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WO1996008237A2 - Pressure-sensitive adhesive plaster for releasing active substance into the environment of a support - Google Patents

Pressure-sensitive adhesive plaster for releasing active substance into the environment of a support Download PDF

Info

Publication number
WO1996008237A2
WO1996008237A2 PCT/EP1995/003568 EP9503568W WO9608237A2 WO 1996008237 A2 WO1996008237 A2 WO 1996008237A2 EP 9503568 W EP9503568 W EP 9503568W WO 9608237 A2 WO9608237 A2 WO 9608237A2
Authority
WO
WIPO (PCT)
Prior art keywords
skin
active substance
active ingredient
plaster
environment
Prior art date
Application number
PCT/EP1995/003568
Other languages
German (de)
French (fr)
Other versions
WO1996008237A3 (en
Inventor
Frank Becher
Original Assignee
Lts Lohmann Therapie-Systeme Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lts Lohmann Therapie-Systeme Gmbh filed Critical Lts Lohmann Therapie-Systeme Gmbh
Publication of WO1996008237A2 publication Critical patent/WO1996008237A2/en
Publication of WO1996008237A3 publication Critical patent/WO1996008237A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/02—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings containing insect repellants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • Self-adhesive plaster for delivering active substance to the environment of a wearer
  • the invention relates to a self-adhesive plaster for delivering active substance by evaporation to the environment of a carrier.
  • active substance is to be understood in the broadest sense to mean all substances which, in the vapor phase, act as aerosols in the ambient air against the carrier of the plaster or other organisms, for example substances having a therapeutic or psychotherapeutic effect, odorous substances, bactericides, Kepellents, breath-relieving, snuff-reducing substances etc.
  • solutions and in particular alcoholic solutions to the skin. This is particularly common in the area of perfumes, etc.; Kepellents are also applied to the skin in this form and evaporate from there into the ambient air.
  • Dispensing directly from the surface of the skin to the environment has the disadvantage that the skin can be exposed to irritation in some cases and can have an allergic reaction, although the concentration of the active ingredients must be relatively low because of possible damaging effects on the skin.
  • Skin-damaging active ingredients are completely ruled out for one application.
  • the invention is based on the object of specifying a self-adhesive plaster for delivering active ingredient by evaporation to the environment of a carrier, which avoids the disadvantages and technical limits of the prior art and without arousing skin irritation in a relative manner small adhesion or release surface sufficiently intensive discharge of irk W ⁇ material allows to the immediate ambient atmosphere of the carrier.
  • the object is achieved according to the invention by a structure of the plaster according to claim 1.
  • a "reverse dermal system” is applied to the skin practically as both as a membrane patch, on the other hand as ⁇ matrix patch prior art.
  • D abei ver ⁇ prevents the impermeable for active ingredient carrier layer, he d on the skin-facing side a Selb ⁇ tklebe Anlagen un d on the skin distal side of one or more active ingredient re ⁇ errium are associated with skin irritation.
  • a nderer ⁇ hand enables the one or more drug reservoirs a very high loading of active ingredient for a very intense A BGA b e.
  • separation of the adhesive layer and active substance reservoir it is possible, a relatively large W irk ⁇ molar entered.
  • the freedom of design is also relatively unlimited.
  • plaster of the invention similar to be ⁇ known membrane patches to be designed for the controlled release of active substance and also have a greater thickness and consequently absorb greater amounts of the active ingredient.
  • the application of the plaster is possible without problems, an active substance plaster being applied to the skin and the protective layer being removed, after which the plaster releases active substances into the environment over a longer period of time.
  • the plaster according to the invention comprises, in the layer structure, a carrier film (1) with at least one adhesive layer (2) on the side facing the skin and with at least one or more Keservoir layers (3 or 4) on the side facing away from the skin, in which there is a preparation containing the active ingredient is located, which is initially covered with a protective layer (5) until application.
  • Both the carrier film (1) and the protective layer (5) consist of a material that is impermeable to the active ingredient.
  • a membrane (6) controlling the release of the active ingredient can be arranged between a reservoir (3 or 4) and the protective layer (5).
  • the adhesive layer (2) is initially covered with a protective film as a covering layer (7).
  • the cover layer (7) is first removed from the adhesive layer (2) to be turned towards the skin and the plaster is applied to the substrate, for example the skin.
  • the protective film (5) is then pulled off the plaster, so that the reservoir layer (3) or (4) can release active substance to the surroundings of the substrate. Occasionally the dispensing is timed by a control membrane (6) resting on the reservoir slides (3) or (4).
  • Preferred active ingredients are those which have a sufficiently high vapor pressure so that they can penetrate the control membrane (6) in a targeted manner.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Pest Control & Pesticides (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Birds (AREA)
  • Plant Pathology (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

A pressure-sensitive adhesive plaster for releasing active substance into the environment of a support by evaporation consists of several layers and is characterised by a series of layers arranged as follows: (a) an active substance-impervious carrier layer that faces the skin and arranged thereon (b) an adhesive layer that faces the skin; and opposite the skin (c) one or several active substance reservoirs, and arranged thereon (d) an active substance-impervious protecting layer that is removed before the plaster is applied, allowing the active substance to be released into the environment; and (e) if required a covering layer that protects the adhesive layer prior to application.

Description

Selbstklebendes Pflaster zur Abgabe von Wirkstoff an die Umgebung eines Trägers Self-adhesive plaster for delivering active substance to the environment of a wearer

Die Erfindung betrifft ein selbstklebendeβ Pflaster zur Abgabe von Wirkstoff durch Verdampfung an die Umgebung ei¬ nes Trägers.The invention relates to a self-adhesive plaster for delivering active substance by evaporation to the environment of a carrier.

Unter dem Begriff "Wirkstoff" βollen hierunter im weitesten Sinne alle Stoffe verstanden sein, die in der Dampfphase als Aerosole in der Umgebungsluft eine Wirkung gegenüber dem Träger des Pflasters oder anderen Organismen entfalten, beispielsweise therapeutisch oder psychotherapeutisch wir¬ kende Stoffe, Geruchsstoffe, Bakterizide, Kepellents, atmungserleichternde, schnupfenmildernde Stoffe etc. Um Düfte bzw. Wirkstoffe unmittelbar von der Haut abzuge¬ ben, ist es bekannt, Lösungen und insbesondere alkoholische Lösungen auf die Haut zu applizieren. Dies ist vor allem im Bereich von Parfüms usw. üblich; auch Kepellents werden in dieser Form auf die Haut appliziert und verdampfen von dort in die Umgebungsluft.The term “active substance” is to be understood in the broadest sense to mean all substances which, in the vapor phase, act as aerosols in the ambient air against the carrier of the plaster or other organisms, for example substances having a therapeutic or psychotherapeutic effect, odorous substances, bactericides, Kepellents, breath-relieving, snuff-reducing substances etc. In order to release fragrances or active substances directly from the skin, it is known to apply solutions and in particular alcoholic solutions to the skin. This is particularly common in the area of perfumes, etc.; Kepellents are also applied to the skin in this form and evaporate from there into the ambient air.

Die Abgabe unmittelbar von der Hautoberfläche an die Umge¬ bung hat den Nachteil, daß die Haut fallweise Reizungen ausgesetzt sein und allergisch reagieren kann, wobei über¬ dies die Konzentration der Wirkstoffe wegen möglicher schädigender Einwirkungen auf die Haut relativ gering sein muß.Dispensing directly from the surface of the skin to the environment has the disadvantage that the skin can be exposed to irritation in some cases and can have an allergic reaction, although the concentration of the active ingredients must be relatively low because of possible damaging effects on the skin.

Hautschädigende Wirkstoffe scheiden für eine Applikation vollkommen aus. Andererseits kann es wünschenswert sein, bestimmte Stoffe unter Umständen von einer relativ kleinen Oberfläche aus sehr intensiv an die Umgebung abzugeben. Dies gilt beispielsweise für Duftstoffe, fallweise auch für Kepellents, ebenso wie für schleimlösende, atmungβerleich- ternde Wirkstoffe sowie unter Umständen auch für Insekten¬ vertilgungsmittel und ähnliche.Skin-damaging active ingredients are completely ruled out for one application. On the other hand, it may be desirable to release certain substances very intensively into the environment from a relatively small surface. This applies, for example, to fragrances, and occasionally also to Kepellents, as well as expectorant, atmungβerleich- ternde agents and possibly also for insect control agent ¬ and the like.

Der Erfindung liegt, ausgehend vom vorgenannten Stand der Technik, die Aufgabe zugrunde, ein selbstklebendes Pflaster zur Abgabe von Wirkstoff durch Verdampfung an die Umgebung eines Trägers anzugeben, das die Nachteile und technischen Grenzen des Standes der Technik vermeidet und ohne Erregung von Hautirritationen bei einer relativ kleinen Haft- bzw. Abgabefläche eine ausreichend intensive Abgabe von Wirk¬ stoff an die unmittelbare UmgebungsatmoSphäre des Trägers ermöglicht.Starting from the aforementioned prior art, the invention is based on the object of specifying a self-adhesive plaster for delivering active ingredient by evaporation to the environment of a carrier, which avoids the disadvantages and technical limits of the prior art and without arousing skin irritation in a relative manner small adhesion or release surface sufficiently intensive discharge of irk W ¬ material allows to the immediate ambient atmosphere of the carrier.

Die Aufgabe wird erfindungs emäß durch einen Aufbau des Pflasters entsprechend dem Anspruch 1 gelöst. Damit wird praktisch ein "umgekehrtes dermales System" auf die Haut appliziert, wie es einerseits als Membranpflaster, anderer¬ seits als Matrixpflaster Stand der Technik ist. Dabei ver¬ hindert die für Wirkstoff undurchlässige Trägerschicht, der auf der hautzugewandten Seite eine Selbεtklebeschicht und auf der hautabgewandten Seite ein oder mehrere Wirkstoff- reεervoire zugeordnet sind, eine Hautirritation. Anderer¬ seits ermöglicht das oder die Wirkstoffreservoire eine sehr hohe Beladung mit Wirkstoff für eine sehr intensive Abgabe. Infolge Trennung von Klebstoffschicht und Wirkstoffreservoir gelingt es, eine relativ große Wirk¬ stoffmenge einzutragen. Dabei ist auch die Ge¬ staltungsfreiheit relativ unbegrenzt.The object is achieved according to the invention by a structure of the plaster according to claim 1. For a "reverse dermal system" is applied to the skin practically as both as a membrane patch, on the other hand as ¬ matrix patch prior art. D abei ver ¬ prevents the impermeable for active ingredient carrier layer, he d on the skin-facing side a Selbεtklebeschicht un d on the skin distal side of one or more active ingredient reεervoire are associated with skin irritation. A nderer ¬ hand, enables the one or more drug reservoirs a very high loading of active ingredient for a very intense A BGA b e. As a result, separation of the adhesive layer and active substance reservoir, it is possible, a relatively large W irk ¬ molar entered. The freedom of design is also relatively unlimited.

Weiterhin können erfindungsgemäße Pflaster, ähnlich den be¬ kannten Membranpflastern, zur gesteuerten Wirkstoffabgabe gestaltet sein und auch eine größere Dicke aufweisen und infolgedessen größere Mengen an Wirkstoff aufnehmen. Die Applikation des Pflasters ist problemlos möglich, wobei ein Wirkstoffpflaster auf die Haut aufgebracht und die Schutzschicht entfernt wird, wonach das Pflaster über län¬ gere Zeit Wirkstoffe an die Umgebung abgibt.Furthermore, plaster of the invention, similar to be ¬ known membrane patches to be designed for the controlled release of active substance and also have a greater thickness and consequently absorb greater amounts of the active ingredient. The application of the plaster is possible without problems, an active substance plaster being applied to the skin and the protective layer being removed, after which the plaster releases active substances into the environment over a longer period of time.

Dabei wird eine Hautreizung oder Hautschädigung vermieden und der Effekt von Kepellents, Parfüms usw. bleibt voll erhalten. Im Zusammenhang mit Parfüms und ähnlichen Duft- stoffen können die Eigenschaften des Pflasters im Rahmen einer plakativen Kosmetik, analog zu früheren Schönheits¬ pflästerchen, ausgestaltet werden.Skin irritation or skin damage is avoided and the effect of kepellents, perfumes etc. is fully retained. In connection with perfumes and similar fragrances, the properties of the plaster can be developed in the context of striking cosmetics, analogous to earlier beauty patches.

Beispiel:Example:

Das Pflaster nach der Erfindung umfaßt im Schichtaufbau eine Trägerfolie (1) mit wenigstens einer Klebschicht (2) auf der hautzugewandten Seite sowie mit wenigstens einer oder mehreren Keservoirschichten (3 bzw. 4) auf der haut- abgewandten Seite, in welchen sich eine wirkstoffhaltige Zubereitung befindet, die zunächst bis zur Applikation mit einer Schutzschicht (5) abgedeckt ist. Sowohl die Trägerfo¬ lie (1) als auch die Schutzschicht (5) bestehen aus einem für Wirkstoff undurchlässigen Material. Zwischen einem Reservoir (3 oder 4) und der Schutzschicht (5) kann eine die Wirkstofffreiεetzung steuernde Membran (6) angeordnet sein. Die Klebschicht (2) ist zunächst mit einer Schutzfo¬ lie als Abdeckschicht (7) abgedeckt.The plaster according to the invention comprises, in the layer structure, a carrier film (1) with at least one adhesive layer (2) on the side facing the skin and with at least one or more Keservoir layers (3 or 4) on the side facing away from the skin, in which there is a preparation containing the active ingredient is located, which is initially covered with a protective layer (5) until application. Both the carrier film (1) and the protective layer (5) consist of a material that is impermeable to the active ingredient. A membrane (6) controlling the release of the active ingredient can be arranged between a reservoir (3 or 4) and the protective layer (5). The adhesive layer (2) is initially covered with a protective film as a covering layer (7).

Bei der Anwendung wird zunächst die Abdeckschicht (7) von der der Haut zuzuwendenden Kleberschicht (2) entfernt und das Pflaster auf dem Substrat, z.B. der Haut, aufgebracht. Anschließend wird die Schutzfolie (5) vom Pflaster abgezo¬ gen, so daß die Reservoirschicht (3) bzw. (4) Wirkstoff an die Umgebung des Substrats abgeben kann. Fallweise wird dabei die Abgabe durch eine der Reservoirschiebt (3) bzw. (4) aufliegende Steuermembran (6) zeitlich gesteuert.During use, the cover layer (7) is first removed from the adhesive layer (2) to be turned towards the skin and the plaster is applied to the substrate, for example the skin. The protective film (5) is then pulled off the plaster, so that the reservoir layer (3) or (4) can release active substance to the surroundings of the substrate. Occasionally the dispensing is timed by a control membrane (6) resting on the reservoir slides (3) or (4).

Bevorzugte Wirkstoffe sind solche, die einen genügend hohen Dampfdruck haben, so daß sie die Steuermembran (6) gezielt durchdringen können. Preferred active ingredients are those which have a sufficiently high vapor pressure so that they can penetrate the control membrane (6) in a targeted manner.

Claims

A N S P R Ü C H E EXPECTATIONS 1. Selbstklebendes Pflaster zur Abgabe von Wirkstoff durch Verdampfung an die Umgebung eines Trägers, bestehend aus mehreren Schichten, gekennzeichnet durch eine Folge von Schichten mit a) einer hautzugewandten und für. irkstoff undurchlässigen Trägerschicht (1), und auf dieser b) einer hautseitigen Kleberschicht (2), sowie auf der hautabgewandten Seite c) einem oder mehreren Wirkstoffreservoirs (3) bzw. (4), und auf diesen d) einer wirkstoffundurchlässigen Schutzschicht (5), wel¬ che vor der Applikation des Pflasters entfernt wird und die Wirkstoffabgäbe an die Umgebung freigibt, sowie e) fallweise einer die Kleberschicht (2) bis zur Applika¬ tion schützenden Abdeckschicht (7).1. Self-adhesive plaster for delivering active ingredient by evaporation to the environment of a carrier, consisting of several layers, characterized by a sequence of layers with a) a skin-facing and for. Resilient layer impermeable to active substance (1), and on this b) a skin-side adhesive layer (2), and on the side facing away from the skin c) one or more active substance reservoirs (3) or (4), and on this d) a protective layer impermeable to active substance (5) which is removed prior to application of the plaster and releases the active ingredient release into the environment, and e) in some cases a cover layer (7) protecting the adhesive layer (2) up to the application. 2. Pflaster nach Anspruch 1, dadurch gekennzeichnet, daß das Wirkstoffreservoir (3) bzw. (4) eine Steuermembran (6) zur Steuerung einer gezielten Wirkstofffreisetzung auf¬ weist.2. Patch according to claim 1, characterized in that the drug reservoir (3) or (4) has a control membrane (6) for controlling a targeted drug release. 3. Pflaster nach Anspruch 1, dadurch gekennzeichnet, daß die Haftkleberschicht einen die Durchblutung der Haut anre¬ genden Wirkstoff enthält.3. A plaster according to claim 1, characterized in that the layer of pressure-sensitive adhesive contains an active ingredient which stimulates blood flow to the skin. 4. Pflaster nach Anspruch 1 oder 2, dadurch gekennzeich¬ net, daß die Wirkstoffe wenigtsens eine spasmolytische Kom¬ ponente enthalten.4. Patch according to claim 1 or 2, characterized gekennzeich¬ net that the active ingredients contain at least one spasmolytic component. 5. Pflaster nach Anspruch 1, dadurch gekennzeichnet, daß es einen broncholytiεchen Wirkstoff enthält. 5. Patch according to claim 1, characterized in that it contains a broncholytic active ingredient. 6. Pflaster nach Anspruch 1, dadurch gekennzeichnet, daß es einen antiasthmatischen Wirkstoff enthält.6. Patch according to claim 1, characterized in that it contains an anti-asthmatic active ingredient. 7. Pflaster nach Anspruch 1, dadurch gekennzeichnet, daß es ein Insektenrepellent als Wirkstoff enthält.7. Patch according to claim 1, characterized in that it contains an insect repellent as an active ingredient. 8. Pflaster anch Anspruch 1, dadurch gekennzeichnet, daß es einen kosmetischen Wirkstoff,"bevorzugt einen DuftStoff enthält. 8. Patch according to claim 1, characterized in that it contains a cosmetic active ingredient, "preferably a fragrance.
PCT/EP1995/003568 1994-09-17 1995-09-11 Pressure-sensitive adhesive plaster for releasing active substance into the environment of a support WO1996008237A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4433191.6 1994-09-17
DE19944433191 DE4433191A1 (en) 1994-09-17 1994-09-17 Self-adhesive plaster for delivering active substance to the environment of a wearer

Publications (2)

Publication Number Publication Date
WO1996008237A2 true WO1996008237A2 (en) 1996-03-21
WO1996008237A3 WO1996008237A3 (en) 1996-04-18

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Application Number Title Priority Date Filing Date
PCT/EP1995/003568 WO1996008237A2 (en) 1994-09-17 1995-09-11 Pressure-sensitive adhesive plaster for releasing active substance into the environment of a support

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Country Link
DE (1) DE4433191A1 (en)
WO (1) WO1996008237A2 (en)

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* Cited by examiner, † Cited by third party
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US6106857A (en) * 1998-03-10 2000-08-22 Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. Fragranced cosmetic product for removal of keratotic plugs from skin pores

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