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WO1998002139A1 - Savon liquide antiseptique dermatologique - Google Patents

Savon liquide antiseptique dermatologique Download PDF

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Publication number
WO1998002139A1
WO1998002139A1 PCT/BR1997/000028 BR9700028W WO9802139A1 WO 1998002139 A1 WO1998002139 A1 WO 1998002139A1 BR 9700028 W BR9700028 W BR 9700028W WO 9802139 A1 WO9802139 A1 WO 9802139A1
Authority
WO
WIPO (PCT)
Prior art keywords
weight
agent
agents
fact
skin
Prior art date
Application number
PCT/BR1997/000028
Other languages
English (en)
Inventor
Simoni Chitarra Souza
Luiz Gustavo Martins Matheus
Original Assignee
Indústria e Comércio de Cosméticos Natura Ltda.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indústria e Comércio de Cosméticos Natura Ltda. filed Critical Indústria e Comércio de Cosméticos Natura Ltda.
Publication of WO1998002139A1 publication Critical patent/WO1998002139A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
    • C11D17/08—Liquid soap, e.g. for dispensers; capsuled
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
    • C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
    • C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions

Definitions

  • the present invention provides a liquid soap composition, antiseptic, of mild action, intended for skin impurities removal, protecting the skin against exogenous germs, avoiding their propagation.
  • the referred components physical or aggregation state is also important.
  • the composition shall present the form of a viscous liquid of easy skin application, with no free flowing, exhibiting adequate organoleptic properties referring to pleasant aroma and color, and be lightly colorless to light yellow and transparent to lightly translucent.
  • the here described cosmetic composition was developed as the result of several researches, exhibiting physicochemical and microbiological stabilities and also a pleasant sensorial when applied to the skin.
  • the cosmetic composition basis is an aqueous phase, which can contain sodium salts and, eventually, potassium and/or ammonium salts, of fatty acids C12-C18, of saponaceous nature, which constitutes the present invention vehicle, corresponding to 40,00% to 70,00%, by weight, in relation to the global composition.
  • composition active principles are: (i) surfactant agents,
  • a keratolytic agent (ii) a keratolytic agent, (iii) antiseptic agents, and the usual additives that are chosen among the group comprising: preservatives, thickeners, solutizers, humectants, refreshing agents and fragrance or perfumes.
  • the active principles, associated in the present liquid soap comprise mild action surfactant compounds as cleansing surfactant agents. These compounds promote skin cleansing and excessive oiliness removal, with no skin aggressing action.
  • These surfactants are already usual by themselves, and it is possible to name, among others, ethylene and/or propylene oxide adducts as fatty alcohols or fatty acids, their derivatives, as esters including amino derivatives, as, for example, ethanolamines, and amides, that belong to the non-ionic surfactants class; eventually, it is possible to add cationic surfactants, specially quaternary ammonium compounds, mainly as additive to non-ionic surfactants.
  • these active components are used in a ratio varying between 10,00% to 30,00%, by weight, in relation to the global composition.
  • the keratolytic agent chosen is tartaric acid, which can be considered a natural product, since it is obtained as a byproduct of the wine-growing industry. It is a dioxide-diacid or an alpha-hydroxy acid exhibiting the following formula:
  • CHOH-COOH being used, preferably, dextrogyrate among the several optical isomers of this acid, added in a 0,05 to 2,00% ratio, by weight.
  • this active component is to help in the sebaceous follicle clearance, allowing free sebum, or fat, secretion (formed in these follicles). Consequently, the component contributes for a good sebaceous glands functioning, whose disturbance is one of the causes responsible for their inflammation, with consequent skin affection.
  • the tartaric acid also reduces the corneal layer cells cohesion, causing a microexfoliation, mainly of cells exhibiting low or none vitality, removing them.
  • the second antiseptic agent is thymol, a natural product, being extracted of the Thymus vulgaris and Monarda punctata plants.
  • This two antiseptics exhibit synergistic cooperation in the fight against microbial proliferation, to which the air exposed skin (hands, arms, face and neck) is more subjected. They are added in a rather low ratio, between 0,05 to 0,50%, by weight, for triclosan, and between 0,001 to 0,100%, by weight, for thymol. These values refer to the global composition.
  • these additives comprise: a) A preservative agent, to protect the composition against the degrading action of actinic light, oxygen contained in air and accidental components, as acid vapors and gases, oxidants and other degrading agents, which can also be biological, for example bacteria.
  • the preservative agent(s) is(are) chosen within the group comprising parabens, thiazolidines, imidazolidinyl urea, diazolidinyl urea, formaldehyde, or formaldehyde in situ forming compounds, as paraformaldehyde, benzoic acid and their alkyl and benzyl esters, quaternium 15, phenoxyethanol, 2-bromo-2-nitropropane-1 ,3-diol. These preserving agents are added in a 0,10 to 1 ,00% ratio, by weight, in relation to the composition.
  • a thickener is incorporated to improve compoj ⁇ itFon's consistency an undesirable product flowing when it is applied onto the skin.
  • poly(vinyl acetate) which can be associated to poly(vinyl alcohol), acrylic, as the acids themselves or their acrylic and metaacrylic acid esters, natural gums, starch or modified starch, for example, hydrolyzed, cellulose derivative, for example ethers and esters and/or salts, fatty alcohols, polyethylene glycol stearates, or inorganic, as modified aluminium or magnesium silicates, esmectitas and hydrated aluminium silicates.
  • poly(vinyl acetate) which can be associated to poly(vinyl alcohol), acrylic, as the acids themselves or their acrylic and metaacrylic acid esters, natural gums, starch or modified starch, for example, hydrolyzed, cellulose derivative, for example ethers and esters and/or salts, fatty alcohols, polyethylene glycol stearates, or inorganic, as modified aluminium or magnesium silicates, esmectitas and hydrated aluminium silicates.
  • solutizing agents function is to facilitate the solid components or little hydrophilic oils dissolution or fine dispersion; these are chosen between ethanol, its lower ethers and esters, ethoxylated fatty alcohols derivatives, in other words, containing more than 5 ethylene oxide units for each alcohol molecule, and/or hydrogenated fatty alcohols, their sulphonic derivatives and respective alkaline and alkaline-earth salts, as for example sodium and calcium dodecylbenzenesulphonate.
  • Refreshing agents as camphor and menthol, are simple compositions refining complements, in order to associate a skin freshness sensation, being usually used in a rather low ratio of 0,01 to 0,20%, by weight.
  • Fragrance and perfume are also optional additives, usually added in a 0,05 to 0,50% ratio, by weight, being chosen between those usually used in toilet soaps, as for example lavender, floral, cologne and others.
  • these additives can be omitted in some cases, specially in the manufacturing of neutral and odorless soaps, meant for sensitive skins.
  • the vehicle itself can also dispense the presence of usual soaps, so that the cleansing action is performed by the surfactants.
  • liquid soap preparation process although employing customary operations for components dissolution and dispersion in the aqueous vehicle, requires some special precautions.
  • the antiseptic agents and the fragrance usually being an oily essence, should be previously solubilized in the solutizing agent (c) or in a specific and adequate solvent.
  • the resulting solution is added after concluding total dispersion or mixture of the other components in the aqueous phase.
  • This can contain fatty acids Ci2-C 18 alkaline salt, or, for some specific applications, as soaps meant for sensitive skins, these salts are not added.
  • the aqueous phase constitutes global composition's 40% to 70%, by weight.
  • the chosen ratios of surfactants, humectant, tartaric acid, preserving and, eventually, refreshing agents, thickener and, at last, the previously prepared solution containing antiseptic agents and essence or fragrance are dissolved or dispersed in the aqueous phase, through vigorous stirring until complete homogenization.
  • the components quantity is adjusted to result in 100%, by weight total, being also by weight the component ratios described bellow.
  • 2,50% thickener chosen between hydrolyzed starch, solubilized gum tragacanth, carboxymethylcellulose and their mixtures;
  • solutizer which can be pure ethanol, preferably an ethoxylated cetyl or myristyl alcohol derivative, or the mixture of them;
  • the example 1 was repeated, having 60,00% water as vehicle and the adjunction of the other above mentioned components.
  • the example 1 was repeated, using diethylene glycol stearate and/or glycerol monostearate as thickener together with poly(vinyl alcohol) and/or poly(vinyl acetate). Conducted Tests

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Cosmetics (AREA)
  • Detergent Compositions (AREA)

Abstract

La présente invention concerne une composition antiseptique liquide à action lénifiante possédant une fonction spécifique de nettoyage de la peau de ses impuretés et d'un éventuel excès de sébum afin d'éviter, en particulier, l'inflammation et l'infection des follicules pilo-sébacés. On obtient ce résultat par une association de composants actifs, constituée d'agents de surfaces lénifiants, pour le nettoyage de la peau, associés à un agent kératolitique spécifique, l'acide tartrique-d et à deux agents antiseptiques, du triclosan majoritairement et du thymol en coopération. On prépare ces composants actifs par solution et/ou dispersion dans un excipient aqueux, qui peut aussi contenir d'autres adjuvants, tels que conservateurs, épaississants, solutés, humectants ainsi que d'autres agents rafraîchissants et les fragrances que l'on trouve couramment dans les cosmétiques liquides aqueux, tous ces agents coopérant pour assurer la stabilité physico-chimique, l'action germicide et/ou antibactérienne et la sensation agréable sur la peau lorsque la composition décrite ci-dessus y est appliquée.
PCT/BR1997/000028 1996-07-12 1997-07-10 Savon liquide antiseptique dermatologique WO1998002139A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI9603085-2 1996-07-12
BR9603085A BR9603085A (pt) 1996-07-12 1996-07-12 Sabonete antisséptico líquido para cuidado da pele

Publications (1)

Publication Number Publication Date
WO1998002139A1 true WO1998002139A1 (fr) 1998-01-22

Family

ID=4064625

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR1997/000028 WO1998002139A1 (fr) 1996-07-12 1997-07-10 Savon liquide antiseptique dermatologique

Country Status (5)

Country Link
AR (1) AR007869A1 (fr)
BR (1) BR9603085A (fr)
CO (1) CO6040037A1 (fr)
UY (1) UY24615A1 (fr)
WO (1) WO1998002139A1 (fr)

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037800A1 (fr) * 1998-01-23 1999-07-29 Trustees Of Tufts College Composes antimicrobiens
GB2339799A (en) * 1998-07-23 2000-02-09 Magdelena Christiana Cor Stols Cleaning composition containing tartaric acid
US6248343B1 (en) 1998-01-20 2001-06-19 Ethicon, Inc. Therapeutic antimicrobial compositions
WO2004108877A1 (fr) * 2003-06-04 2004-12-16 Unilever Plc Composition de nettoyage amelioree
WO2006027551A3 (fr) * 2004-09-11 2006-04-27 Reckitt Benckiser Inc Ameliorations apportees a des compositions organiques
WO2009090153A1 (fr) * 2008-01-17 2009-07-23 Lanxess Deutschland Gmbh Procédé d'incorporation de produits antimicrobiens dans des matières savonneuses
WO2014037167A1 (fr) * 2012-09-07 2014-03-13 Unilever N.V. Composition de savon
US8945596B2 (en) 2008-10-20 2015-02-03 Conopco, Inc. Antimicrobial composition
US9132103B2 (en) 2009-09-24 2015-09-15 Conopco, Inc. Disinfecting agent comprising eugenol, terpineol and thymol
US9408870B2 (en) 2010-12-07 2016-08-09 Conopco, Inc. Oral care composition
US9693941B2 (en) 2011-11-03 2017-07-04 Conopco, Inc. Liquid personal wash composition

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2401752A1 (de) * 1973-01-15 1974-07-18 Unilever Nv Reinigungsmittelstueck
EP0670158A2 (fr) * 1994-02-14 1995-09-06 Colgate-Palmolive Company Composition de nettoyage
WO1996006152A2 (fr) * 1994-08-25 1996-02-29 Ciba Specialty Chemicals Holding Inc. Formulations tensioactives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2401752A1 (de) * 1973-01-15 1974-07-18 Unilever Nv Reinigungsmittelstueck
EP0670158A2 (fr) * 1994-02-14 1995-09-06 Colgate-Palmolive Company Composition de nettoyage
WO1996006152A2 (fr) * 1994-08-25 1996-02-29 Ciba Specialty Chemicals Holding Inc. Formulations tensioactives

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6248343B1 (en) 1998-01-20 2001-06-19 Ethicon, Inc. Therapeutic antimicrobial compositions
WO1999037800A1 (fr) * 1998-01-23 1999-07-29 Trustees Of Tufts College Composes antimicrobiens
GB2339799A (en) * 1998-07-23 2000-02-09 Magdelena Christiana Cor Stols Cleaning composition containing tartaric acid
US6200942B1 (en) 1998-07-23 2001-03-13 Magdelena Christiana Cornelia Stols Cleaning composition
GB2339799B (en) * 1998-07-23 2003-04-09 Magdelena Christiana Cor Stols A cleaning composition
WO2004108877A1 (fr) * 2003-06-04 2004-12-16 Unilever Plc Composition de nettoyage amelioree
WO2006027551A3 (fr) * 2004-09-11 2006-04-27 Reckitt Benckiser Inc Ameliorations apportees a des compositions organiques
AU2005281566B2 (en) * 2004-09-11 2011-02-10 Rb Health (Us) Llc Improvements in or relating to organic compositions
WO2009090153A1 (fr) * 2008-01-17 2009-07-23 Lanxess Deutschland Gmbh Procédé d'incorporation de produits antimicrobiens dans des matières savonneuses
US8945596B2 (en) 2008-10-20 2015-02-03 Conopco, Inc. Antimicrobial composition
US9132103B2 (en) 2009-09-24 2015-09-15 Conopco, Inc. Disinfecting agent comprising eugenol, terpineol and thymol
US9408870B2 (en) 2010-12-07 2016-08-09 Conopco, Inc. Oral care composition
US9693941B2 (en) 2011-11-03 2017-07-04 Conopco, Inc. Liquid personal wash composition
WO2014037167A1 (fr) * 2012-09-07 2014-03-13 Unilever N.V. Composition de savon

Also Published As

Publication number Publication date
UY24615A1 (es) 1997-12-24
CO6040037A1 (es) 2009-05-29
BR9603085A (pt) 1998-05-05
AR007869A1 (es) 1999-11-24

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