TNSN98035A1 - Atropisomeres de 3-aryl-4(3h)-quinazolinones, procede pour leur preparation et compositions les contenant - Google Patents
Atropisomeres de 3-aryl-4(3h)-quinazolinones, procede pour leur preparation et compositions les contenantInfo
- Publication number
- TNSN98035A1 TNSN98035A1 TNTNSN98035A TNSN98035A TNSN98035A1 TN SN98035 A1 TNSN98035 A1 TN SN98035A1 TN TNSN98035 A TNTNSN98035 A TN TNSN98035A TN SN98035 A TNSN98035 A TN SN98035A TN SN98035 A1 TNSN98035 A1 TN SN98035A1
- Authority
- TN
- Tunisia
- Prior art keywords
- preparation
- compositions containing
- quinazolinones
- atropisomers
- aryl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000014674 injury Diseases 0.000 abstract 1
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000008733 trauma Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Adhesives Or Adhesive Processes (AREA)
Abstract
L'INVENTION CONCERNE UN ATROPISOMERE DE FORMULE DANS LAQUELLE R2,R3,R5,R6,R7 et R8 REPRESENTENT DIVERS RADICAUX ELLE CONCERNE EGALEMENT UN PROCEDE POUR SA PREPARATION ET DES COMPOSITIONS PHARMACEUTIQUES LE CONTENANT APPLICATION : UTILISATION DE CES COMPOSES ET COMPOSITIONS POUR LE TRAITEMENT DE MALADIES NEURODEGENERATIVES ET D'AFFECTIONS LIEES A UN TRAUMATISME DU SYSTEME NERVEUX CENTRAL.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3890597P | 1997-02-28 | 1997-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TNSN98035A1 true TNSN98035A1 (fr) | 2005-03-15 |
Family
ID=21902563
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TNTNSN98035A TNSN98035A1 (fr) | 1997-02-28 | 1998-02-25 | Atropisomeres de 3-aryl-4(3h)-quinazolinones, procede pour leur preparation et compositions les contenant |
Country Status (40)
| Country | Link |
|---|---|
| US (1) | US6306864B1 (fr) |
| EP (1) | EP0968194B1 (fr) |
| JP (1) | JP2000509731A (fr) |
| KR (1) | KR100358636B1 (fr) |
| CN (1) | CN1248248A (fr) |
| AP (1) | AP859A (fr) |
| AR (1) | AR011170A1 (fr) |
| AT (1) | ATE267817T1 (fr) |
| AU (1) | AU744028B2 (fr) |
| BG (1) | BG103689A (fr) |
| BR (1) | BR9807872A (fr) |
| CA (1) | CA2282277C (fr) |
| DE (1) | DE69824157T2 (fr) |
| DK (1) | DK0968194T3 (fr) |
| DZ (1) | DZ2440A1 (fr) |
| EA (1) | EA001963B1 (fr) |
| ES (1) | ES2219866T3 (fr) |
| GT (1) | GT199800038A (fr) |
| HR (1) | HRP980106A2 (fr) |
| HU (1) | HUP0000914A3 (fr) |
| ID (1) | ID22711A (fr) |
| IL (1) | IL130900A0 (fr) |
| IS (1) | IS1952B (fr) |
| MA (1) | MA24484A1 (fr) |
| NO (1) | NO313630B1 (fr) |
| NZ (1) | NZ336628A (fr) |
| OA (1) | OA11089A (fr) |
| PA (1) | PA8447001A1 (fr) |
| PE (1) | PE58399A1 (fr) |
| PL (1) | PL335418A1 (fr) |
| PT (1) | PT968194E (fr) |
| SK (1) | SK113299A3 (fr) |
| TN (1) | TNSN98035A1 (fr) |
| TR (1) | TR199902093T2 (fr) |
| TW (1) | TW504508B (fr) |
| UA (1) | UA61097C2 (fr) |
| UY (1) | UY24897A1 (fr) |
| WO (1) | WO1998038173A1 (fr) |
| YU (1) | YU41299A (fr) |
| ZA (1) | ZA981666B (fr) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2198546T3 (es) | 1996-05-15 | 2004-02-01 | Pfizer Inc. | 4(3h)-quinazolinonas 2,3,6 trisustituidas. |
| US6323208B1 (en) * | 1997-09-05 | 2001-11-27 | Pfizer Inc | Atropisomers of 2,3-disubstituted-(5.6)-heteroaryl fused-pyrimidin-4-ones |
| JPH11279158A (ja) * | 1998-02-09 | 1999-10-12 | Pfizer Prod Inc | キナゾリン―４―オン誘導体の製造方法 |
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| JP4642309B2 (ja) * | 2000-04-25 | 2011-03-02 | イコス・コーポレイション | ヒトホスファチジル−イノシトール３−キナーゼデルタの阻害剤 |
| DK1300396T3 (da) | 2000-06-12 | 2009-04-06 | Eisai R&D Man Co Ltd | 1,2-dihydropyridinforbindelser, fremgangsmåde til fremstilling deraf og anvendelse deraf |
| BRPI0113331B8 (pt) | 2000-08-18 | 2021-05-25 | Ajinomoto Kk | derivados de fenilalanina ou seus sais parmaceuticamente aceitáveis, antagonista de integrina alfa 4, agente terapêutico ou agente preventivo para doenças inflamatórias, e, composição farmacêutica |
| GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
| US6939968B2 (en) * | 2002-12-23 | 2005-09-06 | Bristol-Myers Squibb Company | Atropisomers of 3-substituted-4-arylquinolin-2-one derivatives |
| WO2005014585A1 (fr) * | 2003-08-08 | 2005-02-17 | Ulysses Pharmaceutical Products Inc. | Quinazolinyl nitrofuranes halogenes utilises comme agents antibacteriens |
| US20080146562A1 (en) * | 2003-08-08 | 2008-06-19 | Ulysses Pharmaceutical Products Inc., | Halogenated quinazolinyl nitrofurans as antibacterial agents |
| GB0325390D0 (en) * | 2003-10-30 | 2003-12-03 | Novartis Ag | Organic compounds |
| AU2004303696B2 (en) | 2003-12-22 | 2011-03-31 | Ea Pharma Co., Ltd. | Novel phenylalanine derivative |
| ES2873875T3 (es) | 2004-05-13 | 2021-11-04 | Icos Corp | Quinazolinonas como inhibidores de fosfatidilinositol 3-quinasa delta humano |
| MY148809A (en) | 2004-07-06 | 2013-05-31 | Eisai R&D Man Co Ltd | Crystals of 1,2-dihydropyridine compound and their production process |
| GB0416730D0 (en) * | 2004-07-27 | 2004-09-01 | Novartis Ag | Organic compounds |
| CA2628441A1 (fr) | 2005-11-04 | 2007-05-18 | Hydra Biosciences, Inc. | Composes destines a moduler la fonction de trpv3 |
| AU2007303846B2 (en) | 2006-10-04 | 2011-03-10 | Pfizer Products Inc. | Pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as calcium receptor antagonists |
| WO2008140750A1 (fr) | 2007-05-10 | 2008-11-20 | Hydra Biosciences Inc. | Composés modulant la fonction du trp v3 |
| CN101429166B (zh) * | 2007-11-07 | 2013-08-21 | 上海特化医药科技有限公司 | 喹唑啉酮衍生物及其制备方法和用途 |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| SG195655A1 (en) | 2008-11-13 | 2013-12-30 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| SG174529A1 (en) | 2009-03-24 | 2011-10-28 | Gilead Calistoga Llc | Atropisomers of2-purinyl-3-tolyl-quinazolinone derivatives and methods of use |
| EP2456443A1 (fr) | 2009-07-21 | 2012-05-30 | Gilead Calistoga LLC | Traitement de troubles du foie par des inhibiteurs de pi3k |
| WO2013134288A1 (fr) | 2012-03-05 | 2013-09-12 | Gilead Calistoga Llc | Formes polymorphes de l'acide -2-(1-(9h-purine-6-ylamino)propyl)-5-fluoro-3-phénylquinazolin-4(3h)-one |
| CN103275086B (zh) * | 2013-05-30 | 2015-04-15 | 温州大学 | 一种6-取代喹唑啉并喹唑啉酮化合物及其合成方法和用途 |
| SI3083630T1 (sl) | 2013-12-20 | 2019-11-29 | Gilead Calistoga Llc | Postopek sinteze inhibitorjev fosfatidilinozitol 3-kinaze |
| EP3083623A1 (fr) | 2013-12-20 | 2016-10-26 | Gilead Calistoga LLC | Formes polymorphes d'un sel chlorhydrate de la (s)-2-(9h-purine-6-ylamino)propyl)-5-fluoro-3-phénylquinazolin-4(3h)-one |
| US9533909B2 (en) | 2014-03-31 | 2017-01-03 | Corning Incorporated | Methods and apparatus for material processing using atmospheric thermal plasma reactor |
| CN106459005A (zh) | 2014-06-13 | 2017-02-22 | 吉利德科学公司 | 磷脂酰肌醇3‑激酶抑制剂 |
| DE102014217021A1 (de) * | 2014-08-27 | 2016-03-03 | Skf Lubrication Systems Germany Ag | Gehäuse für eine Vorrichtung zum dosierten Verteilen eines Mediums sowie eine Dosiereinrichtung zur Verwendung in dem Gehäuse |
| US12303499B2 (en) | 2018-12-14 | 2025-05-20 | Eisai R&D Management Co., Ltd. | Aqueous based pharmaceutical formulations of 1,2-dihydropyridine compounds |
| WO2021154966A1 (fr) | 2020-01-29 | 2021-08-05 | Kamari Pharma Ltd. | Composés et compositions pour leur utilisation dans le traitement de troubles cutanés |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1195321B (de) * | 1962-03-16 | 1965-06-24 | Troponwerke Dinklage & Co | Verfahren zur Herstellung von substituierten Chinazolon-(4)-derivaten |
| DE1670416A1 (de) * | 1966-12-30 | 1971-02-11 | Chem Fab Von Heyden Gmbh Muenc | Verfahren zur Herstellung von aminosubstituierten Chinazolinonderivaten |
| GB1298603A (en) * | 1970-04-06 | 1972-12-06 | Karamchand Premchand Private | Quinazolinone derivatives |
| US4183931A (en) * | 1977-09-08 | 1980-01-15 | Research Corporation | 2-Ketoalkyl-4(3H)-quinazolinones |
| GB9022785D0 (en) * | 1990-10-19 | 1990-12-05 | Merck Sharp & Dohme | Therapeutic agents |
| WO1992013535A1 (fr) * | 1991-02-06 | 1992-08-20 | Research Corporation Technologies, Inc. | Quinazolones substituees a activite anticonvulsivante |
| US5777271A (en) * | 1996-01-18 | 1998-07-07 | Commscope, Inc. | Cable having an at least partially oxidized armor layer |
| ES2198546T3 (es) * | 1996-05-15 | 2004-02-01 | Pfizer Inc. | 4(3h)-quinazolinonas 2,3,6 trisustituidas. |
-
1998
- 1998-02-06 KR KR1019997007887A patent/KR100358636B1/ko not_active Expired - Fee Related
- 1998-02-06 PT PT98900978T patent/PT968194E/pt unknown
- 1998-02-06 TR TR1999/02093T patent/TR199902093T2/xx unknown
- 1998-02-06 EP EP98900978A patent/EP0968194B1/fr not_active Expired - Lifetime
- 1998-02-06 IL IL13090098A patent/IL130900A0/xx unknown
- 1998-02-06 YU YU41299A patent/YU41299A/sh unknown
- 1998-02-06 BR BR9807872A patent/BR9807872A/pt not_active Application Discontinuation
- 1998-02-06 CA CA002282277A patent/CA2282277C/fr not_active Expired - Fee Related
- 1998-02-06 NZ NZ336628A patent/NZ336628A/xx unknown
- 1998-02-06 AT AT98900978T patent/ATE267817T1/de not_active IP Right Cessation
- 1998-02-06 AU AU56768/98A patent/AU744028B2/en not_active Ceased
- 1998-02-06 PL PL98335418A patent/PL335418A1/xx unknown
- 1998-02-06 DK DK98900978T patent/DK0968194T3/da active
- 1998-02-06 CN CN98802638A patent/CN1248248A/zh active Pending
- 1998-02-06 WO PCT/IB1998/000150 patent/WO1998038173A1/fr not_active Application Discontinuation
- 1998-02-06 SK SK1132-99A patent/SK113299A3/sk unknown
- 1998-02-06 EA EA199900693A patent/EA001963B1/ru not_active IP Right Cessation
- 1998-02-06 US US09/367,960 patent/US6306864B1/en not_active Expired - Fee Related
- 1998-02-06 JP JP10537448A patent/JP2000509731A/ja active Pending
- 1998-02-06 DE DE69824157T patent/DE69824157T2/de not_active Expired - Fee Related
- 1998-02-06 ES ES98900978T patent/ES2219866T3/es not_active Expired - Lifetime
- 1998-02-06 ID IDW990937A patent/ID22711A/id unknown
- 1998-02-06 HU HU0000914A patent/HUP0000914A3/hu unknown
- 1998-02-17 PA PA19988447001A patent/PA8447001A1/es unknown
- 1998-02-19 GT GT199800038A patent/GT199800038A/es unknown
- 1998-02-20 UY UY24897A patent/UY24897A1/es not_active Application Discontinuation
- 1998-02-23 PE PE1998000126A patent/PE58399A1/es not_active Application Discontinuation
- 1998-02-25 TW TW087102714A patent/TW504508B/zh not_active IP Right Cessation
- 1998-02-25 DZ DZ980050A patent/DZ2440A1/fr active
- 1998-02-25 MA MA24978A patent/MA24484A1/fr unknown
- 1998-02-25 TN TNTNSN98035A patent/TNSN98035A1/fr unknown
- 1998-02-26 AP APAP/P/1998/001199A patent/AP859A/en active
- 1998-02-26 AR ARP980100871A patent/AR011170A1/es not_active Application Discontinuation
- 1998-02-27 ZA ZA9801666A patent/ZA981666B/xx unknown
- 1998-02-27 HR HR60/038,905A patent/HRP980106A2/hr not_active Application Discontinuation
- 1998-06-02 UA UA99084849A patent/UA61097C2/uk unknown
-
1999
- 1999-07-30 IS IS5140A patent/IS1952B/is unknown
- 1999-08-20 OA OA9900187A patent/OA11089A/en unknown
- 1999-08-24 BG BG103689A patent/BG103689A/bg unknown
- 1999-08-27 NO NO19994177A patent/NO313630B1/no not_active IP Right Cessation
Also Published As
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