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WO1995028184B1 - Article enrobe biocompatible - Google Patents

Article enrobe biocompatible

Info

Publication number
WO1995028184B1
WO1995028184B1 PCT/US1995/004584 US9504584W WO9528184B1 WO 1995028184 B1 WO1995028184 B1 WO 1995028184B1 US 9504584 W US9504584 W US 9504584W WO 9528184 B1 WO9528184 B1 WO 9528184B1
Authority
WO
WIPO (PCT)
Prior art keywords
copolymer
coating
range
membrane
biocompatibility
Prior art date
Application number
PCT/US1995/004584
Other languages
English (en)
Other versions
WO1995028184A1 (fr
Filing date
Publication date
Application filed filed Critical
Priority to DE69521690T priority Critical patent/DE69521690T2/de
Priority to AU22898/95A priority patent/AU692252B2/en
Priority to AT95916378T priority patent/ATE202942T1/de
Priority to JP52709195A priority patent/JP3228752B2/ja
Priority to EP95916378A priority patent/EP0755272B1/fr
Publication of WO1995028184A1 publication Critical patent/WO1995028184A1/fr
Publication of WO1995028184B1 publication Critical patent/WO1995028184B1/fr

Links

Definitions

  • a method of coating an article having a polymeric or metal blood-contacting surface comprising wetting the surface with a solution of an LSL triblock copolymer in a solvent for the copolymer and removing the solvent, thereby coating the surface with the polymer.
  • a method according to claim 55 comprising the additional step of subjecting the article having a surface coating of copolymer to ionizing radiation to produce an insoluble and tenaciously adhering coating.
  • ionizing radiation is in the form of x-rays, ⁇ -rays or an electron beam.
  • a method according to claim 61 wherein the radiation is x- rays in the dose range of 0.25 to 13.0.
  • a polymeric article having a base polymer and a biocompatible coating thereon comprising a polylactone- polysiloxane-polylactone triblock copolymer, said coating having a relative surface concentration sufficient to provide an X-ray fluorescence intensity ratio in the range 0.1 to 0.25.
  • a polymeric article according to claim 64 wherein the X- ray fluorescence intensity ratio is in the range 0.14 to 0.22.
  • a polymeric article according to claim 66 wherein said porous membrane is a polypropylene membrane.
  • a polymeric article according to claim 66 wherein said porous membrane is a polyethylene membrane.
  • a polymeric article according to claim 64 wherein the triblock copolymer is a polycaprolactone-polysiloxane- polycaprolactone copolymer.
  • a polymeric article according to claim 70 wherein the triblock copolymer comprises polycaprolactone blocks having each a nominal molecular weight in the range 1000 to 10,000 and a polysiloxane block having a nominal molecular weight in the range 1000 to 5000.
  • a polymeric article according to claim 71 wherein the triblock copolymer comprises polycaprolactone blocks having a nominal molecular weight of 2000 and a polysiloxane block having a nominal molecular weight in the range 2000-3000.
  • a method of coating a porous membrane with a LSL triblock copolymer comprising the steps of contacting the membrane with a solution of the copolymer having a specified concentration of the copolymer, said concentration imparting to the membrane, after drying, a surface concentration of copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.1 to 0.25.
  • a method of coating a porous membrane with a LSL triblock copolymer comprising passing said membrane through a solution of the copolymer at a constant rate, the solution having a specified concentration of the copolymer, said rate and concentration being such that, after drying, the membrane has a surface concentration of the copolymer sufficient to provide an X-ray fluorescence relative intensity in the range 0.1 to 0.25.
  • porous membrane is a polypropylene microporous membrane.

Abstract

On peut sensiblement améliorer la biocompatibilité d'articles polymères et métalliques qui, en cours d'utilisation, se trouvent en contact avec du sang, en les recouvrant d'une couche de revêtement. Les matières de revêtement sont des copolymères triséquencés du type polylactone-polysiloxane-polylactone. On obtient la biocompatibilité optimale avec un revêtement à concentration superficielle optimale. On peut recouvrir de cette manière des membranes poreuses afin d'améliorer les biocompatibilités des oxygénateurs de sang, des hémodialyseurs et autres dispositifs similaires.
PCT/US1995/004584 1994-04-15 1995-04-14 Article enrobe biocompatible WO1995028184A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE69521690T DE69521690T2 (de) 1994-04-15 1995-04-14 Blutverträglicher beschichteter artikel
AU22898/95A AU692252B2 (en) 1994-04-15 1995-04-14 Biocompatible coated article
AT95916378T ATE202942T1 (de) 1994-04-15 1995-04-14 Blutverträglicher beschichteter artikel
JP52709195A JP3228752B2 (ja) 1994-04-15 1995-04-14 生体適合性被覆製品
EP95916378A EP0755272B1 (fr) 1994-04-15 1995-04-14 Article enrobe biocompatible

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22795594A 1994-04-15 1994-04-15
US08/227,955 1994-04-15

Publications (2)

Publication Number Publication Date
WO1995028184A1 WO1995028184A1 (fr) 1995-10-26
WO1995028184B1 true WO1995028184B1 (fr) 1995-11-09

Family

ID=22855140

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/004584 WO1995028184A1 (fr) 1994-04-15 1995-04-14 Article enrobe biocompatible

Country Status (8)

Country Link
US (3) US5643681A (fr)
EP (1) EP0755272B1 (fr)
JP (1) JP3228752B2 (fr)
AT (1) ATE202942T1 (fr)
AU (1) AU692252B2 (fr)
CA (1) CA2187616A1 (fr)
DE (1) DE69521690T2 (fr)
WO (1) WO1995028184A1 (fr)

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