WO1996000503B1 - Nouveaux peptides - Google Patents
Nouveaux peptidesInfo
- Publication number
- WO1996000503B1 WO1996000503B1 PCT/US1995/008156 US9508156W WO9600503B1 WO 1996000503 B1 WO1996000503 B1 WO 1996000503B1 US 9508156 W US9508156 W US 9508156W WO 9600503 B1 WO9600503 B1 WO 9600503B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- seq
- ser
- sequence
- amino acids
- oligopeptides
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 102000015636 Oligopeptides Human genes 0.000 claims abstract 6
- 108010038807 Oligopeptides Proteins 0.000 claims abstract 6
- 108010072866 Prostate-Specific Antigen Proteins 0.000 claims abstract 4
- 102000007066 Prostate-Specific Antigen Human genes 0.000 claims abstract 3
- 150000001413 amino acids Chemical class 0.000 claims 4
- XZKQVQKUZMAADP-IMJSIDKUSA-N Ser-Ser Chemical compound OC[C@H](N)C(=O)N[C@@H](CO)C(O)=O XZKQVQKUZMAADP-IMJSIDKUSA-N 0.000 claims 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N Arginine Chemical compound OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 1
- QUOGESRFPZDMMT-UHFFFAOYSA-N L-Homoarginine Natural products OC(=O)C(N)CCCCNC(N)=N QUOGESRFPZDMMT-UHFFFAOYSA-N 0.000 claims 1
- QUOGESRFPZDMMT-YFKPBYRVSA-N L-homoarginine Chemical compound OC(=O)[C@@H](N)CCCCNC(N)=N QUOGESRFPZDMMT-YFKPBYRVSA-N 0.000 claims 1
- 102100037550 Semenogelin-1 Human genes 0.000 claims 1
- 101710089345 Semenogelin-1 Proteins 0.000 claims 1
- 102100037547 Semenogelin-2 Human genes 0.000 claims 1
- 101710089335 Semenogelin-2 Proteins 0.000 claims 1
- VEVYMLNYMULSMS-AVGNSLFASA-N Ser-Tyr-Gln Chemical compound [H]N[C@@H](CO)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(O)=O VEVYMLNYMULSMS-AVGNSLFASA-N 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 238000003556 assay Methods 0.000 abstract 1
- 229940127089 cytotoxic agent Drugs 0.000 abstract 1
- 239000002254 cytotoxic agent Substances 0.000 abstract 1
- 231100000599 cytotoxic agent Toxicity 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
Abstract
L'invention concerne des oligopeptides comprenant des séquences d'acides aminés reconnues et clivées protéolytiquement par un antigène spécifique de la prostate (PSA). L'invention concerne également des dosages comprenant ces oligopeptides utiles pour déterminer l'activité de la protéase de PSA libre in vitro et in vivo. En outre, l'invention concerne des agents thérapeutiques comprenant des conjugués de ces oligopeptides ainsi que des agents cytotoxiques connus.
Priority Applications (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT95926602T ATE223224T1 (de) | 1994-06-28 | 1995-06-07 | Neuartige peptide |
| JP8503422A JPH10502619A (ja) | 1994-06-28 | 1995-06-07 | 新規ペプチド |
| MX9700043A MX9700043A (es) | 1994-06-28 | 1995-06-07 | Peptidos novedosos. |
| HU9603564A HU220877B1 (en) | 1994-06-28 | 1995-06-07 | Novel olygopeptides, diagnostic methods for use thereof and conjugates for treatment of prostata cancer |
| EP95926602A EP0771209B1 (fr) | 1994-06-28 | 1995-06-07 | Nouveaux peptides |
| PL95317872A PL186341B1 (pl) | 1994-06-28 | 1995-06-07 | Oligopeptyd, sposób oznaczania aktywności proteolitycznej wolnego antygenu swoistego dla prostaty wpróbce, sposób identyfikacji związków, hamującychaktywność proteolityczną antygenu swoistego dla prostaty, oraz koniugat użyteczny do leczenia raka prostaty |
| NZ290239A NZ290239A (en) | 1994-06-28 | 1995-06-07 | Peptides, oligopeptides with amino acid sequences that are recognised and proteolytically cleaved by free prostate specific antigen, assays and medicaments comprising such peptides |
| BR9508151A BR9508151A (pt) | 1994-06-28 | 1995-06-07 | Oligopeptídeo testes para determinar a atividade proteolítica de antígeno livre específico para próstata em uma amostra e para identificar compostos que inibem atividade proteolítica de antígeno específico para próstata e conjugado |
| DK95926602T DK0771209T3 (da) | 1994-06-28 | 1995-06-07 | Hidtil ukendte peptider |
| FI965225A FI965225A7 (fi) | 1994-06-28 | 1995-06-07 | Uusia peptidejä |
| RO96-02483A RO116198B1 (ro) | 1994-06-28 | 1995-06-07 | Oligopeptida si conjugat al acesteia, clivate selectiv de antigenul specific de prostata |
| AU30922/95A AU689934B2 (en) | 1994-06-28 | 1995-06-07 | Novel peptides |
| HK98109815.7A HK1009038B (en) | 1994-06-28 | 1995-06-07 | Novel peptides |
| DE69528064T DE69528064T2 (de) | 1994-06-28 | 1995-06-07 | Neuartige peptide |
| SK1640-96A SK164096A3 (en) | 1994-06-28 | 1995-06-07 | Oligopeptide and a conjugate containing it |
| UA97010353A UA55371C2 (uk) | 1994-06-28 | 1995-07-06 | Олігопептид, який розпізнається та протеолітично розщеплюється вільним простатичним антигеном, спосіб визначення протеолітичної активності вказаного антигену, спосіб ідентифікації сполук, які інгібують протеолітичну активність вказаного антигену, кон'югат, який використовують для лікування раку передміхурової залози |
| NO965592A NO965592L (no) | 1994-06-28 | 1996-12-27 | Nye peptider |
| BG101077A BG63453B1 (bg) | 1994-06-28 | 1996-12-27 | Пептиди |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/267,092 US5599686A (en) | 1994-06-28 | 1994-06-28 | Peptides |
| US40483395A | 1995-03-15 | 1995-03-15 | |
| US404,833 | 1995-03-15 | ||
| US267,092 | 1995-03-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996000503A1 WO1996000503A1 (fr) | 1996-01-11 |
| WO1996000503B1 true WO1996000503B1 (fr) | 1996-02-22 |
Family
ID=26952210
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/008156 WO1996000503A1 (fr) | 1994-06-28 | 1995-06-07 | Nouveaux peptides |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US6143864A (fr) |
| EP (1) | EP0771209B1 (fr) |
| JP (1) | JPH10502619A (fr) |
| KR (1) | KR100379351B1 (fr) |
| CN (1) | CN1156964A (fr) |
| AT (1) | ATE223224T1 (fr) |
| AU (1) | AU689934B2 (fr) |
| BG (1) | BG63453B1 (fr) |
| BR (1) | BR9508151A (fr) |
| CA (1) | CA2192957A1 (fr) |
| CZ (1) | CZ381096A3 (fr) |
| DE (1) | DE69528064T2 (fr) |
| DK (1) | DK0771209T3 (fr) |
| ES (1) | ES2182908T3 (fr) |
| FI (1) | FI965225A7 (fr) |
| HU (1) | HU220877B1 (fr) |
| MX (1) | MX9700043A (fr) |
| NO (1) | NO965592L (fr) |
| NZ (1) | NZ290239A (fr) |
| PL (1) | PL186341B1 (fr) |
| PT (1) | PT771209E (fr) |
| RO (1) | RO116198B1 (fr) |
| RU (1) | RU2162855C2 (fr) |
| SK (1) | SK164096A3 (fr) |
| UA (1) | UA55371C2 (fr) |
| WO (1) | WO1996000503A1 (fr) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5502037A (en) * | 1993-07-09 | 1996-03-26 | Neuromed Technologies, Inc. | Pro-cytotoxic drug conjugates for anticancer therapy |
| US5866679A (en) * | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
| EP1880737A1 (fr) * | 1994-08-19 | 2008-01-23 | La Region Wallonne | Composés, composition pharmaceutique et dispositif de diagnostic les comprenant et leur utilisation |
| WO1997014416A1 (fr) * | 1995-10-18 | 1997-04-24 | Merck & Co., Inc. | Conjugues utiles pour traiter l'adenome prostatique benin |
| US5952294A (en) * | 1996-07-31 | 1999-09-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peptidyl prodrugs and methods of making and using the same |
| US5998362A (en) * | 1996-09-12 | 1999-12-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US6177404B1 (en) | 1996-10-15 | 2001-01-23 | Merck & Co., Inc. | Conjugates useful in the treatment of benign prostatic hyperplasia |
| US5948750A (en) * | 1996-10-30 | 1999-09-07 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| HRP970566A2 (en) * | 1996-10-30 | 1998-08-31 | Jones Deborah Defeo | Conjugates useful in the treatment of prostate canser |
| CA2271291A1 (fr) | 1996-11-06 | 1998-05-14 | The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services | Proproteines similaires a l'exotoxine de pseudomonas, pouvant etre activees par une protease |
| AU7582298A (en) | 1997-05-19 | 1998-12-11 | Johns Hopkins University School Of Medicine, The | Tissue specific prodrug |
| US6545131B1 (en) | 1997-05-19 | 2003-04-08 | The Johns Hopkins University | Tissue specific prodrug |
| US6504014B1 (en) | 1997-05-19 | 2003-01-07 | The John Hopkins University | Tissue specific prodrug |
| US6391305B1 (en) * | 1997-09-10 | 2002-05-21 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| TR200002260T2 (tr) * | 1997-12-02 | 2000-12-21 | Merck & Co., Inc. | Prostat kanserinin tedavisinde yararlı konjugatlar |
| WO1999044628A1 (fr) * | 1998-03-05 | 1999-09-10 | Merck & Co., Inc. | Conjugues convenant au traitement du cancer de la prostate |
| US6174858B1 (en) | 1998-11-17 | 2001-01-16 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US7425541B2 (en) | 1998-12-11 | 2008-09-16 | Medarex, Inc. | Enzyme-cleavable prodrug compounds |
| BR0010700A (pt) * | 1999-04-30 | 2002-02-13 | Slil Biomedical Corp | Conjugados análogos de poliamina e conjugados de quinona como terapias para cânceres e doenças na próstata |
| US6482943B1 (en) | 1999-04-30 | 2002-11-19 | Slil Biomedical Corporation | Quinones as disease therapies |
| US6649587B1 (en) | 1999-04-30 | 2003-11-18 | Slil Biomedical Corporation | Polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases |
| DE60032784T2 (de) * | 1999-10-07 | 2007-11-08 | Ciphergen Biosystems, Inc., Fremont | Markerproteine für prostatakrebs |
| GB9924759D0 (en) | 1999-10-19 | 1999-12-22 | Merck Sharp & Dohme | Process for preparing peptide intermediates |
| PL360826A1 (en) | 2000-03-15 | 2004-09-20 | Bristol-Myers Squibb Pharma Company | Peptidase-cleavable, targeted antineoplastic drugs and their therapeutic use |
| AU6685301A (en) * | 2000-06-14 | 2001-12-24 | Corixa Corp | Prodrug compounds with isoleucine |
| EP1337504A4 (fr) | 2000-11-08 | 2005-10-05 | Cellgate Inc | Nouveaux conjugues d'acide amine et d'analogues de polyamine utiles en tant qu'agents anticancer |
| EP1219634A1 (fr) * | 2000-12-27 | 2002-07-03 | Bayer Aktiengesellschaft | Glycoconjugués d'agents cytostatiques avec lien peptidique spécifiquement clivable |
| WO2002081630A2 (fr) * | 2001-04-06 | 2002-10-17 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Utilisation de semenogeline dans le diagnostic, le pronostic et le traitement du cancer |
| CA2457903C (fr) * | 2001-08-24 | 2018-04-17 | University Of Victoria Innovation And Development Corporation | Proaerolysine contenant des sequences d'activation de protease et procedes destines au traitement du cancer de la prostate |
| JP2005510240A (ja) * | 2001-11-28 | 2005-04-21 | セローノ ジェネティクス インスティテュート ソシエテ アノニム | ヒトcDNA及びタンパク質及びその使用 |
| US7108976B2 (en) * | 2002-06-17 | 2006-09-19 | Affymetrix, Inc. | Complexity management of genomic DNA by locus specific amplification |
| MXPA05004504A (es) * | 2002-10-31 | 2005-08-16 | Metabasis Therapeutics Inc | Nuevos di-esteres de fosfato ciclicos de 1,3-propano-1-aril-dioles y su uso en la preparacion de profarmacos. |
| WO2005041981A1 (fr) * | 2003-10-31 | 2005-05-12 | Kurume University | Traitement combine vaccin peptidique et estramustine |
| WO2006133553A1 (fr) | 2005-06-14 | 2006-12-21 | Protox Therapeutics Incorporated | Méthode pour traiter ou prévenir l’hyperplasie bénigne de la prostate au moyen de protéines formatrices de pores modifiées |
| JP5278873B2 (ja) * | 2008-05-14 | 2013-09-04 | 国立大学法人九州工業大学 | 癌診断用試薬 |
| WO2010117768A1 (fr) * | 2009-04-10 | 2010-10-14 | The Regents Of The University Of California | Antigènes associés à la prostatite et leurs méthodes d'utilisation |
| KR20110069618A (ko) * | 2009-12-17 | 2011-06-23 | 주식회사 셀앤바이오 | 전립선암 진단용 키트 및 진단방법 |
| US10449210B2 (en) | 2014-02-13 | 2019-10-22 | Ligand Pharmaceuticals Inc. | Prodrug compounds and their uses |
| EP3164136A4 (fr) | 2014-07-02 | 2018-04-04 | Ligand Pharmaceuticals, Inc. | Composés de promédicaments et leurs utilisations |
| EP3737676B1 (fr) | 2018-01-09 | 2024-03-06 | Ligand Pharmaceuticals, Inc. | Composés acétal et leurs utilisations thérapeutiques |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4296105A (en) * | 1978-08-03 | 1981-10-20 | Institut International De Pathologie Cellulaire Et Moleculaire | Derivatives of doxorubicine, their preparation and use |
| US4277466A (en) * | 1978-08-29 | 1981-07-07 | Institut International De Pathologie Cellulaire Et Moleculaire | Complexes of DNA and esters derived from daunorubicine, their preparation and use |
| US4446122A (en) * | 1979-12-28 | 1984-05-01 | Research Corporation | Purified human prostate antigen |
| OA06421A (fr) * | 1980-06-10 | 1981-09-30 | Omnium Chimique Sa | Procédé de préparation de dérivés N-(vinblastinoyl-23) d'acides aminés et de peptides. |
| EP0124502B1 (fr) * | 1983-04-29 | 1991-06-12 | OMNICHEM Société anonyme | Nouveaux conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques contenant ces conjugués |
| JPS6034997A (ja) * | 1983-05-09 | 1985-02-22 | ジヨージ、ジヨセフ、トダロ | 生物学的活性ポリペプチド類 |
| FR2546163B1 (fr) * | 1983-05-16 | 1987-10-09 | Centre Nat Rech Scient | Nouveaux derives acyles hydrosolubles de peptides ou d'amino-acides, leur preparation et leur application |
| EP0126344A2 (fr) * | 1983-05-20 | 1984-11-28 | Abbott Laboratories | Esters tripeptidiques d'agents thérapeutiques |
| FR2583983B1 (fr) * | 1985-06-07 | 1988-05-27 | Centre Nat Rech Scient | Nouvelles prodrogues macromoleculaires hydrosolubles, leur preparation et leur utilisation comme medicaments notamment antitumoraux et antiparasitaires |
| EP0232693A3 (fr) * | 1985-12-16 | 1988-04-06 | La Region Wallonne | Conjugués de la vinblastine et de ses dérivés, procédé pour leur préparation et compositions pharmaceutiques les contenant |
| FR2626882B1 (fr) * | 1988-02-08 | 1991-11-08 | Ire Celltarg Sa | Conjugues de derives de vinca comportant une chaine detergente en position c-3 |
| US5391723A (en) * | 1989-05-31 | 1995-02-21 | Neorx Corporation | Oligonucleotide conjugates |
| DE3930696A1 (de) * | 1989-09-14 | 1991-03-28 | Hoechst Ag | Gallensaeurederivate, verfahren zu ihrer herstellung, verwendung als arzneimittel |
| US5220001A (en) * | 1989-10-25 | 1993-06-15 | Zaidan Hojim Biseibutsu Dong-A Pharm Co. | Anthracycline glycoside derivatives |
| IT1241927B (it) * | 1990-05-14 | 1994-02-01 | Menarini Farma Ind | 3'-deamino-4'-deossi-4'-amino-8-fluoroantra- cicline processi per la loro preparazione e composizioni farmaceutiche che le contengono |
| US5137877B1 (en) * | 1990-05-14 | 1996-01-30 | Bristol Myers Squibb Co | Bifunctional linking compounds conjugates and methods for their production |
| SE9002480D0 (sv) * | 1990-07-23 | 1990-07-23 | Hans Lilja | Assay of free and complexed prostate-specific antigen |
| EP0671412A1 (fr) * | 1990-11-30 | 1995-09-13 | Asahi Glass Company Ltd. | Peptides inhibant l'infiltration de cellules tumorales et inhibiteurs de la métastase du cancer |
| FR2678274A1 (fr) * | 1991-06-25 | 1992-12-31 | Medgenix Group Sa | N-leucyl epirubicine application a titre de medicament antitumoral et procede de preparation. |
| US5288612A (en) * | 1991-07-03 | 1994-02-22 | The Scripps Research Institute | Assay methods for detecting serum proteases, particularly activated protein C |
| US5622929A (en) * | 1992-01-23 | 1997-04-22 | Bristol-Myers Squibb Company | Thioether conjugates |
| DE4233152A1 (de) * | 1992-10-02 | 1994-04-07 | Behringwerke Ag | Antikörper-Enzym-Konjugate zur Prodrug-Aktivierung |
| PT667920E (pt) * | 1992-10-29 | 2003-06-30 | Univ Jefferson | Metodos de deteccao de micrometasteses do cancro da prostata |
| WO1994020114A1 (fr) * | 1993-03-12 | 1994-09-15 | Board Of Regents, The University Of Texas System | Anthracyclines ayant une action inhabituellement forte contre les cellules resistant a la doxorubicine et a ses analogues |
| GB9320191D0 (en) * | 1993-09-30 | 1993-11-17 | Univ Napier | Compounds |
| JPH10500294A (ja) * | 1994-05-10 | 1998-01-13 | マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチ | 組換え型hk2ポリペプチド |
| US5599686A (en) * | 1994-06-28 | 1997-02-04 | Merck & Co., Inc. | Peptides |
| US5866679A (en) * | 1994-06-28 | 1999-02-02 | Merck & Co., Inc. | Peptides |
| EP1880737A1 (fr) * | 1994-08-19 | 2008-01-23 | La Region Wallonne | Composés, composition pharmaceutique et dispositif de diagnostic les comprenant et leur utilisation |
| AUPM769394A0 (en) * | 1994-08-25 | 1994-09-15 | Commonwealth Scientific And Industrial Research Organisation | Assay for the detection of proteases |
-
1995
- 1995-06-06 US US08/468,161 patent/US6143864A/en not_active Expired - Fee Related
- 1995-06-07 EP EP95926602A patent/EP0771209B1/fr not_active Expired - Lifetime
- 1995-06-07 PL PL95317872A patent/PL186341B1/pl not_active IP Right Cessation
- 1995-06-07 BR BR9508151A patent/BR9508151A/pt not_active IP Right Cessation
- 1995-06-07 SK SK1640-96A patent/SK164096A3/sk unknown
- 1995-06-07 AT AT95926602T patent/ATE223224T1/de not_active IP Right Cessation
- 1995-06-07 AU AU30922/95A patent/AU689934B2/en not_active Revoked
- 1995-06-07 FI FI965225A patent/FI965225A7/fi unknown
- 1995-06-07 PT PT95926602T patent/PT771209E/pt unknown
- 1995-06-07 DK DK95926602T patent/DK0771209T3/da active
- 1995-06-07 CZ CZ963810A patent/CZ381096A3/cs unknown
- 1995-06-07 MX MX9700043A patent/MX9700043A/es active IP Right Grant
- 1995-06-07 RU RU97101169/04A patent/RU2162855C2/ru not_active IP Right Cessation
- 1995-06-07 WO PCT/US1995/008156 patent/WO1996000503A1/fr not_active Application Discontinuation
- 1995-06-07 KR KR1019960707514A patent/KR100379351B1/ko not_active Expired - Fee Related
- 1995-06-07 NZ NZ290239A patent/NZ290239A/en not_active IP Right Cessation
- 1995-06-07 CN CN95194855A patent/CN1156964A/zh active Pending
- 1995-06-07 CA CA002192957A patent/CA2192957A1/fr not_active Abandoned
- 1995-06-07 JP JP8503422A patent/JPH10502619A/ja active Pending
- 1995-06-07 HU HU9603564A patent/HU220877B1/hu not_active IP Right Cessation
- 1995-06-07 ES ES95926602T patent/ES2182908T3/es not_active Expired - Lifetime
- 1995-06-07 DE DE69528064T patent/DE69528064T2/de not_active Expired - Fee Related
- 1995-06-07 RO RO96-02483A patent/RO116198B1/ro unknown
- 1995-07-06 UA UA97010353A patent/UA55371C2/uk unknown
-
1996
- 1996-12-27 BG BG101077A patent/BG63453B1/bg unknown
- 1996-12-27 NO NO965592A patent/NO965592L/no unknown
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| Bächle | Cathepsin D: design and characterisation of new in vitro and in vivo substrates applied to biological samples |