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WO2000027365A8 - Nanocristaux fonctionnalises et leur utilisation dans des systemes de detection - Google Patents

Nanocristaux fonctionnalises et leur utilisation dans des systemes de detection

Info

Publication number
WO2000027365A8
WO2000027365A8 PCT/US1999/026487 US9926487W WO0027365A8 WO 2000027365 A8 WO2000027365 A8 WO 2000027365A8 US 9926487 W US9926487 W US 9926487W WO 0027365 A8 WO0027365 A8 WO 0027365A8
Authority
WO
WIPO (PCT)
Prior art keywords
functionalized nanocrystals
substrate
nanocrystals
functionalized
complexes
Prior art date
Application number
PCT/US1999/026487
Other languages
English (en)
Other versions
WO2000027365A9 (fr
WO2000027365A1 (fr
Inventor
Emilio Barbera-Guillem
Stephanie Castro
Original Assignee
Biocrystal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/372,729 external-priority patent/US6114038A/en
Application filed by Biocrystal Ltd filed Critical Biocrystal Ltd
Priority to AU21470/00A priority Critical patent/AU2147000A/en
Priority to EP99965776A priority patent/EP1128818A4/fr
Publication of WO2000027365A1 publication Critical patent/WO2000027365A1/fr
Publication of WO2000027365A8 publication Critical patent/WO2000027365A8/fr
Publication of WO2000027365A9 publication Critical patent/WO2000027365A9/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/22—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material
    • G01N23/223—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by measuring secondary emission from the material by irradiating the sample with X-rays or gamma-rays and by measuring X-ray fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/07—Investigating materials by wave or particle radiation secondary emission
    • G01N2223/076—X-ray fluorescence

Landscapes

  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)

Abstract

L'invention concerne des compositions renfermant des nanocristaux hydrosolubles fonctionnalisés. Ces nanocristaux hydrosolubles fonctionnalisés comprennent des points quantiques coiffés d'une couche d'un composé de coiffage, ainsi qu'un ou plusieurs composés additionnels, liés par la suite de manière opérationnelle. Un composé additionnel contient de préférence de l'acide diaminocarboxylique lié de manière opérationnelle audit composé de coiffage, ainsi qu'un acide aminé, un ligand d'affinité, ou une combinaison de ceux-ci. Cette invention concerne par ailleurs des procédés d'utilisation des nanocristaux fonctionnalisés susmentionnés comprenant un ligand d'affinité, ces procédés étant destinés à détecter la présence ou l'absence d'un substrat cible dans un échantillon. Ces procédés consistent tout d'abord à mettre lesdits nanocristaux fonctionnalisés en présence de cet échantillon, afin de former des complexes entre les nanocristaux et le substrat, si ce dernier est présent, puis à exposer ces complexes du système de détection à une source de lumière d'excitation, et enfin à détecter le pic de fluorescence émise.
PCT/US1999/026487 1998-11-10 1999-11-10 Nanocristaux fonctionnalises et leur utilisation dans des systemes de detection WO2000027365A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU21470/00A AU2147000A (en) 1998-11-10 1999-11-10 Functionalized nanocrystals and their use in detection systems
EP99965776A EP1128818A4 (fr) 1998-11-10 1999-11-10 Nanocristaux fonctionnalises et leur utilisation dans des systemes de detection

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US60/109,626 1998-11-10
US10962698P 1998-11-24 1998-11-24
US09/372,729 1999-08-11
US09/372,729 US6114038A (en) 1998-11-10 1999-08-11 Functionalized nanocrystals and their use in detection systems

Publications (3)

Publication Number Publication Date
WO2000027365A1 WO2000027365A1 (fr) 2000-05-18
WO2000027365A8 true WO2000027365A8 (fr) 2000-09-14
WO2000027365A9 WO2000027365A9 (fr) 2000-11-23

Family

ID=26807171

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/026487 WO2000027365A1 (fr) 1998-11-10 1999-11-10 Nanocristaux fonctionnalises et leur utilisation dans des systemes de detection

Country Status (1)

Country Link
WO (1) WO2000027365A1 (fr)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
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US6607829B1 (en) 1997-11-13 2003-08-19 Massachusetts Institute Of Technology Tellurium-containing nanocrystalline materials
US6207392B1 (en) 1997-11-25 2001-03-27 The Regents Of The University Of California Semiconductor nanocrystal probes for biological applications and process for making and using such probes
US6306610B1 (en) 1998-09-18 2001-10-23 Massachusetts Institute Of Technology Biological applications of quantum dots
US6251303B1 (en) 1998-09-18 2001-06-26 Massachusetts Institute Of Technology Water-soluble fluorescent nanocrystals
US6617583B1 (en) 1998-09-18 2003-09-09 Massachusetts Institute Of Technology Inventory control
US6261779B1 (en) 1998-11-10 2001-07-17 Bio-Pixels Ltd. Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
US6454789B1 (en) 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
HK1049923A1 (zh) 2000-03-14 2003-05-30 Massachusetts Institute Of Technology 光学放大镜及激光器
DE60128458T2 (de) 2000-03-20 2008-01-10 Massachusetts Institute Of Technology, Cambridge Anorganische teilchenkonjugate
WO2001090716A2 (fr) * 2000-05-24 2001-11-29 Vanderbilt University Bras de liaison pour nanocristaux et composes de ces derniers
CA2428732C (fr) * 2000-11-15 2018-07-31 Minerva Biotechnologies Corporation Procedes et trousse pour l'analyse simultanee des interactions entre diverses especes chimiques ou biologiques et utilisations associees
US20020110180A1 (en) 2001-02-09 2002-08-15 Barney Alfred A. Temperature-sensing composition
WO2002073155A1 (fr) * 2001-03-09 2002-09-19 Scientific Development Service Stroisnabservice Nanocristaux ultrasensibles, non isotopes, solubles dans l'eau
GB0113772D0 (en) * 2001-06-06 2001-07-25 Dynal Biotech Asa Process
US7205048B2 (en) * 2001-09-17 2007-04-17 Invitrogen Corporation Functionalized fluorescent nanocrystal compositions and methods of making
JP4383865B2 (ja) 2001-09-17 2009-12-16 マサチューセッツ・インスティテュート・オブ・テクノロジー 半導体ナノ結晶複合材
AU2002362013B2 (en) 2001-11-21 2008-04-24 Applied Biosystems, Llc. Digital assay
US7998923B2 (en) 2002-05-07 2011-08-16 The Regents Of The University Of California Bioactivation of particles
US7319709B2 (en) 2002-07-23 2008-01-15 Massachusetts Institute Of Technology Creating photon atoms
WO2004042784A2 (fr) 2002-08-15 2004-05-21 Massachussetts Institute Of Technology Nanocristaux semiconducteurs stabilises
US7181266B2 (en) 2003-03-04 2007-02-20 Massachusetts Institute Of Technology Materials and methods for near-infrared and infrared lymph node mapping
US7917298B1 (en) 2003-04-17 2011-03-29 Nanosys, Inc. Nanocrystal taggants
WO2005024425A1 (fr) * 2003-09-09 2005-03-17 Koninklijke Philips Electronics N.V. Nanoparticules destinees a la detection d'analytes
US7943396B2 (en) 2004-06-22 2011-05-17 The Regents Of The University Of California Peptide-coated nanoparticles with graded shell compositions
US7229690B2 (en) 2004-07-26 2007-06-12 Massachusetts Institute Of Technology Microspheres including nanoparticles
US20110129944A1 (en) * 2005-01-17 2011-06-02 Agency For Science, Technology And Research Water-soluble nanocrystals and methods of preparing them
EP1883820A4 (fr) * 2005-05-04 2010-06-16 Agency Science Tech & Res Nanocristaux hydrosolubles innovants comprenant un reactif de revetement a faible poids moleculaire et leurs procedes de preparation
WO2007120762A2 (fr) * 2006-04-14 2007-10-25 Cambrios Technologies Corporation Particules fluorescentes liées à des ossatures multifonctionnelles et leurs utilisations
WO2008070459A2 (fr) * 2006-11-22 2008-06-12 Alnis Biosciences, Inc. Nanoparticules enrobées pour des systèmes aqueux
GB0813273D0 (en) * 2008-07-19 2008-08-27 Nanoco Technologies Ltd Method for producing aqueous compatible nanoparticles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6048616A (en) * 1993-04-21 2000-04-11 Philips Electronics N.A. Corp. Encapsulated quantum sized doped semiconductor particles and method of manufacturing same
WO1996014206A1 (fr) * 1994-11-08 1996-05-17 Spectra Science Corporation Substances d'affichage constituees de nanocristaux semi-conducteurs et dispositif d'affichage faisant appel a ces substances
US5908608A (en) * 1996-11-08 1999-06-01 Spectra Science Corporation Synthesis of metal chalcogenide quantum
JPH1187689A (ja) * 1997-09-04 1999-03-30 Fujitsu Ltd 量子ドットの製造方法
JP2980175B2 (ja) * 1997-11-20 1999-11-22 日本電気株式会社 量子ドット構造の製造方法及びそれを用いた半導体発光素子の製造方法
US5990479A (en) * 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes

Also Published As

Publication number Publication date
WO2000027365A9 (fr) 2000-11-23
WO2000027365A1 (fr) 2000-05-18

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