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WO1996001320A3 - Sequence genomique complete du virus autographa californica de la polyhedrose nucleaire - Google Patents

Sequence genomique complete du virus autographa californica de la polyhedrose nucleaire Download PDF

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Publication number
WO1996001320A3
WO1996001320A3 PCT/IB1995/000578 IB9500578W WO9601320A3 WO 1996001320 A3 WO1996001320 A3 WO 1996001320A3 IB 9500578 W IB9500578 W IB 9500578W WO 9601320 A3 WO9601320 A3 WO 9601320A3
Authority
WO
WIPO (PCT)
Prior art keywords
acnpv
orfs
genome
virus
nuclear polyhedrosis
Prior art date
Application number
PCT/IB1995/000578
Other languages
English (en)
Other versions
WO1996001320A2 (fr
Inventor
David Bishop
Robert Possee
Martin Ayres
Original Assignee
Natural Enviroment Res Council
David Bishop
Robert Possee
Martin Ayres
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natural Enviroment Res Council, David Bishop, Robert Possee, Martin Ayres filed Critical Natural Enviroment Res Council
Priority to AU28972/95A priority Critical patent/AU2897295A/en
Publication of WO1996001320A2 publication Critical patent/WO1996001320A2/fr
Publication of WO1996001320A3 publication Critical patent/WO1996001320A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

La présente invention concerne la séquence nucléotidique complète du génome du clone 6 du baculovirus Autographa californica du virus de la polyhédrose nucléaire (AcNPV). La molécule comporte 133 894 paires de bases et une teneur globale en A+T de 59 %. Des analyses effectuées, il semble découler que le virus est capable de coder environ 154 cadres de lecture ouverts (ORF) d'au moins 150 nucléotides à médiation méthioninique, et potentiellement exprimés. Ces ORF sont régulièrement répartis sur chacun des brins du génome de tout le virus. Ces ORF sont disposés en cadres de lecture adjacents et ne se chevauchant pas, séparés grâce à de courtes régions intergéniques. D'après la séquence nucléotidique primaire, il semble possible de déterminer les fonctions de certains gènes, les sites initiaux de réplication de l'ADN viral, les modalités de régulation des transcriptions géniques précoce et tardive, et des facteurs susceptibles d'affecter l'efficacité translationnelle du gène de l'AcNPV. Les données concernant la séquence génomique confirment, à quelques différences mineures près, les informations obtenues dans le cas des autres clones d'AcNPV. Le clone C6 semble donc proposable comme archétype de l'AcNPV pour les modalités comparatives.
PCT/IB1995/000578 1994-07-04 1995-06-30 Sequence genomique complete du virus autographa californica de la polyhedrose nucleaire WO1996001320A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU28972/95A AU2897295A (en) 1994-07-04 1995-06-30 Autographa californica complete genome sequence

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9413420.2 1994-07-04
GB9413420A GB9413420D0 (en) 1994-07-04 1994-07-04 Autographa californica nuclear polyhedrosis virus dna sequences

Publications (2)

Publication Number Publication Date
WO1996001320A2 WO1996001320A2 (fr) 1996-01-18
WO1996001320A3 true WO1996001320A3 (fr) 1996-07-25

Family

ID=10757768

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB1995/000578 WO1996001320A2 (fr) 1994-07-04 1995-06-30 Sequence genomique complete du virus autographa californica de la polyhedrose nucleaire

Country Status (3)

Country Link
AU (1) AU2897295A (fr)
GB (1) GB9413420D0 (fr)
WO (1) WO1996001320A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPN570295A0 (en) * 1995-09-29 1995-10-26 Commonwealth Scientific And Industrial Research Organisation Biologically active proteins of viral origin
AU1726199A (en) 1997-12-31 1999-07-19 Chiron Corporation Metastatic cancer regulated gene
AU775017B2 (en) * 1998-07-21 2004-07-15 Dow Agrosciences Llc Antibody-mediated down-regulation of plant proteins
CN114317608B (zh) * 2020-12-28 2023-08-22 陕西杆粒生物科技有限公司 一种基因敲除型杆状病毒表达载体
CN114058598B (zh) * 2021-11-04 2023-04-28 中国科学院精密测量科学与技术创新研究院 新的重组杆状病毒基因组插入位点及其应用
CN118086400B (zh) * 2024-04-17 2024-07-19 和元生物技术（上海）股份有限公司 核酸分子、包含其的重组杆状病毒及其应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
M. KOOL AND J.M. VLAK;: "The structural and functional organization of the autographa californica nuclear polyhedrosis virus genome", ARCH. VIROL., vol. 130, pages 1 - 16 *
M.D. AYRES ET AL.;: "The complete DNA sequence of Autographa californica nuclear polyhedrosis virus", VIROLOGY, vol. 202, pages 586 - 605 *
R.D. POSSEE ET AL.;: "Nucleotide sequence of the Autographa californica nuclear polyhedrosis 9.4 kbp Eco RI-I and -R (polyhedrin gene) region", VIROLOGY, vol. 185, pages 229 - 241 *
S.C. BRAUNAGEL ET AL.;: "Sequence, genomic organization of the EcoRI-A fragment of Autographica californica nuclear polyhedrosis virus, and identification of a viral-encoded protein resembling the outer capsid protein VP8 of Rotavirus", VIROLOGY, vol. 191, pages 1003 - 1008 *

Also Published As

Publication number Publication date
WO1996001320A2 (fr) 1996-01-18
GB9413420D0 (en) 1994-08-24
AU2897295A (en) 1996-01-25

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