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WO1992012733A1 - Procede d'elimination de l''odeur de verrat' de la viande - Google Patents

Procede d'elimination de l''odeur de verrat' de la viande Download PDF

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Publication number
WO1992012733A1
WO1992012733A1 PCT/NL1992/000021 NL9200021W WO9212733A1 WO 1992012733 A1 WO1992012733 A1 WO 1992012733A1 NL 9200021 W NL9200021 W NL 9200021W WO 9212733 A1 WO9212733 A1 WO 9212733A1
Authority
WO
WIPO (PCT)
Prior art keywords
male pigs
meat
immunisation
gnrh
carried out
Prior art date
Application number
PCT/NL1992/000021
Other languages
English (en)
Inventor
Leo Kruijt
Tette Van Der Lende
Original Assignee
Instituut Voor Veeteeltkundig Onderzoek 'schoonoord'
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Instituut Voor Veeteeltkundig Onderzoek 'schoonoord' filed Critical Instituut Voor Veeteeltkundig Onderzoek 'schoonoord'
Publication of WO1992012733A1 publication Critical patent/WO1992012733A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Definitions

  • the invention relates to a method for the complete or virtually complete elimination of the "boar odour" from meat from reared male pigs by immunising said pigs against the GnRH hormone during the rearing period and to the meat which is obtained by slaughtering male pigs treated in this way.
  • the gonadotropin-releasing hormone As is generally known, the gonadotropin-releasing hormone
  • GnRH luteinisin ⁇ hormone-releasing hormone
  • LHRH luteinisin ⁇ hormone-releasing hormone
  • GnRH has a direct action on the hypophysis, which, by reason of this, initiates a secretion of the luteinising hormone (LH) and the follicle stimulating hormone (FSH) , which, in their turn, act on both male and female gonads with the development of, on the one hand, sperm and, on the other hand, egg cells.
  • LH luteinising hormone
  • FSH follicle stimulating hormone
  • This hormone is known to accumulate in the fat layers of male pigs (boars) .
  • This accumulation of the androsterone hormone is considered to be responsible for the occurrence of the so-called "boar odour", a repellent odour belonging to the meat of fully grown male pigs.
  • boar odour a repellent odour belonging to the meat of fully grown male pigs.
  • the method according to the invention it is possible by means of a single injection of the young male pigs with GnRH antibodies, completely or virtually completely to eliminate the boar odour from the meat from subsequently slaughtered male pigs.
  • This injection with GnRH antibodies must be carried out about 2-4 weeks and in particular about 3 weeks before slaughter, which in the case of these pigs usually takes place at an age of about 24 weeks. It is regarded as a particular feature of the invention that the boar odour can still be eliminated despite the fact that the injection of the male f>igs with GnRH antibodies is carried out "late", that is to say shortly before slaughter.
  • the method according to the invention has numerous advantages. Firstly, the more rapid rate of growth or better food conversion efficiency of male pigs compared with castrated pigs is turned to maximum benefit and, at the same time, a smaller amount of manure is produced. Secondly, the possibility of a single injection offers considerable advantages in practice since the number of pigs per farm runs into the hundreds or thousands. In addition, it is pointed out that the quality of the meat from the male pigs treated according to the invention is considered to be better than that from the castrated pigs. Moreover, the method according to the invention has the significant advantage that it is reproducible, which is regarded as essential in view of the large number of pigs to be injected.
  • GnRH antibodies As already stated, the young male pigs are injected with GnRH antibodies about 2-4 weeks before slaughter, which takes place at an age of about 24 weeks. These GnRH antibodies can be produced in diverse ways. Hybridomas which produce these (monoclonal) antibodies may be mentioned as an important source of said antibodies. Examples of such hybridomas are derived from mouse cells and myeloma cells or from pig cells and myeloma cells. These hybridomas, which are produced with the aid of the cell fusion procedure, can be created using the methods known from the general prior art.
  • the invention also relates to the meat from male pigs treated using the method according to the invention, which meat is suitable for human consumption as it lacks the boar odour.

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Procédé d'élimination complète ou sensiblement complète de l''odeur de verrat' de la viande provenant des verrats abattus, par l'immunisation des verrats contre l'hormone gonadolibérine pendant la période d'élevage au moyen d'une immunisation passive par des anticorps dirigés contre la gonadolibérine. Cette immunisation passive s'effectue de préférence en une seule étape entre 2 et 4 semaines environ avant l'abattage des verrats.
PCT/NL1992/000021 1991-01-29 1992-01-28 Procede d'elimination de l''odeur de verrat' de la viande WO1992012733A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL9100151A NL9100151A (nl) 1991-01-29 1991-01-29 Werkwijze voor het volledig c.q. nagenoeg volledig elimineren van de "beregeur" van vlees van opgefokte mannelijke varkens door tijdens het opfokken de mannelijke varkens te immuniseren tegen het gnrh-hormoon.

Publications (1)

Publication Number Publication Date
WO1992012733A1 true WO1992012733A1 (fr) 1992-08-06

Family

ID=19858792

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/NL1992/000021 WO1992012733A1 (fr) 1991-01-29 1992-01-28 Procede d'elimination de l''odeur de verrat' de la viande

Country Status (3)

Country Link
AU (1) AU1325192A (fr)
NL (1) NL9100151A (fr)
WO (1) WO1992012733A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688506A (en) * 1994-01-27 1997-11-18 Aphton Corp. Immunogens against gonadotropin releasing hormone
US5911986A (en) * 1992-12-21 1999-06-15 Unilever Patent Holdings, B.V. Foodstuffs and other compositions
CN102335422A (zh) * 2011-10-11 2012-02-01 江苏省农业科学院 公猪去异味重组噬菌体疫苗
EP2900275A4 (fr) * 2012-09-29 2016-05-25 Univ Pennsylvania Composition à usage vétérinaire et procédés de stérilisation et de castration non chirurgicaux

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556555A (en) * 1985-01-25 1985-12-03 North Carolina State University Process for the immunological neutering of animals
US4676981A (en) * 1984-02-07 1987-06-30 University Of Saskatchewan Monoclonal antibodies against GnRH

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4676981A (en) * 1984-02-07 1987-06-30 University Of Saskatchewan Monoclonal antibodies against GnRH
US4556555A (en) * 1985-01-25 1985-12-03 North Carolina State University Process for the immunological neutering of animals

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5911986A (en) * 1992-12-21 1999-06-15 Unilever Patent Holdings, B.V. Foodstuffs and other compositions
US5688506A (en) * 1994-01-27 1997-11-18 Aphton Corp. Immunogens against gonadotropin releasing hormone
US6132720A (en) * 1994-01-27 2000-10-17 Aphton Corp. Immunogens against gonadotropin releasing hormone
US6303123B1 (en) 1994-01-27 2001-10-16 Aphton Corporation Methods for the treatment of hormone-dependent tumors with immunogens against gonadotropin releasing hormone
CN102335422A (zh) * 2011-10-11 2012-02-01 江苏省农业科学院 公猪去异味重组噬菌体疫苗
EP2900275A4 (fr) * 2012-09-29 2016-05-25 Univ Pennsylvania Composition à usage vétérinaire et procédés de stérilisation et de castration non chirurgicaux
US9770011B2 (en) 2012-09-29 2017-09-26 The Trustees Of The University Of Pennsylvania Veterinary composition and methods for non-surgical neutering and castration

Also Published As

Publication number Publication date
NL9100151A (nl) 1992-08-17
AU1325192A (en) 1992-08-27

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