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WO1997015672A1 - Adn contenant un nouveau gene - Google Patents

Adn contenant un nouveau gene Download PDF

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Publication number
WO1997015672A1
WO1997015672A1 PCT/JP1996/003127 JP9603127W WO9715672A1 WO 1997015672 A1 WO1997015672 A1 WO 1997015672A1 JP 9603127 W JP9603127 W JP 9603127W WO 9715672 A1 WO9715672 A1 WO 9715672A1
Authority
WO
WIPO (PCT)
Prior art keywords
dna
dnas
novel gene
endothelial cells
vascular endothelial
Prior art date
Application number
PCT/JP1996/003127
Other languages
English (en)
Japanese (ja)
Inventor
Yoshio Takada
Chihiro Kato
Original Assignee
Asahi Kasei Kogyo Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Kasei Kogyo Kabushiki Kaisha filed Critical Asahi Kasei Kogyo Kabushiki Kaisha
Publication of WO1997015672A1 publication Critical patent/WO1997015672A1/fr

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

ADN concernant au moins la région codante de peptides d'un ADN de longueur intégrale, caractérisé par les sites de clivage d'enzymes de restriction illustrés par la figure 1. Cet ADN contient un nouveau gène exprimé en fonction de la contrainte de cisaillement exercée sur les cellules endothéliales vasculaires. L'utilisation de cet ADN permet de discerner si les cellules endothéliales vasculaires se trouvent dans un milieu physiologique normal avec l'application de la contrainte de cisaillement, ce qui n'a pas été explicité jusqu'à maintenant. L'invention concerne également un ADN comprenant une partie de l'ADN décrit ci-dessus; un ADN hybridable avec ladite partie; des ADNs complémentaires à ces ADNs, des ARNs complémentaires à ces ADNs; des ADNs de recombinaison réplicables construits par intégration de ces ADNs dans des vecteurs d'expression réplicables, de façon à permettre la réplication; peptides codés par lesdits ADNs et anticorps pouvant se fixer à ces peptides.
PCT/JP1996/003127 1995-10-25 1996-10-25 Adn contenant un nouveau gene WO1997015672A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP7/277781 1995-10-25
JP27778195 1995-10-25

Publications (1)

Publication Number Publication Date
WO1997015672A1 true WO1997015672A1 (fr) 1997-05-01

Family

ID=17588224

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1996/003127 WO1997015672A1 (fr) 1995-10-25 1996-10-25 Adn contenant un nouveau gene

Country Status (1)

Country Link
WO (1) WO1997015672A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064021A1 (fr) * 1998-06-11 1999-12-16 Smithkline Beecham Corporation RECEPTEUR DE hCEPR

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BIOCHIM. BIOPHYS. ACTA, Vol. 1219, No. 1, 1994, WANG D.Z. et al., "Molecular Cloning and Sequence Analysis of Rat Bradykinin B2 Receptor Gene", pages 171-174. *
JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 269, No. 28, 1994, SUZUKI H. et al., "The N Terminus of Interleukin-8 (IL-8) Receptor Confers High Affinity Binding to Human IL-8", pages 18263-18266. *
SCIENCE, Vol. 253, 1991, HOLMES W.E. et al., "Structure and Functional Expression of a Human Interleukin-8 Receptor", pages 1278-1280. *
SCIENCE, Vol. 253, 1991, MURPHY P.M. et al., "Cloning of Complementary DNA Encoding a Functional Human Interleukin-8 Receptor", pages 1280-1283. *
SCIENCE, Vol. 257, 1992, PENG LIANG et al., "Differential Display of Eukaryotic Messenger RNA by Means of the Polymerase Chain Reaction", pages 967-971. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064021A1 (fr) * 1998-06-11 1999-12-16 Smithkline Beecham Corporation RECEPTEUR DE hCEPR

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