en)	2000-03-07
HUT74639A (en)	1997-01-28
IE990430A1 (en)	2000-11-15
RU2115647C1 (ru)	1998-07-20
YU48063B (sh)	1996-10-18
DK0563128T3 (da)	1999-10-11
CZ121393A3 (en)	1994-02-16

Publication	Publication Date	Title
PT99901A (pt)	1992-12-31	Processo para preparacao de novos derivados da 3,4-dihidro-isoquinolina e de composicoes farmaceuticas que os contem
DE69022078D1 (de)	1995-10-12	Pyridazinon Derivate und Verfahren zur deren Herstellung.
PL313589A1 (en)	1996-07-08	Hydroxyl derivatives of compounds of azetidinone type useful as hypocholesterolaemic agents
IL100384A0 (en)	1992-09-06	Serotonin antagonists,their preparation and pharmaceutical compositions containing them
IL57577A0 (en)	1979-10-31	1,2-dihydroquinolin-2-one derivatives,process for their preparation and pharmaceutical compositions containing the same
ES8404349A1 (es)	1984-04-16	Un procedimiento para la prepracion de nuevas benzolactamas.
PT83277B (pt)	1989-03-30	Processo para a preparacao de carboxi-tiadiazois, -oxadiazois, -triazois, -tiadiazinas, -oxidiazinas e -triazinas, substituidos
YU22183A (en)	1986-02-28	Process for obtaiing new pyridyl derivatives
FI923540A0 (fi)	1992-08-06	Arylalkylaminer och -amider med antikonvulsiva och nervskyddande egenskaper.
DE3663660D1 (en)	1989-07-06	Û4.2.0¨bicyclooctane derivatives, process for their preparation and pharmaceutical compositions containing same
YU45642B (sh)	1992-07-20	Postupak za dobijanje 5-tiokso-2-imidazolinil benzoevih kiselina
YU47508B (sh)	1995-10-03	Novi feniletanolamino derivati i postupak za njihovo dobijanje
ES2031855T3 (es)	1993-01-01	Un metodo para preparar una composicion para reducir la presion intraocular en mamiferos.
FI844940A0 (fi)	1984-12-13	1,5-bensoxatiepinderivat, deras framstaellning och anvaendning.
SE8103325L (sv)	1981-11-28	Kardiotoniska aminofenylpyridinderivat och framstellning derav
PT87954A (pt)	1989-06-30	Processo para a preparacao de composicoes farmaceuticas contendo derivados de dioxopiperidina, com efeito antipsicotico
ES8502972A1 (es)	1985-02-01	Procedimiento para la preparacion de esteres piridincarboxilicos de dipamina y de sus derivados n-alquilicos.
YU153590A (sh)	1993-05-28	Derivati indola
HUT63836A (en)	1993-10-28	Process for producing acridine derivatives
BR9706491A (pt)	1999-05-18	Compostos de elipticina processo para a sua preparação e composições farmacêuticas contendo os mesmos
FI870098A0 (fi)	1987-01-12	Nya pregnanderivat, foerfaranden foer deras framstaellning och farmaceutiska preparat, vilka innehaoller desamma.

Legal Events

Date	Code	Title	Description
1992-12-31	BB1A	Laying open of patent application	Effective date: 19920814
1999-06-30	FG3A	Patent granted, date of granting	Effective date: 19990302
2003-12-31	MM3A	Annulment or lapse	Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20030930

Date

Code

Title

Description

1992-12-31

BB1A

Laying open of patent application

Effective date: 19920814

1999-06-30

FG3A

Patent granted, date of granting

Effective date: 19990302

2003-12-31

MM3A

Annulment or lapse

Free format text: LAPSE DUE TO NON-PAYMENT OF FEES

Effective date: 20030930