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WO1999036100A3 - Excipient polymere - Google Patents

Excipient polymere Download PDF

Info

Publication number
WO1999036100A3
WO1999036100A3 PCT/IL1999/000023 IL9900023W WO9936100A3 WO 1999036100 A3 WO1999036100 A3 WO 1999036100A3 IL 9900023 W IL9900023 W IL 9900023W WO 9936100 A3 WO9936100 A3 WO 9936100A3
Authority
WO
WIPO (PCT)
Prior art keywords
polymeric carrier
bioactive
bioreactive
molecule
bioreactive molecule
Prior art date
Application number
PCT/IL1999/000023
Other languages
English (en)
Other versions
WO1999036100A2 (fr
Inventor
Avraham J Domb
Zeev Zehavi
Original Assignee
Efrat Biopolymers Ltd
Avraham J Domb
Zeev Zehavi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Efrat Biopolymers Ltd, Avraham J Domb, Zeev Zehavi filed Critical Efrat Biopolymers Ltd
Priority to EP99900284A priority Critical patent/EP0967998A2/fr
Priority to CA002283648A priority patent/CA2283648C/fr
Priority to JP53697199A priority patent/JP2001515522A/ja
Priority to AU18889/99A priority patent/AU1888999A/en
Publication of WO1999036100A2 publication Critical patent/WO1999036100A2/fr
Publication of WO1999036100A3 publication Critical patent/WO1999036100A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un excipient polymère destiné à l'administration d'une molécule bioactive ou bioréactive, l'excipient comprenant un stéréocomplexe d'au moins un polymère stéréosélectif biocompatible et d'une molécule bioactive ou bioréactive.
PCT/IL1999/000023 1998-01-14 1999-01-14 Excipient polymere WO1999036100A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP99900284A EP0967998A2 (fr) 1998-01-14 1999-01-14 Excipient polymere
CA002283648A CA2283648C (fr) 1998-01-14 1999-01-14 Excipient polymere
JP53697199A JP2001515522A (ja) 1998-01-14 1999-01-14 ポリマーキャリア
AU18889/99A AU1888999A (en) 1998-01-14 1999-01-14 Polymeric carrier

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12293398A IL122933A (en) 1998-01-14 1998-01-14 Polymeric carrier for delivery of a bioactive molecule
IL122933 1998-01-14

Publications (2)

Publication Number Publication Date
WO1999036100A2 WO1999036100A2 (fr) 1999-07-22
WO1999036100A3 true WO1999036100A3 (fr) 1999-09-23

Family

ID=11071088

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1999/000023 WO1999036100A2 (fr) 1998-01-14 1999-01-14 Excipient polymere

Country Status (6)

Country Link
EP (1) EP0967998A2 (fr)
JP (1) JP2001515522A (fr)
AU (1) AU1888999A (fr)
CA (1) CA2283648C (fr)
IL (1) IL122933A (fr)
WO (1) WO1999036100A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1183016B1 (fr) * 1999-02-19 2004-04-21 Universiteit Utrecht Hydrogels stereocomplexes
WO2000050050A1 (fr) * 1999-02-23 2000-08-31 Isis Pharmaceuticals, Inc. Formulation multiparticulaire
WO2002083166A1 (fr) * 2001-04-10 2002-10-24 Santen Pharmaceutical Co., Ltd. Complexes de polymeres d'interferons et leur utilisation medicinale
DE10154924A1 (de) * 2001-11-08 2003-05-28 Medinnova Ges Med Innovationen Bioabbaubare Kopolymere
CN1290893C (zh) * 2002-05-03 2006-12-20 詹森药业有限公司 聚合物微乳状液
US8012488B2 (en) 2005-02-18 2011-09-06 Nof Corporation Polyoxyalkylene derivative
US8067398B2 (en) 2005-06-01 2011-11-29 Yissum Research Development Company Of The Hebrew University Of Jerusalem Biodegradable polymers having a pre-determined chirality
WO2007088957A1 (fr) * 2006-02-03 2007-08-09 National University Corporation Hokkaido University Nanodisque comprenant un copolymere sequence
EP2135887B1 (fr) 2008-06-18 2010-12-22 Instytut Biopolimeròw I Wlókien Chemicznych Procédé de production de poudre stéréocomplexe d'acide polylactique
CA2804815C (fr) * 2010-07-09 2016-06-07 The University Of Tokyo Composition d'administration d'acides nucleiques, composition d'excipient, composition pharmaceutique contenant la composition d'administration d'acides nucleiques ou la composition d'excipient et methode d'administration d'acides nucleiques
CN108559084B (zh) * 2018-04-13 2020-12-04 华东理工大学 一种聚乳酸基疏水薄膜的制备方法
CN109908106A (zh) * 2019-03-04 2019-06-21 北京化工大学 一种可供静脉注射的甲氨蝶呤纳米胶囊及其制备方法
JP7050734B2 (ja) * 2019-09-30 2022-04-08 鳥居薬品株式会社 舌下アレルゲン免疫療法におけるフィルム製剤
CN115785471B (zh) * 2022-12-16 2023-08-08 华中科技大学 一种二氧化碳基超分子聚合物及其制备方法和应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003783A1 (fr) * 1988-10-12 1990-04-19 E.I. Du Pont De Nemours And Company Compositions de polylactides
EP0467389A2 (fr) * 1990-07-19 1992-01-22 University Of Kentucky Research Foundation Système de délivrance de drogue à l'aide de l'interaction entre une protéine ou polypeptide et un polymère biodégradable hydrophobe

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6136321A (ja) * 1984-07-27 1986-02-21 Daicel Chem Ind Ltd 新規なポリマ−およびその樹脂組成物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990003783A1 (fr) * 1988-10-12 1990-04-19 E.I. Du Pont De Nemours And Company Compositions de polylactides
EP0467389A2 (fr) * 1990-07-19 1992-01-22 University Of Kentucky Research Foundation Système de délivrance de drogue à l'aide de l'interaction entre une protéine ou polypeptide et un polymère biodégradable hydrophobe

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J.S, HRKACH ET AL.: "synthesis of poy (l-lactic acid-co-L-lysine) graft copolymers", MACROMOLECULES, vol. 28, no. 13, 19 June 1995 (1995-06-19), Easton (US), pages 4736 - 4739, XP000512312 *

Also Published As

Publication number Publication date
EP0967998A2 (fr) 2000-01-05
JP2001515522A (ja) 2001-09-18
CA2283648A1 (fr) 1999-07-22
IL122933A (en) 2005-03-20
AU1888999A (en) 1999-08-02
IL122933A0 (en) 1998-08-16
CA2283648C (fr) 2007-04-17
WO1999036100A2 (fr) 1999-07-22

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