WO2002036007A1 - Images fluorescentes de transmission video d'une capsule ingestible - Google Patents
Images fluorescentes de transmission video d'une capsule ingestible Download PDFInfo
- Publication number
- WO2002036007A1 WO2002036007A1 PCT/US2001/032420 US0132420W WO0236007A1 WO 2002036007 A1 WO2002036007 A1 WO 2002036007A1 US 0132420 W US0132420 W US 0132420W WO 0236007 A1 WO0236007 A1 WO 0236007A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- medical information
- human
- animal
- transmitter
- capsule
- Prior art date
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 52
- 238000000034 method Methods 0.000 claims abstract description 31
- 239000007850 fluorescent dye Substances 0.000 claims abstract description 20
- 239000000463 material Substances 0.000 claims abstract description 18
- 241001465754 Metazoa Species 0.000 claims abstract description 17
- 238000003384 imaging method Methods 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 239000000975 dye Substances 0.000 claims description 24
- 239000000126 substance Substances 0.000 claims description 16
- 238000011503 in vivo imaging Methods 0.000 claims description 7
- 239000000427 antigen Substances 0.000 claims description 5
- 102000036639 antigens Human genes 0.000 claims description 5
- 108091007433 antigens Proteins 0.000 claims description 5
- 230000005284 excitation Effects 0.000 claims description 5
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 230000000903 blocking effect Effects 0.000 claims description 3
- 238000005286 illumination Methods 0.000 claims description 3
- 239000004054 semiconductor nanocrystal Substances 0.000 claims description 3
- 239000000919 ceramic Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 description 14
- 201000011510 cancer Diseases 0.000 description 13
- 210000001519 tissue Anatomy 0.000 description 12
- 238000001514 detection method Methods 0.000 description 10
- 239000002159 nanocrystal Substances 0.000 description 10
- 210000004027 cell Anatomy 0.000 description 9
- 238000002052 colonoscopy Methods 0.000 description 8
- 238000003745 diagnosis Methods 0.000 description 8
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 239000002105 nanoparticle Substances 0.000 description 6
- 206010009944 Colon cancer Diseases 0.000 description 4
- 210000001072 colon Anatomy 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 239000006187 pill Substances 0.000 description 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 description 3
- 230000003466 anti-cipated effect Effects 0.000 description 3
- 238000001839 endoscopy Methods 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 239000003550 marker Substances 0.000 description 3
- 208000037062 Polyps Diseases 0.000 description 2
- 230000009833 antibody interaction Effects 0.000 description 2
- 230000009831 antigen interaction Effects 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000008602 contraction Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000002405 diagnostic procedure Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000008855 peristalsis Effects 0.000 description 2
- 239000002243 precursor Substances 0.000 description 2
- 210000000664 rectum Anatomy 0.000 description 2
- 238000002579 sigmoidoscopy Methods 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 241000792859 Enema Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 208000031481 Pathologic Constriction Diseases 0.000 description 1
- 208000006994 Precancerous Conditions Diseases 0.000 description 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 description 1
- 206010038678 Respiratory depression Diseases 0.000 description 1
- 206010039897 Sedation Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000002583 angiography Methods 0.000 description 1
- 238000003782 apoptosis assay Methods 0.000 description 1
- 229910052788 barium Inorganic materials 0.000 description 1
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 210000003850 cellular structure Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000008984 colonic lesion Effects 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000007920 enema Substances 0.000 description 1
- 229940095399 enema Drugs 0.000 description 1
- 210000002919 epithelial cell Anatomy 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 230000002550 fecal effect Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000009541 flexible sigmoidoscopy Methods 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 238000000799 fluorescence microscopy Methods 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 210000003405 ileum Anatomy 0.000 description 1
- 238000010324 immunological assay Methods 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003750 lower gastrointestinal tract Anatomy 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 210000000663 muscle cell Anatomy 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000001599 sigmoid colon Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 230000036269 ulceration Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
- A61B1/041—Capsule endoscopes for imaging
Definitions
- the present invention relates to a novel ingestible capsule for use in the field of medicine and method of using the capsule for the accumulation of medical data from within the body of animals, and in particular humans .
- a colonoscopy generally includes direct visual examination of the colon, ileocecal value, and portions of the terminal ileum by means' of a fiberoptic endoscope.
- a colonoscopy is typically performed by a qualified gastroenterologist. During a colonoscopy the patient is generally awake but sedated. During the procedure a flexible endoscope is inserted in rectum and advanced through the various portions of the lower GI tract. Important anatomic landmarks are identified and surfaces are examined for ulcerations, polyps, hemorrhagic sites, neoplasms, strictures, etc. Dependent upon identified conditions, colorectal cancer, or precancerous conditions of the colon are diagnosed. In many instances, of this invasive procedure, complications arise.
- Perforation The most common complication being perforation of the colon in which diagnosis may be delayed for days until an infection is present .
- Perforation may be caused by mechanical trauma from the instrument tip, especially if the wall is weakened. Less commonly, perforation may be non- instrumental, secondary to aggressive insufflation with air. However, serious complications from perforation have been reported in routine cases.
- hemorrhaging can arise as a complication and many times requires repeat colonoscopy to coagulate the bleeding. In a few instances angiography and surgery have been required.
- a third less common complication is respiratory depression, which is usually due to oversedation in the patient with chronic lung disease.
- cancer detection means are known in the medical field, one of such is the use of cancer markers.
- identification of appropriate and reliable diagnostic markers is essential.
- One such procedure currently being utilized in the medical field to detect early stages of pre-colon cancer polyp development is the physical characterization of inner surfaces of the intestine using the endoscopy imaging techniques, such as those previously described with respect to colonoscopy, and flexible sigmoidoscopy and in-vivo imaging capsules.
- Endoscopy and in-vivo imaging capsule techniques rely on the examination of physical appearance of the gastrointestinal tract for diagnosis, and thus lack the specificity and sensitivity provided by the inclusion of a biochemical sensor.
- endoscopy, colonoscopy and in-vivo imaging capsules as we know them today rely on the illumination of the alimentary canal solely for imaging purposes.
- cancer specific markers One method of utilizing these specific markers is based on the highly specific antigen/antibody interaction. It has been found that the specificity of the diagnosis resulting from antibody/antigen interaction can not be matched by any type of physical appearance evaluation. Therefore, chemical detection means are the most logical to pursue for in-vivo mode of detection. Thus, the combination of chemical detection with illuminated imaging would provide for an enhanced method of detection.
- an ingestible capsule for determining medical information from within the alimentary canal of a human or an animal including a non-digestible outer shell that is configured to pass through the alimentary canal.
- a lens housed within the outer shell are a lens, an illuminating LED, a filter, a CMOS imager, a transmitter, an antenna, and a miniature battery for powering the imager, the LED, and transmitter.
- a method for obtaining diagnostic medical information including the steps of ingesting a fluorescent dye, such as an antibody-labeled fluorescent dye, thereby tagging predetermined target tissue, ingesting a rinsing liquid to wash away nonspecific fluorescent dye, and ingesting a capsule, characterized as illuminating and imaging the predetermined target tissue.
- a fluorescent dye such as an antibody-labeled fluorescent dye
- a rinsing liquid to wash away nonspecific fluorescent dye
- ingesting a capsule characterized as illuminating and imaging the predetermined target tissue.
- FIG. 1 illustrates a cross-sectional view of an ingestible capsule according to the present invention
- FIG. 2 illustrates a simplified schematic circuit diagram of the ingestible capsule according to the present invention.
- FIG. 1 illustrates in simplified cross- sectional view an ingestible capsule according to the present invention. More specifically, illustrated in FIG.l, is an ingestible capsule, designated 10 and the manner in which the components housed with ingestible capsule 10 are interrelated in general.
- Ingestible capsule 10 typically comprises an optical dome 12, a lens 14, at least one illuminating LED 16, a filter 18, a CMOS imager 20, a transmitter 22, an antenna 24, and a power source 26, such as a miniature battery power source.
- Components 12, 14, 16, 18, 20 and 22 are interrelated to provide for the detection of a predetermined factor or condition, such as the presence of an enzyme, antigen, antibody, specific pH level, or the like. Illustrated in a schematic flow diagram, referenced FIG. 2, are steps 30 included in the method of obtaining diagnostic medical information from within the alimentary canal of a human or animal according to the present invention.
- a chemical dye material more specifically an ingestible fluorescent dye, such as an antibody- labeled dye, is ingested 32 by the patient.
- a fluorescent rinsing liquid is ingested 34 by the patient to wash away any non-specific fluorescent dye.
- This process provide for the dye labeling of specific tissue, that is pre-identified by the ingestion 32 of the chemical dye material, more particularly the fluorescent dye.
- ingestible capsule 10 is swallowed 36 by the patient similar to a conventional pill/capsule and propelled through the alimentary canal by natural contractions, called peristalsis.
- This propelling of capsule 10 through the alimentary canal provides for the collection 38 of image data.
- Illuminating LEDs 16 are fabricated to illuminate the alimentary canal, through the optical dome 12.
- Illuminating LEDs 16 provide the light to illuminate the inner walls of the alimentary canal as the capsule 10 passes therethrough.
- Lens 14 provides for the focusing of the light emitted from illuminating LEDs 16, back onto the imager 20.
- Filter 18 provides for the blocking out of excitation light and allow for the transmission of emitted fluorescent light from dye labeled tissue. Filter 18 serves to detect a fluorescence signal from the dye labeled tissue notifying imager 20 to respond.
- Low frequency transmitter 22 is then switched on upon the receipt of image data and is characterized as sending 40 a signal of the images to a receiver positioned outside the body. This presence of fluorescent labeled tissue which is imaged, means the presence of a predetermined factor or condition.
- capsule 10 is passed through the alimentary canal and exits the body, while image data is received and interpreted by medical professionals 42.
- capsule 10 is fabricated small enough to be easily swallowed by a human or animal.
- capsule 10 is fabricated to be approximately 30 mm as illustrated by reference X, by less than approximately 11mm as illustrated by reference Y. More specifically, capsule 10 is approximately less than ⁇ 1" long, by less than " wide and is fabricated of a sealed,
- non-digestible outer shell 11 that is shaped so as to easily pass through the alimentary canal.
- Capsule 10 does not include any external wires, fibers, optical bundles or cables, although it is anticipated that capsule 10 can additionally include further optical components, etc., to further aid in diagnosing. As previously stated, capsule 10 is propelled by peristalsis, or natural contractions, through the alimentary canal, or gastrointestinal tract, and does not require any pushing force to propel it through the bowel.
- biosensing in conjunction with fluorescence imaging.
- biosensing involves the use of biological materials, such as enzymes, cells, antibodies, antigens, or the like, that interact in ⁇ some manner when the biological material (receptor) comes into contact with the substance of interest in the tested sample.
- a fluorescent dye 32 and more particularly an antibody- labeled fluorescent dye, is utilized to detect and mark the existence of certain pre-identified condition or material.
- the step of ingesting an antibody-labeled fluorescent dye 32 provides for diagnosis of a specific condition, such as that indicative of a cancer precursor.
- an antibody-labeled fluorescent dye material is utilized, such as a semiconductor nanocrystal dye, for the purpose of in vivo labeling and serving as a staining agent for in-vivo fluorescence detection.
- Nanocrystal dyes can be made from different kinds of semiconductor material. Compared to organic dyes, nanocrystal dyes have several unique characters and advantages. First, the size and in some cases the shape of the nanocrystal particles can be controlled during manufacture. It is anticipated that in some instances, the size of the nanoparticles can be tailored to suit specific applications, more particularly, the size of the particles can be fabricated to either penetrate or not penetrate a particular cell.
- emission wavelength of the nanocrystal is size dependent, therefore by monitoring the emission wavelength of the nanocrystal, one can tell the size of the nanoparticles.
- any light with a wavelength shorter than the nanoparticle' s emission wavelength will contribute to its excitation. Therefore nanocrystal dyes, have a better excitation efficiency compared to that of organic dyes.
- nanocrystal dyes are more photostable than organic dyes .
- these fluorescent nanoparticles or dyes 32 can be used to label other cell types.
- the fluorescent nanoparticles can be used to selectively label muscle cells from a mixture of fibroblast cells, epithelial cells, etc. This has great implications for disease diagnostics in that any organ/structure of a human or animal consists of a mixture of cell types. In many cases, the abnormality of particular cell types has to be known before correct diagnostics.
- the advantage of cell labeling by nanoparticles can improve many traditional biological assays, such as apoptosis assay, immunological assays and in situ hybridization.
- the fluorescent nanocrystals are used in-vivo and are imaged by ingestible capsule 10.
- specific antibody or chemical tagged semiconductor nanocrystal dyes are ingested 32 and thus delivered to the alimentary canal.
- the fluorescent nanocrystal dyes are deposited either on a surface of the cancer tissue or actually penetrate into the cancer cell to stain the cell components.
- the unbonded nanocrystal dyes are then washed away by the ingesting of a rinsing agent 34.
- Capsule 10 travels through the alimentary canal and collects imaged data 38.
- the fluorescent tagged cancer tissue is detected by capsule 10, by imaging the fluorescent matter. This image data is transmitted 40 via transmitter 22 to a remotely positioned receiver.
- Sensing capsule 10 is ultimately passed 42 through the alimentary canal and exits the body.
- Image data provided by imager 22 is received by a remote receiver and interpreted by a medical professional 42 for diagnosis.
- numerous fluorescent dye materials 32 including antibody-labeled fluorescent dye materials, are utilized with differing marker properties, thereby serving as a diagnostic tool for a plurality of conditions, simultaneously.
- a positioning indicator (not shown) can optionally be included for the purpose of determining the exact position of the capsule 10 at any given time in the alimentary canal.
- an ingestible capsule including a small power source, such as a battery, a filtering means and an imager for the purpose of obtaining images of fluorescent tagged tissue is disclosed.
- the transmitter emits a signal to an externally located receiver as it travels through the alimentary canal, thereby providing for images of an identified predetermined substance of interest .
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Optics & Photonics (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Endoscopes (AREA)
Abstract
L'invention concerne une nouvelle capsule ingestible améliorée (10) et un procédé permettant de déterminer des informations médicales de l'intérieur du canal alimentaire d'un être humain ou d'un animal à l'aide d'une capsule ingestible comprenant une enveloppe extérieure non digestible (11). L'enveloppe extérieure renferme une lentille (14), une diode électroluminescente (16) d'éclairage, un filtre (18), un imageur (20), un émetteur (22), une antenne (24), et une batterie miniature (26) d'alimentation de l'imageur, de la diode électroluminescente et de l'émetteur. L'invention concerne un procédé amélioré permettant d'obtenir des informations médicales de diagnostic, consistant à ingérer (32) un colorant fluorescent, par exemple une matière colorante fluorescente étiquetée anticorps, marquant ainsi une région d'intérêt, à ingérer (34) un liquide de rinçage destiné à éliminer tout colorant fluorescent non spécifique, et à ingérer une capsule (36), se caractérisant par l'éclairage et la mise en images de la région d'intérêt marquée. Lorsque les images sont reçues, un émetteur basse fréquence, alimenté par une batterie miniature, envoie (40) un signal vidéo à l'extérieur du corps à un récepteur. Le signal transmis permet de générer des images de la région d'intérêt marquée.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002538823A JP2004522467A (ja) | 2000-10-30 | 2001-10-17 | 蛍光画像を映像送信する摂取可能カプセル |
| EP01981710A EP1331881A1 (fr) | 2000-10-30 | 2001-10-17 | Images fluorescentes de transmission video d'une capsule ingestible |
| AU2002213335A AU2002213335A1 (en) | 2000-10-30 | 2001-10-17 | Ingestible capsule video transmitting fluorescent images |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70294100A | 2000-10-30 | 2000-10-30 | |
| US09/702,941 | 2000-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| WO2002036007A1 true WO2002036007A1 (fr) | 2002-05-10 |
Family
ID=24823243
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/US2001/032420 WO2002036007A1 (fr) | 2000-10-30 | 2001-10-17 | Images fluorescentes de transmission video d'une capsule ingestible |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1331881A1 (fr) |
| JP (1) | JP2004522467A (fr) |
| AU (1) | AU2002213335A1 (fr) |
| WO (1) | WO2002036007A1 (fr) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10146197A1 (de) * | 2001-09-14 | 2003-04-03 | Storz Karl Gmbh & Co Kg | Intrakorporale Sonde zur Analyse oder Diagnose beispielsweise von Hohlorganen und Körperhöhlen im menschlichen oder tierischen Körper |
| WO2004112595A1 (fr) * | 2003-06-16 | 2004-12-29 | Siemens Aktiengesellschaft | Dispositif d'examen intracorporel a l'aide de lumiere |
| JP2005074034A (ja) * | 2003-09-01 | 2005-03-24 | Olympus Corp | カプセル型内視鏡 |
| WO2005103962A1 (fr) * | 2004-03-30 | 2005-11-03 | Eastman Kodak Company | Classification des images en fonction de la structure anatomique |
| JP2006507885A (ja) * | 2002-11-29 | 2006-03-09 | ギブン イメージング リミテッド | 生体内診断の方法、装置及びシステム |
| WO2007066288A3 (fr) * | 2005-12-07 | 2007-09-13 | Koninkl Philips Electronics Nv | Depistage gastro-intestinal electronique |
| US8089508B2 (en) | 2003-11-18 | 2012-01-03 | Olympus Corporation | Capsule type medical system |
| US8353821B2 (en) | 2007-05-08 | 2013-01-15 | Olympus Medical Systems Corp. | Capsule-type medical apparatus and method of manufacturing capsule-type medical apparatus |
| US8771176B2 (en) | 2006-07-24 | 2014-07-08 | Koninklijke Philips N.V. | Capsule camera with variable illumination of the surrounding tissue |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4278077A (en) * | 1978-07-27 | 1981-07-14 | Olympus Optical Co., Ltd. | Medical camera system |
| EP0667115A1 (fr) * | 1994-01-17 | 1995-08-16 | State Of Israel - Ministry Of Defence | Caméra vidéo à usage in-vivo |
| US6240312B1 (en) * | 1997-10-23 | 2001-05-29 | Robert R. Alfano | Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment |
| WO2001050941A2 (fr) * | 2000-01-13 | 2001-07-19 | Capsule View Inc. | Medicale encapsule, et procede associe |
-
2001
- 2001-10-17 WO PCT/US2001/032420 patent/WO2002036007A1/fr not_active Application Discontinuation
- 2001-10-17 AU AU2002213335A patent/AU2002213335A1/en not_active Abandoned
- 2001-10-17 JP JP2002538823A patent/JP2004522467A/ja active Pending
- 2001-10-17 EP EP01981710A patent/EP1331881A1/fr not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4278077A (en) * | 1978-07-27 | 1981-07-14 | Olympus Optical Co., Ltd. | Medical camera system |
| EP0667115A1 (fr) * | 1994-01-17 | 1995-08-16 | State Of Israel - Ministry Of Defence | Caméra vidéo à usage in-vivo |
| US6240312B1 (en) * | 1997-10-23 | 2001-05-29 | Robert R. Alfano | Remote-controllable, micro-scale device for use in in vivo medical diagnosis and/or treatment |
| WO2001050941A2 (fr) * | 2000-01-13 | 2001-07-19 | Capsule View Inc. | Medicale encapsule, et procede associe |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10146197B4 (de) * | 2001-09-14 | 2016-04-21 | Karl Storz Gmbh & Co. Kg | Intrakorporale Sonde zur Analyse oder Diagnose beispielsweise von Hohlorganen und Körperhöhlen im menschlichen oder tierischen Körper |
| WO2003024328A3 (fr) * | 2001-09-14 | 2003-07-17 | Storz Karl Gmbh & Co Kg | Sonde intracorporelle pour l'analyse, le diagnostic et/ou la therapie, par exemple d'organes creux ou de cavites organiques dans le corps humain ou animal |
| DE10146197A1 (de) * | 2001-09-14 | 2003-04-03 | Storz Karl Gmbh & Co Kg | Intrakorporale Sonde zur Analyse oder Diagnose beispielsweise von Hohlorganen und Körperhöhlen im menschlichen oder tierischen Körper |
| JP2006507885A (ja) * | 2002-11-29 | 2006-03-09 | ギブン イメージング リミテッド | 生体内診断の方法、装置及びシステム |
| WO2004112595A1 (fr) * | 2003-06-16 | 2004-12-29 | Siemens Aktiengesellschaft | Dispositif d'examen intracorporel a l'aide de lumiere |
| JP2005074034A (ja) * | 2003-09-01 | 2005-03-24 | Olympus Corp | カプセル型内視鏡 |
| US8089508B2 (en) | 2003-11-18 | 2012-01-03 | Olympus Corporation | Capsule type medical system |
| WO2005103962A1 (fr) * | 2004-03-30 | 2005-11-03 | Eastman Kodak Company | Classification des images en fonction de la structure anatomique |
| US7623690B2 (en) | 2004-03-30 | 2009-11-24 | Carestream Health, Inc. | System and method for classifying in vivo images according to anatomical structure |
| WO2007066288A3 (fr) * | 2005-12-07 | 2007-09-13 | Koninkl Philips Electronics Nv | Depistage gastro-intestinal electronique |
| US9417104B2 (en) | 2005-12-07 | 2016-08-16 | MEDIMETRICS Personalized Drug Delivery B.V. | Electronic gastrointestinal screening |
| US8771176B2 (en) | 2006-07-24 | 2014-07-08 | Koninklijke Philips N.V. | Capsule camera with variable illumination of the surrounding tissue |
| US9011321B2 (en) | 2006-07-24 | 2015-04-21 | Koninklijke Philips N.V. | Capsule camera with variable illumination of the surrounding tissue |
| US8353821B2 (en) | 2007-05-08 | 2013-01-15 | Olympus Medical Systems Corp. | Capsule-type medical apparatus and method of manufacturing capsule-type medical apparatus |
| US9538906B2 (en) | 2007-05-08 | 2017-01-10 | Olympus Corporation | Capsule-type medical apparatus and method of manufacturing capsule-type medical apparatus |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002213335A1 (en) | 2002-05-15 |
| EP1331881A1 (fr) | 2003-08-06 |
| JP2004522467A (ja) | 2004-07-29 |
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