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WO2003066830A3 - Anticorps monoclonaux humains diriges contre des proteines membranaires - Google Patents

Anticorps monoclonaux humains diriges contre des proteines membranaires Download PDF

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Publication number
WO2003066830A3
WO2003066830A3 PCT/US2003/003763 US0303763W WO03066830A3 WO 2003066830 A3 WO2003066830 A3 WO 2003066830A3 US 0303763 W US0303763 W US 0303763W WO 03066830 A3 WO03066830 A3 WO 03066830A3
Authority
WO
WIPO (PCT)
Prior art keywords
membrane proteins
monoclonal antibodies
screening
antibodies against
methods
Prior art date
Application number
PCT/US2003/003763
Other languages
English (en)
Other versions
WO2003066830A2 (fr
Inventor
Shaobing Hua
Michelle H Pauling
Li Zhu
Original Assignee
Genetastix Corp
Shaobing Hua
Michelle H Pauling
Li Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/071,866 external-priority patent/US20030165988A1/en
Priority claimed from US10/072,031 external-priority patent/US6766082B2/en
Application filed by Genetastix Corp, Shaobing Hua, Michelle H Pauling, Li Zhu filed Critical Genetastix Corp
Priority to AU2003209059A priority Critical patent/AU2003209059A1/en
Publication of WO2003066830A2 publication Critical patent/WO2003066830A2/fr
Publication of WO2003066830A3 publication Critical patent/WO2003066830A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés de criblage efficaces à haut rendement de banques d'anticorps dirigés contre des cibles protéiques, notamment des protéines membranaires. Cette invention concerne plus particulièrement des procédés de criblage d'une banque d'anticorps entièrement humains dirigés contre des protéines membranaires telles que des récepteurs de la chimiokine dans des levures. De manière plus particulière, on crible une banque d'anticorps monocaténaires humains dirigés contre des fragments peptidiques dérivés respectivement de domaines extracellulaires de CXCR4 et CCR5 humains et on sélectionne des anticorps monoclonaux à haute affinité dirigés contre CXCR4 et CCR5. Ces anticorps peuvent être utilisés en tant qu'agents prophylactiques ou thérapeutiques pour prévenir et traiter l'infection par le VIH, le cancer et d'autres maladies ou pathologies, ainsi que pour cribler des médicaments et diagnostiquer des maladies ou des pathologies associées aux interactions avec les protéines membranaires.
PCT/US2003/003763 2002-02-08 2003-02-07 Anticorps monoclonaux humains diriges contre des proteines membranaires WO2003066830A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003209059A AU2003209059A1 (en) 2002-02-08 2003-02-07 Human monoclonal antibodies against membrane proteins

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US10/071,866 US20030165988A1 (en) 2002-02-08 2002-02-08 High throughput generation of human monoclonal antibody against peptide fragments derived from membrane proteins
US10/072,031 2002-02-08
US10/072,031 US6766082B2 (en) 2000-10-18 2002-02-08 Waveguide-type optical device and manufacturing method therefor
US10/071,866 2002-02-08
US13397802A 2002-04-25 2002-04-25
US10/133,978 2002-04-25

Publications (2)

Publication Number Publication Date
WO2003066830A2 WO2003066830A2 (fr) 2003-08-14
WO2003066830A3 true WO2003066830A3 (fr) 2009-06-18

Family

ID=27738990

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/003763 WO2003066830A2 (fr) 2002-02-08 2003-02-07 Anticorps monoclonaux humains diriges contre des proteines membranaires

Country Status (2)

Country Link
AU (1) AU2003209059A1 (fr)
WO (1) WO2003066830A2 (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101044242B (zh) * 2004-06-10 2013-10-30 维文蒂阿生物技术股份有限公司 肿瘤特异性抗体
WO2006068646A1 (fr) * 2004-12-20 2006-06-29 Xiaoming Chen Méthodes d'identification et d'isolement d'anticorps spécifiques d'un épitope
WO2006089141A2 (fr) * 2005-02-18 2006-08-24 Dana-Farber Cancer Institute Anticorps contre cxcr4 et leurs procédés d'utilisation
TW200720289A (en) 2005-04-01 2007-06-01 Hoffmann La Roche Antibodies against CCR5 and uses thereof
US8628750B2 (en) 2006-02-27 2014-01-14 Technische Universitat Munchen Cancer imaging and treatment
TW200817438A (en) 2006-08-17 2008-04-16 Hoffmann La Roche A conjugate of an antibody against CCR5 and an antifusogenic peptide
EP2054086A1 (fr) 2006-08-17 2009-05-06 F. Hoffmann-Roche AG Conjugué d'un anticorps dirigé contre le ccr5 et peptide antifusiogène
BRPI0717512A2 (pt) 2006-09-29 2013-11-19 Hoffmann La Roche Anticorpos contra ccr5 e usos dos mesmos
US9512236B2 (en) 2006-12-19 2016-12-06 Ablynx N.V. Amino acid sequences directed against GPCRS and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
CL2008000707A1 (es) 2007-03-13 2008-09-22 Hoffmann La Roche Conjugado de polipeptidos antifusogenicos y polipeptidos derivados de la cabeza globular del factor del complemento c1q; composicion farmaceutica que lo comprende; su uso para tratar infecciones viricas; y metodo de produccion.
US7892546B2 (en) 2008-05-14 2011-02-22 Eli Lilly And Company Anti-CXCR4 antibodies
BRPI0911984A2 (pt) * 2008-05-16 2016-09-20 Ablynx Nv sequências de aminoácidos direncionadas contra cxcr4 e outros compostos gpcrs compreendendo os mesmos
EP2321351B1 (fr) * 2008-08-18 2017-11-01 Pfizer Inc. Anticorps anti-ccr2
US20110275535A1 (en) 2008-12-16 2011-11-10 Novartis Ag Yeast Display Systems
GB201002238D0 (en) 2010-02-10 2010-03-31 Affitech As Antibodies
EP2552962B1 (fr) 2010-03-26 2016-03-23 Ablynx N.V. Domaines variables uniques d'immunoglobulines dirigés contre cxcr7
US20150158948A9 (en) 2011-03-28 2015-06-11 Francis Descamps Bispecific anti-cxcr7 immunoglobulin single variable domains
CN102323423A (zh) * 2011-05-31 2012-01-18 昆明理工大学 检测曲妥珠影响MCF-7细胞中Trx-1蛋白表达的方法
ES2758884T3 (es) 2011-06-24 2020-05-06 Stephen D Gillies Proteínas de fusión de inmunoglobulina a través de cadena ligera y métodos de uso de ellas
WO2013024022A1 (fr) 2011-08-12 2013-02-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Méthodes et compositions pharmaceutiques pour traiter l'hypertension pulmonaire
US10787512B2 (en) 2013-03-15 2020-09-29 Salimetrics, Llc Melatonin monoclonal antibody, detection, methods and uses thereof
WO2017220988A1 (fr) 2016-06-20 2017-12-28 Kymab Limited Anticorps multispécifiques pour l'immuno-oncologie
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
CN112646833A (zh) 2020-11-05 2021-04-13 杭州阿诺生物医药科技有限公司 一种全人源抗体酵母展示技术的设计与构建
WO2023016454A1 (fr) * 2021-08-12 2023-02-16 The University Of Hong Kong Matériaux et procédés pour définir de manière complète des réponses immunitaires adaptatives
CN116731165B (zh) * 2023-03-23 2024-08-13 北京巴瑞医疗器械有限公司 一种抗血清素抗体及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869250A (en) * 1996-12-02 1999-02-09 The University Of North Carolina At Chapel Hill Method for the identification of peptides that recognize specific DNA sequences
WO1999028502A1 (fr) * 1997-11-28 1999-06-10 Invitrogen Corporation Reactifs de fusion d'anticorps monoclonal a chaine unique regulant une transcription in vivo

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869250A (en) * 1996-12-02 1999-02-09 The University Of North Carolina At Chapel Hill Method for the identification of peptides that recognize specific DNA sequences
WO1999028502A1 (fr) * 1997-11-28 1999-06-10 Invitrogen Corporation Reactifs de fusion d'anticorps monoclonal a chaine unique regulant une transcription in vivo

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
UEDA M.: "Genetic immobilization of proteins on the yeast cell surface", BIOTECHNOLOGY ADVANCES, vol. 18, 2000, pages 121 - 140, XP004205315, DOI: doi:10.1016/S0734-9750(00)00031-8 *

Also Published As

Publication number Publication date
AU2003209059A1 (en) 2003-09-02
WO2003066830A2 (fr) 2003-08-14
AU2003209059A8 (en) 2009-07-30

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