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WO1999053052A3 - Lignees cellulaires srebp-2-deficientes - Google Patents

Lignees cellulaires srebp-2-deficientes Download PDF

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Publication number
WO1999053052A3
WO1999053052A3 PCT/DE1999/001143 DE9901143W WO9953052A3 WO 1999053052 A3 WO1999053052 A3 WO 1999053052A3 DE 9901143 W DE9901143 W DE 9901143W WO 9953052 A3 WO9953052 A3 WO 9953052A3
Authority
WO
WIPO (PCT)
Prior art keywords
cell lines
srebp
deficient cell
arterioscelerosis
hypercholesterolaemia
Prior art date
Application number
PCT/DE1999/001143
Other languages
German (de)
English (en)
Other versions
WO1999053052A2 (fr
Inventor
Wilhelm Krone
Dirk Mueller-Wieland
Original Assignee
Wilhelm Krone
Mueller Wieland Dirk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wilhelm Krone, Mueller Wieland Dirk filed Critical Wilhelm Krone
Priority to EP99927674A priority Critical patent/EP1071778A2/fr
Priority to AU44969/99A priority patent/AU4496999A/en
Publication of WO1999053052A2 publication Critical patent/WO1999053052A2/fr
Publication of WO1999053052A3 publication Critical patent/WO1999053052A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne des lignées cellulaires eucaryotes SREBP(Sterol Regulatory Element Binding Protein)-2-négatives, leur utilisation par échantillonnage et test des substances, ainsi que des médicaments utilisés pour traiter ou assurer la prophylaxie par ex. de l'hypercholestérolémie, de l'artériosclérose ou de maladies cardiaques coronariennes.
PCT/DE1999/001143 1998-04-16 1999-04-15 Lignees cellulaires srebp-2-deficientes WO1999053052A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP99927674A EP1071778A2 (fr) 1998-04-16 1999-04-15 Lignees cellulaires srebp-2-deficientes
AU44969/99A AU4496999A (en) 1998-04-16 1999-04-15 Srebp-2-deficient cell lines

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19816894.2 1998-04-16
DE19816894A DE19816894C1 (de) 1998-04-16 1998-04-16 SREBP-2-defiziente Zellinien

Publications (2)

Publication Number Publication Date
WO1999053052A2 WO1999053052A2 (fr) 1999-10-21
WO1999053052A3 true WO1999053052A3 (fr) 2000-01-20

Family

ID=7864731

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1999/001143 WO1999053052A2 (fr) 1998-04-16 1999-04-15 Lignees cellulaires srebp-2-deficientes

Country Status (4)

Country Link
EP (1) EP1071778A2 (fr)
AU (1) AU4496999A (fr)
DE (1) DE19816894C1 (fr)
WO (1) WO1999053052A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005295867A (ja) * 2004-04-09 2005-10-27 Japan Science & Technology Agency ２型糖尿病モデルとしての非ヒトトランスジェニック動物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026922A2 (fr) * 1993-05-13 1994-11-24 Board Of Regents, The University Of Texas System Procedes et compositions relatives a des proteines de liaison d'elements regulatoires de sterol

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026922A2 (fr) * 1993-05-13 1994-11-24 Board Of Regents, The University Of Texas System Procedes et compositions relatives a des proteines de liaison d'elements regulatoires de sterol

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BROWN MS UND GOLDSTEIN JL: "The SREBP pathway: Regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor", CELL, vol. 89, 2 May 1997 (1997-05-02), NA US, pages 331 - 340, XP002123067 *
SATO R ET AL.: "Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 43, 25 October 1996 (1996-10-25), MD US, pages 26461 - 26464, XP002123065 *
STREICHER R ET AL: "SREBP-1 mediates activation of the low density lipoprotein receptor promoter by insulin and insulin-like growth factor-I", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 271, no. 12, 22 March 1996 (1996-03-22), MD US, pages 7128 - 7133, XP002123066 *

Also Published As

Publication number Publication date
EP1071778A2 (fr) 2001-01-31
WO1999053052A2 (fr) 1999-10-21
AU4496999A (en) 1999-11-01
DE19816894C1 (de) 2000-03-02

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WO1999053052A3 (fr) Lignees cellulaires srebp-2-deficientes

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