[go: up one dir, main page]

SI1781662T1 - Zaviralci RNA-odvisne RNA-polimeraze hepatitisa C in sestavki in zdravljenja, v katerih se uporabljajo - Google Patents

Zaviralci RNA-odvisne RNA-polimeraze hepatitisa C in sestavki in zdravljenja, v katerih se uporabljajo

Info

Publication number
SI1781662T1
SI1781662T1 SI200531314T SI200531314T SI1781662T1 SI 1781662 T1 SI1781662 T1 SI 1781662T1 SI 200531314 T SI200531314 T SI 200531314T SI 200531314 T SI200531314 T SI 200531314T SI 1781662 T1 SI1781662 T1 SI 1781662T1
Authority
SI
Slovenia
Prior art keywords
hepatitis
treatments
inhibitors
compositions
same
Prior art date
Application number
SI200531314T
Other languages
English (en)
Inventor
Javier Gonzalez
Tanya Michelle Jewell
Hui Li
Angelica Linton
John Howard Tatlock
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SI1781662T1 publication Critical patent/SI1781662T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI200531314T 2004-08-18 2005-08-05 Zaviralci RNA-odvisne RNA-polimeraze hepatitisa C in sestavki in zdravljenja, v katerih se uporabljajo SI1781662T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60261804P 2004-08-18 2004-08-18
EP05775853A EP1781662B1 (en) 2004-08-18 2005-08-05 Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same
PCT/IB2005/002697 WO2006018725A1 (en) 2004-08-18 2005-08-05 Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same

Publications (1)

Publication Number Publication Date
SI1781662T1 true SI1781662T1 (sl) 2011-07-29

Family

ID=35429645

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200531314T SI1781662T1 (sl) 2004-08-18 2005-08-05 Zaviralci RNA-odvisne RNA-polimeraze hepatitisa C in sestavki in zdravljenja, v katerih se uporabljajo

Country Status (42)

Country Link
US (3) US7151105B2 (sl)
EP (1) EP1781662B1 (sl)
JP (1) JP4372195B2 (sl)
KR (1) KR100851178B1 (sl)
CN (2) CN101006092B (sl)
AP (1) AP2313A (sl)
AR (1) AR050699A1 (sl)
AT (1) ATE506364T1 (sl)
AU (1) AU2005273619B2 (sl)
BR (1) BRPI0514425A (sl)
CA (1) CA2577525C (sl)
CR (2) CR8935A (sl)
CY (1) CY1111480T1 (sl)
DE (1) DE602005027580D1 (sl)
DK (1) DK1781662T3 (sl)
EA (1) EA012605B1 (sl)
EC (1) ECSP077264A (sl)
ES (1) ES2361845T3 (sl)
GE (2) GEP20094751B (sl)
GT (1) GT200500221A (sl)
HN (1) HN2005000449A (sl)
HR (1) HRP20110458T1 (sl)
IL (2) IL180933A (sl)
MA (1) MA28803B1 (sl)
MX (1) MX2007001527A (sl)
MY (1) MY146123A (sl)
NI (1) NI200700043A (sl)
NL (1) NL1029755C2 (sl)
NO (1) NO20071274L (sl)
NZ (1) NZ552874A (sl)
PE (1) PE20060677A1 (sl)
PL (1) PL1781662T3 (sl)
PT (1) PT1781662E (sl)
RS (1) RS51794B (sl)
SI (1) SI1781662T1 (sl)
SV (1) SV2007002202A (sl)
TN (1) TNSN07066A1 (sl)
TW (1) TWI376379B (sl)
UA (1) UA88909C2 (sl)
UY (1) UY29068A1 (sl)
WO (1) WO2006018725A1 (sl)
ZA (1) ZA200700779B (sl)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1781662T1 (sl) * 2004-08-18 2011-07-29 Pfizer Zaviralci RNA-odvisne RNA-polimeraze hepatitisa C in sestavki in zdravljenja, v katerih se uporabljajo
BRPI0615016A2 (pt) * 2005-08-24 2011-05-03 Pfizer compostos inibidores de hcv polimerase, métodos para prepará-los e forma cristalina
EP2142215B1 (en) 2007-05-04 2012-03-07 Vertex Pharmceuticals Incorporated Combination therapy for the treatment of hcv infection
EP2008996A1 (en) * 2007-06-27 2008-12-31 Syngeta Participations AG Process for the production of pyrazoles
JP5820722B2 (ja) 2008-06-06 2015-11-24 スシネキス インク シクロスポリン類似体及びhcv感染の治療におけるその使用
PL2320905T3 (pl) 2008-08-11 2018-04-30 Glaxosmithkline Llc Nowe pochodne adeniny
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
US20110135671A1 (en) 2008-08-11 2011-06-09 Glaxosmithkline Llc Purine derivatives for use in the treatment of allergic, inflammatory and infectious diseases
UY32940A (es) 2009-10-27 2011-05-31 Bayer Cropscience Ag Amidas sustituidas con halogenoalquilo como insecticidas y acaricidas
KR20120106942A (ko) 2009-10-30 2012-09-27 베링거 인겔하임 인터내셔날 게엠베하 Bi201335, 인터페론 알파 및 리바비린을 포함하는 hcv 병용 치료요법을 위한 투여 용법
EP2325173A1 (de) 2009-11-19 2011-05-25 Bayer CropScience AG Verfahren zum Herstellen von 5-Fluor-1-alkyl-3-fluoralkyl-1H-pyrazol-4-carbonsäurechloriden
JP5536229B2 (ja) * 2009-12-18 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Hcv併用療法
PL2534149T3 (pl) 2010-02-10 2015-03-31 Glaxosmithkline Llc Maleinian 6-amino-2-{[(1s)-1-metylobutylo]oksy}-9-[5-(1-piperydynylo)pentylo]-7,9-dihydro-8h-puryn-8-onu
EP2534148A1 (en) 2010-02-10 2012-12-19 GlaxoSmithKline LLC Purine derivatives and their pharmaceutical uses
EP2571854B1 (en) * 2010-05-20 2014-11-05 Bayer Intellectual Property GmbH Method for manufacturing 1-alkyl-3-difluormethyl-5-hydroxypyrazoles
US8987307B2 (en) 2011-03-03 2015-03-24 Hoffmann-La Roche Inc. 3-amino-pyridines as GPBAR1 agonists
FR2972452B1 (fr) * 2011-03-09 2013-03-15 Rhodia Operations Procede de preparation du difluoroacetonitrile et de ses derives
WO2013171134A1 (de) 2012-05-14 2013-11-21 Bayer Cropscience Ag Verfahren zum herstellen von 1-alkyl-3-fluoralkyl-1h-pyrazol-4-carbonsäurechloriden
US9657024B2 (en) 2012-11-21 2017-05-23 Stategics, Inc. Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival
TWI597270B (zh) 2013-01-17 2017-09-01 拜耳作物科學公司 製備5-氟-1-甲基-3-二氟甲基-1h-吡唑-4-甲醛的方法
US9487489B2 (en) 2013-02-06 2016-11-08 Bayer Cropscience Aktiengesellschaft Halogen-substituted pyrazole derivatives as pest-control agents
MX2016008653A (es) 2014-01-03 2016-09-26 Bayer Animal Health Gmbh Nuevas pirazolil-heteroarilamidas como agentes plaguicidas.
JP6462703B2 (ja) 2014-01-24 2019-01-30 バイエル・クロップサイエンス・アクチェンゲゼルシャフト 1−アルキル−3−ジフルオロメチル−5−フルオロ−1h−ピラゾール−4−カルバルデヒド類及び1−アルキル−3−ジフルオロメチル−5−フルオロ−1h−ピラゾール−4−カルボキシレート類を調製する方法
JP6452711B2 (ja) 2014-02-20 2019-01-16 グラクソスミスクライン、インテレクチュアル、プロパティー、(ナンバー2)、リミテッドGlaxosmithkline Intellectual Property (No.2) Limited ヒトインターフェロンの誘導物質としてのピロロ[3,2]ピリミジン誘導体
KR101906031B1 (ko) 2014-06-03 2018-10-08 이도르시아 파마슈티컬스 리미티드 피라졸 화합물 및 t-형 칼슘 채널 차단제로서의 이의 용도
JP2017533925A (ja) 2014-11-13 2017-11-16 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム アレルギー性疾患又は他の炎症状態の治療に有用なアデニン誘導体
WO2017093180A1 (de) 2015-12-01 2017-06-08 Bayer Cropscience Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
AU2016362697B2 (en) 2015-12-03 2018-07-12 Glaxosmithkline Intellectual Property Development Limited Cyclic purine dinucleotides as modulators of STING
EA201892128A1 (ru) 2016-04-07 2019-04-30 Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед Гетероциклические амиды, полезные в качестве модуляторов
JP6746712B2 (ja) 2016-04-07 2020-08-26 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited タンパク質調節因子として有用な複素環式アミド
EP3497102B1 (de) 2016-08-15 2022-12-07 Bayer CropScience Aktiengesellschaft Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel
EP3301094A1 (en) * 2016-09-30 2018-04-04 Mutabilis Heterocyclic compounds and their use in preventing or treating bacterial infections
HRP20220463T1 (hr) 2016-12-16 2022-05-27 Idorsia Pharmaceuticals Ltd Farmaceutska kombinacija koja sadrži blokator kalcijevih kanala t-tipa
EP3577099B1 (en) 2017-02-06 2024-01-24 Idorsia Pharmaceuticals Ltd A novel process for the synthesis of 1-aryl-1-trifluoromethylcyclopropanes
KR102622644B1 (ko) 2017-10-04 2024-01-10 바이엘 악티엔게젤샤프트 해충 방제제로서의 헤테로시클릭 화합물의 유도체
WO2019069269A1 (en) 2017-10-05 2019-04-11 Glaxosmithkline Intellectual Property Development Limited INTERFERON GENE STIMULATOR MODULATORS USEFUL IN THE TREATMENT OF HIV
EP3692034A1 (en) 2017-10-05 2020-08-12 GlaxoSmithKline Intellectual Property Development Limited Modulators of stimulator of interferon genes (sting)
JP2021517148A (ja) 2018-03-12 2021-07-15 バイエル・アクチエンゲゼルシヤフト 有害生物防除剤としての縮合二環式ヘテロ環式誘導体
US20210169080A1 (en) 2018-04-20 2021-06-10 Bayer Aktiengesellschaft Heterocycle derivatives as pesticides
GB201807924D0 (en) 2018-05-16 2018-06-27 Ctxt Pty Ltd Compounds
WO2020151589A1 (zh) 2019-01-25 2020-07-30 北京赛特明强医药科技有限公司 酰胺基桥连杂环类化合物、及其组合物与应用
CN114302875A (zh) 2019-05-16 2022-04-08 斯汀塞拉股份有限公司 氧代吖啶基乙酸衍生物及使用方法
JP2022533194A (ja) 2019-05-16 2022-07-21 スティングセラ インコーポレイテッド ベンゾ[b][1,8]ナフチリジン酢酸誘導体および使用方法
GB201910304D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
GB201910305D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
WO2021119753A1 (en) 2019-12-18 2021-06-24 Ctxt Pty Limited Compounds
US12274700B1 (en) 2020-10-30 2025-04-15 Accencio LLC Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors
CN112194620B (zh) * 2020-12-04 2021-02-26 苏州开元民生科技股份有限公司 一种2-乙基-4-氰基吡啶的制备方法
CN113563167B (zh) * 2021-07-16 2023-09-08 南通华祥医药科技有限公司 一种2-甲基-1-四氢萘酮的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786063A (en) * 1971-05-24 1974-01-15 Universal Oil Prod Co Thiazolethiosulfonates
DE2155360C3 (de) * 1971-11-08 1980-04-03 Cassella Ag, 6000 Frankfurt Verfahren zur Herstellung von Acylbernsteinsäuredialkylestern
CA1140049A (en) * 1977-12-22 1983-01-25 Dke J.E. Helgstran Pharmaceutical preparations from derivatives of hydroxycarbonylphosphonic acid
US4326058A (en) * 1979-02-05 1982-04-20 Sumitomo Chemical Company, Limited Organo-phosphoric esters and their production and use
US4489077A (en) * 1983-03-23 1984-12-18 Warner-Lambert Company 3-Isoxa-zolyl-2H-1,2-benzothiazine-3-carboxamide, 1,1-dioxides
US6174868B1 (en) * 1992-09-10 2001-01-16 Isis Pharmaceuticals, Inc. Compositions and methods for treatment of hepatitis C virus-associated diseases
AU688344B2 (en) * 1993-07-19 1998-03-12 Mitsubishi-Tokyo Pharmaceuticals, Inc. Hepatitis C virus proliferation inhibitor
US6005103A (en) * 1993-11-19 1999-12-21 Warner-Lambert Company Pyrone derivatives as protease inhibitors and antiviral agents
EP0729463B1 (en) 1993-11-19 2002-05-22 PARKE DAVIS & COMPANY 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
RU2140917C1 (ru) 1993-11-19 1999-11-10 Парк, Дэвис энд Компани Производные 5,6-дигидропирона и фармацевтическая композиция на их основе
US5504104A (en) * 1993-11-19 1996-04-02 Warner-Lambert Company Tricyclic pyrone derivatives as protease inhibitors and antiviral agents
US5840751A (en) * 1993-11-19 1998-11-24 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US5834506A (en) * 1996-11-01 1998-11-10 Warner-Lambert Company Dihydropyrones with improved antiviral activity
CA2339275A1 (en) * 1998-09-11 2000-03-23 Warner-Lambert Company 5,6-dihydro-4-hydroxy-2-pyranones as hiv aspartyl protease inhibitors
US6512006B1 (en) * 1999-12-09 2003-01-28 Warner-Lambert Company HIV protease inhibitors
EP1256628A3 (en) 2001-05-10 2003-03-19 Agouron Pharmaceuticals, Inc. Hepatitis c virus (hcv) ns5b rna polymerase and mutants thereof
DOP2003000641A (es) * 2002-05-10 2003-11-15 Pfizer Inhibidores de las arn polimerasa dependiente de arn del virus de las hepatitis c y composiciones y tratamiento que los usan
US7148226B2 (en) * 2003-02-21 2006-12-12 Agouron Pharmaceuticals, Inc. Inhibitors of hepatitis C virus RNA-dependent RNA polymerase, and compositions and treatments using the same
SI1781662T1 (sl) * 2004-08-18 2011-07-29 Pfizer Zaviralci RNA-odvisne RNA-polimeraze hepatitisa C in sestavki in zdravljenja, v katerih se uporabljajo

Also Published As

Publication number Publication date
US20090281122A1 (en) 2009-11-12
PL1781662T3 (pl) 2011-08-31
RS51794B (en) 2011-12-31
TWI376379B (en) 2012-11-11
JP2008509984A (ja) 2008-04-03
US20060122399A1 (en) 2006-06-08
CN101538268A (zh) 2009-09-23
CY1111480T1 (el) 2015-08-05
EA200700338A1 (ru) 2007-08-31
GT200500221A (es) 2006-06-21
AP2313A (en) 2011-10-31
CA2577525C (en) 2010-03-30
KR100851178B1 (ko) 2008-08-08
UA88909C2 (ru) 2009-12-10
EP1781662B1 (en) 2011-04-20
DK1781662T3 (da) 2011-06-27
NL1029755A1 (nl) 2006-02-21
AR050699A1 (es) 2006-11-15
ATE506364T1 (de) 2011-05-15
IL180933A (en) 2011-08-31
AU2005273619B2 (en) 2009-05-28
NI200700043A (es) 2008-01-02
AP2007003918A0 (en) 2007-02-28
DE602005027580D1 (de) 2011-06-01
HN2005000449A (es) 2009-10-30
CR20110153A (es) 2011-04-26
CN101006092A (zh) 2007-07-25
EP1781662A1 (en) 2007-05-09
EA012605B1 (ru) 2009-10-30
ES2361845T3 (es) 2011-06-22
CN101538268B (zh) 2011-07-27
US7151105B2 (en) 2006-12-19
TW200612898A (en) 2006-05-01
GEP20115305B (en) 2011-10-10
AU2005273619A1 (en) 2006-02-23
ZA200700779B (en) 2008-11-26
PE20060677A1 (es) 2006-08-11
CR8935A (es) 2007-07-24
MA28803B1 (fr) 2007-08-01
CA2577525A1 (en) 2006-02-23
US20070015764A1 (en) 2007-01-18
HK1109617A1 (en) 2008-06-13
ECSP077264A (es) 2007-04-26
US7622605B2 (en) 2009-11-24
KR20070044057A (ko) 2007-04-26
NZ552874A (en) 2010-04-30
WO2006018725A1 (en) 2006-02-23
JP4372195B2 (ja) 2009-11-25
CN101006092B (zh) 2013-04-17
PT1781662E (pt) 2011-07-01
NO20071274L (no) 2007-05-14
UY29068A1 (es) 2006-03-31
BRPI0514425A (pt) 2008-06-10
GEP20094751B (en) 2009-08-10
IL192919A0 (en) 2009-02-11
MY146123A (en) 2012-06-29
SV2007002202A (es) 2007-03-20
NL1029755C2 (nl) 2006-10-18
HRP20110458T1 (hr) 2011-07-31
MX2007001527A (es) 2007-03-27
US8268835B2 (en) 2012-09-18
IL180933A0 (en) 2007-07-04
TNSN07066A1 (fr) 2008-06-02

Similar Documents

Publication Publication Date Title
IL180933A0 (en) Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same
AU2003224371A1 (en) Inhibitors of hepatitis c virus rna-dependent rna polymerase, and compositions and treatments using the same
WO2007140200A3 (en) Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors
WO2007140254A3 (en) Cyclopropyl fused indolobenzazepine hcv ns5b inhibitors
WO2007092888A3 (en) Hcv ns5b inhibitors
AP2406A (en) Macrocydic inhibitors of hepatitis C virus.
NL1025544A1 (nl) Remmers van rna-afhankelijk rna-polymerase van hepatitis-c-virus en preparaten en behandelingen waarbij ze worden gebruikt.
WO2004073599A3 (en) Inhibitors of hepatitis c virus, compositions and treatments using the same
SI1414441T1 (sl) Inhibitorji polimeraze virusa hepatitisa c, ki imajo heterobicikliäśno strukturo
IL198248A0 (en) Hepatitis c virus inhibitors and compositions comprising the same
AU2002252183A1 (en) Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases
AU2003256619A8 (en) Thionucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
HUP0400726A3 (en) Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
EP1684787A4 (en) INHIBITORS OF HEPATITIS C VIRUS
TW200745035A (en) Cyclopropyl fused indolobenzazepine HCV NS5B inhibitors
WO2007092645A3 (en) Novel hcv inhibitor combinations and methods
TW200745120A (en) Indolobenzazepine HCV NS5B inhibitors
IL182583A0 (en) 4-methoxymethyl-pyrrolidine-2-carboxylic acid compounds and derivatives thereof as hepatitis c virus inhibitors
MX2010005226A (es) Inhibidores de ns5b de hcv de indolobenzazepina fusionados a ciclopropilo.
WO2009029384A3 (en) Compounds for the treatment of hepatitis c
WO2005034850A3 (en) Cycloalkyl heterocycles for treating hepatitis c virus
ZA200701674B (en) Vaccine composition against Hepatitis C virus
HUE026600T2 (hu) Készítmények és eljárások virális hepatitis kezelésére
EP1711516A4 (en) RNA POLYMERASE DEPENDENT OF HCV RNA
AP2387A (en) Macrocyclic inhibitors of hepatitis C virus.