WO1998006690B1 - UTILISATION D'AMIDES DE L'ACIDE η-HYDROXYBUTYRIQUE DANS LE TRAITEMENT DES TOXICOMANIES ET NOTAMMENT DE L'ALCOOLISME - Google Patents
UTILISATION D'AMIDES DE L'ACIDE η-HYDROXYBUTYRIQUE DANS LE TRAITEMENT DES TOXICOMANIES ET NOTAMMENT DE L'ALCOOLISMEInfo
- Publication number
- WO1998006690B1 WO1998006690B1 PCT/EP1997/004309 EP9704309W WO9806690B1 WO 1998006690 B1 WO1998006690 B1 WO 1998006690B1 EP 9704309 W EP9704309 W EP 9704309W WO 9806690 B1 WO9806690 B1 WO 9806690B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- compound
- formula
- amide
- alcohol
- butyrolactone
- Prior art date
Links
- 208000007848 Alcoholism Diseases 0.000 title abstract 2
- 201000007930 alcohol dependence Diseases 0.000 title abstract 2
- 206010013663 drug dependence Diseases 0.000 title abstract 2
- 208000011117 substance-related disease Diseases 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 5
- YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 claims 8
- 150000001408 amides Chemical class 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- -1 CH3 compound Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 125000001037 p-tolyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1*)C([H])([H])[H] 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- GLGNXYJARSMNGJ-VKTIVEEGSA-N (1s,2s,3r,4r)-3-[[5-chloro-2-[(1-ethyl-6-methoxy-2-oxo-4,5-dihydro-3h-1-benzazepin-7-yl)amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide Chemical compound CCN1C(=O)CCCC2=C(OC)C(NC=3N=C(C(=CN=3)Cl)N[C@H]3[C@H]([C@@]4([H])C[C@@]3(C=C4)[H])C(N)=O)=CC=C21 GLGNXYJARSMNGJ-VKTIVEEGSA-N 0.000 claims 2
- SZUVGFMDDVSKSI-WIFOCOSTSA-N (1s,2s,3s,5r)-1-(carboxymethyl)-3,5-bis[(4-phenoxyphenyl)methyl-propylcarbamoyl]cyclopentane-1,2-dicarboxylic acid Chemical compound O=C([C@@H]1[C@@H]([C@](CC(O)=O)([C@H](C(=O)N(CCC)CC=2C=CC(OC=3C=CC=CC=3)=CC=2)C1)C(O)=O)C(O)=O)N(CCC)CC(C=C1)=CC=C1OC1=CC=CC=C1 SZUVGFMDDVSKSI-WIFOCOSTSA-N 0.000 claims 2
- ONBQEOIKXPHGMB-VBSBHUPXSA-N 1-[2-[(2s,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,6-dihydroxyphenyl]-3-(4-hydroxyphenyl)propan-1-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 ONBQEOIKXPHGMB-VBSBHUPXSA-N 0.000 claims 2
- 239000003377 acid catalyst Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 239000003054 catalyst Substances 0.000 claims 2
- 229940126543 compound 14 Drugs 0.000 claims 2
- 229940125758 compound 15 Drugs 0.000 claims 2
- 229940126142 compound 16 Drugs 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- QFLWZFQWSBQYPS-AWRAUJHKSA-N (3S)-3-[[(2S)-2-[[(2S)-2-[5-[(3aS,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-[1-bis(4-chlorophenoxy)phosphorylbutylamino]-4-oxobutanoic acid Chemical compound CCCC(NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)CCCCC1SC[C@@H]2NC(=O)N[C@H]12)C(C)C)P(=O)(Oc1ccc(Cl)cc1)Oc1ccc(Cl)cc1 QFLWZFQWSBQYPS-AWRAUJHKSA-N 0.000 claims 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229940125773 compound 10 Drugs 0.000 claims 1
- 229940125797 compound 12 Drugs 0.000 claims 1
- 229940125782 compound 2 Drugs 0.000 claims 1
- 229940125898 compound 5 Drugs 0.000 claims 1
- ZLVXBBHTMQJRSX-VMGNSXQWSA-N jdtic Chemical compound C1([C@]2(C)CCN(C[C@@H]2C)C[C@H](C(C)C)NC(=O)[C@@H]2NCC3=CC(O)=CC=C3C2)=CC=CC(O)=C1 ZLVXBBHTMQJRSX-VMGNSXQWSA-N 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 235000011149 sulphuric acid Nutrition 0.000 claims 1
- 239000001117 sulphuric acid Substances 0.000 claims 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 abstract 2
- SJZRECIVHVDYJC-UHFFFAOYSA-N 4-hydroxybutyric acid Chemical compound OCCCC(O)=O SJZRECIVHVDYJC-UHFFFAOYSA-N 0.000 abstract 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 abstract 1
- 235000013334 alcoholic beverage Nutrition 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 229960002069 diamorphine Drugs 0.000 abstract 1
- 229960005181 morphine Drugs 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 208000011580 syndromic disease Diseases 0.000 abstract 1
Abstract
L'invention concerne l'utilisation d'amides de l'acide η-hydroxybutyrique, dénommés ici GHB, dans le traitement des toxicomanies, telles que les toxicomanies à l'héroïne, à la morphine et aux psychotropes, dans le traitement de l'alcoolisme, notamment pour diminuer l'envie de boissons alcoolisées qu'ont les alcooliques chroniques et leur habitude d'en consommer, et dans le traitement du syndrome de sevrage.
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU9902437A HU228595B1 (en) | 1996-08-09 | 1997-08-07 | Gamma-hydroxybutyric acid amides, process to prepare them, use gamma-hydroxybutyric acid amides, and pharmaceuticals contg. them for the treatmant of drug abusing |
| JP50937298A JP4259615B2 (ja) | 1996-08-09 | 1997-08-07 | 薬物常用および特にアルコール中毒の治寮へのγ―ヒドロキシ酪酸アミドの使用 |
| DK97941921T DK0932597T3 (da) | 1996-08-09 | 1997-08-07 | Anvendelse af gamma-hydroxysmørsyreamider til behandling af lægemiddelafhængighed og især alkoholisme |
| EP97941921A EP0932597B1 (fr) | 1996-08-09 | 1997-08-07 | Utilisation d'amides de l'acide gamma-hydroxybutyrique dans le traitement des toxicomanies et notamment de l'alcoolisme |
| US09/242,048 US6436998B1 (en) | 1996-08-09 | 1997-08-07 | Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism |
| DE69711411T DE69711411T2 (de) | 1996-08-09 | 1997-08-07 | Verwendung von gamma-hydroxybuttersäureamiden in der behandlung von drogenabhängigkeit und insbesondere von alcoholismus |
| AU43790/97A AU4379097A (en) | 1996-08-09 | 1997-08-07 | Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism |
| AT97941921T ATE215065T1 (de) | 1996-08-09 | 1997-08-07 | Verwendung von gamma-hydroxybuttersäureamiden in der behandlung von drogenabhängigkeit und insbesondere von alcoholismus |
| CA002263328A CA2263328C (fr) | 1996-08-09 | 1997-08-07 | Utilisation d'amides de l'acide .gamma.-hydroxybutyrique dans le traitement des toxicomanies et notamment de l'alcoolisme |
| SI9730343T SI0932597T1 (en) | 1996-08-09 | 1997-08-07 | Use of gamma-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI96A001732 | 1996-08-09 | ||
| IT96MI001732A IT1283782B1 (it) | 1996-08-09 | 1996-08-09 | Uso di ammidi dell'acido gamma-idrossibutirrico nel trattamento di tossicodipendenze,ed in particolare sell'alcolismo |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US10/013,971 Division US6770784B2 (en) | 1996-08-09 | 2001-12-11 | Use of γ-hydroxybutyric acid amides in the treatment of drug addiction and in particular of alcoholism |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO1998006690A1 WO1998006690A1 (fr) | 1998-02-19 |
| WO1998006690B1 true WO1998006690B1 (fr) | 1998-04-16 |
Family
ID=11374795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/EP1997/004309 WO1998006690A1 (fr) | 1996-08-09 | 1997-08-07 | UTILISATION D'AMIDES DE L'ACIDE η-HYDROXYBUTYRIQUE DANS LE TRAITEMENT DES TOXICOMANIES ET NOTAMMENT DE L'ALCOOLISME |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6436998B1 (fr) |
| EP (1) | EP0932597B1 (fr) |
| JP (1) | JP4259615B2 (fr) |
| AT (1) | ATE215065T1 (fr) |
| AU (1) | AU4379097A (fr) |
| CA (1) | CA2263328C (fr) |
| DE (1) | DE69711411T2 (fr) |
| DK (1) | DK0932597T3 (fr) |
| ES (1) | ES2174287T3 (fr) |
| HU (1) | HU228595B1 (fr) |
| IT (1) | IT1283782B1 (fr) |
| PT (1) | PT932597E (fr) |
| WO (1) | WO1998006690A1 (fr) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6472431B2 (en) | 1998-12-23 | 2002-10-29 | Orphan Medical, Inc. | Microbiologically sound and stable solutions of gamma-hydroxybutyrate salt for the treatment of narcolepsy |
| FR2827859B1 (fr) | 2001-07-30 | 2005-09-23 | Lipha | Derives 4-(arylthio) - ou 4-(heteroarylthio) -butyrique dans la preparation de medicaments destines au traitement du diabete |
| AU2003295393A1 (en) * | 2002-11-01 | 2004-06-07 | Baylor Research Institute | Ghb treatment methods |
| US7838556B2 (en) * | 2006-02-21 | 2010-11-23 | University Of Maryland, Baltimore | Ethers of 3-hydroxyphenylacetic acid as selective gamma-hydroxybutyric acid receptor ligands |
| EP2062875A1 (fr) | 2007-11-13 | 2009-05-27 | LABORATORIO FARMACEUTICO C.T. S.r.l. | Nouvelles formes polymorphes de N-[4-(trifluorométhyl)benzyl)-4-méthoxybutyramide |
| US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
| US8771735B2 (en) * | 2008-11-04 | 2014-07-08 | Jazz Pharmaceuticals, Inc. | Immediate release dosage forms of sodium oxybate |
| US20120076865A1 (en) | 2010-03-24 | 2012-03-29 | Jazz Pharmaceuticals, Inc. | Controlled release dosage forms for high dose, water soluble and hygroscopic drug substances |
| US8591922B1 (en) | 2012-12-14 | 2013-11-26 | Jazz Pharmacuticals, Inc. | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| ITMI20132041A1 (it) * | 2013-12-06 | 2015-06-07 | Ct Lab Farm Srl | Derivati dell'acido gamma-idrossibutirrico, loro preparazione e loro uso medico. |
| US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
| ITUB20152860A1 (it) * | 2015-08-04 | 2017-02-04 | Laboratorio Farm C T S R L | Selezionata amide dell?acido ?-idrossibutirrico e suoi usi nel trattamento dell?abuso da alcool |
| ITUA20164040A1 (it) * | 2016-06-01 | 2017-12-01 | Laboratorio Farm C T S R L | Procedimento per la preparazione di polimorfo a |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US12186296B1 (en) | 2016-07-22 | 2025-01-07 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
| KR20210094513A (ko) | 2018-11-19 | 2021-07-29 | 재즈 파마슈티칼즈 아일랜드 리미티드 | 알코올-내성 약물 제형 |
| CA3127871A1 (fr) | 2019-03-01 | 2020-09-10 | Flamel Ireland Limited | Compositions de gamma-hydroxybutyrate presentant une pharmacocinetique amelioree a l'etat alimente |
| TW202139986A (zh) | 2020-02-21 | 2021-11-01 | 愛爾蘭商爵士製藥愛爾蘭有限責任公司 | 治療原發性嗜睡症之方法 |
| WO2023126076A1 (fr) | 2022-01-03 | 2023-07-06 | Laboratorio Farmaceutico C.T. S.R.L. | Utilisation médicale d'un amide d'acide y-hydroxybutyrique dans le traitement du syndrome de l'x fragile |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940258A (en) * | 1971-11-26 | 1976-02-24 | Gaf Corporation | Method for controlling aquatic weeds with N-phenylalkyl-γ-hydroxybutyramide |
| JPS6016432B2 (ja) * | 1977-07-26 | 1985-04-25 | グレラン製薬株式会社 | 複素環式化合物類およびその製造法 |
| ES2052619T3 (es) * | 1987-02-23 | 1994-07-16 | Ono Pharmaceutical Co | Un procedimiento para la preparacion de los nuevos derivados de tiazolidina. |
| IT1217783B (it) * | 1988-06-03 | 1990-03-30 | Farmaceutico Ct S R L Lab | Impiego di salo dell,acido gamma idrossi butirrico per la preparazione di composizioni farmaceutiche adatta ad essereimpiegate nella terapia dell,alcolismo e composizioni relative |
| IT1248588B (it) | 1991-06-28 | 1995-01-19 | Gaetano Crepaldi | Composizioni farmaceutiche per la terapia dell'astinenza, del " craving", della dipendenza da sostanze stupefacenti, da sostanze psicoattive, da nicotina e dei disturbi alimentari. |
| AU2764495A (en) * | 1994-06-01 | 1995-12-21 | Arris Pharmaceutical Corporation | Compositions and methods for treating mast-cell mediated conditions |
| MX9604165A (es) * | 1995-09-18 | 1997-10-31 | Sankyo Co | Nuevos derivados de urea que tienen actividad inhibidora de acil-coa: colesterol acil transferasa; su preparacion y su uso terapeutico y profilactico. |
| ATE293603T1 (de) * | 1997-10-14 | 2005-05-15 | Mitsubishi Pharma Corp | Piperazin-verbindungen und ihre medizinische verwendung |
-
1996
- 1996-08-09 IT IT96MI001732A patent/IT1283782B1/it active IP Right Grant
-
1997
- 1997-08-07 US US09/242,048 patent/US6436998B1/en not_active Expired - Lifetime
- 1997-08-07 WO PCT/EP1997/004309 patent/WO1998006690A1/fr active IP Right Grant
- 1997-08-07 DK DK97941921T patent/DK0932597T3/da active
- 1997-08-07 PT PT97941921T patent/PT932597E/pt unknown
- 1997-08-07 DE DE69711411T patent/DE69711411T2/de not_active Expired - Lifetime
- 1997-08-07 JP JP50937298A patent/JP4259615B2/ja not_active Expired - Lifetime
- 1997-08-07 ES ES97941921T patent/ES2174287T3/es not_active Expired - Lifetime
- 1997-08-07 AU AU43790/97A patent/AU4379097A/en not_active Abandoned
- 1997-08-07 AT AT97941921T patent/ATE215065T1/de active
- 1997-08-07 CA CA002263328A patent/CA2263328C/fr not_active Expired - Lifetime
- 1997-08-07 HU HU9902437A patent/HU228595B1/hu unknown
- 1997-08-07 EP EP97941921A patent/EP0932597B1/fr not_active Expired - Lifetime
-
2001
- 2001-12-11 US US10/013,971 patent/US6770784B2/en not_active Expired - Lifetime
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