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WO1998021365A3 - Procede de detection du cancer de la prostate metastatique - Google Patents

Procede de detection du cancer de la prostate metastatique Download PDF

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Publication number
WO1998021365A3
WO1998021365A3 PCT/US1997/020948 US9720948W WO9821365A3 WO 1998021365 A3 WO1998021365 A3 WO 1998021365A3 US 9720948 W US9720948 W US 9720948W WO 9821365 A3 WO9821365 A3 WO 9821365A3
Authority
WO
WIPO (PCT)
Prior art keywords
prostate cancer
detection
metastatic prostate
polypeptide
rna
Prior art date
Application number
PCT/US1997/020948
Other languages
English (en)
Other versions
WO1998021365A2 (fr
Inventor
Donald J Tindall
Charles Y F Young
Daniel J Mccormick
George G Klee
Mohammad Saeed Saedi
Abhay Kumar
Harry G Rittenhouse
Robert L Wolfert
Original Assignee
Mayo Foundation
Hybritech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Foundation, Hybritech Inc filed Critical Mayo Foundation
Priority to CA002271770A priority Critical patent/CA2271770A1/fr
Priority to EP97947550A priority patent/EP0941368A2/fr
Priority to AU52602/98A priority patent/AU737659B2/en
Priority to JP52288898A priority patent/JP2001503991A/ja
Publication of WO1998021365A2 publication Critical patent/WO1998021365A2/fr
Publication of WO1998021365A3 publication Critical patent/WO1998021365A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Selon le procédé de la présente invention, on détecte le cancer de la prostate en déterminant la présence d'un polypeptide glandullaire spécifique de la prostate appelé Kallikrein (hK2) ou d'un ARN de hK2 dans un échantillon physiologique.
PCT/US1997/020948 1996-11-14 1997-11-14 Procede de detection du cancer de la prostate metastatique WO1998021365A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002271770A CA2271770A1 (fr) 1996-11-14 1997-11-14 Procede de detection du cancer de la prostate metastatique
EP97947550A EP0941368A2 (fr) 1996-11-14 1997-11-14 Procede de detection du cancer de la prostate metastatique
AU52602/98A AU737659B2 (en) 1996-11-14 1997-11-14 Method for detection of metastatic prostate cancer
JP52288898A JP2001503991A (ja) 1996-11-14 1997-11-14 転移性前立腺癌の検出方法

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75935496A 1996-11-14 1996-11-14
US08/759,354 1996-11-14

Publications (2)

Publication Number Publication Date
WO1998021365A2 WO1998021365A2 (fr) 1998-05-22
WO1998021365A3 true WO1998021365A3 (fr) 1998-10-15

Family

ID=25055346

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/020948 WO1998021365A2 (fr) 1996-11-14 1997-11-14 Procede de detection du cancer de la prostate metastatique

Country Status (6)

Country Link
EP (1) EP0941368A2 (fr)
JP (1) JP2001503991A (fr)
CN (1) CN1238013A (fr)
AU (1) AU737659B2 (fr)
CA (1) CA2271770A1 (fr)
WO (1) WO1998021365A2 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6551778B1 (en) 1999-01-28 2003-04-22 Gen-Probe Incorporated Nucleic acid sequences for detecting genetic markers for cancer in a biological sample
FI990382A0 (fi) * 1999-02-23 1999-02-23 Arctic Partners Oy Ab Uusi diagnostinen menetelmä
US8663600B2 (en) 2005-02-17 2014-03-04 Diaprost Ab Diagnosis of prostate cancer
FR2906537A1 (fr) * 2006-09-28 2008-04-04 Biomerieux Sa Procede de diagnostic in vitro du cancer broncho-pulmonaire par detection des transcrits majoritaires alternatifs du gene klk8 codant la kallicreine 8 et son utilisation pour le pronostic de survie
MX353964B (es) 2011-10-28 2018-02-06 Fredax Ab Agentes terapeuticos y usos de los mismos.
HRP20191095T1 (hr) 2013-11-19 2019-09-20 Fredax Ab Humanizirano anti kallikrein-2 antitijelo
CN119125561B (zh) * 2023-09-12 2025-09-16 宁波大学附属第一医院 小细胞外囊泡内蛋白作为前列腺癌诊断标志物的应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010343A1 (fr) * 1992-10-29 1994-05-11 Thomas Jefferson University Procedes de detection de micrometastase du cancer de la prostate
WO1995028498A1 (fr) * 1994-04-15 1995-10-26 The Trustees Of Columbia University In The City Of New York Procede de d'evaluation au niveau moleculaire des stades d'evolution du cancer de la prostate
WO1995030758A1 (fr) * 1994-05-10 1995-11-16 Mayo Foundation For Medical Education And Research Polypeptide hk2 recombine
WO1996021042A2 (fr) * 1995-01-04 1996-07-11 Trustees Of Boston University Amorces destinees a l'amplification pcr de sequences metastatiques
WO1996026272A1 (fr) * 1995-02-24 1996-08-29 Sloan-Kettering Institute For Cancer Research Antigene membranaire specifique de la prostate et ses utilisations

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994010343A1 (fr) * 1992-10-29 1994-05-11 Thomas Jefferson University Procedes de detection de micrometastase du cancer de la prostate
WO1995028498A1 (fr) * 1994-04-15 1995-10-26 The Trustees Of Columbia University In The City Of New York Procede de d'evaluation au niveau moleculaire des stades d'evolution du cancer de la prostate
WO1995030758A1 (fr) * 1994-05-10 1995-11-16 Mayo Foundation For Medical Education And Research Polypeptide hk2 recombine
WO1996021042A2 (fr) * 1995-01-04 1996-07-11 Trustees Of Boston University Amorces destinees a l'amplification pcr de sequences metastatiques
WO1996026272A1 (fr) * 1995-02-24 1996-08-29 Sloan-Kettering Institute For Cancer Research Antigene membranaire specifique de la prostate et ses utilisations

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DEGUCHI ET AL.: "Detection of micrometastatic prostate cancer cells in lymph nodes by RT-PCR", CANCER RESEARCH, vol. 53, November 1993 (1993-11-01), pages 5350 - 5354, XP002059297 *
SAEDI M S ET AL: "OVEREXPRESSION OF A HUMAN PROSTATE-SPECIFIC GLANDULAR KALLIKREIN, HK2, IN E. COLI AND GENERATION OF ANTIBODIES", MOLECULAR AND CELLULAR ENDOCRINOLOGY, vol. 109, 1995, pages 237 - 241, XP002015421 *
SCHEDLICH L J ET AL: "PRIMARY STRUCTURE OF A HUMAN GLANDULAR KALLIKREIN GENE", DNA, vol. 6, no. 5, 1987, pages 429 - 437, XP002044466 *
TAKAYAMA ET AL.: "Newer applications of serum PSA in the management of prostate cancer", SEMINARS IN ONCOLOGY, vol. 21, no. 5, October 1994 (1994-10-01), pages 542 - 533, XP002059296 *
YOUNG C Y -F ET AL: "TISSUE-SPECIFIC AND HORMONAL REGULATION OF HUMAN PROSTATE-SPECIFIC GLANDULAR KALLIKREIN", BIOCHEMISTRY, vol. 31, no. 3, 1992, pages 818 - 824, XP002050778 *

Also Published As

Publication number Publication date
AU737659B2 (en) 2001-08-23
JP2001503991A (ja) 2001-03-27
WO1998021365A2 (fr) 1998-05-22
CN1238013A (zh) 1999-12-08
AU5260298A (en) 1998-06-03
CA2271770A1 (fr) 1998-05-22
EP0941368A2 (fr) 1999-09-15

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