WO1996001846B1 - Proinsulin peptide compounds for detecting and treating type i diabetes - Google Patents
Proinsulin peptide compounds for detecting and treating type i diabetesInfo
- Publication number
- WO1996001846B1 WO1996001846B1 PCT/US1995/008596 US9508596W WO9601846B1 WO 1996001846 B1 WO1996001846 B1 WO 1996001846B1 US 9508596 W US9508596 W US 9508596W WO 9601846 B1 WO9601846 B1 WO 9601846B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- proinsulin
- arg
- ser
- amino acid
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 19
- 108010076181 Proinsulin Proteins 0.000 title claims abstract 16
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 10
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 title claims abstract 5
- 230000028993 immune response Effects 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims abstract 3
- 108010075254 C-Peptide Proteins 0.000 claims abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract 2
- 230000002401 inhibitory effect Effects 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 150000001412 amines Chemical group 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 108010063718 gamma-glutamylaspartic acid Proteins 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003614 tolerogenic effect Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Abstract
Proinsulin peptide compounds that modulate an immunological response by T cells of Type I diabetic subjects are disclosed. The proinsulin peptide compounds of the invention are preferably derived from a region of proinsulin that spans the junction between the B chain and C peptide of proinsulin. Pharmaceutical compositions comprising the proinsulin peptide compounds are also disclosed. An immunological response to a proinsulin peptide compound of the invention can be used as an indicator of Type I diabetes in a subject. Accordingly, the invention provides diagnostic assays for Type I diabetes using the proinsulin peptide compounds. Methods for inhibiting the development or progression of Type I diabetes in a subject by administering a proinsulin peptide compound are also disclosed.
Claims
-46-
AMENDED CLAIMS
[received by the International Bureau on 5 February 1996 (05.02.96); original claims unchanged; new claims 33-42 added; (2 pages)]
31. The method of claim 29, wherein the agent is a compound derived from human proinsulin.
32. The method of claim 29, wherein the compound comprises an amino acid sequence comprising the formula:
Yl-P^aa)n-(SerTrιx)-Pro-Lys-(Ser/Thr)-Arg-Arg-(Glu/Asp)-(Zaa)m-Y2
wherein Xaa and Zaa, which may or may not be present, represent amino acid residues, n and m are integers from 1 to 15, Yi is hydrogen or an amino-derivative group and Y2 is hydrogen or a carboxy-derivative group.
33. Use of a proinsulin peptide compound which modulates an immunological response by T cells of Type I diabetic subjects for the manufacture of a medicament for inhibiting the development or progression of Type I diabetes in a subject.
34. The use of claim 33, wherein the compound is identical or substantially similar to a region of proinsulin that spans the junction between the B chain and the C peptide of proinsulin.
35. The use of claim 33, wherein the compound is derived from human proinsulin.
36. The use of claim 33, wherein the compound comprises an amino acid sequence comprising the formula:
Y 1 -(Xaa)n-(Ser Tr-r)-Pro-Lys-(Ser Thr)-Arg-Arg-(GluAsp)-(Zaa)rn- Y2
wherein Xaa and Zaa, which may or may not be present, represent amino acid residues, n and m are integers from 1 to 15, Y1 is hydrogen or an amino-derivative group and Y2 is hydrogen or a carboxy-derivative group.
37. The use of claim 36, wherein the compound is 10-35 amino acids in length.
38. The use of claim 36, wherein the compound is 10-20 amino acids in length.
39. The use of claim 36, wherein the compound is 12-17 amino acids in length.
40. The use of claim 33. where in the compound comprises an amino acid sequence:
-47-
Y i -Gly-Phe-Phe-Tyr-(Ser Trιr)-Pro-Lys-(Ser/Trιr)-Arg-Arg-(Glu/Asp)-Ala- Glu-(Glu/Asp)-Leu-Gln-Val-Gly-Y2
41. The use of claim 33 , wherein the compound is a modified form of a proinsulin peptide.
42. The use of claim 33, which comprises a tolerogenic amount of the proinsulin peptide compound.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK95926642T DK0788512T3 (en) | 1994-07-08 | 1995-07-07 | Proinsulin Peptide Compounds for the Detection and Treatment of Type I Diabetes |
| EP95926642A EP0788512B1 (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for detecting and treating type i diabetes |
| DE69508605T DE69508605T2 (en) | 1994-07-08 | 1995-07-07 | PROINSULIN PEPTIDE COMPOUNDS FOR DETECTING AND TREATING TYPE I DIABETES |
| MX9700198A MX9700198A (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for detecting and treating type i diabetes. |
| JP8504435A JPH10505821A (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for the detection and treatment of type I diabetes - Patents.com |
| AU30947/95A AU3094795A (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for detecting and treating type i diabetes |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27222094A | 1994-07-08 | 1994-07-08 | |
| US08/272,220 | 1994-07-08 | ||
| US47270495A | 1995-06-06 | 1995-06-06 | |
| US08/472,704 | 1995-06-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996001846A1 WO1996001846A1 (en) | 1996-01-25 |
| WO1996001846B1 true WO1996001846B1 (en) | 1996-03-07 |
Family
ID=26955374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/008596 WO1996001846A1 (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for detecting and treating type i diabetes |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20030220229A1 (en) |
| EP (1) | EP0788512B1 (en) |
| JP (1) | JPH10505821A (en) |
| CN (1) | CN1157621A (en) |
| AT (1) | ATE178074T1 (en) |
| AU (1) | AU3094795A (en) |
| CA (1) | CA2194548A1 (en) |
| DE (1) | DE69508605T2 (en) |
| DK (1) | DK0788512T3 (en) |
| ES (1) | ES2130629T3 (en) |
| MX (1) | MX9700198A (en) |
| WO (1) | WO1996001846A1 (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69637130T2 (en) | 1995-02-20 | 2008-02-21 | The Walter And Eliza Hall Institute Of Medical Research, Parkville | IMMUNOREACTIVE AND IMMUNOTHERAPEUTIC MOLECULES THAT INTERACT IN INDIVIDUALS WITH INSULIN-DEPENDENT DIABETES MELLITUS |
| SE520392C2 (en) | 1996-09-27 | 2003-07-01 | Creative Peptides Sweden Ab C | Specific peptides for the treatment of diabetes mellitus |
| AUPO269996A0 (en) * | 1996-10-01 | 1996-10-24 | Walter And Eliza Hall Institute Of Medical Research, The | A method of prophylaxis and treatment |
| ES2331342B1 (en) * | 2006-05-22 | 2010-10-13 | Consejo Superior Investg.Cientificas | USE OF PROINSULIN FOR THE PREPARATION OF A NEUROPROTECTING PHARMACEUTICAL COMPOSITION, THERAPEUTIC COMPOSITION CONTAINING IT AND ITS APPLICATIONS. |
| CN103630692B (en) * | 2013-06-02 | 2015-05-06 | 马鞍山国声生物技术有限公司 | Colloidal gold immunochromatography kit for rapidly detecting urine C peptide and detecting method thereof |
| WO2015057968A2 (en) * | 2013-10-17 | 2015-04-23 | The General Hospital Corporation | Methods of identifying subjects responsive to treatment for an autoimmune disease and compositions for treating the same |
| GB2523399B (en) * | 2014-02-25 | 2019-03-13 | Orban Tihamer | A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence |
| GB2559499A (en) * | 2014-02-25 | 2018-08-08 | Orban Tihamer | Immunomodulatory therapy for type 1 diabetes mellitus autoimmunity |
| GB201913408D0 (en) * | 2019-09-17 | 2019-10-30 | King S College London | Proinsulin peptides for type 1 diabetes |
| WO2025035125A1 (en) * | 2023-08-10 | 2025-02-13 | The Curators Of The University Of Missouri | Suppression of type 1 diabetes by intrathymic il-4 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5210872B2 (en) * | 1973-07-14 | 1977-03-26 | ||
| US4308181A (en) * | 1980-12-08 | 1981-12-29 | American Home Products Corporation | Polypeptide compositions |
| US4652548A (en) * | 1981-08-27 | 1987-03-24 | Eli Lilly And Company | Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin |
| US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
| NL9001083A (en) * | 1990-05-04 | 1991-12-02 | Rijksuniversiteit | BETA-CELL ANTIGEN. |
| CA2089742C (en) * | 1990-08-17 | 2002-05-14 | Mark A. Atkinson | Methods and compositions for early detection and treatment of insulin dependent diabetes mellitus |
-
1995
- 1995-07-07 AT AT95926642T patent/ATE178074T1/en not_active IP Right Cessation
- 1995-07-07 AU AU30947/95A patent/AU3094795A/en not_active Abandoned
- 1995-07-07 CA CA002194548A patent/CA2194548A1/en not_active Abandoned
- 1995-07-07 ES ES95926642T patent/ES2130629T3/en not_active Expired - Lifetime
- 1995-07-07 WO PCT/US1995/008596 patent/WO1996001846A1/en active IP Right Grant
- 1995-07-07 JP JP8504435A patent/JPH10505821A/en not_active Ceased
- 1995-07-07 DE DE69508605T patent/DE69508605T2/en not_active Expired - Fee Related
- 1995-07-07 EP EP95926642A patent/EP0788512B1/en not_active Revoked
- 1995-07-07 DK DK95926642T patent/DK0788512T3/en active
- 1995-07-07 MX MX9700198A patent/MX9700198A/en not_active IP Right Cessation
- 1995-07-07 CN CN95194541A patent/CN1157621A/en active Pending
-
2003
- 2003-01-16 US US10/346,563 patent/US20030220229A1/en not_active Abandoned
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