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WO2003014110A1 - Derive de benzazepine, son procede de preparation et d'utilisation - Google Patents

Derive de benzazepine, son procede de preparation et d'utilisation Download PDF

Info

Publication number
WO2003014110A1
WO2003014110A1 PCT/JP2002/008045 JP0208045W WO03014110A1 WO 2003014110 A1 WO2003014110 A1 WO 2003014110A1 JP 0208045 W JP0208045 W JP 0208045W WO 03014110 A1 WO03014110 A1 WO 03014110A1
Authority
WO
WIPO (PCT)
Prior art keywords
producing
same
benzazepine derivative
optionally substituted
aromatic ring
Prior art date
Application number
PCT/JP2002/008045
Other languages
English (en)
French (fr)
Inventor
Mitsuru Shiraishi
Masanori Baba
Masaki Seto
Yoshio Aramaki
Naoyuki Kanzaki
Naoki Miyamoto
Yuji Iizawa
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Priority to CA002456754A priority Critical patent/CA2456754A1/en
Priority to US10/486,002 priority patent/US7262185B2/en
Priority to EP02762752A priority patent/EP1422228A1/en
Publication of WO2003014110A1 publication Critical patent/WO2003014110A1/ja

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16Benzazepines; Hydrogenated benzazepines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/18Sulfonamides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
PCT/JP2002/008045 2001-08-08 2002-08-07 Derive de benzazepine, son procede de preparation et d'utilisation WO2003014110A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CA002456754A CA2456754A1 (en) 2001-08-08 2002-08-07 Benzazepine derivative, process for producing the same, and use
US10/486,002 US7262185B2 (en) 2001-08-08 2002-08-07 Benzazepine derivative, process for producing the same, and use
EP02762752A EP1422228A1 (en) 2001-08-08 2002-08-07 BENZAZEPINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND USE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001240718 2001-08-08
JP2001-240718 2001-08-08

Publications (1)

Publication Number Publication Date
WO2003014110A1 true WO2003014110A1 (fr) 2003-02-20

Family

ID=19071283

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/008045 WO2003014110A1 (fr) 2001-08-08 2002-08-07 Derive de benzazepine, son procede de preparation et d'utilisation

Country Status (4)

Country Link
US (1) US7262185B2 (ja)
EP (1) EP1422228A1 (ja)
CA (1) CA2456754A1 (ja)
WO (1) WO2003014110A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090320A3 (en) * 2004-03-12 2006-04-27 Wyeth Corp Triazole derivatives and method of using the same to treat hiv infections
US8480868B2 (en) 2005-08-05 2013-07-09 Bayer Healthcare Llc Method for distinguishing electrochemical sensors
US8993577B2 (en) 2009-02-20 2015-03-31 Astrazeneca Ab Cyclopropyl amide derivatives
US9012452B2 (en) 2010-02-18 2015-04-21 Astrazeneca Ab Processes for making cyclopropyl amide derivatives and intermediates associated therewith
US9029381B2 (en) 2007-08-22 2015-05-12 Astrazeneca Ab Cyclopropyl amide derivatives

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2483253A1 (en) * 2002-04-24 2003-11-06 Takeda Pharmaceutical Company Limited Use of compounds having ccr antagonism
WO2004069834A1 (ja) * 2003-02-07 2004-08-19 Takeda Pharmaceutical Company Limited 三環性化合物、その製造方法および用途
ES2441718T3 (es) * 2004-11-02 2014-02-06 Northwestern University Compuestos de piridazina, composiciones y métodos
JP4954085B2 (ja) 2004-12-06 2012-06-13 メディシノバ, インコーポレイテッド 神経障害性疼痛及びその関連する症状を治療するためのイブジラスト
US8158627B2 (en) * 2006-04-28 2012-04-17 Northwestern University Compositions and treatments using pyridazine compounds and cholinesterase inhibitors
TW200824693A (en) * 2006-08-28 2008-06-16 Jazz Pharmaceuticals Inc Pharmaceutical compositions of clonazepam and methods of use thereof
WO2008056356A2 (en) 2006-11-07 2008-05-15 Proteologics Ltd. Pyrimidine derivatives as posh and posh-ap inhibitors
US7638541B2 (en) 2006-12-28 2009-12-29 Metabolex Inc. 5-ethyl-2-{4-[4-(4-tetrazol-1-yl-phenoxymethyl)-thiazol-2-yl]-piperidin-1-yl}-pyrimidine
US20080181876A1 (en) * 2007-01-30 2008-07-31 Johnson Kirk W Methods for treating acute and subchronic pain
WO2008137012A1 (en) * 2007-05-03 2008-11-13 Avigen, Inc. Use of a glial attenuator to prevent amplified pain responses caused by glial priming
CA2693169C (en) 2007-07-19 2016-01-12 Metabolex, Inc. N-linked heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders
WO2011041154A1 (en) 2009-10-01 2011-04-07 Metabolex, Inc. Substituted tetrazol-1-yl-phenoxymethyl-thiazol-2-yl-piperidinyl-pyrimidine salts
ES2676209T3 (es) 2010-06-23 2018-07-17 Metabolex Inc. Composiciones de 5-etil-2-{4-[4-(4-tetrazol-1-il-fenoximetil)-tiazol-2-il]-piperidin-1-il}-pirimidina
JP6087836B2 (ja) 2011-01-11 2017-03-01 ディメリックス バイオサイエンス プロプライアタリー リミテッド 併用療法
CA3032432A1 (en) 2016-08-03 2018-02-08 Charles A. Mcwherter Oxymethylene aryl compounds for treating inflammatory gastrointestinal diseases or gastrointestinal conditions
WO2018103757A1 (zh) 2016-12-09 2018-06-14 广东众生药业股份有限公司 作为ccr2/ccr5受体拮抗剂的联苯化合物
ES2995012T3 (en) * 2019-06-24 2025-02-05 Wuxi Life Fountain Biotech Co Ltd Heterocyclo alkyl compounds used as ccr2/ccr5 antagonists
US11629196B2 (en) 2020-04-27 2023-04-18 Incelldx, Inc. Method of treating SARS-CoV-2-associated hypercytokinemia by administering a human monoclonal antibody (PRO-140) that inhibits CCR5/CCL5 binding interactions
WO2023143112A1 (zh) * 2022-01-26 2023-08-03 无锡瓴方生物医药科技有限公司 氮杂苯并八元环化合物的盐型、晶型及其应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032100A2 (en) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Pharmaceutical composition for antagonizing ccr5 comprising anilide derivative
WO1999032468A1 (en) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Anilide derivative, production and use thereof
WO2000037455A1 (en) * 1998-12-21 2000-06-29 Takeda Chemical Industries, Ltd. Benzothiepin-anilide derivatives, their production and their use for antagonizing ccr-5
WO2000076993A1 (fr) * 1999-06-16 2000-12-21 Takeda Chemical Industries, Ltd. Derives de benzazepine, procede de preparation de ces derives et utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6096780A (en) 1998-08-20 2000-08-01 Takeda Chemical Industries, Ltd. Quaternary ammonium salts and their use

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999032100A2 (en) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Pharmaceutical composition for antagonizing ccr5 comprising anilide derivative
WO1999032468A1 (en) * 1997-12-19 1999-07-01 Takeda Chemical Industries, Ltd. Anilide derivative, production and use thereof
WO2000037455A1 (en) * 1998-12-21 2000-06-29 Takeda Chemical Industries, Ltd. Benzothiepin-anilide derivatives, their production and their use for antagonizing ccr-5
WO2000076993A1 (fr) * 1999-06-16 2000-12-21 Takeda Chemical Industries, Ltd. Derives de benzazepine, procede de preparation de ces derives et utilisation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005090320A3 (en) * 2004-03-12 2006-04-27 Wyeth Corp Triazole derivatives and method of using the same to treat hiv infections
US7563905B2 (en) 2004-03-12 2009-07-21 Wyeth Triazole derivatives and method of using the same to treat HIV infections
US8480868B2 (en) 2005-08-05 2013-07-09 Bayer Healthcare Llc Method for distinguishing electrochemical sensors
US9029381B2 (en) 2007-08-22 2015-05-12 Astrazeneca Ab Cyclopropyl amide derivatives
US8993577B2 (en) 2009-02-20 2015-03-31 Astrazeneca Ab Cyclopropyl amide derivatives
US9012452B2 (en) 2010-02-18 2015-04-21 Astrazeneca Ab Processes for making cyclopropyl amide derivatives and intermediates associated therewith

Also Published As

Publication number Publication date
US7262185B2 (en) 2007-08-28
CA2456754A1 (en) 2003-02-20
EP1422228A1 (en) 2004-05-26
US20040235822A1 (en) 2004-11-25

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