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WO1996004032A1 - Embout interchangeable pour inhalateurs a tablette de substance active integree, consolidee, annulaire - Google Patents

Embout interchangeable pour inhalateurs a tablette de substance active integree, consolidee, annulaire Download PDF

Info

Publication number
WO1996004032A1
WO1996004032A1 PCT/EP1995/002750 EP9502750W WO9604032A1 WO 1996004032 A1 WO1996004032 A1 WO 1996004032A1 EP 9502750 W EP9502750 W EP 9502750W WO 9604032 A1 WO9604032 A1 WO 9604032A1
Authority
WO
WIPO (PCT)
Prior art keywords
tablet
mouthpiece
tablet holder
interchangeable
ring
Prior art date
Application number
PCT/EP1995/002750
Other languages
German (de)
English (en)
Inventor
Bernhard Hugemann
Original Assignee
BUKOR, Ruth-Maria
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE4429707A external-priority patent/DE4429707C1/de
Application filed by BUKOR, Ruth-Maria filed Critical BUKOR, Ruth-Maria
Priority to AU31105/95A priority Critical patent/AU3110595A/en
Publication of WO1996004032A1 publication Critical patent/WO1996004032A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/0065—Inhalators with dosage or measuring devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder
    • A61M2202/066—Powder made from a compacted product by abrading

Definitions

  • the invention relates to an interchangeable mouthpiece for inhalers for the mechanical production of dosed inhalable active ingredient particles with an integrated, solidified, ring-shaped active ingredient tablet and an inhalation tube which can be axially displaced in the mouthpiece, at the end of which is directed towards the dosing agent, the tablet is fastened in a tablet holder .
  • the object of the invention is to improve and simplify the interchangeability of the mouthpiece and at the same time the axial and radial stability of the mouthpiece with respect to the inhaler drive unit, i.e. especially to optimize their dosing agents.
  • a tablet holder guide is proposed for this purpose, which connects the mouthpiece to the inhaler drive unit.
  • This tablet holder guide creates an integral unit between the mouthpiece and the inhaler drive unit.
  • the tablet holder guide stabilizes the position of the tablet in relation to the dosing agent in a very precise way. This makes it possible to generate the required doses of the active ingredient tablet very precisely and reproducibly.
  • the invention makes the handling of the inhaler by the user more consumer-friendly.
  • the tablet holder guide according to the invention enables the mouthpiece to be replaced by movements which are also common in everyday life, in particular in older people - lifting off a closure cap by tilting the spray can, rotating the tank cap. Despite these simple movements, the tablet according to the invention stabilizes the connection between the mouthpiece and the inhaler drive unit is surprisingly very precise.
  • the tablet holder guide has an annular bead at the end directed towards the mouthpiece which engages in an annular recess in the mouthpiece.
  • the dimensions of the bead and the ring groove are chosen so that due to a certain flexibility of the tablet holder guide and mouthpiece, both a snap-in and a take-out are possible. Tilting the mouthpiece is enough to take it out, an inclined insertion and pressing is enough to insert it.
  • This compound is referred to herein as a -Sia ⁇ M- compound.
  • the axial guidance of the tablet holder has, according to the invention, at least one rotating lug on the circumference, which is arranged to be axially movable in a slot in the tablet holder guide.
  • the axial guidance is not limited to the area of the munster / inhalation tube alone, as in the prior art. This area becomes smaller as the tablet is removed.
  • the guidance of the tablet holder in the slots of the tablet holder guide is always uniformly and precisely independent of the degree of removal of the tablet.
  • the tablet holder guide has, according to the invention, a locking bead which interacts with locking pins on the inhaler drive unit.
  • the locking bead has at least two recesses distributed symmetrically on the circumference, which cooperate with the locking pins in a bayonet-like manner. That is, by inserting the pins into the recess and making a small rotation, the mouthpiece and the inhaler drive unit are connected to one another or detached from one another.
  • a cover cap is provided to cover the locking mechanisms and can be fastened to the locking pin via a further snap-in connection.
  • the tablet holder has molded parts protruding on the surface directed against the tablet, which correspond to correspondingly shaped depressions in the tablet surface. This improves the integration of the tablet in the tablet holder.
  • This configuration of the tablet and tablet holder according to the invention makes it possible, compared to the prior art, to do without the tablet being fixed in the tablet holder by gluing. Adhesives are fundamentally disadvantageous for medication and require elaborate approvals.
  • clamping elements can be assigned to the molded parts.
  • the invention proposes to design it in two parts, the inhalation tube being attachable to the tablet holder.
  • the solidified, ring-shaped active ingredient tablets can be produced by means of various known techniques, the number of individual dosages in the range of 50-300 or more can be predetermined via the length dimension of the ring tablet.
  • active ingredients which can be micronized and which have to be dosed at a low level can be used. This also applies in particular to the active ingredients that cannot be suspended in CFCs or that are denatured by CFCs. All active ingredients that are absorbed by inhalation in the lungs can be used. These are in particular:
  • Respiratory therapy e.g.
  • budesonide from the group of steroids: budesonide, R-budesonide, beclometasone, fluticasone and others;
  • - peptide hormones insulin, calcitonin, desmopressin and others;
  • - chemotherapy drugs e.g. Pentamidine and others
  • the mouthpiece unit is advantageously housed in an airtight container with desiccant. After replacing the used unit or tablet, the container can be used as a new closure cap for the inhaler.
  • the container is designed in such a way that a special holder provides the prerequisite for also accommodating individual active ingredient ring tablets.
  • FIG. 1 shows the core of the subject matter of the invention inhalation tube / tablet holder / ring tablet
  • Fig. 2 shows the mouthpiece unit
  • FIG 3 shows the complete inhaler consisting of inhaler drive unit and mouthpiece unit.
  • Fig. 1 denotes the ring tablet, which is located in the tablet holder 2.
  • 2 molded parts 5 are arranged on the tablet holder for fastening them. These can consist of simple pins of different cross-sections, for example cones, the O 96/04032 -, ⁇ -, -., ⁇ -.
  • Corresponding depressions are assigned to the molded parts 5 in the ring tablet 2.
  • clamping elements 6, for example Feder ⁇ elements are all or only some mold parts 5 clamping elements 6, for example Feder ⁇ elements, assigned to the ring tablet 4 to be fixed in the axial direction and secure it against falling out.
  • the inhalation tube 1 is attached to the tablet holder 2 in the form of a cone connection.
  • a one-piece design tablet holder / inhalation tube - as shown in FIG. 2 - is also encompassed by the invention.
  • Two opposite guide lugs 3 are formed on the tablet holder 2 and are used to secure the tablet holder 2 against rotation.
  • the guide lugs 3 also serve in the axial direction as a stop to limit the tablets when they reach the locking bead 11.
  • the inhalation tube 1 located on the tablet holder 2 is guided precisely on its outer diameter in the inhaler mouthpiece 7.
  • a compression spring 8 which fits onto the inhalation tube 1 ensures that the end face of the ring tablet 4 is pressed onto the metering means 16 of the inhaler with a predeterminable spring force.
  • a dosing agent elements are used which cause abrasion from the ring tablet by rotation and thus generate a dose of active ingredient.
  • Such a dosing agent is known in the form of an end mill from WO 93 / - ⁇ - £ l.
  • the tablet holder 2 is additionally guided precisely in the tablet holder guide 9, namely through the guide lugs 3. These are located in slot-shaped recesses which run vertically in the tablet holder guide 9. The tablet holder is also secured against twisting.
  • the tablet holder guide 9 is rigidly attached on its other side to the mouthpiece 7 with a snap-in connection 19 and secured by a stiff coupling ring 10.
  • the mouthpiece unit is constantly pressed in the axial direction onto the abutment surfaces 15 of the inhaler drive unit 18 by means of a cover cap 13 which engages with the inhaler guide pins 14 in a snap-in connection.
  • the cover cap 13 can be easily removed by hand, so that the exchange of a used active ingredient ring tablet 4 or the entire mouthpiece unit is possible at any time.
  • All parts can be made of plastic using injection molding technology or using conventional machining methods.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Anesthesiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)

Abstract

Embout interchangeable pour inhalateurs de poche, à tablette de substance active intégrée, très rigide, annulaire, à la partie avant desquels des particules de grosseur inhalable sont générées de façon dosée, de telle manière que même des substances hautement actives nécessitant un faible dosage et qui sont résorbées dans les poumons peuvent être administrées par inhalation pour des usages thérapeutiques.
PCT/EP1995/002750 1994-08-04 1995-07-13 Embout interchangeable pour inhalateurs a tablette de substance active integree, consolidee, annulaire WO1996004032A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU31105/95A AU3110595A (en) 1994-08-04 1995-07-13 Exchangeable mouthpiece for inhalers with integrated, consolidated, ring-shaped active substance tablet

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DEP4427527.7 1994-08-04
DE4427527 1994-08-04
DEP4429707.6 1994-08-22
DE4429707A DE4429707C1 (de) 1994-08-04 1994-08-22 Inhalator mit integrierter, verfestigter, ringförmiger Wirkstofftablette

Publications (1)

Publication Number Publication Date
WO1996004032A1 true WO1996004032A1 (fr) 1996-02-15

Family

ID=25938934

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1995/002750 WO1996004032A1 (fr) 1994-08-04 1995-07-13 Embout interchangeable pour inhalateurs a tablette de substance active integree, consolidee, annulaire

Country Status (2)

Country Link
AU (1) AU3110595A (fr)
WO (1) WO1996004032A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10326830B3 (de) * 2003-06-12 2004-06-24 Msa Auer Gmbh Steckverbindung für Atemanschlüsse

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024165A1 (fr) * 1992-05-29 1993-12-09 Ggu Gesellschaft Für Gesundheits- Und Umweltforschung Mbh & Co. Vertriebs Kg Dispositif generateur de particules inhalables de substances actives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993024165A1 (fr) * 1992-05-29 1993-12-09 Ggu Gesellschaft Für Gesundheits- Und Umweltforschung Mbh & Co. Vertriebs Kg Dispositif generateur de particules inhalables de substances actives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10326830B3 (de) * 2003-06-12 2004-06-24 Msa Auer Gmbh Steckverbindung für Atemanschlüsse

Also Published As

Publication number Publication date
AU3110595A (en) 1996-03-04

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