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WO1997032992B1 - Lignees cellulaires hematopoietiques immortalisees, systeme cellulaire de ces lignees avec des cellules du stroma, applications in vitro, ex vivo et in vivo, et generation in vivo de cellules dendritiques et de macrophages - Google Patents

Lignees cellulaires hematopoietiques immortalisees, systeme cellulaire de ces lignees avec des cellules du stroma, applications in vitro, ex vivo et in vivo, et generation in vivo de cellules dendritiques et de macrophages

Info

Publication number
WO1997032992B1
WO1997032992B1 PCT/US1997/003186 US9703186W WO9732992B1 WO 1997032992 B1 WO1997032992 B1 WO 1997032992B1 US 9703186 W US9703186 W US 9703186W WO 9732992 B1 WO9732992 B1 WO 9732992B1
Authority
WO
WIPO (PCT)
Prior art keywords
cells
stem cells
hematopoietic stem
cell
hematopoietic
Prior art date
Application number
PCT/US1997/003186
Other languages
English (en)
Other versions
WO1997032992A1 (fr
Filing date
Publication date
Priority claimed from US08/612,302 external-priority patent/US5811297A/en
Application filed filed Critical
Priority to JP9531851A priority Critical patent/JP2000508885A/ja
Priority to EP97915851A priority patent/EP0954594A2/fr
Publication of WO1997032992A1 publication Critical patent/WO1997032992A1/fr
Publication of WO1997032992B1 publication Critical patent/WO1997032992B1/fr

Links

Abstract

Cette invention concerne des lignées cellulaires hématopoïétiques ayant une durée de vie plus longue, notamment des lignées cellulaires du stroma utiles dans la conservation in vitro de cellules souches hématopoïétiques pluripotentielles non différentiées. Les cellules souches immortalisées différentiées et non différentiées peuvent être utilisées dans la transplantation de moelle osseuse, dans des applications de thérapie génique et de thérapie cellulaire, ainsi que dans des systèmes de modèles in vitro afin de découvrir des médicaments ou d'effectuer des analyses toxicologiques.
PCT/US1997/003186 1996-03-07 1997-03-07 Lignees cellulaires hematopoietiques immortalisees, systeme cellulaire de ces lignees avec des cellules du stroma, applications in vitro, ex vivo et in vivo, et generation in vivo de cellules dendritiques et de macrophages WO1997032992A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP9531851A JP2000508885A (ja) 1996-03-07 1997-03-07 不死化造血細胞系、該細胞系とストロマ細胞との細胞システム、ｉｎ ｖｉｔｒｏ、ｅｘ ｖｉｖｏ および ｉｎ ｖｉｖｏ における使用、ならびに樹状細胞およびマクロファージの ｉｎ ｖｉｔｒｏ 産生
EP97915851A EP0954594A2 (fr) 1996-03-07 1997-03-07 Lignees cellulaires hematopoietiques immortalisees, systeme cellulaire de ces lignees avec des cellules du stroma, applications in vitro, ex vivo et in vivo, et generation in vivo de cellules dendritiques et de macrophages

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/612,302 US5811297A (en) 1996-03-07 1996-03-07 Immortalized hematopoietic cell lines, cell system thereof with stromal cells, in vitro, ex vivo and in vivo uses, & in vitro generation of dendritic cells and macrophages
US08/612,302 1996-03-07

Publications (2)

Publication Number Publication Date
WO1997032992A1 WO1997032992A1 (fr) 1997-09-12
WO1997032992B1 true WO1997032992B1 (fr) 1997-11-06

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/003186 WO1997032992A1 (fr) 1996-03-07 1997-03-07 Lignees cellulaires hematopoietiques immortalisees, systeme cellulaire de ces lignees avec des cellules du stroma, applications in vitro, ex vivo et in vivo, et generation in vivo de cellules dendritiques et de macrophages

Country Status (5)

Country Link
US (1) US5811297A (fr)
EP (1) EP0954594A2 (fr)
JP (1) JP2000508885A (fr)
CA (1) CA2248555A1 (fr)
WO (1) WO1997032992A1 (fr)

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JP2005514071A (ja) * 2001-12-21 2005-05-19 ザ ユナイテッド ステイツ オブ アメリカ レプレゼンティッド バイ ザ セクレタリー オブ ザ ユー．エス． デパートメント オブ ザ ネイビー 内皮細胞との前培養による遺伝子導入効率の上昇
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