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WO1996039101B1 - Compositions et procedes relatifs a une matrice extracellulaire secretee naturellement - Google Patents

Compositions et procedes relatifs a une matrice extracellulaire secretee naturellement

Info

Publication number
WO1996039101B1
WO1996039101B1 PCT/US1996/009482 US9609482W WO9639101B1 WO 1996039101 B1 WO1996039101 B1 WO 1996039101B1 US 9609482 W US9609482 W US 9609482W WO 9639101 B1 WO9639101 B1 WO 9639101B1
Authority
WO
WIPO (PCT)
Prior art keywords
extracellular matrix
cells
naturally secreted
framework
composition according
Prior art date
Application number
PCT/US1996/009482
Other languages
English (en)
Other versions
WO1996039101A1 (fr
Filing date
Publication date
Priority claimed from US08/470,101 external-priority patent/US5830708A/en
Application filed filed Critical
Priority to AU62609/96A priority Critical patent/AU708090B2/en
Priority to EP96921369A priority patent/EP0967934B1/fr
Priority to NZ311313A priority patent/NZ311313A/xx
Priority to AT96921369T priority patent/ATE290350T1/de
Priority to DE69634454T priority patent/DE69634454T2/de
Priority to JP50179097A priority patent/JP3709487B2/ja
Publication of WO1996039101A1 publication Critical patent/WO1996039101A1/fr
Publication of WO1996039101B1 publication Critical patent/WO1996039101B1/fr

Links

Abstract

L'invention concerne des compositions contenant des matrices extracellulaires humaines sécrétées naturellement, leurs procédés de fabrication et d'utilisation. On obtient une matrice extracellulaire selon l'invention en mettant des cellules en culture dans une structure de support tridimensionnelle de sorte que ces dernières sécrètent une matrice extracellulaire. On tue ensuite les cellules et on les retire de la structure de support pour n'y laisser que la matrice extracellulaire, après quoi on peut enlever cette dernière du support, la combiner avec un véhicule approprié pharmacologiquement acceptable et l'injecter dans une zone tissulaire anormale de la peau d'un patient.
PCT/US1996/009482 1995-06-06 1996-06-06 Compositions et procedes relatifs a une matrice extracellulaire secretee naturellement WO1996039101A1 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
AU62609/96A AU708090B2 (en) 1995-06-06 1996-06-06 Compositions and methods for naturally secreted extracellular matrix
EP96921369A EP0967934B1 (fr) 1995-06-06 1996-06-06 Compositions et procedes relatifs a une matrice extracellulaire secretee naturellement
NZ311313A NZ311313A (en) 1995-06-06 1996-06-06 Composition and method for making compositions for treatment of wrinkles and scars using human extracellular matrix
AT96921369T ATE290350T1 (de) 1995-06-06 1996-06-06 Zusammensetzungen und verfahren mit bezug auf eine auf natürliche weise sekretierte matrix
DE69634454T DE69634454T2 (de) 1995-06-06 1996-06-06 Zusammensetzungen und Verfahren mit Bezug auf eine auf natürliche Weise sekretierte Matrix
JP50179097A JP3709487B2 (ja) 1995-06-06 1996-06-06 自然分泌細胞外マトリックスのための組成物及び方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US470,101 1995-06-06
US08/470,101 US5830708A (en) 1995-06-06 1995-06-06 Methods for production of a naturally secreted extracellular matrix

Publications (2)

Publication Number Publication Date
WO1996039101A1 WO1996039101A1 (fr) 1996-12-12
WO1996039101B1 true WO1996039101B1 (fr) 1997-01-09

Family

ID=23866272

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1996/009482 WO1996039101A1 (fr) 1995-06-06 1996-06-06 Compositions et procedes relatifs a une matrice extracellulaire secretee naturellement

Country Status (11)

Country Link
US (1) US5830708A (fr)
EP (1) EP0967934B1 (fr)
JP (1) JP3709487B2 (fr)
KR (1) KR19990022216A (fr)
AT (1) ATE290350T1 (fr)
AU (1) AU708090B2 (fr)
CA (1) CA2223892A1 (fr)
DE (1) DE69634454T2 (fr)
ES (1) ES2238076T3 (fr)
NZ (1) NZ311313A (fr)
WO (1) WO1996039101A1 (fr)

Families Citing this family (119)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6974571B2 (en) * 1995-03-28 2005-12-13 Thomas Jefferson University Isolated stromal cells and methods of using the same
US6284284B1 (en) * 1995-06-06 2001-09-04 Advanced Tissue Sciences, Inc. Compositions and methods for production and use of an injectable naturally secreted extracellular matrix
US7767452B2 (en) 1997-02-20 2010-08-03 Kleinsek Don A Tissue treatments with adipocyte cells
WO1998036704A1 (fr) * 1997-02-20 1998-08-27 Keller Gregory S Amelioration et reparation de defauts des tissus dermiques ou sous-cutanes et des tissus des cordes vocales
GB9720987D0 (en) * 1997-10-01 1997-12-03 Biocure Ltd A multicellular in vitro assay of angiogenesis
US6225118B1 (en) 1997-10-01 2001-05-01 Biocure Limited Multicellular in vitro assay of angiogenesis
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
WO1999047186A1 (fr) * 1998-03-18 1999-09-23 University Of Pittsburgh Matieres composites a base de chitosane contenant du glycosaminoglycane pour la reparation du cartilage
US6378527B1 (en) * 1998-04-08 2002-04-30 Chondros, Inc. Cell-culture and polymer constructs
US6428978B1 (en) * 1998-05-08 2002-08-06 Cohesion Technologies, Inc. Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
EP2295540A1 (fr) * 1998-11-19 2011-03-16 Organogenesis, Inc. Constructions de tissu issues de la bioingénierie et leurs procédés de fabrication et d'utilisation
US7615373B2 (en) 1999-02-25 2009-11-10 Virginia Commonwealth University Intellectual Property Foundation Electroprocessed collagen and tissue engineering
US6662805B2 (en) 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
US20030007954A1 (en) 1999-04-12 2003-01-09 Gail K. Naughton Methods for using a three-dimensional stromal tissue to promote angiogenesis
US6372494B1 (en) 1999-05-14 2002-04-16 Advanced Tissue Sciences, Inc. Methods of making conditioned cell culture medium compositions
WO2001003750A1 (fr) * 1999-07-09 2001-01-18 Advanced Tissue Sciences, Inc. Appareil revetu d'une matrice extracellulaire naturellement secretee par l'homme
CA2383398C (fr) * 1999-08-23 2013-06-11 Organogenesis, Inc. Compositions et traitements pour soins cutanes
AU1472501A (en) * 1999-11-05 2001-05-14 Gerigene Medical Corporation Augmentation and repair of age-related soft tissue defects
US20080286242A2 (en) * 1999-11-05 2008-11-20 Donald Kleinsek Augmentation and repair of spincter defects with cells including mesenchymal cells
US20090074729A2 (en) * 1999-11-05 2009-03-19 Donald Kleinsek Augmentation and repair of spincter defects with cells including fibroblasts
US20080267923A2 (en) * 1999-11-05 2008-10-30 Donald Kleinsek Hair undifferentiated cells
US7799325B2 (en) * 1999-11-05 2010-09-21 Kleinsek Donald A Removal of hypertrophic scars
EP1259634A4 (fr) 2000-03-02 2004-07-07 Univ Rochester Generation ex vivo de cellules leucemiques fonctionnelles dans un bioreacteur tridimensionnel
US6436424B1 (en) * 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
ATE327783T1 (de) 2000-03-20 2006-06-15 Biosphere Medical Inc Injizierbare mikrokügelchen für den gewebeaufbau
US7338657B2 (en) * 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
WO2001070289A2 (fr) 2000-03-20 2001-09-27 Biosphere Medical, Inc. Microspheres injectables, susceptibles de foisonnement, visant a faire gonfler un tissu
US8366787B2 (en) * 2000-08-04 2013-02-05 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
US6638312B2 (en) 2000-08-04 2003-10-28 Depuy Orthopaedics, Inc. Reinforced small intestinal submucosa (SIS)
EP1315796B1 (fr) * 2000-08-16 2006-07-12 Duke University Constructions de tissu decellularise issues de l'ingenierie tissulaire et tissus ainsi produits
JP2004508305A (ja) 2000-09-01 2004-03-18 ヴァージニア　コモンウェルス　ユニバーシティ　インテレクチュアル　プロパティー　ファンデーション 電気処理されたフィブリンをベースとするマトリックスおよび組織
US20090130066A1 (en) * 2000-11-06 2009-05-21 Gerigene Medical Corporation Augmentation and repair of sphincter defects with cells including muscle cells
ATE402002T1 (de) * 2000-11-17 2008-08-15 Univ Virginia Commonwealth Elektroverarbeitetes kollagen
AU2002220209B2 (en) 2000-12-06 2006-05-25 Robert J. Hariri Method of collecting placental stem cells
US7311905B2 (en) 2002-02-13 2007-12-25 Anthrogenesis Corporation Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells
US7041868B2 (en) 2000-12-29 2006-05-09 Kimberly-Clark Worldwide, Inc. Bioabsorbable wound dressing
EP2316919B1 (fr) 2001-02-14 2015-10-07 Anthrogenesis Corporation Placenta post-gravidique de mammifère, son utilisation et céllules souches placentaires correspondantes
CA2796875A1 (fr) 2001-02-14 2002-08-22 Anthrogenesis Corporation Placenta post-gravidique de mammifere, son utilisation et cellules souches placentaires correspondantes
US7163563B2 (en) 2001-07-16 2007-01-16 Depuy Products, Inc. Unitary surgical device and method
WO2003007879A2 (fr) * 2001-07-16 2003-01-30 Depuy Products, Inc. Structure de support et methode de reparation et de regeneration de cartilage
US7819918B2 (en) * 2001-07-16 2010-10-26 Depuy Products, Inc. Implantable tissue repair device
JP4294474B2 (ja) 2001-07-16 2009-07-15 デピュイ・プロダクツ・インコーポレイテッド 半月板再生装置
DE60239342D1 (de) * 2001-07-16 2011-04-14 Depuy Products Inc Gerät zur reparatur von knorpelmaterial
WO2003007790A2 (fr) 2001-07-16 2003-01-30 Depuy Products, Inc. Echafaudages de matrice extracellulaire poreux hybrides biologique/synthetique
EP1416866A4 (fr) * 2001-07-16 2007-04-18 Depuy Products Inc Dispositifs a base de matieres biologiquement derivees d'origine naturelle
US8025896B2 (en) 2001-07-16 2011-09-27 Depuy Products, Inc. Porous extracellular matrix scaffold and method
WO2003007786A2 (fr) 2001-07-16 2003-01-30 Depuy Products, Inc. Echafaudage a distribution poreuse t procede correspondant
EP2292091A1 (fr) 2002-02-13 2011-03-09 Anthrogenesis Corporation Cellules souches de type embryonnaire dérivées de placenta mammalien post-partum, utilisations, et procédés de traitement à base de cellules de ce type
WO2003072128A2 (fr) * 2002-02-22 2003-09-04 Ebi, L.P. Procedes et composes destines a traiter des defauts osseux ou du cartilage
US7498171B2 (en) 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
KR100527623B1 (ko) * 2002-06-01 2005-11-15 라이프코드인터내셔날 주식회사 세포외기질을 포함하는 인공장기 제조용 생분해성 고분자기질 및 그의 제조방법
MXPA05005673A (es) 2002-11-26 2005-11-23 Anthrogenesis Corp Productos citoterapeuticos, unidades citoterapeuticas y metodos para tratamientos que usan los mismos.
IL156945A0 (en) * 2003-07-15 2004-02-08 Itzhak Tavori Device and a method for orthopedic delivery of bone reconstruction medium
US7326571B2 (en) * 2003-07-17 2008-02-05 Boston Scientific Scimed, Inc. Decellularized bone marrow extracellular matrix
JP2005211099A (ja) * 2004-01-27 2005-08-11 Olympus Corp 人工臓器構成材および人工臓器構成体の製造方法および人工臓器
US7569233B2 (en) 2004-05-04 2009-08-04 Depuy Products, Inc. Hybrid biologic-synthetic bioabsorbable scaffolds
CA2566765C (fr) * 2004-05-11 2011-08-23 Synthasome Inc. Supports tissulaires hybrides contenant une matrice extracellulaire
US20070190108A1 (en) * 2004-05-17 2007-08-16 Arindam Datta High performance reticulated elastomeric matrix preparation, properties, reinforcement, and use in surgical devices, tissue augmentation and/or tissue repair
CA2578951A1 (fr) * 2004-08-30 2006-03-09 Theregen, Inc. Tissus tridimensionnels de culture et utilisations de ceux-ci
US7513866B2 (en) 2004-10-29 2009-04-07 Depuy Products, Inc. Intestine processing device and associated method
US7354627B2 (en) 2004-12-22 2008-04-08 Depuy Products, Inc. Method for organizing the assembly of collagen fibers and compositions formed therefrom
CA2612188A1 (fr) * 2005-06-17 2007-01-04 Theregen, Inc. Methodes de traitement d'un tissu ischemique
US7595062B2 (en) 2005-07-28 2009-09-29 Depuy Products, Inc. Joint resurfacing orthopaedic implant and associated method
US20070065415A1 (en) * 2005-09-16 2007-03-22 Kleinsek Donald A Compositions and methods for the augmentation and repair of defects in tissue
SI1957633T1 (sl) 2005-10-13 2014-04-30 Anthrogenesis Corporation Imunomodulacija z uporabo matičnih celic iz placente
WO2007064305A1 (fr) * 2005-12-01 2007-06-07 Agency For Science, Technology And Research Matrices extracellulaires reconstituees en trois dimensions servant d'echafaudage pour le genie tissulaire
JP2009521930A (ja) 2005-12-29 2009-06-11 アントフロゲネシス コーポレーション 胎盤幹細胞及び第２供給源由来幹細胞の共存培養
KR101900809B1 (ko) 2005-12-29 2018-09-20 안트로제네시스 코포레이션 태반 줄기 세포 집단
US20070178137A1 (en) * 2006-02-01 2007-08-02 Toby Freyman Local control of inflammation
ES2709205T3 (es) 2006-10-23 2019-04-15 Celularity Inc Métodos y composiciones para el tratamiento de defectos óseos con poblaciones de células placentarias
US7871440B2 (en) 2006-12-11 2011-01-18 Depuy Products, Inc. Unitary surgical device and method
MX2009008559A (es) 2007-02-12 2009-08-21 Anthrogenesis Corp Hepatocitos y condorcitos de celulas madre de la placenta adherentes, y poblaciones de celulas enriquecidas con celulas madre de la placenta cd34+, cd45-.
NZ612888A (en) 2007-02-12 2015-02-27 Anthrogenesis Corp Treatment of inflammatory diseases using placental stem cells
US9200253B1 (en) 2007-08-06 2015-12-01 Anthrogenesis Corporation Method of producing erythrocytes
CA2700617C (fr) 2007-09-28 2018-11-06 Celgene Cellular Therapeutics Elimination des tumeurs au moyen d'un perfusat placentaire humain et de cellules tueuses naturelles intermediaires provenant d'un placenta humain
WO2009061447A2 (fr) 2007-11-07 2009-05-14 Anthrogenesis Corporation Traitement de complications de naissance prématurée
MX2010000394A (es) 2007-11-30 2010-05-13 Rnl Bio Co Ltd Agente celular terapeutico para la incontinencia de la orina, que comprende celulas madres originadas de decidua o tejido adiposo.
WO2009073178A1 (fr) 2007-12-03 2009-06-11 Sanbio, Inc. Matrice extracellulaire provenant de cellules pluripotentes
KR101650957B1 (ko) 2008-01-30 2016-08-24 히스토젠, 인코포레이티드 세포외 기질 조성물
EP2740498A3 (fr) * 2008-07-02 2014-09-10 Allergan, Inc. Compositions et procédés de remplissage et de régénération de tissus
NZ591292A (en) 2008-08-20 2012-10-26 Anthrogenesis Corp Improved cell composition and methods of making the same
EP2365815B1 (fr) 2008-11-14 2019-09-18 Histogen, Inc. Compositions de matrice extracellulaire pour le traitement du cancer
JP5869342B2 (ja) 2008-11-19 2016-02-24 アンスロジェネシス コーポレーション 羊膜由来接着細胞
AU2010271212B2 (en) 2009-07-10 2015-07-16 Histogen, Inc. Conditioned medium and extracellular matrix compositions from cells cultured under hypoxic conditions
WO2011084925A2 (fr) 2010-01-05 2011-07-14 Cell Constructs, Inc. Biomatériaux fabriqués à partir de cheveux humains
DK3284818T3 (da) 2010-01-26 2022-06-20 Celularity Inc Behandling af knoglerelateret kræft ved hjælp af placenta stamceller
NZ602808A (en) 2010-04-07 2014-10-31 Anthrogenesis Corp Angiogenesis using placental stem cells
KR20180099915A (ko) 2010-07-13 2018-09-05 안트로제네시스 코포레이션 천연 킬러 세포의 생성 방법
CN103830383A (zh) 2010-11-12 2014-06-04 阿勒根公司 经代谢的经调节的生长培养基和使用方法
AR084754A1 (es) 2010-12-30 2013-06-05 Anthrogenesis Corp Composiciones que comprenden celulas madre de placenta y plasma rico en plaquetas, y sus metodos de uso
AR084753A1 (es) 2010-12-30 2013-06-05 Anthrogenesis Corp Composiciones que comprenden celulas adherentes derivadas del saco amniotico (amdac) y plasma rico en plaquetas (prp)
AR093183A1 (es) 2010-12-31 2015-05-27 Anthrogenesis Corp Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras
CA2822689C (fr) 2011-01-06 2015-12-29 Humacyte Constructions obtenues par genie tissulaire
PL2714059T3 (pl) 2011-06-01 2019-04-30 Celularity Inc Leczenie bólu z użyciem komórek macierzystych łożyska
WO2013055995A2 (fr) 2011-10-14 2013-04-18 President And Fellows Of Harvard College Séquençage par assemblage structurel
CA2859761C (fr) 2011-12-22 2023-06-20 President And Fellows Of Harvard College Compositions et procedes pour la detection d'analytes
ES2991004T3 (es) 2011-12-22 2024-12-02 Harvard College Métodos para la detección de analitos
EP2847700B1 (fr) * 2012-05-09 2022-12-07 Koninklijke Philips N.V. Interface de suivi médical de courtage d'informations interventionnelles
WO2013184754A2 (fr) 2012-06-05 2013-12-12 President And Fellows Of Harvard College Séquençage spatial d'acides nucléiques à l'aide de sondes d'origami d'adn
EP2953635A4 (fr) 2013-02-05 2016-10-26 Anthrogenesis Corp Cellules tueuses naturelles provenant du placenta
EP2971184B1 (fr) 2013-03-12 2019-04-17 President and Fellows of Harvard College Procédé de génération d'une matrice tridimensionnelle contenant des acides nucléiques
AU2014274939B2 (en) 2013-06-04 2020-03-19 President And Fellows Of Harvard College RNA-guideded transcriptional regulation
WO2016007839A1 (fr) 2014-07-11 2016-01-14 President And Fellows Of Harvard College Méthodes de marquage et de détection à haut rendement de caractéristiques biologiques in situ à l'aide de microscopie
EP3371329A4 (fr) 2015-11-03 2019-06-19 President and Fellows of Harvard College Procédé et appareil pour imagerie volumétrique d'une matrice tridimensionnelle contenant des acides nucléiques
AU2017257624B2 (en) 2016-04-25 2023-05-25 President And Fellows Of Harvard College Hybridization chain reaction methods for in situ molecular detection
CN105920679B (zh) * 2016-04-26 2018-10-19 青岛大学 一种具有三维梯度孔结构的皮肤支架材料的制备方法
GB2569252A (en) 2016-08-31 2019-06-12 Harvard College Methods of combining the detection of biomolecules into a single assay using fluorescent in situ sequencing
GB2570412A (en) 2016-08-31 2019-07-24 Harvard College Methods of generating libraries of nucleic acid sequences for detection via fluorescent in situ sequencing
WO2018191672A1 (fr) * 2017-04-14 2018-10-18 President And Fellows Of Harvard College Procédés de génération d'un réseau de microfilaments dérivés de cellules
US11718829B2 (en) 2017-07-28 2023-08-08 Breakthrough Tech Llc Methods and compositions for manufacturing extracellular matrix
WO2019152522A1 (fr) 2018-01-30 2019-08-08 Histogen, Inc. Vésicules extracellulaires issues de cellules cultivées dans des conditions hypoxiques et leurs utilisations
SG11202101934SA (en) 2018-07-30 2021-03-30 Readcoor Llc Methods and systems for sample processing or analysis
WO2020076976A1 (fr) 2018-10-10 2020-04-16 Readcoor, Inc. Indexation moléculaire spatiale tridimensionnelle
CN111084788A (zh) * 2018-10-22 2020-05-01 上海蓝盎电子科技发展有限公司 人工细胞间质
US12077780B2 (en) 2020-02-14 2024-09-03 Allergan Sales, Llc Conditioned medium from cells cultured under hypoxic conditions and uses thereof
US20220049303A1 (en) 2020-08-17 2022-02-17 Readcoor, Llc Methods and systems for spatial mapping of genetic variants
EP4395796A4 (fr) 2021-09-01 2024-12-25 Shanghai Qisheng Biological Preparation Co., Ltd. Régénération de cartilage à l'aide de compositions de collagène injectables polymérisables in situ contenant des chondrocytes ou des cellules souches
EP4457266A1 (fr) 2021-12-28 2024-11-06 Shanghai Qisheng Biological Preparation Co., Ltd. Compositions de copolymère d'acide hyaluronique-collagène et leurs applications médicales
CN115006597B (zh) * 2022-06-02 2024-01-19 上海威高医疗技术发展有限公司 一种口腔修复膜及其制备方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3949073A (en) * 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
US4424208A (en) * 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4582640A (en) * 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4837285A (en) * 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
US5288617A (en) * 1984-10-31 1994-02-22 Commonwealth Scientific And Industrial Research Organization Method of producing an antigenic preparation
US5460939A (en) * 1986-04-18 1995-10-24 Advanced Tissue Sciences, Inc. Temporary living skin replacement
US5160490A (en) * 1986-04-18 1992-11-03 Marrow-Tech Incorporated Three-dimensional cell and tissue culture apparatus
US5032508A (en) * 1988-09-08 1991-07-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US5266480A (en) * 1986-04-18 1993-11-30 Advanced Tissue Sciences, Inc. Three-dimensional skin culture system
US4721096A (en) * 1986-04-18 1988-01-26 Marrow-Tech Incorporated Process for replicating bone marrow in vitro and using the same
US4963489A (en) * 1987-04-14 1990-10-16 Marrow-Tech, Inc. Three-dimensional cell and tissue culture system
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
JPH041118Y2 (fr) * 1986-07-31 1992-01-14
GB8708009D0 (en) * 1987-04-03 1987-05-07 Clayton Found Res Injectable soft tissue augmentation materials
US5342765A (en) * 1991-08-01 1994-08-30 Occidental Chemical Corporation Method of producing extracellular products from aerobic microorganisms
US5204382A (en) * 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
US5478739A (en) * 1992-10-23 1995-12-26 Advanced Tissue Sciences, Inc. Three-dimensional stromal cell and tissue culture system
US5541106A (en) * 1993-04-05 1996-07-30 Desmos, Inc. Cell matrix stimulated attachment and hemidesmosome assembly
US5397352A (en) * 1993-08-27 1995-03-14 Burres; Steven Method of recollagenation
US5516532A (en) * 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation

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