[go: up one dir, main page]

WO1998039358B1 - Lipides cationiques oligomeres - Google Patents

Lipides cationiques oligomeres

Info

Publication number
WO1998039358B1
WO1998039358B1 PCT/US1998/004344 US9804344W WO9839358B1 WO 1998039358 B1 WO1998039358 B1 WO 1998039358B1 US 9804344 W US9804344 W US 9804344W WO 9839358 B1 WO9839358 B1 WO 9839358B1
Authority
WO
WIPO (PCT)
Prior art keywords
cationic lipids
oligomeric cationic
oligomeric
present
compositions
Prior art date
Application number
PCT/US1998/004344
Other languages
English (en)
Other versions
WO1998039358A9 (fr
WO1998039358A1 (fr
Filing date
Publication date
Priority claimed from US08/812,775 external-priority patent/US5877220A/en
Application filed filed Critical
Priority to AU66879/98A priority Critical patent/AU6687998A/en
Publication of WO1998039358A1 publication Critical patent/WO1998039358A1/fr
Publication of WO1998039358B1 publication Critical patent/WO1998039358B1/fr
Publication of WO1998039358A9 publication Critical patent/WO1998039358A9/fr

Links

Abstract

La présente invention concerne de nouveaux lipides cationiques oligomères. La présente invention concerne également des compositions de ces nouveaux lipides cationiques avec des macromolécules anioniques, des méthodes d'interférence avec une expression de protéines dans une cellule faisant appel à ces compositions, ainsi qu'une trousse destinée à leur préparation.
PCT/US1998/004344 1997-03-06 1998-03-05 Lipides cationiques oligomeres WO1998039358A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU66879/98A AU6687998A (en) 1997-03-06 1998-03-05 Oligomeric cationic lipids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/812,775 1997-03-06
US08/812,775 US5877220A (en) 1997-03-06 1997-03-06 Amide-based oligomeric cationic lipids

Publications (3)

Publication Number Publication Date
WO1998039358A1 WO1998039358A1 (fr) 1998-09-11
WO1998039358B1 true WO1998039358B1 (fr) 1998-11-26
WO1998039358A9 WO1998039358A9 (fr) 1999-02-25

Family

ID=25210592

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1998/004344 WO1998039358A1 (fr) 1997-03-06 1998-03-05 Lipides cationiques oligomeres

Country Status (3)

Country Link
US (1) US5877220A (fr)
AU (1) AU6687998A (fr)
WO (1) WO1998039358A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003507430A (ja) * 1999-08-25 2003-02-25 ジーエムピー カンパニーズ，インコーポレーテッド 哺乳動物中で酸素運搬を向上する薬剤
EP1242609A2 (fr) * 1999-12-30 2002-09-25 Novartis AG Nouveaux vecteurs synthetiques colloides destines a la therapie genique
US6686461B1 (en) * 2000-03-22 2004-02-03 Solulink Bioscience, Inc. Triphosphate oligonucleotide modification reagents and uses thereof
US7102024B1 (en) 2000-08-01 2006-09-05 Schwartz David A Functional biopolymer modification reagents and uses thereof
CA2723664A1 (fr) * 2000-03-22 2001-09-27 Solulink, Incorporated Agents de reticulation bifonctionnels a base d'hydrazine et de carbonyle
WO2003040399A2 (fr) * 2001-11-02 2003-05-15 Intradigm Corporation Procedes therapeutiques pour vehicules d'administration d'acides nucleiques
ES2354607T3 (es) 2002-06-28 2011-03-16 Protiva Biotherapeutics Inc. Procedimiento y aparato para producir liposomas.
NZ581166A (en) 2003-09-15 2011-06-30 Protiva Biotherapeutics Inc Polyethyleneglycol-modified lipid compounds and uses thereof
US7158353B2 (en) * 2003-11-06 2007-01-02 Seagate Technology Llc Magnetoresistive sensor having specular sidewall layers
WO2005058941A2 (fr) 2003-12-17 2005-06-30 Elan Pharmaceuticals, Inc. Conjugues porteurs de peptide immunogene a? les techniques de production de ces conjugues
PL1701968T3 (pl) * 2003-12-17 2015-11-30 Wyeth Llc Koniugaty nośników z peptydami immunogennymi i sposoby ich wytwarzania
US7799565B2 (en) * 2004-06-07 2010-09-21 Protiva Biotherapeutics, Inc. Lipid encapsulated interfering RNA
US20060134189A1 (en) * 2004-11-17 2006-06-22 Protiva Biotherapeutics, Inc siRNA silencing of apolipoprotein B
EP1948674A4 (fr) 2005-11-02 2009-02-04 Protiva Biotherapeutics Inc Molecules d'arnsi modifiees et utilisations de celles-ci
JP5697988B2 (ja) * 2007-12-27 2015-04-08 プロチバ バイオセラピューティクス インコーポレイティッド 干渉ｒｎａを使用したポロ様キナーゼ発現のサイレンシング方法
JP5749494B2 (ja) * 2008-01-02 2015-07-15 テクミラ ファーマシューティカルズ コーポレイション 核酸の送達のための改善された組成物および方法
NZ588583A (en) 2008-04-15 2012-08-31 Protiva Biotherapeutics Inc Novel lipid formulations for nucleic acid delivery
EP2350043B9 (fr) 2008-10-09 2014-08-20 TEKMIRA Pharmaceuticals Corporation Lipides aminés améliorés et procédés d'administration d'acides nucléiques
EP2405921A4 (fr) 2009-01-26 2013-05-22 Protiva Biotherapeutics Inc Compositions et procédés d'inactivation de l'expression de l'apolipoprotéine c-iii
ES2613498T3 (es) 2009-07-01 2017-05-24 Protiva Biotherapeutics Inc. Nuevas formulaciones de lípidos para el suministro de agentes terapéuticos a tumores sólidos
WO2011000106A1 (fr) 2009-07-01 2011-01-06 Protiva Biotherapeutics, Inc. Lipides cationiques et procédés améliorés pour l'administration d'agents thérapeutiques
US9018187B2 (en) 2009-07-01 2015-04-28 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
WO2011011447A1 (fr) 2009-07-20 2011-01-27 Protiva Biotherapeutics, Inc. Compositions et méthodes pour rendre silencieuse l’expression du gène du virus ebola
WO2011084721A2 (fr) * 2009-12-21 2011-07-14 Agave Pharma Inc Molécule cationique et procédé d'utilisation
US8455455B1 (en) 2010-03-31 2013-06-04 Protiva Biotherapeutics, Inc. Compositions and methods for silencing genes involved in hemorrhagic fever
WO2012000104A1 (fr) 2010-06-30 2012-01-05 Protiva Biotherapeutics, Inc. Systèmes non liposomaux pour une administration d'acide nucléique
US8466122B2 (en) 2010-09-17 2013-06-18 Protiva Biotherapeutics, Inc. Trialkyl cationic lipids and methods of use thereof
US9035039B2 (en) 2011-12-22 2015-05-19 Protiva Biotherapeutics, Inc. Compositions and methods for silencing SMAD4
WO2018209130A1 (fr) 2017-05-11 2018-11-15 Tc1 Llc Interconnexion thermique pour pompe à sang implantable
WO2022115645A1 (fr) 2020-11-25 2022-06-02 Akagera Medicines, Inc. Nanoparticules lipidiques utilisées pour l'administration d'acides nucléiques, et méthodes d'utilisation associées
JP2025522311A (ja) 2022-05-25 2025-07-15 アカゲラ・メディスンズ，インコーポレイテッド 核酸を送達するための脂質ナノ粒子およびその使用方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4897355A (en) * 1985-01-07 1990-01-30 Syntex (U.S.A.) Inc. N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5693622A (en) * 1989-03-21 1997-12-02 Vical Incorporated Expression of exogenous polynucleotide sequences cardiac muscle of a mammal
FR2645866B1 (fr) * 1989-04-17 1991-07-05 Centre Nat Rech Scient Nouvelles lipopolyamines, leur preparation et leur emploi
US5614617A (en) * 1990-07-27 1997-03-25 Isis Pharmaceuticals, Inc. Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
EP0558634A4 (en) * 1990-11-23 1995-06-28 Gilead Sciences Inc Triplex-forming oligomers containing modified bases
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5777153A (en) * 1994-07-08 1998-07-07 Gilead Sciences, Inc. Cationic lipids
JPH11507352A (ja) * 1995-06-07 1999-06-29 ジンタ・インコーポレイテッド 新規カルバメート基本カチオン性脂質
CA2227373A1 (fr) * 1995-07-21 1997-02-06 Promega Biosciences, Inc. Nouveaux lipides cationiques a base d'amides

Similar Documents

Publication Publication Date Title
WO1998039358B1 (fr) Lipides cationiques oligomeres
WO1998039359B1 (fr) Lipides cationiques dimeres sur une base de cystine
IL126666A0 (en) Process for the preparation of polyalkenamines
WO1999030548B1 (fr) Procede de preparation de la citaloprame
WO2003006570B1 (fr) Nouveaux mesogenes et procedes de synthese et d'utilisation de ces derniers
TR199801179T2 (xx) Yeni taksoitler, bunlar�n haz�rlanmalar� ve ila� bile�imleri.
WO2001036433A3 (fr) Analogues de lipide-a de synthese et leur utilisation
WO2002072588A3 (fr) Molecules detectrices de fluorescence par transfert d'electrons photo-induits
KR960034204A (ko) 항-천식 작용을 지닌 피리도[3,2-e]피라지논 및 이의 제조방법
CA2266189A1 (fr) Melanges de colorants azoiques disperses
RU94042935A (ru) Водорастворенные комплексы включения соединений бензотиофена с водорастворимыми циклодекстринами, способ их получения и фармацевтический состав
KR890002198A (ko) 유기 규소 화합물
CA2181841A1 (fr) Dispositif pour la manipulation de macromolecules
WO1994020463B1 (fr) Nouveaux analogues de distamycine
AU3394793A (en) Substituted aminophosphonate derivatives, process for their preparation and pharmaceutical compositions containing them
WO1999050269A3 (fr) Nouvelles porphyrines et leur utilisation
CA2053820A1 (fr) Methode d'inhibition du metabolisme du cholesterol
DE69808435D1 (de) Wässerige dispersionen von einem hydrophoben leimungsmittel
MY120683A (en) New phenylamidine derivatives, processes for their preparation and their use as pharmaceuticals.
ZA858169B (en) New adamantanamine derivatives,processes for their preparation and drugs in which they are present
AU2309695A (en) Process for preparing 7-trialkylsilyl baccatin iii
CA2334821A1 (fr) Synthese chimique de derives de morpholine
PT99738A (pt) Processo para a preparacao de compostos de fluor contendo por exemplo um grupo triazolilo
TR199800403A2 (xx) a-Bromo-laktam t�revlerinin haz�rlanmas� i�in y�ntem.
KR910000775A (ko) 무라밀 디펩티드 유도체