WO1998010767A3 - Utilisation de derives de la quinazoline pour la fabrication d'un medicament destine au traitement de troubles cutanes hyperproliferatifs - Google Patents
Utilisation de derives de la quinazoline pour la fabrication d'un medicament destine au traitement de troubles cutanes hyperproliferatifs Download PDFInfo
- Publication number
- WO1998010767A3 WO1998010767A3 PCT/US1997/016145 US9716145W WO9810767A3 WO 1998010767 A3 WO1998010767 A3 WO 1998010767A3 US 9716145 W US9716145 W US 9716145W WO 9810767 A3 WO9810767 A3 WO 9810767A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- medicament
- skin disorders
- manufacture
- treatment
- hyperproliferative skin
- Prior art date
Links
- 230000003463 hyperproliferative effect Effects 0.000 title abstract 2
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title abstract 2
- 208000017520 skin disease Diseases 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP97941542A EP0954315A2 (fr) | 1996-09-13 | 1997-09-11 | Utilisation de derives de la quinazoline pour la fabrication d'un medicament destine au traitement de troubles cutanes hyperproliferatifs |
AU43429/97A AU4342997A (en) | 1996-09-13 | 1997-09-11 | Use of quinazoline derivatives for the manufacture of a medicament in the reatment of hyperproliferative skin disorders |
CA002265630A CA2265630A1 (fr) | 1996-09-13 | 1997-09-11 | Utilisation de derives de la quinazoline pour la fabrication d'un medicament destine au traitement de troubles cutanes hyperproliferatifs |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2606796P | 1996-09-13 | 1996-09-13 | |
US60/026,067 | 1996-09-13 | ||
US3143696P | 1996-11-20 | 1996-11-20 | |
US60/031,436 | 1996-11-20 | ||
US3498197P | 1997-01-08 | 1997-01-08 | |
US60/034,981 | 1997-01-08 | ||
US4837297P | 1997-06-03 | 1997-06-03 | |
US60/048,372 | 1997-06-03 |
Publications (3)
Publication Number | Publication Date |
---|---|
WO1998010767A2 WO1998010767A2 (fr) | 1998-03-19 |
WO1998010767A9 WO1998010767A9 (fr) | 1998-07-02 |
WO1998010767A3 true WO1998010767A3 (fr) | 1998-08-06 |
Family
ID=27487474
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1997/016145 WO1998010767A2 (fr) | 1996-09-13 | 1997-09-11 | Utilisation de derives de la quinazoline pour la fabrication d'un medicament destine au traitement de troubles cutanes hyperproliferatifs |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0954315A2 (fr) |
AU (1) | AU4342997A (fr) |
CA (1) | CA2265630A1 (fr) |
WO (1) | WO1998010767A2 (fr) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7160889B2 (en) | 2000-04-07 | 2007-01-09 | Astrazeneca Ab | Quinazoline compounds |
US7173038B1 (en) | 1999-11-05 | 2007-02-06 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
USRE42353E1 (en) | 1996-09-25 | 2011-05-10 | Astrazeneca Uk Limited | Quinazoline derivatives and pharmaceutical compositions containing them |
Families Citing this family (135)
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IL125686A (en) | 1996-02-13 | 2002-11-10 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical preparations containing them and their use in the manufacture of a drug with an anti-angiogenic effect and / or an effect of reducing vascular permeability |
IL125954A (en) | 1996-03-05 | 2003-06-24 | Zeneca Ltd | Quinazoline derivatives, processes for their preparation, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments having an antiangiogenic and/or vascular permeability reducing effect |
US6258820B1 (en) | 1999-03-19 | 2001-07-10 | Parker Hughes Institute | Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines |
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WO1996009294A1 (fr) * | 1994-09-19 | 1996-03-28 | The Wellcome Foundation Limited | Composes heteroaromatiques substitues et leur utilisation en medecine |
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- 1997-09-11 AU AU43429/97A patent/AU4342997A/en not_active Abandoned
- 1997-09-11 CA CA002265630A patent/CA2265630A1/fr not_active Abandoned
- 1997-09-11 EP EP97941542A patent/EP0954315A2/fr not_active Withdrawn
- 1997-09-11 WO PCT/US1997/016145 patent/WO1998010767A2/fr not_active Application Discontinuation
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US5457105A (en) * | 1992-01-20 | 1995-10-10 | Zeneca Limited | Quinazoline derivatives useful for treatment of neoplastic disease |
WO1996009294A1 (fr) * | 1994-09-19 | 1996-03-28 | The Wellcome Foundation Limited | Composes heteroaromatiques substitues et leur utilisation en medecine |
WO1996027797A2 (fr) * | 1995-03-08 | 1996-09-12 | Hsc Research And Development Limited Partnership | Inhibiteurs de zap 70 et procedes de traitement de troubles de la transduction de signaux de zap 70 |
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Cited By (4)
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USRE42353E1 (en) | 1996-09-25 | 2011-05-10 | Astrazeneca Uk Limited | Quinazoline derivatives and pharmaceutical compositions containing them |
US7173038B1 (en) | 1999-11-05 | 2007-02-06 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
US9040548B2 (en) | 1999-11-05 | 2015-05-26 | Astrazeneca Ab | Quinazoline derivatives as VEGF inhibitors |
US7160889B2 (en) | 2000-04-07 | 2007-01-09 | Astrazeneca Ab | Quinazoline compounds |
Also Published As
Publication number | Publication date |
---|---|
CA2265630A1 (fr) | 1998-03-19 |
AU4342997A (en) | 1998-04-02 |
EP0954315A2 (fr) | 1999-11-10 |
WO1998010767A2 (fr) | 1998-03-19 |
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