WO1996001846B1 - Composes de peptide de pro-insuline utiles pour detecter et traiter le diabete du type i - Google Patents
Composes de peptide de pro-insuline utiles pour detecter et traiter le diabete du type iInfo
- Publication number
- WO1996001846B1 WO1996001846B1 PCT/US1995/008596 US9508596W WO9601846B1 WO 1996001846 B1 WO1996001846 B1 WO 1996001846B1 US 9508596 W US9508596 W US 9508596W WO 9601846 B1 WO9601846 B1 WO 9601846B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- proinsulin
- arg
- ser
- amino acid
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 19
- 108010076181 Proinsulin Proteins 0.000 title claims abstract 16
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 10
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 title claims abstract 5
- 230000028993 immune response Effects 0.000 claims abstract 3
- 238000000034 method Methods 0.000 claims abstract 3
- 108010075254 C-Peptide Proteins 0.000 claims abstract 2
- 210000001744 T-lymphocyte Anatomy 0.000 claims abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract 2
- 230000002401 inhibitory effect Effects 0.000 claims abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 150000001412 amines Chemical group 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 108010063718 gamma-glutamylaspartic acid Proteins 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003614 tolerogenic effect Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Abstract
Composés de peptide de pro-insuline modulant une réponse immunologique par les lymphocyte T de sujets diabétiques du type I. Les composés de peptide de pro-insuline de cette invention sont préférablement extraits d'une région de pro-insuline qui couvre la jonction existant entre la chaîne B et le peptide C de la pro-insuline. On décrit également des compositions pharmaceutiques comprenant les composés de peptide de pro-insuline de cette invention. La réponse immunologique induite par un composé de peptide de pro-insuline peut servir d'indicateur pour détecter un diabète du type I chez un sujet et cette invention présente des dosages de diagnostic qui servent à rechercher le diabète du type I avec les composés de peptide de pro-insuline revendiqués. On décrit également des procédés qui permettent d'inhiber le développement ou la progression du diabète du type I chez un sujet et qui consistent à lui administrer un composé de peptide de pro-insuline.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK95926642T DK0788512T3 (da) | 1994-07-08 | 1995-07-07 | Proinsulinpeptidforbindelser til detektion og behandling af Type I-diabetes |
| EP95926642A EP0788512B1 (fr) | 1994-07-08 | 1995-07-07 | Composes de peptide de pro-insuline utiles pour detecter et traiter le diabete du type i |
| DE69508605T DE69508605T2 (de) | 1994-07-08 | 1995-07-07 | Proinsulin-peptid-verbindungen für den nachweis und die behandlung von typ-i-diabetes |
| MX9700198A MX9700198A (es) | 1994-07-08 | 1995-07-07 | Compuestos peptidos de proinsulina para detectar y tratar diabetes tipo 1. |
| JP8504435A JPH10505821A (ja) | 1994-07-08 | 1995-07-07 | Ｉ型糖尿病の検出および処置のためのプロインスリンペプチド化合物 |
| AU30947/95A AU3094795A (en) | 1994-07-08 | 1995-07-07 | Proinsulin peptide compounds for detecting and treating type i diabetes |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27222094A | 1994-07-08 | 1994-07-08 | |
| US08/272,220 | 1994-07-08 | ||
| US47270495A | 1995-06-06 | 1995-06-06 | |
| US08/472,704 | 1995-06-06 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1996001846A1 WO1996001846A1 (fr) | 1996-01-25 |
| WO1996001846B1 true WO1996001846B1 (fr) | 1996-03-07 |
Family
ID=26955374
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US1995/008596 WO1996001846A1 (fr) | 1994-07-08 | 1995-07-07 | Composes de peptide de pro-insuline utiles pour detecter et traiter le diabete du type i |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20030220229A1 (fr) |
| EP (1) | EP0788512B1 (fr) |
| JP (1) | JPH10505821A (fr) |
| CN (1) | CN1157621A (fr) |
| AT (1) | ATE178074T1 (fr) |
| AU (1) | AU3094795A (fr) |
| CA (1) | CA2194548A1 (fr) |
| DE (1) | DE69508605T2 (fr) |
| DK (1) | DK0788512T3 (fr) |
| ES (1) | ES2130629T3 (fr) |
| MX (1) | MX9700198A (fr) |
| WO (1) | WO1996001846A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69637130T2 (de) | 1995-02-20 | 2008-02-21 | The Walter And Eliza Hall Institute Of Medical Research, Parkville | Immunoreaktive und immunotherapeutische moleküle welche in individuen mit insulin-abhängiger diabetes mellitus interagieren |
| SE520392C2 (sv) | 1996-09-27 | 2003-07-01 | Creative Peptides Sweden Ab C | Specifika peptider för behandling av diabetes mellitus |
| AUPO269996A0 (en) * | 1996-10-01 | 1996-10-24 | Walter And Eliza Hall Institute Of Medical Research, The | A method of prophylaxis and treatment |
| ES2331342B1 (es) * | 2006-05-22 | 2010-10-13 | Consejo Superior Investg.Cientificas | Uso de la proinsulina para la elaboracion de una composicion farmaceutica neuroprotectora, composicion terapeutica que la contiene y sus aplicaciones. |
| CN103630692B (zh) * | 2013-06-02 | 2015-05-06 | 马鞍山国声生物技术有限公司 | 快速检测尿液c肽的胶体金免疫层析试剂盒及其检测方法 |
| WO2015057968A2 (fr) * | 2013-10-17 | 2015-04-23 | The General Hospital Corporation | Méthodes pour identifier des sujets répondant au traitement d'une maladie auto-immune et compositions pour traiter ces sujets |
| GB2523399B (en) * | 2014-02-25 | 2019-03-13 | Orban Tihamer | A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence |
| GB2559499A (en) * | 2014-02-25 | 2018-08-08 | Orban Tihamer | Immunomodulatory therapy for type 1 diabetes mellitus autoimmunity |
| GB201913408D0 (en) * | 2019-09-17 | 2019-10-30 | King S College London | Proinsulin peptides for type 1 diabetes |
| WO2025035125A1 (fr) * | 2023-08-10 | 2025-02-13 | The Curators Of The University Of Missouri | Suppression du diabète de type 1 par il-4 intrathymique |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5210872B2 (fr) * | 1973-07-14 | 1977-03-26 | ||
| US4308181A (en) * | 1980-12-08 | 1981-12-29 | American Home Products Corporation | Polypeptide compositions |
| US4652548A (en) * | 1981-08-27 | 1987-03-24 | Eli Lilly And Company | Pharmaceutical formulations comprising human insulin, human C-peptide, and human proinsulin |
| US5114844A (en) * | 1989-03-14 | 1992-05-19 | Yeda Research And Development Co., Ltd. | Diagnosis and treatment of insulin dependent diabetes mellitus |
| NL9001083A (nl) * | 1990-05-04 | 1991-12-02 | Rijksuniversiteit | Beta-cel antigeen. |
| CA2089742C (fr) * | 1990-08-17 | 2002-05-14 | Mark A. Atkinson | Methodes et compositions permettant le depistage precoce et le traitement du diabete sucre insulino-dependant |
-
1995
- 1995-07-07 AT AT95926642T patent/ATE178074T1/de not_active IP Right Cessation
- 1995-07-07 AU AU30947/95A patent/AU3094795A/en not_active Abandoned
- 1995-07-07 CA CA002194548A patent/CA2194548A1/fr not_active Abandoned
- 1995-07-07 ES ES95926642T patent/ES2130629T3/es not_active Expired - Lifetime
- 1995-07-07 WO PCT/US1995/008596 patent/WO1996001846A1/fr active IP Right Grant
- 1995-07-07 JP JP8504435A patent/JPH10505821A/ja not_active Ceased
- 1995-07-07 DE DE69508605T patent/DE69508605T2/de not_active Expired - Fee Related
- 1995-07-07 EP EP95926642A patent/EP0788512B1/fr not_active Revoked
- 1995-07-07 DK DK95926642T patent/DK0788512T3/da active
- 1995-07-07 MX MX9700198A patent/MX9700198A/es not_active IP Right Cessation
- 1995-07-07 CN CN95194541A patent/CN1157621A/zh active Pending
-
2003
- 2003-01-16 US US10/346,563 patent/US20030220229A1/en not_active Abandoned
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